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Volumn 58, Issue SUPPL. 2, 1999, Pages 6-10

Mode of action of fluoroquinolones

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; CLINAFLOXACIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; DOUBLE STRANDED DNA; ENOXACIN; NORFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

EID: 0032705719     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199958002-00002     Document Type: Conference Paper
Times cited : (253)

References (38)
  • 1
    • 0014547446 scopus 로고
    • Escherichia coli K-12 mutants resistant to nalidixic acid: Genetic mapping and dominance studies
    • Hane MW, Wood TH. Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance studies. J Bacteriol 1969; 99: 238-41
    • (1969) J Bacteriol , vol.99 , pp. 238-241
    • Hane, M.W.1    Wood, T.H.2
  • 2
    • 0023906965 scopus 로고
    • Quinolone-resistant mutations of the gyrA gene of Escherichia coli
    • Yoshida H, Kojima T, Yamagishi J, et al. Quinolone-resistant mutations of the gyrA gene of Escherichia coli. Mol Gen Genet 1988; 211: 1-7
    • (1988) Mol Gen Genet , vol.211 , pp. 1-7
    • Yoshida, H.1    Kojima, T.2    Yamagishi, J.3
  • 3
    • 0024505441 scopus 로고
    • gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli
    • Nakamura S, Nakamura M, Kojima T, et al. gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob Agents Chemother 1989; 33: 254-5
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 254-255
    • Nakamura, S.1    Nakamura, M.2    Kojima, T.3
  • 4
    • 0025027077 scopus 로고
    • New topoisomerase essential for chromosome segregation in E. coli
    • Kato J, Nishimura Y, Imamura R, et al. New topoisomerase essential for chromosome segregation in E. coli. Cell 1990; 63: 393-404
    • (1990) Cell , vol.63 , pp. 393-404
    • Kato, J.1    Nishimura, Y.2    Imamura, R.3
  • 5
    • 0027939140 scopus 로고
    • Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition
    • Hoshino K, Kitamura A, Morrissey I, et al. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob Agents Chemother 1994; 38: 2623-7
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2623-2627
    • Hoshino, K.1    Kitamura, A.2    Morrissey, I.3
  • 6
    • 0029043097 scopus 로고
    • Analysis of gyrA and grlA mutations in step wise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus
    • Ferrero L, Cameron B, Crouzet J. Analysis of gyrA and grlA mutations in step wise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother 1995; 39: 1554-8
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1554-1558
    • Ferrero, L.1    Cameron, B.2    Crouzet, J.3
  • 7
    • 0027956736 scopus 로고
    • Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: A primary target of fluoroquinolones
    • Ferrero L, Cameron B, Manse B, et al. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol Microbiol 1994; 13: 641-53
    • (1994) Mol Microbiol , vol.13 , pp. 641-653
    • Ferrero, L.1    Cameron, B.2    Manse, B.3
  • 8
    • 0029824413 scopus 로고    scopus 로고
    • Quinolone resistance mutations in topoisomerase IV: Relationship of flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase the secondary target of fluoroquinolones in Staphylococcus aureus
    • Ng EY, Trucksis M, Hooper DC. Quinolone resistance mutations in topoisomerase IV: relationship of flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrob Agents Chemother 1996; 40: 1881-8
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1881-1888
    • Ng, E.Y.1    Trucksis, M.2    Hooper, D.C.3
  • 10
    • 0031020730 scopus 로고    scopus 로고
    • Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of parE gene encoding a subunit of topoisomerase IV
    • Breines DM, Ouabdesselam S, Ng EY, et al. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of parE gene encoding a subunit of topoisomerase IV. Antimicrob Agents Chemother 1997; 41: 175-9
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 175-179
    • Breines, D.M.1    Ouabdesselam, S.2    Ng, E.Y.3
  • 11
    • 0027489494 scopus 로고
    • Limitations of plasmid complementation test for determination of quinolone resistance due to changes in the gyrase A protein and identification of conditional quinolone resistance locus
    • Soussy CJ, Wolfson JS, Ng EY, et al. Limitations of plasmid complementation test for determination of quinolone resistance due to changes in the gyrase A protein and identification of conditional quinolone resistance locus. Antimicrob Agents Chemother 1993; 37: 2588-92
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2588-2592
    • Soussy, C.J.1    Wolfson, J.S.2    Ng, E.Y.3
  • 12
    • 0033081949 scopus 로고    scopus 로고
    • Mechanisms of quinolone resistance
    • Hooper DC. Mechanisms of quinolone resistance. Drug Resistance Updates 1999; 2: 38-55
