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Volumn 30, Issue 8, 2013, Pages 369-385

Significance of the anti-aging protein Klotho

Author keywords

Aging; Calcium homeostasis; Fibroblast growth factor; Klotho; Parathyroid hormone (PTH); Phosphate; Vitamin D

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CELL SURFACE RECEPTOR; DENTIN MATRIX PROTEIN 1; FIBROBLAST GROWTH FACTOR 23; HUMORAL ANTIBODY; INSULIN; KLOTHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARATHYROID HORMONE; PHOSPHATE; PROTEIN SHC; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM PHOSPHATE COTRANSPORTER 2; SOMATOMEDIN C; STAT1 PROTEIN; VANILLOID RECEPTOR 5; VITAMIN D;

EID: 84888594511     PISSN: 09687688     EISSN: 14645203     Source Type: Journal    
DOI: 10.3109/09687688.2013.837518     Document Type: Review
Times cited : (56)

References (134)
  • 4
    • 84864781443 scopus 로고    scopus 로고
    • FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway
    • AndrukhovaO, ZeitzU, GoetzR, et al. 2012. FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway. Bone 51:621-628.
    • (2012) Bone , vol.51 , pp. 621-628
    • Zeitzu Goetzr, A.1
  • 5
    • 84856530695 scopus 로고    scopus 로고
    • Klotho lacks a vitamin D independent physiological role in glucose homeosta-sis, bone turnover, and steady-state PTH secretion in vivo
    • Anour R, Andrukhova O, Ritter E, et al. 2012. Klotho lacks a vitamin D independent physiological role in glucose homeosta-sis, bone turnover, and steady-state PTH secretion in vivo. PLoS ONE 7:e31376.
    • (2012) PLoS ONE , vol.7
    • Anour, R.1    Andrukhova, O.2    Ritter, E.3
  • 6
    • 33745213611 scopus 로고    scopus 로고
    • Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues
    • Arai E, Kanai Y, Ushijima S, et al. 2006. Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues. Int J Cancer 119:288-296.
    • (2006) Int J Cancer , vol.119 , pp. 288-296
    • Arai, E.1    Kanai, Y.2    Ushijima, S.3
  • 7
    • 9244240970 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders
    • DOI 10.1210/en.2004-0233
    • Bai X, Miao D, Li J, et al. 2004. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 145:5269-5279. (Pubitemid 39551149)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 5269-5279
    • Bai, X.1    Miao, D.2    Li, J.3    Goltzman, D.4    Karaplis, A.C.5
  • 8
    • 77951920659 scopus 로고    scopus 로고
    • Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23
    • Bergwitz C, Juppner H. 2010. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 61:91-104.
    • (2010) Annu Rev Med , vol.61 , pp. 91-104
    • Bergwitz, C.1    Juppner, H.2
  • 9
    • 59849097605 scopus 로고    scopus 로고
    • Novel mechanisms in the regulation of phosphorus homeostasis
    • Berndt T, Kumar R. 2009. Novel mechanisms in the regulation of phosphorus homeostasis. Physiology (Bethesda) 24:17-25.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 17-25
    • Berndt, T.1    Kumar, R.2
  • 10
    • 79958799468 scopus 로고    scopus 로고
    • Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum-and glucocorticoid-inducible kinase 3
    • Bhandaru M, Kempe DS, Rotte A, et al. 2011. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum-and glucocorticoid-inducible kinase 3. Kidney Int 80:61-67.
    • (2011) Kidney Int , vol.80 , pp. 61-67
    • Bhandaru, M.1    Kempe, D.S.2    Rotte, A.3
  • 12
    • 78651431471 scopus 로고    scopus 로고
    • Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility
    • Camilli TC, Xu M, O'Connell MP, et al. 2011. Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res 24:175-186.
    • (2011) Pigment Cell Melanoma Res , vol.24 , pp. 175-186
    • Camilli, T.C.1    Xu, M.2    O'Connell, M.P.3
  • 13
    • 84877097764 scopus 로고    scopus 로고
    • Osteoporosis and adynamic bone in chronic kidney disease
    • Cannata-Andia JB, Rodriguez GM, Gomez AC. 2012. Osteoporosis and adynamic bone in chronic kidney disease. J Nephrol 26 (1):73-80.
