Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 946-961

  McFadden, Jill M ^a   Medghalchi, Susan M ^b   Thupari, Jagan N ^c   Pinn, Michael L ^c   Vadlamudi, Aravinda ^b   Miller, Katherine I ^a   Kuhajda, Francis P ^c   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b FASgen Inc   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETYL 4 HYDROXY 5 METHYL 5 OCTYL 5H THIOPHEN 2 ONE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 4 HYDROXY 3 (1 HYDROXYETHYL) 5 METHYL 5 OCTYL 5H THIOPHEN 2 ONE; 4 HYDROXY 5 METHYL 5 (2 METHYL BUTA 1,3 DIENYL) 5H THIOPHEN 2 ONE; 4 HYDROXY 5 METHYL 5 (2 METHYL PENTA 1,3 DIENYL) 5H THIOPHEN 2 ONE; 4 HYDROXY 5 METHYL 5 HEXA 1,3 DIENYL 5H THIOPHEN 2 ONE; 4 HYDROXY 5 METHYL 5 OCTA 1,3 DIENYL 5H THIOPHEN 2 ONE; 4 HYDROXY 5 METHYL 5 OCTYL 5H THIOPHEN 2 ONE; 5 METHYL 5 OCTYL 5H THIOPHEN 2 ONE 4 CARBONIC ACID ALLYL ESTER; 5 METHYL 5 OCTYL 5H THIOPHEN 2 ONE 4 CARBONIC ACID ETHYL ESTER; 5 METHYL 5 OCTYL 5H THIOPHEN 2 ONE 4 CARBONIC ACID METHYL ESTER; ANTINEOPLASTIC AGENT; ANTIOBESITY AGENT; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; MALONYL COENZYME A; PALMITIC ACID; THIOLACTOMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAMMAL; MOUSE; NONHUMAN; OBESITY; RAT; STRUCTURE ANALYSIS; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; ANTINEOPLASTIC AGENTS; BODY WEIGHT; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACID SYNTHETASE COMPLEX; HUMANS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 13944267828     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049389h     Document Type: Article

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