Microwave assisted combinatorial chemistry. Synthesis of substituted pyridines

Tetrahedron Letters

Volumn 39, Issue 10, 1998, Pages 1117-1120

  Cotterill, Ian C ^a   Usyatinsky, Alexander Ya ^a   Arnold, John M ^a   Clark, Douglas S ^b   Dordick, Jonathan S ^c   Michels, Peter C ^a   Khmelnitsky, Yuri L ^a  

^a EnzyMed Inc   (United States)

^b University of California   (United States)

^c University of Iowa ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; MICROWAVE RADIATION; REACTION ANALYSIS; REACTION TIME; TECHNOLOGY;

EID: 0032485313     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10796-1     Document Type: Article

References (21)

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16. 12. Note that in the case of nonsymmetrical cyclic 1,3-dicarbonyl compounds such as 10 six distinct pyridine derivatives can potentially be formed, including regioisomers that cannot be distinguished by MS analysis.
17. 13. Analyses were performed on a Perkin Elmer SCIEX API100 electrospray LC/MS system with thermo ion spray ionization. Column: IB-SIL 3 μm C18, 2 × 100 mm. Gradient 20% MeCN in water to 100% MeCN in 20 minutes, flow rate 0.4 ml/min. UV detection at 260 nm.
18. 14. In a separate experiment it was confirmed that the starting reagents were fully stable under reaction conditions, and therefore their absence in the final product indicates that they completely reacted rather than decomposed under microwave irradiation.
19. 12
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