    • (2012) J Nephrol , vol.26 , Issue.1 , pp. 73-80
    • Cannata-Andia, J.B.1    Rodriguez, G.M.2    Gomez, A.C.3
  • 15
    • 27144440831 scopus 로고    scopus 로고
    • Cell signalling: The β-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
    • DOI 10.1126/science.1114245
    • Chang Q, Hoefs S, van der Kemp AW, et al. 2005. The beta-glu-curonidase klotho hydrolyzes and activates the TRPV5 channel. Science 310:490-493. (Pubitemid 41507962)
    • (2005) Science , vol.310 , Issue.5747 , pp. 490-493
    • Chang, Q.1    Hoefs, S.2    Van Der Kemp, A.W.3    Topala, C.N.4    Bindels, R.J.5    Hoenderop, J.G.6
  • 16
    • 84867133607 scopus 로고    scopus 로고
    • Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner
    • Chen B, Ma X, Liu S, et al. 2012. Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner. Cancer Biol Ther 13:1221-1228.
    • (2012) Cancer Biol Ther , vol.13 , pp. 1221-1228
    • Chen, B.1    Ma, X.2    Liu, S.3
  • 17
    • 38049144010 scopus 로고    scopus 로고
    • Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
    • Chen CD, Podvin S, Gillespie E, et al. 2007. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA 104:19796-19801.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19796-19801
    • Chen, C.D.1    Podvin, S.2    Gillespie, E.3
  • 18
    • 84874868426 scopus 로고    scopus 로고
    • Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma
    • Chen L, Liu H, Liu J, et al. 2013. Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. PLoS ONE 8:e58413.
    • (2013) PLoS ONE , vol.8
    • Chen, L.1    Liu, H.2    Liu, J.3
  • 20
    • 33947716172 scopus 로고    scopus 로고
    • Endothelial function and dysfunction: Testing and clinical relevance
    • DOI 10.1161/CIRCULATIONAHA.106.652859, PII 0000301720070313000017
    • Deanfield JE, Halcox JP, Rabelink TJ. 2007. Endothelial function and dysfunction: Testing and clinical relevance. Circulation 115:1285-1295. (Pubitemid 46594773)
    • (2007) Circulation , vol.115 , Issue.10 , pp. 1285-1295
    • Deanfield, J.E.1    Halcox, J.P.2    Rabelink, T.J.3
  • 21
    • 80052083885 scopus 로고    scopus 로고
    • Down-regulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho
    • Dermaku-Sopjani M, Sopjani M, Saxena A, et al. 2011. Down-regulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Cell Physiol Biochem 28:251-258.
    • (2011) Cell Physiol Biochem , vol.28 , pp. 251-258
    • Dermaku-Sopjani, M.1    Sopjani, M.2    Saxena, A.3
  • 22
    • 48249123181 scopus 로고    scopus 로고
    • Increased inorganic phosphate induces human endothelial cell apoptosis in vitro
    • Di Marco GS, Hausberg M, Hillebrand U, et al. 2008. Increased inorganic phosphate induces human endothelial cell apoptosis in vitro. Am J Physiol Renal Physiol 294:F1381-F1387.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Di Marco, G.S.1    Hausberg, M.2    Hillebrand, U.3
  • 23
    • 79953138206 scopus 로고    scopus 로고
    • Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    • Doi S, Zou Y, Togao O, et al. 2011. Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286:8655-8665.
    • (2011) J Biol Chem , vol.286 , pp. 8655-8665
    • Doi, S.1    Zou, Y.2    Togao, O.3
  • 24
    • 80555148939 scopus 로고    scopus 로고
    • FGF23 induces left ventricular hypertrophy
    • Faul C, Amaral AP, Oskouei B, et al. 2011. FGF23 induces left ventricular hypertrophy. J Clin Invest 121:4393-4408.
    • (2011) J Clin Invest , vol.121 , pp. 4393-4408
    • Faul, C.1    Amaral, A.P.2    Oskouei, B.3
  • 25
    • 79955608900 scopus 로고    scopus 로고
    • PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria
    • Foller M, Kempe DS, Boini KM, et al. 2011. PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria. J Am Soc Nephrol 22:873-880.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 873-880
    • Foller, M.1    Kempe, D.S.2    Boini, K.M.3
  • 26
    • 44449148691 scopus 로고    scopus 로고
    • Oxidative stress, DNA methylation and carcinogenesis
    • Franco R, Schoneveld O, Georgakilas AG, et al. 2008. Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett 266:6-11.
    • (2008) Cancer Lett , vol.266 , pp. 6-11
    • Franco, R.1    Schoneveld, O.2    Georgakilas, A.G.3
  • 27
    • 0036019481 scopus 로고    scopus 로고
    • Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin
    • DOI 10.1097/00041552-200207000-00003
    • Fukumoto S, Yamashita T. 2002. Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin. Curr Opin Nephrol Hypertens 11:385-389. (Pubitemid 34734616)
    • (2002) Current Opinion in Nephrology and Hypertension , vol.11 , Issue.4 , pp. 385-389
    • Fukumoto, S.1    Yamashita, T.2
  • 28
    • 68049085792 scopus 로고    scopus 로고
    • FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypopho-sphatemia in vivo predominantly via FGF receptor 1
    • Gattineni J, Bates C, Twombley K, et al. 2009. FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypopho-sphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol 297:F282-F291.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Gattineni, J.1    Bates, C.2    Twombley, K.3
  • 29
    • 77951259224 scopus 로고    scopus 로고
    • Regulation of phosphate transport by fibroblast growth factor 23 (FGF23): Implications for disorders of phosphate metabolism
    • Gattineni J, Baum M. 2010. Regulation of phosphate transport by fibroblast growth factor 23 (FGF23): Implications for disorders of phosphate metabolism. Pediatr Nephrol 25:591-601.
