-
1
-
-
0038744264
-
KLOTHO allele status and the risk of early-onset occult coronary artery disease
-
Arking DE, Becker DM, Yanek LR, Fallin D, Judge DP, Moy TF et al. (2003). KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 72: 1154-1161.
-
(2003)
Am J Hum Genet
, vol.72
, pp. 1154-1161
-
-
Arking, D.E.1
Becker, D.M.2
Yanek, L.R.3
Fallin, D.4
Judge, D.P.5
Moy, T.F.6
-
2
-
-
18244372958
-
Association of human aging with a functional variantof klotho
-
Arking DE, Krebsova A, Macek Sr M, Macek Jr M, Arking A, Mian IS et al. (2002). Association of human aging with a functional variantof klotho. Proc Natl Acad Sci 99: 856-861.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 856-861
-
-
Arking, D.E.1
Krebsova, A.2
Macek Sr, M.3
Macek Jr, M.4
Arking, A.5
Mian, I.S.6
-
3
-
-
0035884617
-
Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells
-
Bartucci M, Morelli C, Mauro L, Ando S, Surmacz E. (2001). Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. Cancer Res 61: 6747-6754.
-
(2001)
Cancer Res
, vol.61
, pp. 6747-6754
-
-
Bartucci, M.1
Morelli, C.2
Mauro, L.3
Ando, S.4
Surmacz, E.5
-
4
-
-
47749148805
-
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1
-
Cha S-K, Ortega B, Kurosu H, Rosenblatt KP, Kuro-o M, Huang C-L. (2008). Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci 105: 9805-9810.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 9805-9810
-
-
Cha, S.-K.1
Ortega, B.2
Kurosu, H.3
Rosenblatt, K.P.4
Kuro-o, M.5
Huang, C.-L.6
-
5
-
-
27144440831
-
The {beta}-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
-
Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG. (2005). The {beta}-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310: 490-493.
-
(2005)
Science
, vol.310
, pp. 490-493
-
-
Chang, Q.1
Hoefs, S.2
van der Kemp, A.W.3
Topala, C.N.4
Bindels, R.J.5
Hoenderop, J.G.6
-
6
-
-
38049144010
-
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
-
Chen C-D, Podvin S, Gillespie E, Leeman SE, Abraham CR. (2007). Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci 104: 19796-19801.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 19796-19801
-
-
Chen, C.-D.1
Podvin, S.2
Gillespie, E.3
Leeman, S.E.4
Abraham, C.R.5
-
7
-
-
33746036030
-
Klotho protein promotes adipocyte differentiation
-
Chihara Y, Rakugi H, Ishikawa K, Ikushima M, Maekawa Y, Ohta J et al. (2006). Klotho protein promotes adipocyte differentiation. Endocrinology 147: 3835-3842.
-
(2006)
Endocrinology
, vol.147
, pp. 3835-3842
-
-
Chihara, Y.1
Rakugi, H.2
Ishikawa, K.3
Ikushima, M.4
Maekawa, Y.5
Ohta, J.6
-
8
-
-
33749342012
-
Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
-
de Oliveira RM. (2006). Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Letters 580: 5753-5758.
-
(2006)
FEBS Letters
, vol.580
, pp. 5753-5758
-
-
de Oliveira, R.M.1
-
9
-
-
0037974416
-
The epithelial calcium channels, TRPV5 & TRPV6: From identification towards regulation
-
den Dekker E, Hoenderop JGJ, Nilius B, Bindels RJM. (2003). The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation. Cell Calcium 33: 497-507.
-
(2003)
Cell Calcium
, vol.33
, pp. 497-507
-
-
den Dekker, E.1
Hoenderop, J.G.J.2
Nilius, B.3
Bindels, R.J.M.4
-
10
-
-
0036632316
-
Basic fibroblast growth factor mediated growth inhibition in breast cancer cells is independent of ras signaling pathway
-
Fenig E, Szyper-Kravitz M, Yerushalmi R, Lahav M, Beery E, Wasserman L et al. (2002). Basic fibroblast growth factor mediated growth inhibition in breast cancer cells is independent of ras signaling pathway. Oncol Rep 9: 875-877.
