메뉴 건너뛰기




Volumn 7, Issue 2, 2012, Pages

Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; KLOTHO PROTEIN; PARATHYROID HORMONE; VITAMIN D; BETA GLUCURONIDASE; CALCITRIOL RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 23; GLUCOSE;

EID: 84856530695     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031376     Document Type: Article
Times cited : (48)

References (37)
  • 1
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3    Kawaguchi, H.4    Suga, T.5
  • 2
    • 0033812019 scopus 로고    scopus 로고
    • Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
    • Utsugi T, Ohno T, Ohyama Y, Uchiyama T, Saito Y, et al. (2000) Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49: 1118-1123.
    • (2000) Metabolism , vol.49 , pp. 1118-1123
    • Utsugi, T.1    Ohno, T.2    Ohyama, Y.3    Uchiyama, T.4    Saito, Y.5
  • 3
    • 0036150953 scopus 로고    scopus 로고
    • Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene
    • Yoshida T, Fujimori T, Nabeshima Y, (2002) Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology 143: 683-689.
    • (2002) Endocrinology , vol.143 , pp. 683-689
    • Yoshida, T.1    Fujimori, T.2    Nabeshima, Y.3
  • 4
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444: 770-774.
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5
  • 5
    • 14344279878 scopus 로고    scopus 로고
    • Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
    • Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, et al. (2001) Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A 98: 6500-6505.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6500-6505
    • Shimada, T.1    Mizutani, S.2    Muto, T.3    Yoneya, T.4    Hino, R.5
  • 6
    • 27144440831 scopus 로고    scopus 로고
    • The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
    • Chang Q, Hoefs S, Van Der Kemp AW, Topala CN, Bindels RJ, et al. (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310: 490-493.
    • (2005) Science , vol.310 , pp. 490-493
    • Chang, Q.1    Hoefs, S.2    van der Kemp, A.W.3    Topala, C.N.4    Bindels, R.J.5
  • 7
    • 47749148805 scopus 로고    scopus 로고
    • Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
    • Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro O, et al. (2008) Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A 105: 9805-9810.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9805-9810
    • Cha, S.K.1    Ortega, B.2    Kurosu, H.3    Rosenblatt, K.P.4    Kuro, O.5
  • 8
    • 77956642900 scopus 로고    scopus 로고
    • Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    • Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, et al. (2010) Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J 24: 3438-3450.
    • (2010) FASEB J , vol.24 , pp. 3438-3450
    • Hu, M.C.1    Shi, M.2    Zhang, J.3    Pastor, J.4    Nakatani, T.5
  • 10
    • 27844561111 scopus 로고    scopus 로고
    • Regulation of oxidative stress by the anti-aging hormone klotho
    • Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, et al. (2005) Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280: 38029-38034.
    • (2005) J Biol Chem , vol.280 , pp. 38029-38034
    • Yamamoto, M.1    Clark, J.D.2    Pastor, J.V.3    Gurnani, P.4    Nandi, A.5
  • 11
    • 34250803923 scopus 로고    scopus 로고
    • Alpha-Klotho as a regulator of calcium homeostasis
    • Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, et al. (2007) alpha-Klotho as a regulator of calcium homeostasis. Science 316: 1615-1618.
    • (2007) Science , vol.316 , pp. 1615-1618
    • Imura, A.1    Tsuji, Y.2    Murata, M.3    Maeda, R.4    Kubota, K.5
  • 12
    • 33646578195 scopus 로고    scopus 로고
    • Regulation of fibroblast growth factor-23 signaling by Klotho
    • Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, et al. (2006) Regulation of fibroblast growth factor-23 signaling by Klotho. J Biol Chem 281: 6120-6123.
    • (2006) J Biol Chem , vol.281 , pp. 6120-6123
    • Kurosu, H.1    Ogawa, Y.2    Miyoshi, M.3    Yamamoto, M.4    Nandi, A.5
  • 13
    • 79961141521 scopus 로고    scopus 로고
    • Regulation of Serum 1,25(OH)2Vitamin D3 levels by Fibroblast Growth Factor 23 is Mediated by FGF Receptors 3 and 4
    • Gattineni J, Twombley K, Goetz R, Mohammadi M, Baum M, (2011) Regulation of Serum 1,25(OH)2Vitamin D3 levels by Fibroblast Growth Factor 23 is Mediated by FGF Receptors 3 and 4. Am J Physiol Renal Physiol.
