-
1
-
-
0023007940
-
Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging
-
Baudry, M., Dubrin, R., Beasley, L., Leon, M., and Lynch, G. (1986). Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging. Neurobiol. Aging, 7, 255-258.
-
(1986)
Neurobiol. Aging
, vol.7
, pp. 255-258
-
-
Baudry, M.1
Dubrin, R.2
Beasley, L.3
Leon, M.4
Lynch, G.5
-
2
-
-
0028032459
-
Is the senescent heart overloaded and already failing?
-
Besse, S., Delcayre, C., Chevalier, B., Hardouin, S., Heymes, C., Bourgeois, F., Moalic, J.M., and Swynghedauw, B. (1994). Is the senescent heart overloaded and already failing? Cardiovasc. Drugs Ther., 8, 581-587.
-
(1994)
Cardiovasc. Drugs Ther.
, vol.8
, pp. 581-587
-
-
Besse, S.1
Delcayre, C.2
Chevalier, B.3
Hardouin, S.4
Heymes, C.5
Bourgeois, F.6
Moalic, J.M.7
Swynghedauw, B.8
-
3
-
-
0033216259
-
Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures
-
Blalock, E.M., Porter, N.M., and Landfield, P.W. (1999). Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures. J. Neurosci., 19, 8674-8684.
-
(1999)
J. Neurosci.
, vol.19
, pp. 8674-8684
-
-
Blalock, E.M.1
Porter, N.M.2
Landfield, P.W.3
-
4
-
-
34548186667
-
Cellular senescence: when bad things happen to good cells
-
Campisi, J., and D'adda Di Fagagna, F. (2007). Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol., 8, 729-740.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'adda Di Fagagna, F.2
-
5
-
-
47749148805
-
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
-
Cha, S.K., Ortega, B., Kurosu, H., Rosenblatt, K.P., Kuro, O.M., and Huang, C.L. (2008). Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc. Natl Acad. Sci. USA, 105, 9805-9810.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9805-9810
-
-
Cha, S.K.1
Ortega, B.2
Kurosu, H.3
Rosenblatt, K.P.4
Kuro, O.M.5
Huang, C.L.6
-
6
-
-
27144440831
-
The beta-glucuronidase Klotho hydrolyzes and activates the TRPV5 channel
-
Chang, Q., Hoefs, S., Van Der Kemp, A.W., Topala, C.N., Bindels, R.J., and Hoenderop, J.G. (2005). The beta-glucuronidase Klotho hydrolyzes and activates the TRPV5 channel. Science, 310, 490-493.
-
(2005)
Science
, vol.310
, pp. 490-493
-
-
Chang, Q.1
Hoefs, S.2
Van Der Kemp, A.W.3
Topala, C.N.4
Bindels, R.J.5
Hoenderop, J.G.6
-
7
-
-
77954684957
-
Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
-
Chen, B., Wang, X., Zhao, W., and Wu, J. (2010). Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res, 29, 99.
-
(2010)
J Exp Clin Cancer Res
, vol.29
, pp. 99
-
-
Chen, B.1
Wang, X.2
Zhao, W.3
Wu, J.4
-
8
-
-
53249090604
-
WNT5A expression increases during melanoma progression and correlates with outcome
-
Da Forno, P.D., Pringle, J.H., Hutchinson, P., Osborn, J., Huang, Q., Potter, L., Hancox, R.A., Fletcher, A., and Saldanha, G.S. (2008). WNT5A expression increases during melanoma progression and correlates with outcome. Clin. Cancer Res., 14, 5825-5832.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 5825-5832
-
-
Da Forno, P.D.1
Pringle, J.H.2
Hutchinson, P.3
Osborn, J.4
Huang, Q.5
Potter, L.6
Hancox, R.A.7
Fletcher, A.8
Saldanha, G.S.9
-
9
-
-
33749342012
-
Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
-
De Oliveira, R.M. (2006). Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett., 580, 5753-5758.
-
(2006)
FEBS Lett.
