Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

Kidney International

Volumn 81, Issue 7, 2012, Pages 640-650

  Sun, Chiao Yin ^a,b   Chang, Shih Chung ^c   Wu, Mai Szu ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

DNA methylation; DNA methyltransferase; Klotho; uremic toxin

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CREATININE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GLUTATHIONE TRANSFERASE ALPHA; KLOTHO PROTEIN; MESSENGER RNA; NITROGEN; UREA; UREMIC TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CPG ISLAND; CREATININE BLOOD LEVEL; DNA METHYLATION; DNA MODIFICATION; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; KLOTHO GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; UREA NITROGEN BLOOD LEVEL; UREMIA; WESTERN BLOTTING;

ANIMALS; AZACITIDINE; CELL LINE; CPG ISLANDS; CRESOLS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; GENE EXPRESSION; GLUCURONIDASE; HUMANS; INDICAN; KIDNEY; MICE; PROTEIN BINDING; TOXINS, BIOLOGICAL; UREMIA;

EID: 84863338125     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.445     Document Type: Article

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