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Volumn 8, Issue 3, 2013, Pages

Klotho Endows Hepatoma Cells with Resistance to Anoikis via VEGFR2/PAK1 Activation in Hepatocellular Carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

AXITINIB; KLOTHO PROTEIN; P21 ACTIVATED KINASE 1; SHORT HAIRPIN RNA; VASCULOTROPIN RECEPTOR 2;

EID: 84874868426     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058413     Document Type: Article
Times cited : (38)

References (39)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL, (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 77957603190 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting
    • Thomas MB, Jaffe D, Choti MM, Belghiti J, Curley S, et al. (2010) Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting. J Clin Oncol 28: 3994-4005.
    • (2010) J Clin Oncol , vol.28 , pp. 3994-4005
    • Thomas, M.B.1    Jaffe, D.2    Choti, M.M.3    Belghiti, J.4    Curley, S.5
  • 3
    • 58149376548 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocellular carcinoma
    • Aravalli RN, Steer CJ, Cressman EN, (2008) Molecular mechanisms of hepatocellular carcinoma. Hepatology 48: 2047-2063.
    • (2008) Hepatology , vol.48 , pp. 2047-2063
    • Aravalli, R.N.1    Steer, C.J.2    Cressman, E.N.3
  • 4
    • 34248594553 scopus 로고    scopus 로고
    • Metastasis: recent discoveries and novel treatment strategies
    • Eccles SA, Welch DR, (2007) Metastasis: recent discoveries and novel treatment strategies. Lancet 369: 1742-1757.
    • (2007) Lancet , vol.369 , pp. 1742-1757
    • Eccles, S.A.1    Welch, D.R.2
  • 6
    • 84862742319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1
    • Xu J, Liu H, Chen L, Wang S, Zhou L, et al. (2012) Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1. Gastroenterology 143: 199-212 e194.
    • (2012) Gastroenterology , vol.143
    • Xu, J.1    Liu, H.2    Chen, L.3    Wang, S.4    Zhou, L.5
  • 7
    • 0037827784 scopus 로고    scopus 로고
    • The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis
    • Chen S, Yin X, Zhu X, Yan J, Ji S, et al. (2003) The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. J Biol Chem 278: 20029-20036.
    • (2003) J Biol Chem , vol.278 , pp. 20029-20036
    • Chen, S.1    Yin, X.2    Zhu, X.3    Yan, J.4    Ji, S.5
  • 8
    • 0030724491 scopus 로고    scopus 로고
    • Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    • Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, et al. (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
    • (1997) Nature , vol.390 , pp. 45-51
    • Kuro-o, M.1    Matsumura, Y.2    Aizawa, H.3    Kawaguchi, H.4    Suga, T.5
  • 9
    • 0037268531 scopus 로고    scopus 로고
    • Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress
    • Nagai T, Yamada K, Kim HC, Kim YS, Noda Y, et al. (2003) Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J 17: 50-52.
    • (2003) FASEB J , vol.17 , pp. 50-52
    • Nagai, T.1    Yamada, K.2    Kim, H.C.3    Kim, Y.S.4    Noda, Y.5
  • 10
    • 0034130405 scopus 로고    scopus 로고
    • Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases
    • Nagai R, Saito Y, Ohyama Y, Aizawa H, Suga T, et al. (2000) Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci 57: 738-746.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 738-746
    • Nagai, R.1    Saito, Y.2    Ohyama, Y.3    Aizawa, H.4    Suga, T.5
  • 13
    • 79952281150 scopus 로고    scopus 로고
    • Klotho suppresses RIG-I-mediated senescence-associated inflammation
    • Liu F, Wu S, Ren H, Gu J, (2011) Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13: 254-262.
    • (2011) Nat Cell Biol , vol.13 , pp. 254-262
    • Liu, F.1    Wu, S.2    Ren, H.3    Gu, J.4
  • 14
    • 67649773772 scopus 로고    scopus 로고
    • Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration
    • Cheng C, Kong X, Wang H, Gan H, Hao Y, et al. (2009) Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem 284: 8786-8796.
    • (2009) J Biol Chem , vol.284 , pp. 8786-8796
    • Cheng, C.1    Kong, X.2    Wang, H.3    Gan, H.4    Hao, Y.5
  • 15
    • 77954230484 scopus 로고    scopus 로고
    • Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
    • Xu J, Yun X, Jiang J, Wei Y, Wu Y, et al. (2010) Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology 52: 142-154.
    • (2010) Hepatology , vol.52 , pp. 142-154
    • Xu, J.1    Yun, X.2    Jiang, J.3    Wei, Y.4    Wu, Y.5
  • 16
    • 84255200363 scopus 로고    scopus 로고
    • Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway
    • Liu H, Xu J, Zhou L, Yun X, Chen L, et al. (2011) Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. Cancer Res 71: 7547-7557.
    • (2011) Cancer Res , vol.71 , pp. 7547-7557
    • Liu, H.1    Xu, J.2    Zhou, L.3    Yun, X.4    Chen, L.5
  • 17
    • 84863332428 scopus 로고    scopus 로고
    • Snail is an independent prognostic predictor for progression and patient survival of gastric cancer
    • He H, Chen W, Wang X, Wang C, Liu F, et al. (2012) Snail is an independent prognostic predictor for progression and patient survival of gastric cancer. Cancer Sci.
    • (2012) Cancer Sci
    • He, H.1    Chen, W.2    Wang, X.3    Wang, C.4    Liu, F.5
  • 18
    • 84863317139 scopus 로고    scopus 로고
    • Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling
    • Xu L, Zhu Y, Xu J, Wu K, Li J, et al. (2012) Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling. Cancer Sci.
    • (2012) Cancer Sci
    • Xu, L.1    Zhu, Y.2    Xu, J.3    Wu, K.4    Li, J.5
  • 19
    • 84870712078 scopus 로고    scopus 로고
    • Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis via stabilizing Snail protein
