Comparison of the effects of pyridine and its metabolites on rat liver and kidney

Toxicology Letters

Volumn 85, Issue 3, 1996, Pages 173-178

  Carlson, Gary P ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Kidney; Liver; Pyridine; Rat

Indexed keywords

ETHOXYRESORUFIN DEETHYLASE; IDITOL DEHYDROGENASE; OXYGENASE; PYRIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; LIVER TOXICITY; MALE; METABOLITE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; UREA NITROGEN BLOOD LEVEL;

EID: 0029886581     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(96)03660-0     Document Type: Article

References (26)

1. HSDB (Hazardous Substances Data Bank) (1994) Pyridine. National Library of Medicine, Bethesda, MD, 1994.
2. Schumacher, J.N., Green, C.R., Best, F.W. and Newell, M.P. (1977) Smoke composition: an extensive investigation of the water-soluble portion of cigarette smoke. J. Agric. Food Chem. 25, 310-320.
3. ATSDR (Agency for Toxic Substances and Disease Registry) (1992) Toxicological Profile for Pyridine. TP-91/24.
4. Baxter, J.H. and Mason, M.F. (1947) Studies of the mechanisms of liver and kidney injury. IV. A comparison of the effects of pyridine and methyl pyridinium chloride in the rat. J. Pharmacol. Exp. Ther. 91, 350-356.
5. Jori, A., Calamari, D., Cattabeni, F., Di Domenico, A., Galli, C.L., Galli, E. and Silano, V. (1983) Ecotoxicological profile of pyridine. Ecotoxicol. Environ. Safety 7, 251-275.
6. Reed, R.L. (1990) Pyridine. In: D.R. Buhler and D.J. Reed (Eds), Ethel Browning's Toxicity and Metabolism of Industrial Solvents, Vol. 2, Nitrogen and Phosphorus Solvents, Elsevier, Amsterdam, pp. 259-267.
7. Kaul, K.L. and Novak, R.F. (1987) Inhibition and induction of rabbit liver microsomal cytochrome P450 by pyridine. J. Pharmacol. Exp. Ther. 243, 384-390.
8. Carlson, G.P. and Day, B.J. (1992) Induction by pyridine of cytochrome P450IIE1 and xenobiotic metabolism in rat lung and liver. Pharmacology 44, 117-123.
9. Page, D.A. and Carlson, G.P. (1994) The effect of pyridine on the in vitro and in vivo metabolism of ethyl carbamate (urethane) by rat and mouse. Carcinogenesis 15, 2177-2181.
10. Kim, H., Putt, D., Reddy, S., Hollenberg, P.F. and Novak, R.F. (1993) Enhanced expression of rat hepatic CYP2B1/2B2 and 2E1 by pyridine: differential induction kinetics and molecular basis of expression. J. Pharmacol. Exp. Ther. 267, 927-936.
11. Iba, M.M., Ghosal, A., Thomas, P.E., Bennett, S. and Storch, A. (1993) Tissue microsomal P450 levels in rats exposed to acetone and pyridine. Toxicologist 13, 345.
12. Okuda, Y. (1959) Studies on the methylation of pyridine compound in animal organisms. III. The methylation pattern of pyridine in dog organisms dosed with pyridine. J. Biochem. 46, 967-971.
13. 14C]pyridine. Xenobiotica 10, 151-157.
14. Gorrod, J.W. and Damani, L.A. (1979) Some factors involved in the N-oxidation of 3-substituted pyridines by microsomal preparations in vitro. Xenobiotica 9, 209-218.
15. 14C]pyridine in vivo. Xenobiotica 12, 527-534.
16. 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica 19, 1013-1022.
17. Brazda, R.G. and Coulson, R.A. (1946) Toxicity of nicotinic acid and some of its derivatives. Proc. Soc. Exp. Biol. Med. 62, 19-20.
18. Kozlovskaya, N.E., Grishanova, A.Y., Mishin, V.M. and Lyakhovich, V.V. (1992) Effect of pyridine and pyridine N-oxide on the monooxygenase system of rat liver microsomes. Biochem.-Russia 57, 1104-1107.
19. Bergmann, E.D., Crane, F.E. and Fuoss, R.M. (1952) Experiments in the 1,2-di-(γ-pyridyl)-ethane series. J. Am. Chem. Soc. 74, 5979-5982.
20. Gerlach, U. (1963) Sorbitol Dehydrogenase. In: H.U. Bergmeyer (Ed), Methods in Enzymatic Analysis, Academic Press, New York, pp. 761-764.
21. Korsrud, G.O., Grice, H.C. and McLaughlan, J.M. (1972) Sensitivity of several serum enzymes in detecting carbon tetrachloride-induced liver damage in rats. Toxicol. Appl. Pharmacol. 22, 474-483.
22. Spayd, R.W., Bruschi, B., Burdick, B.A., Dappen, G.M., Eikenberry, J.N., Esders, T.W., Figueras, J., Goodhue, C.T., LaRossa, D.D., Nelson, R.W., Rand, R.N. and Wu, T.-W. (1978) Multilayer film elements for clinical analysis: applications to representative chemical determinations. Clin. Chem. 24, 1343-1350.
23. Reinke, L.A. and Moyer, M.J. (1985) p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab. Dispos. 13, 548-552.
24. Burke, M.D., Thompson, S., Elcombe, C.R., Halpert, J., Haaparanta, T. and Meyer, R.T. (1985) Ethoxy-, pentoxy-, and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem. Pharmacol. 34, 3337-3345.
25. Lowry, O.H., Rosebrough, J.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
26. Gorrod, J.W. and Damani, L.A. (1979) The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro. Xenobiotica 9, 219-226.