    • (2010) Pediatr Nephrol , vol.25 , pp. 591-601
    • Gattineni, J.1    Baum, M.2
  • 30
    • 0025826461 scopus 로고
    • Hyperphosphataemia and hypocalcaemia induced by hypertonic phosphate enema-an experimental study and review of the literature
    • Grosskopf I, Graff E, Charach G, et al. 1991. Hyperphosphataemia and hypocalcaemia induced by hypertonic phosphate enema-an experimental study and review of the literature. Hum Exp Toxicol 10:351-355.
    • (1991) Hum Exp Toxicol , vol.10 , pp. 351-355
    • Grosskopf, I.1    Graff, E.2    Charach, G.3
  • 31
    • 84873263662 scopus 로고    scopus 로고
    • A study of the association between serum bone-specific alkaline phosphatase and serum phosphorus concentration or dietary phosphorus intake
    • Haraikawa M, Tanabe R, Sogabe N, et al. 2012. A study of the association between serum bone-specific alkaline phosphatase and serum phosphorus concentration or dietary phosphorus intake. J Nutr Sci Vitaminol (Tokyo) 58:442-445.
    • (2012) J Nutr Sci Vitaminol (Tokyo) , Issue.58 , pp. 442-445
    • Haraikawa, M.1    Tanabe, R.2    Sogabe, N.3
  • 34
    • 84858128980 scopus 로고    scopus 로고
    • The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis
    • Haussler MR, Whitfield GK, Kaneko I, et al. 2012. The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis. Rev Endocr Metab Disord 13:57-69.
    • (2012) Rev Endocr Metab Disord , vol.13 , pp. 57-69
    • Haussler, M.R.1    Whitfield, G.K.2    Kaneko, I.3
  • 35
    • 56949101730 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fe-toprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention
    • Ho HK, Pok S, Streit S, et al. 2009. Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fe-toprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention. J Hepatol 50:118-127.
    • (2009) J Hepatol , vol.50 , pp. 118-127
    • Ho, H.K.1    Pok, S.2    Streit, S.3
  • 36
    • 79952117128 scopus 로고    scopus 로고
    • The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging
    • Hsieh CC, Kuro-o M, Rosenblatt KP, et al. 2010. The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY) 2:597-611.
    • (2010) Aging (Albany NY) , vol.2 , pp. 597-611
    • Hsieh, C.C.1    Kuro-O, M.2    Rosenblatt, K.P.3
  • 37
    • 77956642900 scopus 로고    scopus 로고
    • Klotho: A novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    • Hu MC, Shi M, Zhang J, et al. 2010a. Klotho: A novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 24:3438-3450.
    • (2010) FASEB J , vol.24 , pp. 3438-3450
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 38
    • 78651408919 scopus 로고    scopus 로고
    • Klotho deficiency causes vascular calcification in chronic kidney disease
    • Hu MC, Shi M, Zhang J, et al. 2011. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 22:124-136.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 124-136
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 39
    • 78649642147 scopus 로고    scopus 로고
    • Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective
    • Hu MC, Shi M, Zhang J, et al. 2010b. Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int 78:1240-1251.
    • (2010) Kidney Int , vol.78 , pp. 1240-1251
    • Hu, M.C.1    Shi, M.2    Zhang, J.3
  • 43
    • 34250803923 scopus 로고    scopus 로고
    • Alpha-Klotho as a regulator of calcium homeostasis
    • Imura A, Tsuji Y, Murata M, et al. 2007. Alpha-Klotho as a regulator of calcium homeostasis. Science 316:1615-1618.
    • (2007) Science , vol.316 , pp. 1615-1618
    • Imura, A.1    Tsuji, Y.2    Murata, M.3
  • 44
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • DOI 10.1016/j.tig.2004.08.007, PII S0168952504002410
    • Itoh N, Ornitz DM. 2004. Evolution of the Fgf and Fgfr gene families. Trends Genet 20:563-569. (Pubitemid 39314564)
    • (2004) Trends in Genetics , vol.20 , Issue.11 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 45
    • 58349089452 scopus 로고    scopus 로고
    • High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling
    • Jin H, Xu CX, Lim HT, et al. 2009. High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling. Am J Respir Crit Care Med 179:59-68.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 59-68
    • Jin, H.1    Xu, C.X.2    Lim, H.T.3
  • 46
    • 79959334891 scopus 로고    scopus 로고
    • Role of Klotho in aging, phosphate metabolism, and CKD
    • John GB, Cheng CY, Kuro-o M. 2011. Role of Klotho in aging, phosphate metabolism, and CKD. Am J Kidney Dis 58:127-134.
