Npt2 gene disruption confers resistance to the inhibitory action of parathyroid hormone on renal sodium-phosphate cotransport

Endocrinology

Volumn 141, Issue 6, 2000, Pages 2159-2165

  Zhao, Ningxia ^a   Tenenhouse, Harriet S ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE; PHOSPHATE; SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FEMALE; GENE DISRUPTION; GENE EXPRESSION; HORMONE ACTION; ION TRANSPORT; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; URINARY EXCRETION; WESTERN BLOTTING;

EID: 0034456670     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.6.7484     Document Type: Article

References (42)

1. Renal regulation of phosphate excretion
2. Molecular regulation of renal phosphate transport
3. Cellular and molecular mechanisms of renal phosphate transport
4. A molecular view of proximal tubular inorganic phosphate (Pi) reabsorption and of its regulation
5. Cellular/molecular control of renal Na/Pi-cotransport
6. Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex
7. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23
8. Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter
9. Expression cloning of human and rat renal cortex Na/Pi cotransport
10. Cloning of a Na/Pi cotransporter from opossum kidney cells
11. Cloning of a rabbit renal Na-Pi cotransporter, which is regulated by dietary phosphate
12. +/Pi) transporter in the control and hypophosphatemic mouse
13. Transport characteristics of a murine renal Na/Pi-cotransporter
14. Cloning, sequence analysis and expression of the cDNA encoding a sodium-dependent phosphate transporter from the bovine renal epithelial cell line NBL-1
15. Localization of NaPi-1, a Na-Pi-cotransporter, in rabbit kidney proximal tubules. I. mRNA-localization by RT-PCR
16. Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry
17. Expression of Na-Pi cotransport in rat kidney: Localization by RT-PCR and immunohistochemistry
18. + -phosphate cotransporter genes in murine kidney
19. Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules
20. Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter
21. Cellular mechanisms involved in the acute adaptation of OK cell Na/Pi-cotransport to high- or low-Pi medium
22. Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content
23. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria and skeletal abnormalities
24. Effects of Npt2 gene ablation and low-phosphate diet on renal Na/phosphate cotransport and cotransporter gene expression
25. + -phosphate cotransport in murine X-linked hypophosphatemic rickets: Molecular characterization
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. +-Pi cotransporter mRNA and immunoreactive protein in X-linked Hyp mice
28. Renal brush border membrane adaptation to phosphorus deprivation in the Hyp/Y mouse
29. Renal resistance to parathyroid hormone during phosphorus deprivation
30. Effect of cAMP analogue infusion on phosphate reabsorption in phosphate-deprived rats
31. +-phosphate cotransport in mouse distal convoluted tubule cells: Evidence for Glvr-1 and Ram-1 gene expression
32. Parathyroid hormone stimulation of calcium transport is mediated by dual signaling mechanisms involving protein kinase A and protein kinase C
33. A dual mechanism for regulation of kidney phosphate transport by parathyroid hormone
34. 4 cotransport type III (PIT1) expression in human embryonic kidney cells and regulation by PTH
35. Parathyroid hormone regulates phosphate transport in OK cells via an irreversible inactivation of a membrane protein
36. Parathyroid hormone-dependent degradation of type II Na/Pi cotransporters
37. Parathyroid hormone: Chemistry, biosynthesis, and mode of action
38. Protein kinase A and the effects of parathyroid hormone on phosphate uptake in opossum kidney cells
39. Effect of U-73,122, an inhibitor of phospholipase C, on actions of parathyroid hormone in opossum kidney cells
40. Sodium-phosphate cotransport in OK cells: Inhibition by PTH and "adaptation" to low phosphate
41. Identification of regulatory sequences and binding proteins in the type II sodium/phosphate cotransporter NPT2 gene responsive to dietary phosphate
42. Rapid downregulation of rat renal Na/P(i) cotransporter in response to parathyroid hormone involves microtubule re-arrangement