    • Liu H, Xu L, He H, Zhu Y, Liu J, et al. (2012) Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis via stabilizing Snail protein. Cancer Sci.
    • (2012) Cancer Sci
    • Liu, H.1    Xu, L.2    He, H.3    Zhu, Y.4    Liu, J.5
  • 20
    • 77953474634 scopus 로고    scopus 로고
    • Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization
    • Zhang W, Xu W, Xiong S, (2010) Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol 184: 6465-6478.
    • (2010) J Immunol , vol.184 , pp. 6465-6478
    • Zhang, W.1    Xu, W.2    Xiong, S.3
  • 21
    • 80051921285 scopus 로고    scopus 로고
    • Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component
    • Zhang W, Xu W, Xiong S, (2011) Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol 187: 1764-1777.
    • (2011) J Immunol , vol.187 , pp. 1764-1777
    • Zhang, W.1    Xu, W.2    Xiong, S.3
  • 23
    • 78650600602 scopus 로고    scopus 로고
    • Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity
    • Kusaba T, Okigaki M, Matui A, Murakami M, Ishikawa K, et al. (2010) Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity. Proc Natl Acad Sci U S A 107: 19308-19313.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19308-19313
    • Kusaba, T.1    Okigaki, M.2    Matui, A.3    Murakami, M.4    Ishikawa, K.5
  • 24
    • 26844471162 scopus 로고    scopus 로고
    • Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells
    • Woolfolk EA, Eguchi S, Ohtsu H, Nakashima H, Ueno H, et al. (2005) Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. Am J Physiol Cell Physiol 289: C1286-1294.
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Woolfolk, E.A.1    Eguchi, S.2    Ohtsu, H.3    Nakashima, H.4    Ueno, H.5
  • 25
    • 33646578195 scopus 로고    scopus 로고
    • Regulation of fibroblast growth factor-23 signaling by klotho
    • Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281: 6120-6123.
    • (2006) J Biol Chem , vol.281 , pp. 6120-6123
    • Kurosu, H.1    Ogawa, Y.2    Miyoshi, M.3    Yamamoto, M.4    Nandi, A.5
  • 26
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, et al. (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444: 770-774.
    • (2006) Nature , vol.444 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5
  • 27
    • 27144440831 scopus 로고    scopus 로고
    • The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel
    • Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, et al. (2005) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310: 490-493.
    • (2005) Science , vol.310 , pp. 490-493
    • Chang, Q.1    Hoefs, S.2    van der Kemp, A.W.3    Topala, C.N.4    Bindels, R.J.5
  • 28
    • 27844561111 scopus 로고    scopus 로고
    • Regulation of oxidative stress by the anti-aging hormone klotho
    • Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, et al. (2005) Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280: 38029-38034.
    • (2005) J Biol Chem , vol.280 , pp. 38029-38034
    • Yamamoto, M.1    Clark, J.D.2    Pastor, J.V.3    Gurnani, P.4    Nandi, A.5
  • 29
  • 32
    • 34547908461 scopus 로고    scopus 로고
    • Augmented Wnt signaling in a mammalian model of accelerated aging
    • Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-806.
    • (2007) Science , vol.317 , pp. 803-806
    • Liu, H.1    Fergusson, M.M.2    Castilho, R.M.3    Liu, J.4    Cao, L.5
  • 33
    • 47149111583 scopus 로고    scopus 로고
    • Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis
    • Nussbaum T, Samarin J, Ehemann V, Bissinger M, Ryschich E, et al. (2008) Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis. Hepatology 48: 146-156.
    • (2008) Hepatology , vol.48 , pp. 146-156
    • Nussbaum, T.1    Samarin, J.2    Ehemann, V.3    Bissinger, M.4    Ryschich, E.5
  • 35
    • 58149229326 scopus 로고    scopus 로고
    • Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer
    • Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, Sredni B, et al. (2008) Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27: 7094-7105.
    • (2008) Oncogene , vol.27 , pp. 7094-7105
    • Wolf, I.1    Levanon-Cohen, S.2    Bose, S.3    Ligumsky, H.4    Sredni, B.5
  • 36
    • 79953138206 scopus 로고    scopus 로고
    • Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice
    • Doi S, Zou Y, Togao O, Pastor JV, John GB, et al. (2011) Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286: 8655-8665.
    • (2011) J Biol Chem , vol.286 , pp. 8655-8665
    • Doi, S.1    Zou, Y.2    Togao, O.3    Pastor, J.V.4    John, G.B.5
  • 37
    • 77954684957 scopus 로고    scopus 로고
    • Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549
    • Chen B, Wang X, Zhao W, Wu J, (2010) Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res 29: 99.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 99
    • Chen, B.1    Wang, X.2    Zhao, W.3    Wu, J.4
  • 38
    • 38949155148 scopus 로고    scopus 로고
    • Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression
    • Lu L, Katsaros D, Wiley A, de la Longrais IA, Puopolo M, et al. (2008) Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression. Cancer Invest 26: 185-192.
    • (2008) Cancer Invest , vol.26 , pp. 185-192
    • Lu, L.1    Katsaros, D.2    Wiley, A.3    de la Longrais, I.A.4    Puopolo, M.5
  • 39
    • 79955433548 scopus 로고    scopus 로고
    • Targeted therapies for hepatocellular carcinoma
    • Villanueva A, Llovet JM, (2011) Targeted therapies for hepatocellular carcinoma. Gastroenterology 140: 1410-1426.
    • (2011) Gastroenterology , vol.140 , pp. 1410-1426
    • Villanueva, A.1    Llovet, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.