    • (2011) Am J Kidney Dis , vol.58 , pp. 127-134
    • John, G.B.1    Cheng, C.Y.2    Kuro-O, M.3
  • 47
    • 84861577327 scopus 로고    scopus 로고
    • 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D
    • Jones G, Prosser DE, Kaufmann M. 2012. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys 523:9-18.
    • (2012) Arch Biochem Biophys , vol.523 , pp. 9-18
    • Jones, G.1    Prosser, D.E.2    Kaufmann, M.3
  • 49
    • 67649559522 scopus 로고    scopus 로고
    • Accelerated suicidal erythrocyte death in Klotho-deficient mice
    • Kempe DS, Ackermann TF, Fischer SS, et al. 2009. Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch 458:503-512.
    • (2009) Pflugers Arch , vol.458 , pp. 503-512
    • Kempe, D.S.1    Ackermann, T.F.2    Fischer, S.S.3
  • 52
    • 0037136563 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
    • Kops GJ, Dansen TB, Polderman PE, et al. 2002. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316-321.
    • (2002) Nature , vol.419 , pp. 316-321
    • Kops, G.J.1    Dansen, T.B.2    Polderman, P.E.3
  • 53
    • 79953268951 scopus 로고    scopus 로고
    • Phosphate and Klotho
    • Kuro O. 2011. Phosphate and Klotho. Kidney Int Suppl S20-S23.
    • (2011) Kidney Int Suppl
    • Kuro, O.1
  • 54
    • 84862149482 scopus 로고    scopus 로고
    • Klotho in health and disease
    • Kuro O. 2012. Klotho in health and disease. Curr Opin Nephrol Hypertens 21:362-368.
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 362-368
    • Kuro, O.1
  • 55
    • 73749087404 scopus 로고    scopus 로고
    • Klotho
    • Kuro-o M. 2010. Klotho. Pflugers Arch 459:333-343.
    • (2010) Pflugers Arch , vol.459 , pp. 333-343
    • Kuro-O, M.1
  • 60
    • 0034722911 scopus 로고    scopus 로고
    • Effect of serum on human bone marrow stromal cells: Ex vivo expansion and in vivo bone formation
    • Kuznetsov SA, Mankani MH, Robey PG. 2000. Effect of serum on human bone marrow stromal cells: ex vivo expansion and in vivo bone formation. Transplantation 70:1780-1787. (Pubitemid 32064834)
    • (2000) Transplantation , vol.70 , Issue.12 , pp. 1780-1787
    • Kuznetsov, S.A.1    Mankani, M.H.2    Robey, P.G.3
  • 61
    • 3042634460 scopus 로고    scopus 로고
    • Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis
    • DOI 10.1210/en.2003-1768
    • Larsson T, Marsell R, Schipani E, et al. 2004. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145:3087-3094. (Pubitemid 38829975)
    • (2004) Endocrinology , vol.145 , Issue.7 , pp. 3087-3094
    • Larsson, T.1    Marsell, R.2    Schipani, E.3    Ohlsson, C.4    Ljunggren, O.5    Tenenhouse, H.S.6    Juppner, H.7    Jonsson, K.B.8
  • 62
    • 77952248261 scopus 로고    scopus 로고
    • The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma
    • Lee J, Jeong DJ, Kim J, et al. 2010. The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer 9:109.
    • (2010) Mol Cancer , vol.9 , pp. 109
    • Lee, J.1    Jeong, D.J.2    Kim, J.3
  • 63
    • 84872145334 scopus 로고    scopus 로고
    • Klotho gene attenuates the progression of hypertension and heart damage in spontaneous hypertensive rats
    • Li BS, Ma HX, Wang YJ, et al. 2012. [Klotho gene attenuates the progression of hypertension and heart damage in spontaneous hypertensive rats]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:662-668.
    • (2012) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.29 , pp. 662-668
    • Li, B.S.1    Ma, H.X.2    Wang, Y.J.3
  • 64
    • 84860778116 scopus 로고    scopus 로고
    • Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    • Lim K, Lu TS, Molostvov G, et al. 2012. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation 125:2243-2255.
