Plasma klotho and mortality risk in older community-dwelling adults

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 7, 2011, Pages 794-800

  Semba, Richard D ^a   Cappola, Anne R ^b   Sun, Kai ^a   Bandinelli, Stefania ^c   Dalal, Mansi ^a   Crasto, Candace ^a   Guralnik, Jack M ^d   Ferrucci, Luigi ^e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Azienda Sanitaria   (Italy)

^d Laboratory of Epidemiology   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Aging; Klotho; Longevity; Mortality

Indexed keywords

MUS;

BETA GLUCURONIDASE; BIOLOGICAL MARKER; KLOTHO PROTEIN;

AGED; AGING; ARTICLE; BLOOD; CAUSE OF DEATH; CLINICAL TRIAL; COMPARATIVE STUDY; CONFIDENCE INTERVAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GERIATRIC ASSESSMENT; HUMAN; ITALY; LONGEVITY; MALE; METHODOLOGY; MOTOR ACTIVITY; MULTICENTER STUDY; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVAL RATE; TIME;

AGED; AGING; BIOLOGICAL MARKERS; CAUSE OF DEATH; CONFIDENCE INTERVALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; GERIATRIC ASSESSMENT; GLUCURONIDASE; HUMANS; ITALY; LONGEVITY; MALE; MOTOR ACTIVITY; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TIME FACTORS;

EID: 80051518025     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr058     Document Type: Article

References (35)

1. Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45-51. (Pubitemid 27494749)
2. Kuro-o M. Klotho. Eur J Physiol. 2010;459:333-343.
3. Kurosu H, Yamamoto M, Clark JE, et al. Suppression of aging in mice by the hormone klotho. Science. 2005;308:1829-1833. (Pubitemid 41325087)
4. Urakawa I, Yamazaki Y, Shimada T, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006;444: 770-774. (Pubitemid 44949607)
5. Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoederop JG. The b-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science. 2005;310:490-493. (Pubitemid 41507962)
6. Imura A, Tsuji Y, Murata M, et al. a-klotho as a regulator of calcium homeostasis. Science. 2007;316:1615-1618.
7. Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun. 1998;242:626-630. (Pubitemid 28412578)
8. Imura A, Iwano A, Tohyama O, et al. Secreted klotho protein in sera and CSF: implications for post-translational cleavage in release of klotho protein from cell membrane. FEBS Lett. 2004;565:143-147. (Pubitemid 38595335)
9. Yamazaki Y, Imura A, Urakawa I, et al. Establishment of a sandwich ELISA for soluble alpha-klotho measurements: age-dependent change of soluble alpha-klotho levels in healthy subjects. Biochem Biophys Res Commun. 2010;398:513-518.
10. Ferrucci L, Bandinelli S, Benvenuti E, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc. 2000;48:1618-1625.
11. Guralnik JM, Fried LP, Simonsick EM, et al. The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability; Bethesda, MD: National Institute on Aging. 1995. NIH Publication No. 95-4009; 1995.
12. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2006;29(suppl 1):S43-S48.
13. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
14. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130:461-470. (Pubitemid 29135798)
15. Ito S, Kinoshita S, Shiraishi N, et al. Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech Dev. 2000;98:115-119.
16. Friedewald WT, Levy RI, Frederickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparation ultracentrifuge. Clin Chem. 1972;18:499-502.
17. Semba RD, Houston DK, Bandinelli S, et al. Relationship of 25-hydroxyvitamin D with all-cause and cardiovascular disease mortality older community-dwelling adults. Eur J Clin Nutr. 2010;64:203-209.
18. Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulin-like signals. Science. 2003;299:1346-1351. (Pubitemid 36254639)
19. Utsugi T, Ohno T, Ohyama Y, et al. Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism. 2000;48:1118-1123.
20. Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S. Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care. 2009;32(suppl 2):S314-S321.
21. Saito Y, Yamagishi T, Nakamura T, et al. Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Comm. 1998;248:324-329. (Pubitemid 28386420)
22. Saito Y, Nakamura T, Ohyama Y, et al. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun. 2000;276:767-772.
23. Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL. Regulation of renal outer medullary potassium channel and renal K+ excretion by klotho. Mol Pharmacol. 2009;76:38-46.
24. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of aging. Nature. 2000;408:239-247.
25. Yamamoto M, Clark JD, Pastor JV, et al. Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem. 2005;280:38029-38034. (Pubitemid 41642417)
26. Arking DE, Krebsova A, Macek M Sr, et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A. 2002;99:856-861. (Pubitemid 34106600)
27. Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res. 2005;96:412-418. (Pubitemid 40354534)
28. Arking DE, Becker DM, Yanek LR, et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet. 2003;72:1154-1161. (Pubitemid 36530003)
29. Imamura A, Okumura K, Ogawa Y, et al. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Clin Chim Acta. 2006;371:66-70. (Pubitemid 44162896)
30. Rhee EJ, Oh KW, Lee WY, et al. The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. Metab Clin Exp. 2006;55:1344-1351.
31. Kim Y, Kim JH, Nam YJ, et al. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett. 2006;407:189-194. (Pubitemid 44402870)
32. Kawano K, Ogata N, Chiano M, et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res. 2002;17:1744-1751.
33. Ogata N, Matsumura Y, Shiraki M, et al. Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Bone. 2002;31:37-42. (Pubitemid 34754423)
34. Yamada Y, Ando F, Niino N, Shimokata H. Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med. 2005;83:50-57. (Pubitemid 40169496)
35. Riancho JA, Valero C, Hernández JL, et al. Association of the F352V variant of the klotho gene with bone mineral density. Biogerontology. 2007;8:121-127. (Pubitemid 46487981)