Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner

Cancer Biology and Therapy

Volumn 13, Issue 12, 2012, Pages 1221-1228

  Chen, Bo ^a   Ma, Xiaoli ^b   Liu, Shifeng ^a   Zhao, Weihong ^a   Wu, Jianqing ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b JINAN CENTRAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Gene therapy; Klotho; Lung cancer; Proliferation; Wnt

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BETA CATENIN; ISOPROTEIN; KLOTHO PROTEIN; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL GROWTH; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; LUNG PARENCHYMA; NICK END LABELING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

ANIMALS; APOPTOSIS; BETA CATENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONIDASE; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MICE; MOLECULAR TARGETED THERAPY; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84867133607     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.21420     Document Type: Article

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