    • (2012) Circulation , vol.125 , pp. 2243-2255
    • Lim, K.1    Lu, T.S.2    Molostvov, G.3
  • 70
    • 0242563912 scopus 로고    scopus 로고
    • Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content
    • Lotscher M, Kaissling B, Biber J, et al. 1997. Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content. J Clin Invest 99:1302-1312. (Pubitemid 27142768)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.6 , pp. 1302-1312
    • Lotscher, M.1    Kaissling, B.2    Biber, J.3    Murer, H.4    Levi, M.5
  • 71
    • 54149087686 scopus 로고    scopus 로고
    • The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6
    • Lu P, Boros S, Chang Q, et al. 2008. The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6. Nephrol Dial Transplant 23:3397-3402.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3397-3402
    • Lu, P.1    Boros, S.2    Chang, Q.3
  • 72
    • 70149098681 scopus 로고    scopus 로고
    • Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation
    • Maekawa Y, Ishikawa K, Yasuda O, et al. 2009. Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine 35:341-346.
    • (2009) Endocrine , vol.35 , pp. 341-346
    • Maekawa, Y.1    Ishikawa, K.2    Yasuda, O.3
  • 74
    • 84856720641 scopus 로고    scopus 로고
    • Regulation and function of the FGF23/klotho endocrine pathways
    • Martin A, David V, Quarles LD. 2012. Regulation and function of the FGF23/klotho endocrine pathways. Physiol Rev 92:131-155.
    • (2012) Physiol Rev , vol.92 , pp. 131-155
    • Martin, A.1    David, V.2    Quarles, L.D.3
  • 78
    • 79960144041 scopus 로고    scopus 로고
    • The inflammatory cytokines TWEAK and TNFalpha reduce renal klotho expression through NFkappaB
    • Moreno JA, Izquierdo MC, Sanchez-Nino MD, et al. 2011. The inflammatory cytokines TWEAK and TNFalpha reduce renal klotho expression through NFkappaB. J Am Soc Nephrol 22:1315-1325.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1315-1325
    • Moreno, J.A.1    Izquierdo, M.C.2    Sanchez-Nino, M.D.3
  • 79
    • 79952277289 scopus 로고    scopus 로고
    • Phosphate transport in the kidney
    • Murer H, Biber J. 2010. Phosphate transport in the kidney. J Nephrol 23(Suppl 16):S145-S151.
    • (2010) J Nephrol , vol.23 , Issue.SUPPL. 16
    • Murer, H.1    Biber, J.2
  • 80
    • 18244392685 scopus 로고    scopus 로고
    • Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone
    • DOI 10.1101/gad.1276205
    • Murshed M, Harmey D, Millan JL, et al. 2005. Unique coexpres-sion in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 19:1093-1104. (Pubitemid 40632454)
    • (2005) Genes and Development , vol.19 , Issue.9 , pp. 1093-1104
    • Murshed, M.1    Harmey, D.2    Millan, J.L.3    McKee, M.D.4    Karsenty, G.5
  • 81
    • 0034130405 scopus 로고    scopus 로고
    • Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases
    • DOI 10.1007/s000180050038
    • Nagai R, Saito Y, Ohyama Y, et al. 2000. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci 57:738-746. (Pubitemid 30392032)
    • (2000) Cellular and Molecular Life Sciences , vol.57 , Issue.5 , pp. 738-746
    • Nagai, R.1    Saito, Y.2    Ohyama, Y.3    Aizawa, H.4    Suga, T.5    Nakamura, T.6    Kurabayashi, M.7    Kuro-O, M.8
  • 82
    • 56649115974 scopus 로고    scopus 로고
    • Renal phosphaturia during metabolic acidosis revisited: Molecular mechanisms for decreased renal phosphate reabsorption
    • Nowik M, Picard N, Stange G, et al. 2008. Renal phosphaturia during metabolic acidosis revisited: Molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch 457:539-549.
    • (2008) Pflugers Arch , vol.457 , pp. 539-549
    • Nowik, M.1    Picard, N.2    Stange, G.3
  • 83
    • 67349229781 scopus 로고    scopus 로고
    • Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase
    • Ohnishi M, Nakatani T, Lanske B, et al. 2009. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 75:1166-1172.
    • (2009) Kidney Int , vol.75 , pp. 1166-1172
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3
  • 84
    • 77956637592 scopus 로고    scopus 로고
    • Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging
    • Ohnishi M, Razzaque MS. 2010. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 24:3562-3571.
    • (2010) FASEB J , vol.24 , pp. 3562-3571
    • Ohnishi, M.1    Razzaque, M.S.2
  • 85
    • 84858832999 scopus 로고    scopus 로고
    • Can features of phosphate toxicity appear in normophosphatemia?
    • Osuka S, Razzaque MS. 2012. Can features of phosphate toxicity appear in normophosphatemia? J Bone Miner Metab 30:10-18.