, vol.580
, pp. 5753-5758
-
-
De Oliveira, R.M.1
-
10
-
-
34447131518
-
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
-
Dissanayake, S.K., Wade, M., Johnson, C.E. et al. (2007). The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem., 282, 17259-17271.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17259-17271
-
-
Dissanayake, S.K.1
Wade, M.2
Johnson, C.E.3
-
11
-
-
57749098673
-
Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation
-
Dissanayake, S.K., Olkhanud, P.B., O'connell, M.P. et al. (2008). Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res., 68, 10205-10214.
-
(2008)
Cancer Res.
, vol.68
, pp. 10205-10214
-
-
Dissanayake, S.K.1
Olkhanud, P.B.2
O'connell, M.P.3
-
12
-
-
33644803883
-
Opticin binds to heparan and chondroitin sulfate proteoglycans
-
Hindson, V.J., Gallagher, J.T., Halfter, W., and Bishop, P.N. (2005). Opticin binds to heparan and chondroitin sulfate proteoglycans. Invest. Ophthalmol. Vis. Sci., 46, 4417-4423.
-
(2005)
Invest. Ophthalmol. Vis. Sci.
, vol.46
, pp. 4417-4423
-
-
Hindson, V.J.1
Gallagher, J.T.2
Halfter, W.3
Bishop, P.N.4
-
13
-
-
2342610541
-
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane
-
Imura, A., Iwano, A., Tohyama, O., Tsuji, Y., Nozaki, K., Hashimoto, N., Fujimori, T., and Nabeshima, Y. (2004). Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett., 565, 143-147.
-
(2004)
FEBS Lett.
, vol.565
, pp. 143-147
-
-
Imura, A.1
Iwano, A.2
Tohyama, O.3
Tsuji, Y.4
Nozaki, K.5
Hashimoto, N.6
Fujimori, T.7
Nabeshima, Y.8
-
14
-
-
0030724491
-
Mutation of the mouse Klotho gene leads to a syndrome resembling ageing
-
Kuro-O, M., Matsumura, Y., Aizawa, H. et al. (1997). Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature, 390, 45-51.
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-O, M.1
Matsumura, Y.2
Aizawa, H.3
-
15
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu, H., Yamamoto, M., Clark, J.D. et al. (2005). Suppression of aging in mice by the hormone Klotho. Science, 309, 1829-1833.
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
16
-
-
33646578195
-
Regulation of fibroblast growth factor-23 signaling by Klotho
-
Kurosu, H., Ogawa, Y., Miyoshi, M. et al. (2006). Regulation of fibroblast growth factor-23 signaling by Klotho. J. Biol. Chem., 281, 6120-6123.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6120-6123
-
-
Kurosu, H.1
Ogawa, Y.2
Miyoshi, M.3
-
17
-
-
42149103884
-
Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program
-
Lachiewicz, A.M., Berwick, M., Wiggins, C.L., and Thomas, N.E. (2008). Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program. J. Invest. Dermatol., 128, 1340-1342.
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 1340-1342
-
-
Lachiewicz, A.M.1
Berwick, M.2
Wiggins, C.L.3
Thomas, N.E.4
-
18
-
-
77952248261
-
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma
-
Lee, J., Jeong, D.J., Kim, J. et al. (2010). The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer, 9, 109.
-
(2010)
Mol Cancer
, vol.9
, pp. 109
-
-
Lee, J.1
Jeong, D.J.2
Kim, J.3
-
19
-
-
34547908461
-
Augmented Wnt signaling in a mammalian model of accelerated aging
-
Liu, H., Fergusson, M.M., Castilho, R.M. et al. (2007). Augmented Wnt signaling in a mammalian model of accelerated aging. Science, 317, 803-806.
-
(2007)
Science
, vol.317
, pp. 803-806
-
-
Liu, H.1
Fergusson, M.M.2
Castilho, R.M.3
-
20
-
-
0022570307
-
An endogenous Ca2 + -sensitive proteinase converts the hepatic alpha 1-adrenergic receptor to guanine nucleotide-insensitive forms
-
Lynch, C.J., Sobo, G.E., and Exton, J.H. (1986). An endogenous Ca2 + -sensitive proteinase converts the hepatic alpha 1-adrenergic receptor to guanine nucleotide-insensitive forms. Biochim. Biophys. Acta, 885, 110-120.
