A polar radical pair pathway to assemble the pyrimidinone core of the HIV integrase inhibitor raltegravir potassium

Angewandte Chemie - International Edition

Volumn 47, Issue 22, 2008, Pages 4134-4136

  Pye, Philip J ^a   Zhong, Yong Li ^a   Jones, Gavin O ^b   Reamer, Robert A ^a   Houk, Kendall N ^b   Askin, David ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Density functional calculations; Heterocycles; Inhibitors; Pericyclic reaction; Radicals

Indexed keywords

CHEMICAL REACTIONS; POTASSIUM; SYNTHESIS (CHEMICAL);

DENSITY FUNCTIONAL CALCULATIONS; HETEROCYCLES; INHIBITORS; PERICYCLIC REACTION; RADICALS;

MECHANISMS;

INTEGRASE INHIBITOR; ORGANIC COMPOUND; POTASSIUM; PYRIMIDINONE DERIVATIVE; RALTEGRAVIR;

ARTICLE; CHEMISTRY; SYNTHESIS;

HIV INTEGRASE INHIBITORS; ORGANIC CHEMICALS; POTASSIUM; PYRIMIDINONES;

EID: 47049102883     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200703681     Document Type: Article

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