    • (2012) J Bone Miner Metab , vol.30 , pp. 10-18
    • Osuka, S.1    Razzaque, M.S.2
  • 86
    • 36049037977 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1α-hydroxylase expression in vitro
    • DOI 10.1152/ajprenal.00463.2006
    • Perwad F, Zhang MY, Tenenhouse HS, et al. 2007. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxy-lase expression in vitro. Am J Physiol Renal Physiol 293:F1577-F1583. (Pubitemid 350085994)
    • (2007) American Journal of Physiology - Renal Physiology , vol.293 , Issue.5
    • Perwad, F.1    Zhang, M.Y.H.2    Tenenhouse, H.S.3    Portale, A.A.4
  • 87
    • 84858719733 scopus 로고    scopus 로고
    • Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth receptor-4 signaling in hepatocellular carcinoma
    • Poh W, Wong W, Ong H, et al. 2012. Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth receptor-4 signaling in hepatocellular carcinoma. Mol Cancer 11:14.
    • (2012) Mol Cancer , vol.11 , pp. 14
    • Poh, W.1    Wong, W.2    Ong, H.3
  • 88
    • 84859852194 scopus 로고    scopus 로고
    • Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease
    • Quarles LD. 2012. Role of FGF23 in vitamin D and phosphate metabolism: Implications in chronic kidney disease. Exp Cell Res 318:1040-1048.
    • (2012) Exp Cell Res , vol.318 , pp. 1040-1048
    • Quarles, L.D.1
  • 89
    • 0032490711 scopus 로고    scopus 로고
    • Endothelial function in health and disease: New insights into the genesis of cardiovascular disease
    • PII S0002934398002095
    • Quyyumi AA. 1998. Endothelial function in health and disease: New insights into the genesis of cardiovascular disease. Am J Med 105:32S-39S. (Pubitemid 28364424)
    • (1998) American Journal of Medicine , vol.105 , Issue.A
    • Quyyumi, A.A.1
  • 91
    • 33646238028 scopus 로고    scopus 로고
    • Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
    • DOI 10.1096/fj.05-5432fje
    • Razzaque MS, Sitara D, Taguchi T, et al. 2006. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. FASEB J 20:720-722. (Pubitemid 46671193)
    • (2006) FASEB Journal , vol.20 , Issue.6 , pp. 720-722
    • Razzaque, M.S.1    Sitara, D.2    Taguchi, T.3    St-Arnaud, R.4    Lanske, B.5
  • 94
    • 72049102165 scopus 로고    scopus 로고
    • Intestinal npt2b plays a major role in phosphate absorption and homeostasis
    • Sabbagh Y, O'Brien SP, Song W, et al. 2009. Intestinal npt2b plays a major role in phosphate absorption and homeostasis. J Am Soc Nephrol 20:2348-2358.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2348-2358
    • Sabbagh, Y.1    O'Brien, S.P.2    Song, W.3
  • 95
    • 0034710838 scopus 로고    scopus 로고
    • In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome
    • Saito Y, Nakamura T, Ohyama Y, et al. 2000. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun 276:767-772.
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 767-772
    • Saito, Y.1    Nakamura, T.2    Ohyama, Y.3
  • 96
    • 84871335138 scopus 로고    scopus 로고
    • Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling
    • Satoh M, Nagasu H, Morita Y, et al. 2012. Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol 303:F1641-F1651.
    • (2012) Am J Physiol Renal Physiol , vol.303
    • Satoh, M.1    Nagasu, H.2    Morita, Y.3
  • 98
    • 80054737745 scopus 로고    scopus 로고
    • Plasma klotho and cardiovascular disease in adults
    • Semba RD, Cappola AR, Sun K, et al. 2011a. Plasma klotho and cardiovascular disease in adults. J Am Geriatr Soc 59:1596-1601.
    • (2011) J Am Geriatr Soc , vol.59 , pp. 1596-1601
    • Semba, R.D.1    Cappola, A.R.2    Sun, K.3
  • 99
    • 80051518025 scopus 로고    scopus 로고
    • Plasma klotho and mortality risk in older community-dwelling adults
    • Semba RD, Cappola AR, Sun K, et al. 2011b. Plasma klotho and mortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci 66:794-800.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , pp. 794-800
    • Semba, R.D.1    Cappola, A.R.2    Sun, K.3
  • 102
    • 84868364558 scopus 로고    scopus 로고
    • Serum levels of soluble secreted alpha-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis
    • Shimamura Y, Hamada K, Inoue K, et al. 2012. Serum levels of soluble secreted alpha-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol 16(5):722-729.
    • (2012) Clin Exp Nephrol , vol.16 , Issue.5 , pp. 722-729
    • Shimamura, Y.1    Hamada, K.2    Inoue, K.3
  • 103
    • 79952346794 scopus 로고    scopus 로고
    • Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-kB
    • Shimizu H, Bolati D, Adijiang A, et al. 2011. Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-kB. Am J Nephrol 33:319-324.