    • (2011) Am J Physiol Renal Physiol
    • Gattineni, J.1    Twombley, K.2    Goetz, R.3    Mohammadi, M.4    Baum, M.5
  • 14
    • 79952161016 scopus 로고    scopus 로고
    • Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
    • Li H, Martin A, David V, Quarles LD, (2011) Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype. Am J Physiol Endocrinol Metab 300: E508-E517.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Li, H.1    Martin, A.2    David, V.3    Quarles, L.D.4
  • 15
    • 85047685376 scopus 로고    scopus 로고
    • Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D
    • Erben RG, Soegiarto DW, Weber K, Zeitz U, Lieberherr M, et al. (2002) Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol 16: 1524-1537.
    • (2002) Mol Endocrinol , vol.16 , pp. 1524-1537
    • Erben, R.G.1    Soegiarto, D.W.2    Weber, K.3    Zeitz, U.4    Lieberherr, M.5
  • 16
    • 0346849707 scopus 로고    scopus 로고
    • Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    • Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y, (2003) Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 17: 2393-2403.
    • (2003) Mol Endocrinol , vol.17 , pp. 2393-2403
    • Tsujikawa, H.1    Kurotaki, Y.2    Fujimori, T.3    Fukuda, K.4    Nabeshima, Y.5
  • 17
    • 0000524953 scopus 로고    scopus 로고
    • Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice
    • Li YC, Amling M, Pirro AE, Priemel M, Meuse J, et al. (1998) Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139: 4391-4396.
    • (1998) Endocrinology , vol.139 , pp. 4391-4396
    • Li, Y.C.1    Amling, M.2    Pirro, A.E.3    Priemel, M.4    Meuse, J.5
  • 18
    • 58149099091 scopus 로고    scopus 로고
    • Vitamin D-independent therapeutic effects of extracellular calcium in a mouse model of adult-onset secondary hyperparathyroidism
    • Weber K, Bergow C, Hirmer S, Schuler C, Erben RG, (2009) Vitamin D-independent therapeutic effects of extracellular calcium in a mouse model of adult-onset secondary hyperparathyroidism. J Bone Miner Res 24: 22-32.
    • (2009) J Bone Miner Res , vol.24 , pp. 22-32
    • Weber, K.1    Bergow, C.2    Hirmer, S.3    Schuler, C.4    Erben, R.G.5
  • 19
    • 67349229781 scopus 로고    scopus 로고
    • Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase
    • Ohnishi M, Nakatani T, Lanske B, Razzaque MS, (2009) Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 75: 1166-1172.
    • (2009) Kidney Int , vol.75 , pp. 1166-1172
    • Ohnishi, M.1    Nakatani, T.2    Lanske, B.3    Razzaque, M.S.4
  • 20
    • 34247545717 scopus 로고    scopus 로고
    • Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals
    • Sitara D, Razzaque MS, St Arnaud R, Huang W, Taguchi T, et al. (2006) Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am J Pathol 169: 2161-2170.
    • (2006) Am J Pathol , vol.169 , pp. 2161-2170
    • Sitara, D.1    Razzaque, M.S.2    St Arnaud, R.3    Huang, W.4    Taguchi, T.5
  • 21
    • 33846566785 scopus 로고    scopus 로고
    • Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice
    • Hesse M, Frohlich LF, Zeitz U, Lanske B, Erben RG, (2007) Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. Matrix Biol 26: 75-84.
    • (2007) Matrix Biol , vol.26 , pp. 75-84
    • Hesse, M.1    Frohlich, L.F.2    Zeitz, U.3    Lanske, B.4    Erben, R.G.5
  • 24
    • 3042647177 scopus 로고    scopus 로고
    • Regulation of gene expression of epithelial calcium channels in intestine and kidney of mice by 1alpha,25-dihydroxyvitamin D3
    • Okano T, Tsugawa N, Morishita A, Kato S, (2004) Regulation of gene expression of epithelial calcium channels in intestine and kidney of mice by 1alpha,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 89-90: 335-338.
