Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3

Kidney International

Volumn 80, Issue 1, 2011, Pages 61-67

  Bhandaru, Madhuri ^a   Kempe, Daniela S ^a   Rotte, Anand ^a   Capuano, Paola ^b   Pathare, Ganesh ^a   Sopjani, Mentor ^a   Alesutan, Ioana ^a   Tyan, Leonid ^a   Huang, Dan Yang ^a   Siraskar, Balasaheb ^a   Judenhofer, Martin S ^a   Stange, Gerti ^b   Pichler, Bernd J ^a   Biber, Jürg ^b   Quintanilla Martinez, Leticia ^a   Wagner, Carsten A ^b   Pearce, David ^c   Föller, Michael ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

calcium; insulin; mineralization; phosphate; PTH

Indexed keywords

CALCITRIOL; FIBROBLAST GROWTH FACTOR 23; PARATHYROID HORMONE; PROTEIN SERINE THREONINE KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 3; SODIUM PHOSPHATE COTRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEMINERALIZATION; BONE DENSITY; BONE MINERALIZATION; CALCIUM EXCRETION; CONTROLLED STUDY; CORTICAL BONE; CREATININE CLEARANCE; FLUID INTAKE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; INTESTINE BRUSH BORDER MEMBRANE; KIDNEY TUBULE ABSORPTION; MOUSE; NONHUMAN; OOCYTE; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATURIA; PRIORITY JOURNAL; PROTEIN FUNCTION; TRABECULAR BONE; URINE FLOW RATE;

EID: 79958799468     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.67     Document Type: Article

References (46)