    • (2011) Am J Nephrol , vol.33 , pp. 319-324
    • Shimizu, H.1    Bolati, D.2    Adijiang, A.3
  • 104
    • 50849104780 scopus 로고    scopus 로고
    • Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
    • Sitara D, Kim S, Razzaque MS, et al. 2008. Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet 4:e1000154.
    • (2008) PLoS Genet , vol.4
    • Sitara, D.1    Kim, S.2    Razzaque, M.S.3
  • 105
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • DOI 10.1016/j.matbio.2004.09.007, PII S0945053X04001155
    • Sitara D, Razzaque MS, Hesse M, et al. 2004. Homozygous ablation of fibroblast growth factor-23 results in hyperphospha-temia and impaired skeletogenesis, and reverses hypophospha-temia in Phex-deficient mice. Matrix Biol 23:421-432. (Pubitemid 39576657)
    • (2004) Matrix Biology , vol.23 , Issue.7 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6    Juppner, H.7    Lanske, B.8
  • 106
  • 107
    • 79958091402 scopus 로고    scopus 로고
    • Regulation of the Na+/K+ ATPase by Klotho
    • Sopjani M, Alesutan I, Dermaku-Sopjani M, et al. 2011. Regulation of the Na+/K+ ATPase by Klotho. FEBS Lett 585:1759-1764.
    • (2011) FEBS Lett , vol.585 , pp. 1759-1764
    • Sopjani, M.1    Alesutan, I.2    Dermaku-Sopjani, M.3
  • 109
    • 72949102617 scopus 로고    scopus 로고
    • Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70
    • Sugiura H, Yoshida T, Mitobe M, et al. 2010. Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70. Nephrol Dial Transplant 25:60-68.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 60-68
    • Sugiura, H.1    Yoshida, T.2    Mitobe, M.3
  • 110
    • 84861168067 scopus 로고    scopus 로고
    • Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis
    • Sugiura H, Yoshida T, Shiohira S, et al. 2012. Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis. Am J Physiol Renal Physiol 302:F1252-F1264.
    • (2012) Am J Physiol Renal Physiol , vol.302
    • Sugiura, H.1    Yoshida, T.2    Shiohira, S.3
  • 112
    • 84863338125 scopus 로고    scopus 로고
    • Suppression of Klotho expres sion by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation
    • Sun CY, Chang SC, Wu MS. 2012. Suppression of Klotho expres sion by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int 81:640-650.
    • (2012) Kidney Int , vol.81 , pp. 640-650
    • Sun, C.Y.1    Chang, S.C.2    Wu, M.S.3
  • 113
    • 84855323187 scopus 로고    scopus 로고
    • High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis
    • Suyama T, Okada S, Ishijima T, et al. 2012. High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis. PLoS ONE 7: e29483.
    • (2012) PLoS ONE , vol.7
    • Suyama, T.1    Okada, S.2    Ishijima, T.3
  • 116
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System
    • DOI 10.1210/me.2003-0048
    • Tsujikawa H, Kurotaki Y, Fujimori T, et al. 2003. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17:2393-2403. (Pubitemid 37542205)
    • (2003) Molecular Endocrinology , vol.17 , Issue.12 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3    Fukuda, K.4    Nabeshima, Y.-I.5
  • 118
    • 0033812019 scopus 로고    scopus 로고
    • Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
    • Utsugi T, Ohno T, Ohyama Y, et al. 2000. Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49:1118-1123.
    • (2000) Metabolism , vol.49 , pp. 1118-1123
    • Utsugi, T.1    Ohno, T.2    Ohyama, Y.3
  • 119
    • 77949885535 scopus 로고    scopus 로고
    • Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis
    • Villa-Bellosta R, Sorribas V. 2010. Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Pflugers Arch 459:499-508.
    • (2010) Pflugers Arch , vol.459 , pp. 499-508
    • Villa-Bellosta, R.1    Sorribas, V.2
  • 121
    • 84862776673 scopus 로고    scopus 로고
    • Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway
    • Wang Y, Kuro O, Sun Z. 2012. Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway. Aging Cell 11(3):410-417.
    • (2012) Aging Cell , vol.11 , Issue.3 , pp. 410-417
    • Wang, Y.1    Kuro, O.2    Sun, Z.3
  • 122
    • 57749190558 scopus 로고    scopus 로고
    • Current understanding of klotho
    • Wang Y, Sun Z. 2009a. Current understanding of klotho. Ageing Res Rev 8:43-51.
    • (2009) Ageing Res Rev , vol.8 , pp. 43-51
    • Wang, Y.1    Sun, Z.2
  • 123
    • 70349659193 scopus 로고    scopus 로고
    • Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage
    • Wang Y, Sun Z. 2009b. Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. Hypertension 54:810-817.