-
(2002)
Oncol Rep
, vol.9
, pp. 875-877
-
-
Fenig, E.1
Szyper-Kravitz, M.2
Yerushalmi, R.3
Lahav, M.4
Beery, E.5
Wasserman, L.6
-
11
-
-
0031041971
-
Basic fibroblast growth factor confers growth inhibition and mitogen-activated protein kinase activation in human breast cancer cells
-
Fenig E, Wieder R, Paglin S, Wang H, Persaud R, Haimovitz-Friedman A et al. (1997). Basic fibroblast growth factor confers growth inhibition and mitogen-activated protein kinase activation in human breast cancer cells. Clin Cancer Res 3: 135-142.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 135-142
-
-
Fenig, E.1
Wieder, R.2
Paglin, S.3
Wang, H.4
Persaud, R.5
Haimovitz-Friedman, A.6
-
12
-
-
0029134568
-
Insulin-like growth factor-1 inhibits cell death induced by anticancer drugs in the MCF-7 cells: Involvement of growth factors in drug resistance
-
Geier A, Beery R, Haimsohn M, Karasik A. (1995). Insulin-like growth factor-1 inhibits cell death induced by anticancer drugs in the MCF-7 cells: involvement of growth factors in drug resistance. Cancer Invest 13: 480-486.
-
(1995)
Cancer Invest
, vol.13
, pp. 480-486
-
-
Geier, A.1
Beery, R.2
Haimsohn, M.3
Karasik, A.4
-
13
-
-
18244397460
-
Down-regulation and growth inhibitory role of C/EBP{alpha} in breast cancer
-
Gery S, Tanosaki S, Bose S, Bose N, Vadgama J, Koeffler HP. (2005). Down-regulation and growth inhibitory role of C/EBP{alpha} in breast cancer. Clin Cancer Res 11: 3184-3190.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3184-3190
-
-
Gery, S.1
Tanosaki, S.2
Bose, S.3
Bose, N.4
Vadgama, J.5
Koeffler, H.P.6
-
14
-
-
33748208668
-
C/EBP[beta] at the core of the TGF[beta] cytostatic response and its evasion in metastatic breast cancer cells
-
Gomis RR, Alarcon C, Nadal C, Van Poznak C, Massague J. (2006). C/EBP[beta] at the core of the TGF[beta] cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 10: 203-214.
-
(2006)
Cancer Cell
, vol.10
, pp. 203-214
-
-
Gomis, R.R.1
Alarcon, C.2
Nadal, C.3
Van Poznak, C.4
Massague, J.5
-
15
-
-
0036171227
-
Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells
-
Haimsohn M, Beery R, Karasik A, Kanety H, Geier A. (2002). Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells. Endocrinology 143: 837-845.
-
(2002)
Endocrinology
, vol.143
, pp. 837-845
-
-
Haimsohn, M.1
Beery, R.2
Karasik, A.3
Kanety, H.4
Geier, A.5
-
16
-
-
31544464616
-
In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417
-
Haluska P, Carboni JM, Loegering DA, Lee FY, Wittman M, Saulnier MG et al. (2006). In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417. Cancer Res 66: 362-371.
-
(2006)
Cancer Res
, vol.66
, pp. 362-371
-
-
Haluska, P.1
Carboni, J.M.2
Loegering, D.A.3
Lee, F.Y.4
Wittman, M.5
Saulnier, M.G.6
-
17
-
-
0036632287
-
High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer
-
Hsiung R, Zhu W, Klein G, Qin W, Rosenberg A, Park P et al. (2002). High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer. Cancer J 8: 303-310.
-
(2002)
Cancer J
, vol.8
, pp. 303-310
-
-
Hsiung, R.1
Zhu, W.2
Klein, G.3
Qin, W.4
Rosenberg, A.5
Park, P.6
-
18
-
-
28844474827
-
Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
-
Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J et al. (2006). Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun 339: 827-832.
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 827-832
-
-
Ikushima, M.1
Rakugi, H.2
Ishikawa, K.3
Maekawa, Y.4
Yamamoto, K.5
Ohta, J.6
-
19
-
-
2342610541
-
Secreted Klotho protein in sera and CSF: Implication for post-translational cleavage in release of Klotho protein from cell membrane
-
Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N et al. (2004). Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett 565: 143-147.
-
(2004)
FEBS Lett
, vol.565
, pp. 143-147
-
-
Imura, A.1
Iwano, A.2
Tohyama, O.3
Tsuji, Y.4
Nozaki, K.5
Hashimoto, N.6
-
20
-
-
34250803923
-
-
alpha}-klotho as a regulator of calcium homeostasis
-
Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A et al. (2007). {alpha}-klotho as a regulator of calcium homeostasis. Science 316: 1615-1618.
-
(2007)
Science
, vol.316
, pp. 1615-1618
-
-
Imura, A.1
Tsuji, Y.2
Murata, M.3
Maeda, R.4
Kubota, K.5
Iwano, A.6
-
21
-
-
0034333526
-
Molecular cloning and expression analyses of mouse [beta]klotho, which encodes a novel Klotho family protein
-
Ito S, Kinoshita S, Shiraishi N, Nakagawa S, Sekine S, Fujimori T et al. (2000). Molecular cloning and expression analyses of mouse [beta]klotho, which encodes a novel Klotho family protein. Mech Dev 98: 115-119.
