A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 285, Issue 19, 2010, Pages 14330-14337

  Luckner, Sylvia R ^a   Liu, Nina ^b   Am Ende, Christopher W ^b   Tonge, Peter J ^b   Kisker, Caroline ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; HYDRAZINE;

ACYL CARRIER PROTEINS; CATALASE-PEROXIDASE; ENZYME INHIBITORS; MYCOBACTERIUM TUBERCULOSIS; NANOMOLAR AFFINITY; RESISTANT STRAINS; STRUCTURE BASED DRUG DESIGNS; TUBERCULOSIS INFECTION;

CRYSTAL STRUCTURE;

2 (ORTHO TOLYLOXY) 5 HEXYLPHENOL; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); INHA PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PT 70; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; INHIBITION KINETICS; MOLECULAR RECOGNITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 77951987627     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.090373     Document Type: Article

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