    • (2009) Hypertension , vol.54 , pp. 810-817
    • Wang, Y.1    Sun, Z.2
  • 124
    • 84875710102 scopus 로고    scopus 로고
    • P-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase
    • Watanabe, et al. 2012. p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase. Kidney Int 83(4):582-592.
    • (2012) Kidney Int , vol.83 , Issue.4 , pp. 582-592
    • Watanabe1
  • 125
    • 58149229326 scopus 로고    scopus 로고
    • Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
    • Wolf I, Levanon-Cohen S, Bose S, et al. 2008. Klotho: A tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27:7094-7105.
    • (2008) Oncogene , vol.27 , pp. 7094-7105
    • Wolf, I.1    Levanon-Cohen, S.2    Bose, S.3
  • 126
    • 84869455662 scopus 로고    scopus 로고
    • Characterization of vitamin D-deficient klotho-/-mice: Do increased levels of serum 1, 25 (OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho-/-mice?
    • Woudenberg-Vrenken TE, van der Eerden BC, van der Kemp AW, et al. 2012. Characterization of vitamin D-deficient klotho-/-mice: do increased levels of serum 1, 25 (OH)2D3 cause disturbed calcium and phosphate homeostasis in klotho-/-mice? Nephrol Dial Transplant 27(11):4061-4068.
    • (2012) Nephrol Dial Transplant , vol.27 , Issue.11 , pp. 4061-4068
    • Woudenberg-Vrenken, T.E.1    Van Der Eerden, B.C.2    Van Der Kemp, A.W.3
  • 127
    • 79952520044 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins
    • Wu S, Zhou F, Zhang Z, et al. 2011. Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins. FEBS J 278:941-954.
    • (2011) FEBS J , vol.278 , pp. 941-954
    • Wu, S.1    Zhou, F.2    Zhang, Z.3
  • 128
    • 84874016733 scopus 로고    scopus 로고
    • Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: Tumor suppressive role of klotho in gastric cancer
    • Xie B, Zhou J, Shu G, et al. 2013. Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: Tumor suppressive role of klotho in gastric cancer. Cancer Cell Int 13:18.
    • (2013) Cancer Cell Int , vol.13 , pp. 18
    • Xie, B.1    Zhou, J.2    Shu, G.3
  • 129
    • 0033383772 scopus 로고    scopus 로고
    • +- P(i)) transporter (SLC34A2)
    • DOI 10.1006/geno.1999.6009
    • Xu H, Bai L, Collins JF, et al. 1999. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2). Genomics 62:281-284. (Pubitemid 30053944)
    • (1999) Genomics , vol.62 , Issue.2 , pp. 281-284
    • Xu, H.1    Bai, L.2    Collins, J.F.3    Ghishan, F.K.4
  • 131
    • 0036150953 scopus 로고    scopus 로고
    • Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1α-hydroxylase gene
    • DOI 10.1210/en.143.2.683
    • Yoshida T, Fujimori T, Nabeshima Y. 2002. Mediation of unusually high concentrations of 1, 25-dihydroxyvitamin D in homo-zygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 143:683-689. (Pubitemid 34107224)
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 683-689
    • Yoshida, T.1    Fujimori, T.2    Nabeshima, Y.O.I.3
  • 132
    • 80053375004 scopus 로고    scopus 로고
    • Dehydration: A new modulator of klotho expression
    • Zacchia M, Capasso G. 2011. Dehydration: A new modulator of klotho expression. Am J Physiol Renal Physiol 301:F743-F744.
    • (2011) Am J Physiol Renal Physiol , vol.301
    • Zacchia, M.1    Capasso, G.2
  • 133
    • 0034456670 scopus 로고    scopus 로고
    • Npt2 gene disruption confers resistance to the inhibitory action of parathyroid hormone on renal sodium-phosphate cotransport
    • DOI 10.1210/en.141.6.2159
    • Zhao N, Tenenhouse HS. 2000. Npt2 gene disruption confers resistance to the inhibitory action of parathyroid hormone on renal sodium-phosphate cotransport. Endocrinology 141:2159-2165. (Pubitemid 32274370)
    • (2000) Endocrinology , vol.141 , Issue.6 , pp. 2159-2165
    • Zhao, N.1    Tenenhouse, H.S.2
  • 134
    • 84878201990 scopus 로고    scopus 로고
    • Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3beta/ Snail signaling in renal cell carcinoma
    • Zhu Y, Xu L, Zhang J, et al. 2013. Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3beta/Snail signaling in renal cell carcinoma. Cancer Sci 104:663-671.
    • (2013) Cancer Sci , vol.104 , pp. 663-671
    • Zhu, Y.1    Xu, L.2    Zhang, J.3


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