Role of klotho in aging, phosphate metabolism, and CKD

American Journal of Kidney Diseases

Volumn 58, Issue 1, 2011, Pages 127-134

  John, George B ^a   Cheng, Chung Yi ^a   Kuro O, Makoto ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

chronic kidney disease; fibroblast growth factor 23 (FGF 23); Klotho; parathyroid hormone (PTH); phosphate; vitamin D

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; AMLODIPINE; BIOLOGICAL MARKER; CARVEDILOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBROBLAST GROWTH FACTOR 23; HUMORAL ANTIBODY; ION CHANNEL; KLOTHO PROTEIN; LOOP DIURETIC AGENT; MEMBRANE PROTEIN; PHOSPHATE; ROSIGLITAZONE; VALSARTAN; VITAMIN D;

AGED; AGING; APPETITE DISORDER; ARTICLE; BLOOD; BONE; CHRONIC DISEASE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DISEASE COURSE; EDEMA; FEMALE; FIBROBLAST; GENE EXPRESSION; GENE FUNCTION; HORMONE RELEASE; HUMAN; HYPERPHOSPHATEMIA; HYPERTENSION; KIDNEY DYSFUNCTION; LEG EDEMA; LIFESPAN; MORTALITY; NEUROENDOCRINE SYSTEM; PARATHYROID GLAND; PATHOPHYSIOLOGY; PHENOTYPE; PHOSPHATE BALANCE; PHOSPHATE METABOLISM; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEINURIA; REGULATORY MECHANISM; SECRETION; SUPPRESSOR GENE; URINE; VITAMIN METABOLISM;

AGED; AGING; ANIMALS; BIOLOGICAL MARKERS; FEMALE; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMANS; PHOSPHATES; RENAL INSUFFICIENCY, CHRONIC;

EID: 79959334891     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2010.12.027     Document Type: Article

References (72)