-
(1986)
Biochim. Biophys. Acta
, vol.885
, pp. 110-120
-
-
Lynch, C.J.1
Sobo, G.E.2
Exton, J.H.3
-
21
-
-
33847419281
-
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts
-
Mammoto, A., Huang, S., and Ingber, D.E. (2007). Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J. Cell Sci., 120, 456-467.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 456-467
-
-
Mammoto, A.1
Huang, S.2
Ingber, D.E.3
-
22
-
-
0037144522
-
Klotho protein deficiency leads to overactivation of mu-calpain
-
Manya, H., Inomata, M., Fujimori, T., Dohmae, N., Sato, Y., Takio, K., Nabeshima, Y., and Endo, T. (2002). Klotho protein deficiency leads to overactivation of mu-calpain. J. Biol. Chem., 277, 35503-35508.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35503-35508
-
-
Manya, H.1
Inomata, M.2
Fujimori, T.3
Dohmae, N.4
Sato, Y.5
Takio, K.6
Nabeshima, Y.7
Endo, T.8
-
23
-
-
0032567647
-
Identification of the human Klotho gene and its two transcripts encoding membrane and secreted Klotho protein
-
Matsumura, Y., Aizawa, H., Shiraki-Iida, T., Nagai, R., Kuro-O, M., and Nabeshima, Y. (1998). Identification of the human Klotho gene and its two transcripts encoding membrane and secreted Klotho protein. Biochem. Biophys. Res. Commun., 242, 626-630.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.242
, pp. 626-630
-
-
Matsumura, Y.1
Aizawa, H.2
Shiraki-Iida, T.3
Nagai, R.4
Kuro-O, M.5
Nabeshima, Y.6
-
24
-
-
3543071604
-
Sialidase and malignancy: a minireview
-
Miyagi, T., Wada, T., Yamaguchi, K., and Hata, K. (2004). Sialidase and malignancy: a minireview. Glycoconj. J., 20, 189-198.
-
(2004)
Glycoconj. J.
, vol.20
, pp. 189-198
-
-
Miyagi, T.1
Wada, T.2
Yamaguchi, K.3
Hata, K.4
-
25
-
-
50449096595
-
Human sialidase as a cancer marker
-
Miyagi, T., Wada, T., Yamaguchi, K., Shiozaki, K., Sato, I., Kakugawa, Y., Yamanami, H., and Fujiya, T. (2008). Human sialidase as a cancer marker. Proteomics, 8, 3303-3311.
-
(2008)
Proteomics
, vol.8
, pp. 3303-3311
-
-
Miyagi, T.1
Wada, T.2
Yamaguchi, K.3
Shiozaki, K.4
Sato, I.5
Kakugawa, Y.6
Yamanami, H.7
Fujiya, T.8
-
26
-
-
33744550350
-
Toward a better understanding of Klotho
-
Nabeshima, Y. (2006). Toward a better understanding of Klotho. Sci Aging Knowledge Environ, 2006, pe11.
-
(2006)
Sci Aging Knowledge Environ
, vol.2006
-
-
Nabeshima, Y.1
-
27
-
-
67449128692
-
Wnt5A activates the calpain-mediated cleavage of filamin A
-
O'Connell, M.P., Fiori, J.L., Baugher, K.M. et al. (2009a). Wnt5A activates the calpain-mediated cleavage of filamin A. J. Invest. Dermatol., 129, 1782-1789.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1782-1789
-
-
O'Connell, M.P.1
Fiori, J.L.2
Baugher, K.M.3
-
28
-
-
70350399516
-
Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells
-
O'Connell, M.P., Fiori, J.L., Kershner, E.K., Frank, B.P., Indig, F.E., Taub, D.D., Hoek, K.S., and Weeraratna, A.T. (2009b). Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells. J. Biol. Chem., 284, 28704-28712.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 28704-28712
-
-
O'Connell, M.P.1
Fiori, J.L.2
Kershner, E.K.3
Frank, B.P.4
Indig, F.E.5
Taub, D.D.6
Hoek, K.S.7
Weeraratna, A.T.8
-
29
-
-
0033080918
-
Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging
-
Ouanounou, A., Zhang, L., Charlton, M.P., and Carlen, P.L. (1999). Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging. J. Neurosci., 19, 906-915.
