Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 513-517

  Enyedy, Istvan J ^a   Sakamuri, Sukumar ^a   Zaman, Wahiduz A ^b   Johnson, Kenneth M ^b   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DOPAMINE TRANSPORTER; DOPAMINE TRANSPORTER INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DATA BASE; DOPAMINE UPTAKE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; CARRIER PROTEINS; COCAINE; DATABASES, PROTEIN; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; DRUG DESIGN; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NERVE TISSUE PROTEINS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN BINDING; PYRIDINES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 0037328212     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00943-5     Document Type: Article

References (19)

1. Chen N., Reith M.E.A. Eur. J. Pharmacol. 405:2000;32939.
2. Carroll F.I., Howell L.L., Kuhar M.J. J. Med. Chem. 42:1999;2721.
3. van Vliet L.A., Rodenhuis N., Wikström H. J. Med. Chem. 43:2000;3549.
4. Wang S., Sakamuri S., Enyedy I.J., Kozikowski A.P., Deschaux O., Bandyopadhyay B.C., Tella S.R., Zaman W.A., Johnson K.M. J. Med. Chem. 43:2000;351.
5. Volkow N.D., Fowler J.S., Wang G.-J. J. Psychopharmacol. 13:1999;337.
6. Sakamuri S., Enyedy I.J., Kozikowski A.P., Zaman W.A., Johnson K.M., Wang S. Bioorg. Med. Chem. Lett. 11:2001;495.
7. Enyedy I.J., Zaman W.A., Sakamuri S., Kozikowski A.P., Johnson K.M., Wang S. Bioorg. Med. Chem. Lett. 11:2001;1113.
8. Enyedy I.J., Wang J., Zaman W.A., Johnson K.M., Wang S. Bioorg. Med. Chem. Lett. 12:2002;1775.
9. Wang S., Sakamuri S., Enyedy I.J., Kozikowski A.P., Zaman W.A., Johnson K.M. Bioorg. Med. Chem. 9:2001;1753.
10. Sakamuri S., Enyedy I.J., Kozikowski A.P., Wang S. Tetrahedron Lett. 41:2000;9949.
11. Hoffman B.T., Kopajtic T., Katz J.L., Newman A.H. J. Med. Chem. 43:2000;4151.
12. Kozikowski A.P., Saiah M.K.E., Johnson K.M., Bergmann J.S. J. Med. Chem. 38:1995;3086.
13. Sakamuri, S.; Enyedy, I. J.; Zaman, W. A.; Tella, S. R.; Kozikowski, A. P.; Flippen-Anderson, J. L.; Farkas, T.; Johnson, K. M.; Wang, S. Bioorg. Med. Chem. In press.
14. Kitayama S., Shimada S., Xu H., Markham L., Donovan D.M., Uhl G.R. Proc. Natl. Acad. Sci. U.S.A. 89:1992;7782.
15. Itokawa M., Lin Z., Cai N.-S., Wu C., Kitayama S., Wang J.-B., Uhl G.R. Mol. Pharmacol. 57:2000;1093.
16. Meltzer P.C., Blundell P., Gonzalez M.D., Chen Z., George C., Madras B.K. J. Med. Chem. 40:1997;2661.
17. Milne G.W.A., Nicklaus M.C., Driscoll J.S., Wang S., Zaharevitz D.W. J. Chem. Inf. Comput. Sci. 34:1994;1219.
18. Chem-X version 96; Oxford Molecular Group, Inc.: Hunt Valley, MD 21030, 2001.
19. Zhang A., Zhou G., Hoepping A., Mukhopadhyaya J., Johnson K.M., Zhang M., Kozikowski A.P. J. Med. Chem. 45:2002;1930.