    • (1999) Drug Resistance Updates , vol.2 , pp. 38-55
    • Hooper, D.C.1
  • 13
    • 0031982852 scopus 로고    scopus 로고
    • Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: Novel pleiotropic effects on quinolone and coumarin activity
    • Fournier B, Hooper DC. Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: Novel pleiotropic effects on quinolone and coumarin activity. Antimicrob Agents Chemother 1998; 42: 121-8
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 121-128
    • Fournier, B.1    Hooper, D.C.2
  • 14
    • 10544254692 scopus 로고    scopus 로고
    • Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases
    • Blanche F, Cameron B, Bernard FX, et al. Differential behaviors of Staphylococcus aureus and Escherichia coli type II DNA topoisomerases. Antimicrob Agents Chemother 1996; 40: 2714-20
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2714-2720
    • Blanche, F.1    Cameron, B.2    Bernard, F.X.3
  • 15
    • 0031046694 scopus 로고    scopus 로고
    • Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: Selective targeting of gyrase or topoisomerase IV by quinolones
    • Pan XS, Fisher LM. Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones. Antimicrob Agents Chemother 1997; 41: 471-4
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 471-474
    • Pan, X.S.1    Fisher, L.M.2
  • 16
    • 0031784975 scopus 로고    scopus 로고
    • DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae
    • Pan XS, Fisher LM. DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother 1998; 42: 2810-6
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2810-2816
    • Pan, X.S.1    Fisher, L.M.2
  • 17
    • 0032946666 scopus 로고    scopus 로고
    • Streptococcus pneumoniae DNA gyrase and topoisomerase IV: Overexpression, purification, and differential inhibition by fluoroquinolones
    • Pan XS, Fisher LM. Streptococcus pneumoniae DNA gyrase and topoisomerase IV: overexpression, purification, and differential inhibition by fluoroquinolones. Antimicrob Agents Chemother 1999; 43: 1129-36
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 1129-1136
    • Pan, X.S.1    Fisher, L.M.2
  • 18
    • 0345414745 scopus 로고    scopus 로고
    • The unique equipotency of sitafloxacin against topoisomerase IV and DNA gyrase from Streptococcus pneumoniae
    • Nov 15-17: Denver, USA
    • Morrissey I, George JT. The unique equipotency of sitafloxacin against topoisomerase IV and DNA gyrase from Streptococcus pneumoniae. Abstract from the 6th International Symposium on New Quinolones; 1998 Nov 15-17: Denver, USA
    • (1998) Abstract from the 6th International Symposium on New Quinolones
    • Morrissey, I.1    George, J.T.2
  • 19
    • 0032508046 scopus 로고    scopus 로고
    • Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
    • Cole ST, Brosch R, Parkhill J, et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998; 393: 537-44
    • (1998) Nature , vol.393 , pp. 537-544
    • Cole, S.T.1    Brosch, R.2    Parkhill, J.3
  • 20
    • 0032540874 scopus 로고    scopus 로고
    • Complete genome sequence of Treponema pallidum, the syphilis spirochete
    • Fraser CM, Norris SJ, Weinstock GM, et al. Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 1998; 281: 375-88
    • (1998) Science , vol.281 , pp. 375-388
    • Fraser, C.M.1    Norris, S.J.2    Weinstock, G.M.3
  • 21
    • 0030835739 scopus 로고    scopus 로고
    • The complete genome sequence of the gastric pathogen Helicobacter pylori
    • Tomb JF, White O, Kerlavage AR, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997; 388: 539-47
    • (1997) Nature , vol.388 , pp. 539-547
    • Tomb, J.F.1    White, O.2    Kerlavage, A.R.3
  • 22
    • 0030045003 scopus 로고    scopus 로고
    • Structure and mechanism of DNA topoisomerase II
    • Berger JM, Gamblin SJ, Harrison SC, et al. Structure and mechanism of DNA topoisomerase II. Nature 1996; 379: 225-32
    • (1996) Nature , vol.379 , pp. 225-232
    • Berger, J.M.1    Gamblin, S.J.2    Harrison, S.C.3
  • 23
    • 0000301456 scopus 로고    scopus 로고
    • Crystal structure of the breakage-reunion domain of DNA gyrase
    • Cabral JH, Jackson AP, Smith CV, et al. Crystal structure of the breakage-reunion domain of DNA gyrase. Nature 1997; 388: 903-6
    • (1997) Nature , vol.388 , pp. 903-906
    • Cabral, J.H.1    Jackson, A.P.2    Smith, C.V.3
  • 24
    • 0028068693 scopus 로고
    • Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein
    • Lewis RJ, Singh OM, Smith CV, et al. Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein. J Mol Biol 1994; 241: 128-30
    • (1994) J Mol Biol , vol.241 , pp. 128-130
    • Lewis, R.J.1    Singh, O.M.2    Smith, C.V.3
  • 25
    • 0032005064 scopus 로고    scopus 로고
    • Type II DNA topoisomerases
    • Berger JM. Type II DNA topoisomerases. Curr Opin Struct Biol 1998; 8: 26-32
    • (1998) Curr Opin Struct Biol , vol.8 , pp. 26-32