1. J. Coresh, E. Selvin, and L.A. Stevens Prevalence of chronic kidney disease in the United States JAMA 298 17 2007 2038 2047 (Pubitemid 350074801)
2. A.S. Levey, R. Atkins, and J. Coresh Chronic kidney disease as a global public health problem: approaches and initiativesa position statement from Kidney Disease: Improving Global Outcomes Kidney Int 72 3 2007 247 259 (Pubitemid 47172384)
3. M. Tonelli, F. Sacks, M. Pfeffer, Z. Gao, and G. Curhan Relation between serum phosphate level and cardiovascular event rate in people with coronary disease Circulation 112 17 2005 2627 2633 (Pubitemid 41532599)
4. S.K. Ganesh, A.G. Stack, N.W. Levin, T. Hulbert-Shearon, and F.K. Port Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients J Am Soc Nephrol 12 10 2001 2131 2138 (Pubitemid 32880350)
5. O. Gutierrez, T. Isakova, and E. Rhee Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease J Am Soc Nephrol 16 7 2005 2205 2215 (Pubitemid 41716454)
6. H. Engberg, A. Oksuzyan, B. Jeune, J.W. Vaupel, and K. Christensen Centenariansa useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905 Aging Cell 8 3 2009 270 276
7. J.E. Martin, and M.T. Sheaff Renal ageing J Pathol 211 2 2007 198 205 (Pubitemid 46195518)
8. J.R. Stubbs, S. Liu, and W. Tang Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice J Am Soc Nephrol 18 7 2007 2116 2124 (Pubitemid 47041077)
9. J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial- mesenchymal transitions in development and disease Cell 139 5 2009 871 890
10. H. Tauchi, K. Tsuboi, and J. Okutomi Age changes in the human kidney of the different races Gerontologia 17 2 1971 87 97
11. C. Kaplan, B. Pasternack, H. Shah, and G. Gallo Age-related incidence of sclerotic glomeruli in human kidneys Am J Pathol 80 2 1975 227 234
12. O. Shemesh, H. Golbetz, J.P. Kriss, and B.D. Myers Limitations of creatinine as a filtration marker in glomerulopathic patients Kidney Int 28 5 1985 830 838 (Pubitemid 16156326)
13. D.F. Davies, and N.W. Shock Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males J Clin Invest 29 5 1950 496 507
14. A.S. Go, G.M. Chertow, D. Fan, C.E. McCulloch, and C.Y. Hsu Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization N Engl J Med 351 13 2004 1296 1305
15. L.A. Stevens, and A.S. Levey Clinical implications of estimating equations for glomerular filtration rate Ann Intern Med 141 12 2004 959 961 (Pubitemid 40040980)
16. N.K. Hollenberg, D.F. Adams, H.S. Solomon, A. Rashid, H.L. Abrams, and J.P. Merrill Senescence and the renal vasculature in normal man Circ Res 34 3 1974 309 316
17. M. Kuro-o, Y. Matsumura, and H. Aizawa Mutation of the mouse klotho gene leads to a syndrome resembling ageing Nature 390 6655 1997 45 51 (Pubitemid 27494749)
18. T. Nagai, K. Yamada, and H.C. Kim Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress FASEB J 17 1 2003 50 52
19. M. Kamemori, Y. Ohyama, M. Kurabayashi, K. Takahashi, R. Nagai, and N. Furuya Expression of klotho protein in the inner ear Hear Res 171 1-2 2002 103 110 (Pubitemid 36158688)
20. Y. Anamizu, H. Kawaguchi, and A. Seichi Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells Acta Neuropathol 109 5 2005 457 466 (Pubitemid 40909189)
21. H. Kurosu, M. Yamamoto, and J.D. Clark Suppression of aging in mice by the hormone Klotho Science 309 5742 2005 1829 1833 (Pubitemid 41325087)
22. K.E. White, W.E. Evans, and J.L.H. O'Rlordan Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 Nat Genet 26 3 2000 345 348
23. L.D. Quarles Endocrine functions of bone in mineral metabolism regulation J Clin Invest 118 12 2008 3820 3828
24. T. Shimada, M. Kakitani, and Y. Yamazaki Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism J Clin Invest 113 4 2004 561 568 (Pubitemid 38542505)
25. M.S. Razzaque, D. Sitara, T. Taguchi, R. St-Arnaud, and B. Lanske Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process FASEB J 20 6 2006 720 722 (Pubitemid 46671193)
26. H. Tsujikawa, Y. Kurotaki, T. Fujimori, K. Fukuda, and Y. Nabeshima Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system Mol Endocrinol 17 12 2003 2393 2403 (Pubitemid 37542205)
27. H. Kurosu, Y. Ogawa, and M. Miyoshi Regulation of fibroblast growth factor-23 signaling by klotho J Biol Chem 281 10 2006 6120 6123 (Pubitemid 43847540)
28. I. Urakawa, Y. Yamazaki, and T. Shimada Klotho converts canonical FGF receptor into a specific receptor for FGF23 Nature 444 7120 2006 770 774 (Pubitemid 44949607)
29. M. Hesse, L.F. Frohlich, U. Zeitz, B. Lanske, and R.G. Erben Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice Matrix Biol 26 2 2007 75 84 (Pubitemid 46187039)
30. M. Ohnishi, T. Nakatani, B. Lanske, and M.S. Razzaque Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase Kidney Int 75 2009 1166 1172
31. M. Ohnishi, T. Nakatani, B. Lanske, and M.S. Razzaque In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels Circ Cardiovasc Genet 2 6 2009 583 590
32. M. Ohnishi, and M.S. Razzaque Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging FASEB J 24 9 2010 3562 3571
33. S.C. Schiavi, and R. Kumar The phosphatonin pathway: new insights in phosphate homeostasis Kidney Int 65 1 2004 1 14 (Pubitemid 38037486)
34. A.S. Dusso, A.J. Brown, and E. Slatopolsky Vitamin D Am J Physiol Renal Physiol 289 1 2005 F8 F28
35. A.J. Felsenfeld, M. Rodriguez, and E. Aguilera-Tejero Dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism Clin J Am Soc Nephrol 2 6 2007 1283 1305
36. T. Berndt, and R. Kumar Novel mechanisms in the regulation of phosphorus homeostasis Physiology (Bethesda) 24 2009 17 25
37. M. Kuro-o Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism Curr Opin Nephrol Hypertens 15 4 2006 437 441