    • (2004) J Steroid Biochem Mol Biol , vol.89-90 , pp. 335-338
    • Okano, T.1    Tsugawa, N.2    Morishita, A.3    Kato, S.4
  • 25
    • 0041314066 scopus 로고    scopus 로고
    • Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice
    • Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, et al. (2003) Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144: 3456-3462.
    • (2003) Endocrinology , vol.144 , pp. 3456-3462
    • Voshol, P.J.1    Haemmerle, G.2    Ouwens, D.M.3    Zimmermann, R.4    Zechner, R.5
  • 28
    • 0038744264 scopus 로고    scopus 로고
    • KLOTHO allele status and the risk of early-onset occult coronary artery disease
    • Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, et al. (2003) KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 72: 1154-1161.
    • (2003) Am J Hum Genet , vol.72 , pp. 1154-1161
    • Arking, D.E.1    Becker, D.M.2    Yanek, L.R.3    Fallin, D.4    Judge, D.P.5
  • 29
    • 14844345016 scopus 로고    scopus 로고
    • Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity
    • Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC, (2005) Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 96: 412-418.
    • (2005) Circ Res , vol.96 , pp. 412-418
    • Arking, D.E.1    Atzmon, G.2    Arking, A.3    Barzilai, N.4    Dietz, H.C.5
  • 30
    • 69949085836 scopus 로고    scopus 로고
    • Klotho and aging
    • Kuro-o M, (2009) Klotho and aging. Biochim Biophys Acta 1790: 1049-1058.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 1049-1058
    • Kuro-o, M.1
  • 31
    • 34848871595 scopus 로고    scopus 로고
    • A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis
    • Ichikawa S, Imel EA, Kreiter ML, Yu X, Mackenzie DS, et al. (2007) A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J Clin Invest 117: 2684-2691.
    • (2007) J Clin Invest , vol.117 , pp. 2684-2691
    • Ichikawa, S.1    Imel, E.A.2    Kreiter, M.L.3    Yu, X.4    Mackenzie, D.S.5
  • 32
    • 77952544259 scopus 로고    scopus 로고
    • A potential link between phosphate and aging-lessons from Klotho-deficient mice
    • Kuro-o M, (2010) A potential link between phosphate and aging-lessons from Klotho-deficient mice. Mech Ageing Dev 131: 270-275.
    • (2010) Mech Ageing Dev , vol.131 , pp. 270-275
    • Kuro-o, M.1
  • 33
    • 0037364216 scopus 로고    scopus 로고
    • Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor
    • Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, et al. (2003) Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 17: 509-511.
    • (2003) FASEB J , vol.17 , pp. 509-511
    • Zeitz, U.1    Weber, K.2    Soegiarto, D.W.3    Wolf, E.4    Balling, R.5
  • 34
    • 0031042663 scopus 로고    scopus 로고
    • Embedding of bone samples in methylmethacrylate: An improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry
    • Erben RG, (1997) Embedding of bone samples in methylmethacrylate: An improved method suitable for bone histomorphometry, histochemistry, and immunohistochemistry. J Histochem Cytochem 45: 307-313.
    • (1997) J Histochem Cytochem , vol.45 , pp. 307-313
    • Erben, R.G.1
  • 35
    • 66049092304 scopus 로고    scopus 로고
    • Inhibition of receptor activator of NF-κB ligand prevents glucocorticoid-induced bone loss in mice
    • Hofbauer LC, Zeitz U, Schoppet M, Skalicky M, Schüler C, et al. (2009) Inhibition of receptor activator of NF-κB ligand prevents glucocorticoid-induced bone loss in mice. Arthritis Rheum 60: 1427-1437.
    • (2009) Arthritis Rheum , vol.60 , pp. 1427-1437
    • Hofbauer, L.C.1    Zeitz, U.2    Schoppet, M.3    Skalicky, M.4    Schüler, C.5
  • 37
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.