-
(1999)
J. Neurosci.
, vol.19
, pp. 906-915
-
-
Ouanounou, A.1
Zhang, L.2
Charlton, M.P.3
Carlen, P.L.4
-
30
-
-
0036929816
-
Calcium pump phosphoenzyme from young and old human red cells
-
Romero, P.J., Salas, V., and Hernandez, C. (2002). Calcium pump phosphoenzyme from young and old human red cells. Cell Biol. Int., 26, 945-949.
-
(2002)
Cell Biol. Int.
, vol.26
, pp. 945-949
-
-
Romero, P.J.1
Salas, V.2
Hernandez, C.3
-
31
-
-
1642352496
-
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides
-
Tohyama, O., Imura, A., Iwano, A., Freund, J.N., Henrissat, B., Fujimori, T., and Nabeshima, Y. (2004). Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J. Biol. Chem., 279, 9777-9784.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 9777-9784
-
-
Tohyama, O.1
Imura, A.2
Iwano, A.3
Freund, J.N.4
Henrissat, B.5
Fujimori, T.6
Nabeshima, Y.7
-
32
-
-
62049084618
-
Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4
-
Uemura, T., Shiozaki, K., Yamaguchi, K., Miyazaki, S., Satomi, S., Kato, K., Sakuraba, H., and Miyagi, T. (2009). Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin beta4. Oncogene, 28, 1218-1229.
-
(2009)
Oncogene
, vol.28
, pp. 1218-1229
-
-
Uemura, T.1
Shiozaki, K.2
Yamaguchi, K.3
Miyazaki, S.4
Satomi, S.5
Kato, K.6
Sakuraba, H.7
Miyagi, T.8
-
33
-
-
0036528247
-
Wnt5A signaling directly affects cell motility and invasion of metastatic melanoma
-
Weeraratna, A.T., Jiang, Y., Hostetter, G., Rosenblatt, K., Duray, P., Bittner, M., and Trent, J.M. (2002). Wnt5A signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell, 1, 279-288.
-
(2002)
Cancer Cell
, vol.1
, pp. 279-288
-
-
Weeraratna, A.T.1
Jiang, Y.2
Hostetter, G.3
Rosenblatt, K.4
Duray, P.5
Bittner, M.6
Trent, J.M.7
-
34
-
-
58149229326
-
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
-
Wolf, I., Levanon-Cohen, S., Bose, S. et al. (2008). Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene, 27, 7094-7105.
-
(2008)
Oncogene
, vol.27
, pp. 7094-7105
-
-
Wolf, I.1
Levanon-Cohen, S.2
Bose, S.3
-
35
-
-
1642293247
-
Ribosomal S6 kinase (RSK) regulates phosphorylation of Filamin A on an important regulatory site
-
Woo, M.S., Ohta, Y., Rabinovitz, I., Stossel, T.P., and Blenis, J. (2004). Ribosomal S6 kinase (RSK) regulates phosphorylation of Filamin A on an important regulatory site. Mol. Cell. Biol., 24, 3025-3035.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3025-3035
-
-
Woo, M.S.1
Ohta, Y.2
Rabinovitz, I.3
Stossel, T.P.4
Blenis, J.5
-
36
-
-
2942536306
-
Klotho is a serum factor related to human aging
-
Xiao, N.M., Zhang, Y.M., Zheng, Q., and Gu, J. (2004). Klotho is a serum factor related to human aging. Chin Med J (Engl), 117, 742-747.
-
(2004)
Chin Med J (Engl)
, vol.117
, pp. 742-747
-
-
Xiao, N.M.1
Zhang, Y.M.2
Zheng, Q.3
Gu, J.4
|