-
(2000)
Mech Dev
, vol.98
, pp. 115-119
-
-
Ito, S.1
Kinoshita, S.2
Shiraishi, N.3
Nakagawa, S.4
Sekine, S.5
Fujimori, T.6
-
22
-
-
0034685014
-
Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys
-
Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K et al. (2000). Establishment of the anti-klotho monoclonal antibodies and detection of klotho protein in kidneys. Biochem Biophys Res Commun 267: 597-602.
-
(2000)
Biochem Biophys Res Commun
, vol.267
, pp. 597-602
-
-
Kato, Y.1
Arakawa, E.2
Kinoshita, S.3
Shirai, A.4
Furuya, A.5
Yamano, K.6
-
23
-
-
33748741795
-
Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females
-
Kim Y, Kim J-H, Nam YJ, Kong M, Kim YJ, Yu K-H et al. (2006). Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett 407: 189-194.
-
(2006)
Neurosci Lett
, vol.407
, pp. 189-194
-
-
Kim, Y.1
Kim, J.-H.2
Nam, Y.J.3
Kong, M.4
Kim, Y.J.5
Yu, K.-H.6
-
24
-
-
0033965233
-
Basic fibroblast growth factor confers a less malignant phenotype in MDA-MB-231 human breast cancer cells
-
Korah RM, Sysounthone V, Golowa Y, Wieder R. (2000). Basic fibroblast growth factor confers a less malignant phenotype in MDA-MB-231 human breast cancer cells. Cancer Res 60: 733-740.
-
(2000)
Cancer Res
, vol.60
, pp. 733-740
-
-
Korah, R.M.1
Sysounthone, V.2
Golowa, Y.3
Wieder, R.4
-
25
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T et al. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-o, M.1
Matsumura, Y.2
Aizawa, H.3
Kawaguchi, H.4
Suga, T.5
Utsugi, T.6
-
26
-
-
33646578195
-
Regulation of fibroblast growth factor-23 signaling by Klotho
-
Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP et al. (2006). Regulation of fibroblast growth factor-23 signaling by Klotho. J Biol Chem 281: 6120-6123.
-
(2006)
J Biol Chem
, vol.281
, pp. 6120-6123
-
-
Kurosu, H.1
Ogawa, Y.2
Miyoshi, M.3
Yamamoto, M.4
Nandi, A.5
Rosenblatt, K.P.6
-
27
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P et al. (2005). Suppression of aging in mice by the hormone Klotho. Science 309: 1829-1833.
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
Pastor, J.V.4
Nandi, A.5
Gurnani, P.6
-
28
-
-
1342326910
-
Relevance of breast cancer cell lines as models for breast tumours: An update
-
Lacroix M, Leclercq G. (2004). Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treatment 83: 249-289.
-
(2004)
Breast Cancer Res Treatment
, vol.83
, pp. 249-289
-
-
Lacroix, M.1
Leclercq, G.2
-
29
-
-
34547491691
-
Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation
-
Li X, Kim JW, Gronborg M, Urlaub H, Lane MD, Tang Q-Q. (2007). Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation. Proc Natl Acad Sci 104: 11597-11602.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 11597-11602
-
-
Li, X.1
Kim, J.W.2
Gronborg, M.3
Urlaub, H.4
Lane, M.D.5
Tang, Q.-Q.6
-
30
-
-
0032567647
-
Identification of the human Klotho gene and its two transcripts encoding membrane and secreted Klotho protein
-
Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, Kuro-o M, Nabeshima Y. (1998). Identification of the human Klotho gene and its two transcripts encoding membrane and secreted Klotho protein. Biochem Biophys Res Commun 242: 626-630.
-
(1998)
Biochem Biophys Res Commun
, vol.242
, pp. 626-630
-
-
Matsumura, Y.1
Aizawa, H.2
Shiraki-Iida, T.3
Nagai, R.4
Kuro-o, M.5
Nabeshima, Y.6
-
31
-
-
12144290914
-
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
-
Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M et al. (2004). Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 5: 221-230.
-
(2004)
Cancer Cell
, vol.5
, pp. 221-230
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
Poulaki, V.4
Shringarpure, R.5
Akiyama, M.6
-
32
-
-
0032578906
-
Molecular cloning of rat klotho cDNA: Markedly decreased expression of klotho by acute inflammatory stress
-
Ohyama Y, Kurabayashi M, Masuda H, Nakamura T, Aihara Y, Kaname T et al. (1998). Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochem Biophys Res Commun 251: 920-925.