38. L.D. Quarles FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization Am J Physiol Endocrinol Metab 285 1 2003 E1 E9
39. S. Liu, W. Tang, and J. Zhou Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D J Am Soc Nephrol 17 5 2006 1305 1315 (Pubitemid 43673410)
40. S. Liu, A. Gupta, and L.D. Quarles Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization Curr Opin Nephrol Hypertens 16 4 2007 329 335 (Pubitemid 46944331)
41. T. Shimada, H. Hasegawa, and Y. Yamazaki FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis J Bone Miner Res 19 3 2004 429 435 (Pubitemid 38787398)
42. M.C. Hu, M. Shi, and J. Zhang Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule FASEB J 24 9 2010 3438 3450
43. E.G. Farrow, S.I. Davis, L.J. Summers, and K.E. White Initial FGF23-mediated signaling occurs in the distal convoluted tubule J Am Soc Nephrol 20 5 2009 955 960
44. I.Z. Ben-Dov, H. Galitzer, and V. Lavi-Moshayoff The parathyroid is a target organ for FGF23 in rats J Clin Invest 117 12 2007 4003 4008 (Pubitemid 350224109)
45. F. Saji, K. Shiizaki, and S. Shimada Regulation of fibroblast growth factor 23 production in bone in uremic rats Nephron Physiol 111 4 2009 59 66
46. O.M. Gutierrez, M. Mannstadt, and T. Isakova Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis N Engl J Med 359 6 2008 584 592
47. M.C. Hu, M. Shi, and J. Zhang Klotho deficiency causes vascular calcification in chronic kidney disease J Am Soc Nephrol 22 1 2011 124 136
48. S.P. O'Brien, J.H. Boulanger, S. Liu, Y. Sabbagh, and S.C. Schiavi Decline in klotho expression precedes FGF23 and PTH induction in the Jck mouse, a progressive genetic model of CKD-MBD [abstract] J Am Soc Nephrol 20 2009 54A
49. M. Kuro-o Klotho in chronic kidney diseasewhat's new? Nephrol Dial Transplant 24 6 2009 1705 1708
50. T. Larsson, U. Nisbeth, O. Ljunggren, H. Juppner, and K.B. Jonsson Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers Kidney Int 64 6 2003 2272 2279 (Pubitemid 37449564)
51. S. Nakanishi, J.J. Kazama, and T. Nii-Kono Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients Kidney Int 67 3 2005 1171 1178 (Pubitemid 41623344)
52. H. Komaba, S. Goto, and H. Fujii Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients Kidney Int 77 3 2010 232 238
53. H. Galitzer, I.Z. Ben-Dov, J. Silver, and T. Naveh-Many Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease Kidney Int 77 3 2010 211 218
54. C. Kumata, M. Mizobuchi, and H. Ogata Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism Am J Nephrol 31 3 2010 230 238
55. T. Krajisnik, H. Olauson, and M.A. Mirza Parathyroid klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients Kidney Int 78 10 2010 1024 1032
56. R. Marsell, T. Krajisnik, and H. Goransson Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23 Nephrol Dial Transplant 23 3 2008 827 833 (Pubitemid 351767553)
57. T. Shimada, I. Urakawa, and T. Isakova Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active J Clin Endocrinol Metab 2 95 2009 578 585
58. T. Nakatani, M. Ohnishi, and M.S. Razzaque Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model FASEB J 23 11 2009 3702 3711
59. C.D. Chen, S. Podvin, E. Gillespie, S.E. Leeman, and C.R. Abraham Insulin stimulates the cleavage and release of the extracellular domain of klotho by ADAM10 and ADAM17 Proc Natl Acad Sci U S A 104 50 2007 19796 19801
60. L. Bloch, O. Sineshchekova, and D. Reichenbach Klotho is a substrate for alpha-, beta- and gamma-secretase FEBS Lett 583 19 2009 3221 3224
61. A. Imura, A. Iwano, and O. Tohyama Secreted klotho protein in sera and CSF: implication for post-translational cleavage in release of klotho protein from cell membrane FEBS Lett 565 1-3 2004 143 147 (Pubitemid 38595335)
62. O. Tohyama, A. Imura, and A. Iwano Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides J Biol Chem 279 11 2004 9777 9784 (Pubitemid 38372575)
63. Q. Chang, S. Hoefs, A.W. van der Kemp, C.N. Topala, R.J. Bindels, and J.G. Hoenderop The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel Science 310 5747 2005 490 493 (Pubitemid 41507962)
64. S.K. Cha, B. Ortega, H. Kurosu, K.P. Rosenblatt, O.M. Kuro, and C.L. Huang Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1 Proc Natl Acad Sci U S A 105 28 2008 9805 9810 (Pubitemid 352031381)
65. S.K. Cha, M.C. Hu, H. Kurosu, M. Kuro-o, O. Moe, and C.L. Huang Regulation of renal outer medullary potassium channel and renal K(+) excretion by klotho Mol Pharmacol 76 1 2009 38 46
66. M.C. Hu, M. Shi, and J. Zhang Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule FASEB J 24 9 2010 3438 3450
67. Y. Yamazaki, A. Imura, and I. Urakawa Establishment of sandwich ELISA for soluble alpha-klotho measurement: age-dependent change of soluble alpha-klotho levels in healthy subjects Biochem Biophys Res Commun 398 3 2010 513 518
68. Y. Haruna, N. Kashihara, and M. Satoh Amelioration of progressive renal injury by genetic manipulation of klotho gene Proc Natl Acad Sci U S A 104 7 2007 2331 2336 (Pubitemid 46391397)
69. H. Sugiura, T. Yoshida, and K. Tsuchiya Klotho reduces apoptosis in experimental ischaemic acute renal failure Nephrol Dial Transplant 20 12 2005 2636 2645 (Pubitemid 41672261)
70. M.C. Hu, M. Shi, and H. Quinones Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective Kidney Int 78 2010 1240 1251
71. H. Mitani, N. Ishizaka, and T. Aizawa In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage Hypertension 39 4 2002 838 843 (Pubitemid 34437536)
72. H. Zhang, Y. Li, and Y. Fan Klotho is a target gene of PPAR-gamma Kidney Int 74 6 2008 732 739