    • Berger, J.M.1
  • 26
    • 0027524110 scopus 로고
    • A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex
    • Willmott CJ, Maxwell A. A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex. Antimicrob Agents Chemother 1993; 37: 126-7
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 126-127
    • Willmott, C.J.1    Maxwell, A.2
  • 27
    • 0032947158 scopus 로고    scopus 로고
    • Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands
    • Fass D, Bogden CE, Berger JM. Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands. Nat Struct Biol 1999; 6: 322-6
    • (1999) Nat Struct Biol , vol.6 , pp. 322-326
    • Fass, D.1    Bogden, C.E.2    Berger, J.M.3
  • 28
    • 0024533317 scopus 로고
    • Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes
    • Shen LL, Kohlbrenner WE, Weigl D, et al. Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes. J Biol Chem 1989; 264: 2973-8
    • (1989) J Biol Chem , vol.264 , pp. 2973-2978
    • Shen, L.L.1    Kohlbrenner, W.E.2    Weigl, D.3
  • 29
    • 0030962482 scopus 로고    scopus 로고
    • Mechanism of quinolone action - A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV
    • Marians KJ, Hiasa H. Mechanism of quinolone action - a drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV. J Biol Chem 1997; 272: 9401-9
    • (1997) J Biol Chem , vol.272 , pp. 9401-9409
    • Marians, K.J.1    Hiasa, H.2
  • 30
    • 0029904283 scopus 로고    scopus 로고
    • DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase - DNA complex
    • Critchlow SE, Maxwell A. DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase - DNA complex. Biochemistry 1996; 35: 7387-93
    • (1996) Biochemistry , vol.35 , pp. 7387-7393
    • Critchlow, S.E.1    Maxwell, A.2
  • 31
    • 0032575610 scopus 로고    scopus 로고
    • Conformational changes in DNA gyrase revealed by limited proteolysis
    • Kampranis SC, Maxwell A. Conformational changes in DNA gyrase revealed by limited proteolysis. J Biol Chem 1998; 273: 22606-14
    • (1998) J Biol Chem , vol.273 , pp. 22606-22614
    • Kampranis, S.C.1    Maxwell, A.2
  • 32
    • 0032575668 scopus 로고    scopus 로고
    • The DNA gyrase-quinolone complex -ATP hydrolysis and the mechanism of DNA cleavage
    • Kampranis SC, Maxwell A. The DNA gyrase-quinolone complex -ATP hydrolysis and the mechanism of DNA cleavage. J Biol Chem 1998; 273: 22615-26
    • (1998) J Biol Chem , vol.273 , pp. 22615-22626
    • Kampranis, S.C.1    Maxwell, A.2
  • 33
    • 0030808667 scopus 로고    scopus 로고
    • The DNA cleavage reaction of DNA gyrase -comparison of stable ternary complexes formed with enoxacin and CcdB protein
    • Scheirer KE, Higgins NP. The DNA cleavage reaction of DNA gyrase -comparison of stable ternary complexes formed with enoxacin and CcdB protein. J Biol Chem 1997; 272: 27202-9
    • (1997) J Biol Chem , vol.272 , pp. 27202-27209
    • Scheirer, K.E.1    Higgins, N.P.2
  • 34
    • 0032538454 scopus 로고    scopus 로고
    • The mechanism of inhibition of topoisomerase IV by quinolone antibacterials
    • Khodursky AB, Cozzarelli NR. The mechanism of inhibition of topoisomerase IV by quinolone antibacterials. J Biol Chem 1998; 273: 27668-77
    • (1998) J Biol Chem , vol.273 , pp. 27668-27677
    • Khodursky, A.B.1    Cozzarelli, N.R.2
  • 35
    • 0029859964 scopus 로고    scopus 로고
    • DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex
    • Hiasa H, Yousef DO, Marians KJ. DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex. J Biol Chem 1996; 271: 26424-9
    • (1996) J Biol Chem , vol.271 , pp. 26424-26429
    • Hiasa, H.1    Yousef, D.O.2    Marians, K.J.3
  • 36
    • 0019119604 scopus 로고
    • DNA gyrase on the bacterial chromosome: Possibility of two levels of action
    • Drlica K, Engle EC, Manes SH. DNA gyrase on the bacterial chromosome: possibility of two levels of action. Proc Natl Acad Sci USA 1980; 77: 6879-83
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 6879-6883
    • Drlica, K.1    Engle, E.C.2    Manes, S.H.3
  • 37
    • 0342377454 scopus 로고    scopus 로고
    • Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation
    • Huang WM, Libbey JL, Van der Hoeven P, et al. Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation. Proc Natl Acad Sci USA 1998; 95: 4652-7
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4652-4657
    • Huang, W.M.1    Libbey, J.L.2    Van Der Hoeven, P.3
  • 38
    • 0028034698 scopus 로고
    • The complex of DNAgyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase
    • Willmott CJ, Critchlow SE, Eperon IC, et al. The complex of DNAgyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase. J Mol Biol 1994; 242: 351-63
    • (1994) J Mol Biol , vol.242 , pp. 351-363
    • Willmott, C.J.1    Critchlow, S.E.2    Eperon, I.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.