-
(1998)
Biochem Biophys Res Commun
, vol.251
, pp. 920-925
-
-
Ohyama, Y.1
Kurabayashi, M.2
Masuda, H.3
Nakamura, T.4
Aihara, Y.5
Kaname, T.6
-
33
-
-
0032489424
-
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein
-
Shiraki-Iida T, Aizawa H, Matsumura Y, Sekine S, Iida A, Anazawa H et al. (1998). Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett 424: 6-10.
-
(1998)
FEBS Lett
, vol.424
, pp. 6-10
-
-
Shiraki-Iida, T.1
Aizawa, H.2
Matsumura, Y.3
Sekine, S.4
Iida, A.5
Anazawa, H.6
-
34
-
-
33845631059
-
Klotho converts canonical FGF receptor into a specific receptor for FGF23
-
Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K et al. (2006). Klotho converts canonical FGF receptor into a specific receptor for FGF23. Science 444: 770-774.
-
(2006)
Science
, vol.444
, pp. 770-774
-
-
Urakawa, I.1
Yamazaki, Y.2
Shimada, T.3
Iijima, K.4
Hasegawa, H.5
Okawa, K.6
-
35
-
-
0033812019
-
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
-
Utsugi T, Ohno T, Ohyama Y, Uchiyama T, Saito Y, Matsumura Y et al. (2000). Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism 49: 1118-1123.
-
(2000)
Metabolism
, vol.49
, pp. 1118-1123
-
-
Utsugi, T.1
Ohno, T.2
Ohyama, Y.3
Uchiyama, T.4
Saito, Y.5
Matsumura, Y.6
-
36
-
-
22744458796
-
The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-[kappa]B activation induced via interaction between Akt and I[kappa]B kinase-[beta] in breast cancer cells
-
Vandermoere F, El Yazidi-Belkoura I, Adriaenssens E, Lemoine J, Hondermarck H. (2005). The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-[kappa]B activation induced via interaction between Akt and I[kappa]B kinase-[beta] in breast cancer cells. Oncogene 24: 5482-5491.
-
(2005)
Oncogene
, vol.24
, pp. 5482-5491
-
-
Vandermoere, F.1
El Yazidi-Belkoura, I.2
Adriaenssens, E.3
Lemoine, J.4
Hondermarck, H.5
-
37
-
-
33846804242
-
FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer
-
Wolf I, Bose S, Williamson EA, Miller CW, Karlan BY, Koeffler HP. (2007). FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer. Int J Cancer 120: 1013-1022.
-
(2007)
Int J Cancer
, vol.120
, pp. 1013-1022
-
-
Wolf, I.1
Bose, S.2
Williamson, E.A.3
Miller, C.W.4
Karlan, B.Y.5
Koeffler, H.P.6
-
38
-
-
33747873279
-
15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer
-
Wolf I, O'Kelly J, Rubinek T, Tong M, Nguyen A, Lin BT et al. (2006a). 15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Res 66: 7818-7823.
-
(2006)
Cancer Res
, vol.66
, pp. 7818-7823
-
-
Wolf, I.1
O'Kelly, J.2
Rubinek, T.3
Tong, M.4
Nguyen, A.5
Lin, B.T.6
-
39
-
-
33646433412
-
Association between diabetes mellitus and adverse characteristics of breast cancer at presentation
-
Wolf I, Sadetzki S, Gluck I, Oberman B, Ben-David M, Papa MZ et al. (2006b). Association between diabetes mellitus and adverse characteristics of breast cancer at presentation. Eur J Cancer 42: 1077-1082.
-
(2006)
Eur J Cancer
, vol.42
, pp. 1077-1082
-
-
Wolf, I.1
Sadetzki, S.2
Gluck, I.3
Oberman, B.4
Ben-David, M.5
Papa, M.Z.6
-
40
-
-
33344467985
-
Targeting insulin-like growth factor pathways
-
Yee D. (2006). Targeting insulin-like growth factor pathways. Br J Cancer 94: 465-468.
-
(2006)
Br J Cancer
, vol.94
, pp. 465-468
-
-
Yee, D.1
-
41
-
-
33846202010
-
Klotho gene polymorphism and male bone mass
-
Zarrabeitia M, Hernández JL, Valero C, Zarrabeitia A, Ortiz F, Gonzalez-Macias J et al. (2007). Klotho gene polymorphism and male bone mass. Calcif Tissue Int 80: 10-14.
-
(2007)
Calcif Tissue Int
, vol.80
, pp. 10-14
-
-
Zarrabeitia, M.1
Hernández, J.L.2
Valero, C.3
Zarrabeitia, A.4
Ortiz, F.5
Gonzalez-Macias, J.6
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