1. Berndt T, Kumar R. Phosphatonins and the regulation of phosphate homeostasis. Annu Rev Physiol 2007; 69: 341-359. (Pubitemid 46457647)
2. Liu S, Quarles LD. How fibroblast growth factor 23 works. J Am Soc Nephrol 2007; 18: 1637-1647. (Pubitemid 46870300)
3. Murer H, Hernando N, Forster I et al. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol Rev 2000; 80: 1373-1409.
4. Takeda E, Taketani Y, Sawada N et al. The regulation and function of phosphate in the human body. Biofactors 2004; 21: 345-355. (Pubitemid 40921881)
5. Forster IC, Hernando N, Biber J et al. Proximal tubular handling of phosphate: a molecular perspective. Kidney Int 2006; 70: 1548-1559. (Pubitemid 44606989)
6. Allon M. Effects of insulin and glucose on renal phosphate reabsorption: interactions with dietary phosphate. J Am Soc Nephrol 1992; 2: 1593-1600.
7. DeFronzo RA, Goldberg M, Agus ZS. The effects of glucose and insulin on renal electrolyte transport. J Clin Invest 1976; 58: 83-90.
8. Feld S, Hirschberg R. Insulinlike growth factor I and the kidney. Trends Endocrinol Metab 1996; 7: 85-93. (Pubitemid 26144498)
9. Jehle AW, Forgo J, Biber J et al. IGF-I and vanadate stimulate Na/Picotransport in OK cells by increasing type II Na/Pi-cotransporter protein stability. Pflugers Arch 1998; 437: 149-154. (Pubitemid 29071325)
10. Kobayashi T, Deak M, Morrice N et al. Characterization of the structure and regulation of two novel isoforms of serum-and glucocorticoidinduced protein kinase. Biochem J 1999; 344(Part 1): 189-197.
11. Alessi DR, Andjelkovic M, Caudwell B et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996; 15: 6541-6551. (Pubitemid 26413787)
12. Kobayashi T, Cohen P. Activation of serum-and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 1999; 339(Part 2): 319-328. (Pubitemid 29209961)
13. Lang F, Bohmer C, Palmada M et al. (Patho)physiological significance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006; 86: 1151-1178. (Pubitemid 44521650)
14. McManus EJ, Sakamoto K, Armit LJ et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J 2005; 24: 1571-1583. (Pubitemid 40646447)
15. Martin DR, Ritter CS, Slatopolsky E et al. Acute regulation of parathyroid hormone by dietary phosphate. Am J Physiol Endocrinol Metab 2005; 289: E729-E734. (Pubitemid 41356098)
16. Kato S. Genetic mutation in the human 25-hydroxyvitamin D3 1alphahydroxylase gene causes vitamin D-dependent rickets type I. Mol Cell Endocrinol 1999; 156: 7-12. (Pubitemid 29460739)
17. Portale AA, Miller WL. Human 25-hydroxyvitamin D-1alpha-hydroxylase: cloning, mutations, and gene expression. Pediatr Nephrol 2000; 14: 620-625. (Pubitemid 30394440)
18. Perwad F, Azam N, Zhang MY et al. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 2005; 146: 5358-5364. (Pubitemid 41653049)
19. Menaa C, Vrtovsnik F, Friedlander G et al. Insulin-like growth factor I, a unique calcium-dependent stimulator of 1,25-dihydroxyvitamin D3 production. Studies in cultured mouse kidney cells. J Biol Chem 1995; 270: 25461-25467.
20. Kurnik BR, Huskey M, Hruska KA. 1,25-Dihydroxycholecalciferol stimulates renal phosphate transport by directly altering membrane phosphatidylcholine composition. Biochim Biophys Acta 1987; 917: 81-85. (Pubitemid 17231050)
21. Brown AJ, Finch J, Slatopolsky E. Differential effects of 19-nor-1,25-dihydroxyvitamin D(2) and 1,25-dihydroxyvitamin D(3) on intestinal calcium and phosphate transport. J Lab Clin Med 2002; 139: 279-284. (Pubitemid 34577479)
22. Capuano P, Radanovic T, Wagner CA et al. Intestinal and renal adaptation to a low-Pi diet of type II NaPi cotransporters in vitamin D receptor-and 1alphaOHase-deficient mice. Am J Physiol Cell Physiol 2005; 288: C429-C434. (Pubitemid 40105354)
23. Sandu C, Rexhepaj R, Grahammer F et al. Decreased intestinal glucose transport in the sgk3-knockout mouse. Pflugers Arch 2005; 451: 437-444. (Pubitemid 41719575)
24. Kempe DS, Ackermann TF, Boini KM et al. Akt2/PKBbeta-sensitive regulation of renal phosphate transport. Acta Physiol (Oxf) 2010; 200: 75-85.
25. Morales O, Samuelsson MK, Lindgren U et al. Effects of 1alpha,25-dihydroxyvitamin D3 and growth hormone on apoptosis and proliferation in UMR 106 osteoblast-like cells. Endocrinology 2004; 145: 87-94. (Pubitemid 38094504)
26. van Driel M, Pols HA, van Leeuwen JP. Osteoblast differentiation and control by vitamin D and vitamin D metabolites. Curr Pharm Des 2004; 10: 2535-2555. (Pubitemid 39004077)
27. Zhang X, Zanello LP. Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts. J Bone Miner Res 2008; 23: 1238-1248. (Pubitemid 352040178)
28. Kanatani M, Sugimoto T, Kano J et al. Effect of high phosphate concentration on osteoclast differentiation as well as bone-resorbing activity. J Cell Physiol 2003; 196: 180-189. (Pubitemid 36676456)
29. Lang F, Cohen P. Regulation and physiological roles of serum-and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001; 2001: RE17.
30. Chaudhary LR, Hruska KA. The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J Cell Biochem 2001; 81: 304-311. (Pubitemid 32298262)
31. Kwak HB, Sun HM, Ha H et al. AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathway. Mol Cells 2008; 26: 436-442.
32. Lee SE, Chung WJ, Kwak HB et al. Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK. J Biol Chem 2001; 276: 49343-49349.
33. Busch AE, Wagner CA, Schuster A et al. Properties of electrogenic Pi transport by a human renal brush border Na+/Pi transporter. J Am Soc Nephrol 1995; 6: 1547-1551.
34. Henrion U, Strutz-Seebohm N, Duszenko M et al. Long QT syndromeassociated mutations in the voltage sensor of I(Ks) channels. Cell Physiol Biochem 2009; 24: 11-16.
35. Boehmer C, Palmada M, Klaus F et al. The peptide transporter PEPT2 is targeted by the protein kinase SGK1 and the scaffold protein NHERF2. Cell Physiol Biochem 2008; 22: 705-714.
36. Boehmer C, Laufer J, Jeyaraj S et al. Modulation of the voltage-gated potassium channel Kv1.5 by the SGK1 protein kinase involves inhibition of channel ubiquitination. Cell Physiol Biochem 2008; 22: 591-600.
37. Laufer J, Boehmer C, Jeyaraj S et al. The C-terminal PDZ-binding motif in the Kv1.5 potassium channel governs its modulation by the Na+/H+ exchanger regulatory factor 2. Cell Physiol Biochem 2009; 23: 25-36.
38. Gehring EM, Zurn A, Klaus F et al. Regulation of the glutamate transporter EAAT2 by PIKfyve. Cell Physiol Biochem 2009; 24: 361-368.
39. McCormick JA, Feng Y, Dawson K et al. Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development. Mol Biol Cell 2004; 15: 4278-4288. (Pubitemid 39122029)
40. Vallon V. In vivo studies of the genetically modified mouse kidney. Nephron Physiol 2003; 94: 1-5.
41. Huang DY, Wulff P, Volkl H et al. Impaired regulation of renal K+ elimination in the sgk1-knockout mouse. J Am Soc Nephrol 2004; 15: 885-891. (Pubitemid 38375307)
42. Huang DY, Vallon V, Zimmermann H et al. Ecto-50-nucleotidase (cd73)-dependent and-independent generation of adenosine participates in the mediation of tubuloglomerular feedback in vivo. Am J Physiol Renal Physiol 2006; 291: F282-F288. (Pubitemid 44148117)
43. Biber J, Stieger B, Stange G et al. Isolation of renal proximal tubular brushborder membranes. Nat Protoc 2007; 2: 1356-1359. (Pubitemid 46952317)
44. Villa-Bellosta R, Ravera S, Sorribas V et al. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am J Physiol Renal Physiol 2009; 296: F691-F699.
45. Custer M, Lotscher M, Biber J et al. Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am J Physiol 1994; 266: F767-F774.
46. Nowik M, Picard N, Stange G et al. Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch 2008; 457: 539-549.