Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 288, Issue 47, 2013, Pages 34190-34204

  Schiebel, Johannes ^a,b   Kapilashrami, Kanishk ^c   Fekete, Agnes ^d   Bommineni, Gopal R ^c   Schaefer, Christin M ^a   Mueller, Martin J ^d   Tonge, Peter J ^c   Kisker, Caroline ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c STONY BROOK UNIVERSITY   (United States)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; BIOCHEMISTRY; CARBON; ENZYMES; PHOSPHOLIPIDS; SUBSTRATES;

BINDING PROCESS; ENZYME CATALYZED REACTION; HYDROXY FATTY ACIDS; INDUCED-FIT MECHANISM; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACID BIOSYNTHESIS; REACTION COORDINATES; STRUCTURAL BASIS;

FATTY ACIDS;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ENZYME PRECURSOR; MYCOBACTERIUM TUBERCULOSIS BETA KETOACYL ACP SYNTHASE; MYCOLIC ACID; PHOSPHOLIPID; THIOLACTOMYCIN; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

ALPHA HELIX; ARTICLE; BACTERIAL SURVIVAL; BINDING KINETICS; BIOSYNTHESIS; CONTROLLED STUDY; DRUG TARGETING; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84888361762     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.511436     Document Type: Article

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