Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of streptococcus pneumoniae

Journal of Biological Chemistry

Volumn 281, Issue 25, 2006, Pages 17390-17399

  Zhang, Yong Mei ^a   Hurlbert, Jason ^a   White, Stephen W ^a   Rock, Charles O ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; CATALYSIS; CONDENSATION; FATTY ACIDS; SYNTHESIS (CHEMICAL); TUMORS;

ELECTRONIC STATES; NEGATIVE CHARGE; NUCLEOPHILIC CYSTEINE; POLYKETIDE SYNTHESIS;

ENZYMES;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; BICARBONATE; CARBONYL DERIVATIVE; CYSTEINE; HISTONE; PHENYLALANINE; THIOESTER;

ARTICLE; CATALYSIS; DRUG BINDING SITE; DRUG TARGETING; ENZYME ACTIVITY; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; FATTY ACID SYNTHETASE COMPLEX; HISTIDINE; LYSINE; MALONATES; MOLECULAR SEQUENCE DATA; PHENYLALANINE; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOCOCCUS PNEUMONIAE; WATER;

PYRONIA TITHONUS; STREPTOCOCCUS PNEUMONIAE;

EID: 33745211232     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513199200     Document Type: Article

References (53)

1. Jackowski, S., and Rock, C. O. (2002) Biochem. Biophys. Res. Commun. 292, 1155-1166
2. Smith, S., Witkowski, A., and Joshi, A. K. (2003) Prog. Lipid Res. 42, 289-317
3. Heath, R. J., and Rock, C. O. (2002) Nat. Prod. Rep. 19, 581-596
4. Greenspan, M. D., Alberts, A. W., and Vagelos, P. R. (1969) J. Biol. Chem. 244, 6477-6485
5. Vagelos, P. R., and Alberts, A. W. (1960) J. Biol. Chem. 235, 2786-2791
6. Witkowski, A., Joshi, A. K., and Smith, S. (2002) Biochemistry 41, 10877-10887
7. Rock, C. O., and Cronan, J. E., Jr. (1996) Biochim. Biophys. Acta 1302, 1-16
8. Smith, S. (1994) FASEB J. 8, 1248-1259
9. Cronan, J. E., Jr., and Rock, C. O. (1996) in Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt, F. C., Curtis, R., Gross, C. A., Ingraham, J. L., Lin, E. C. C., Low, K. B., Magasanik, B., Reznikoff, W., Riley, M., Schaechter, M., and Umbarger, H. E., eds) pp. 612-636, American Society for Microbiology, Washington, D. C.
10. Heath, R. J., White, S. W., and Rock, C. O. (2001) Prog. Lipid Res. 40, 467-497
11. Campbell, J. W., and Cronan, J. E., Jr. (2001) Annu. Rev. Microbiol. 55, 305-332
12. Heath, R. J., and Rock, C. O. (2004) Curr. Opin. Investig. Drugs 5, 146-153
13. Slade, R. F., Hunt, D. A., Pochet, M. M., Venema, V. J., and Hennigar, R. A. (2003) Anticancer Res. 23, 1235-1243
14. Gao, S., and Lane, M. D. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 5628-5633
15. Takahashi, K. A., Smart, J. L., Liu, H., and Cone, R. D. (2004) Endocrinology 145, 184-193
16. Menendez, J. A., Vellon, L., Mehmi, I., Oza, B. P., Ropero, S., Colomer, R., and Lupu, R. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 10715-10720
17. Cha, S. H., Hu, Z., and Lane, M. D. (2004) Biochem. Biophys. Res. Commun. 317, 301-308
18. Khosla, C., and Tang, Y. (2005) Science 308, 367-368
19. Huang, W., Jia, J., Edwards, P., Dehesh, K., Schneider, G., and Lindqvist, Y. (1998) EMBO J. 17, 1183-1191
20. Moche, M., Dehesh, K., Edwards, P., and Lindqvist, Y. (2001) J. Mol. Biol. 305, 491-503
21. Price, A. C., Rock, C. O., and White, S. W. (2003) J. Bacteriol. 185, 4136-4143
22. Amy, C. M., Witkowski, A., Naggert, J., Williams, B., Randhawa, Z., and Smith, S. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 3114-3118
23. Rock, C. O., and Garwin, J. L. (1979) J. Biol. Chem. 254, 7123-7128
24. Rock, C. O., Garwin, J. L., and Cronan, J. E., Jr. (1981) Methods Enzymol. 72, 397-403
25. Zhang, L., Joshi, A. K., Hofmann, J., Schweizer, E., and Smith, S. (2005) J. Biol. Chem. M413686200
26. Davies, C., Heath, R. J., White, S. W., and Rock, C. O. (2000) Structure 8, 185-195
27. Price, A. C., Choi, K. H., Heath, R. J., Li, Z., Rock, C. O., and White, S. W. (2001) J. Biol. Chem. 276, 6551-6559
28. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
29. Garwin, J. L., Klages, A. L., and Cronan, J. E., Jr. (1980) J. Biol. Chem. 255, 11949-11956
30. Heath, R. J., and Rock, C. O. (1996) J. Biol. Chem. 271, 1833-1836
31. Zha, W., Shao, Z., Frost, J. W., and Zhao, H. (2004) J. Am. Chem. Soc. 126, 4534-4535
32. Tsay, J.-T., Rock, C. O., and Jackowski, S. (1992) J. Bacteriol. 174, 508-513
33. Beaudet, L., Bedard, J., Breton, B., Mercuri, R. J., and Budarf, M. L. (2001) Genome Res. 11, 600-608
34. Leslie, A. G. W. (1992) Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography, No. 26
35. Evans, P. R. (1997) Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography 33, 22-24
36. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 869-873
37. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D Biol. Crystallogr. 53, 240-255
38. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D 54, 905-921
39. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
40. McGuire, K. A., Siggaard-Andersen, M., Bangera, M. G., Olsen, J. G., and Wettstein-Knowles, P. (2001) Biochemistry 40, 9836-9845
41. Moche, M., Schneider, G., Edwards, P., Dehesh, K., and Lindqvist, Y. (1999) J. Biol. Chem. 274, 6031-6034
42. Kursula, P., Sikkila, H., Fukao, T., Kondo, N., and Wierenga, R. K. (2005) J. Mol. Biol. 347, 189-201
43. Brock, D. J. H., and Bloch, K. (1966) Biochem. Biophys. Res. Commun. 23, 775-780
44. Nixon, J. E., Putz, G. R., and Porter, J. W. (1968) J. Biol. Chem. 243, 5471-5478
45. Yalpani, M., Willecke, K., and Lynen, F. (1969) Eur. J. Biochem. 8, 495-502
46. Olsen, J. G., Kadziola, A., Wettstein-Knowles, P., Siggaard-Andersen, M., Lindquist, Y., and Larsen, S. (1999) FEBS Lett. 460, 46-52
47. von Wettstein-Knowles, P., Olsen, J. G., McGuire, K. A., and Henriksen, A. (2006) FEBS J. 273, 695-710
48. Mathieu, M., Modis, Y., Zeelen, J. P., Engel, C. K., Abagyan, R. A., Ahlberg, A., Rasmussen, B., Lamzin, V. S., Kunau, W. H., and Wierenga, R. K. (1997) J. Mol. Biol. 273, 714-728
49. Olsen, J. G., Kadziola, A., Wettstein-Knowles, P., Siggaard-Andersen, M., and Larsen, S. (2001) Structure 9, 233-243
50. Qiu, X., Janson, C. A., Konstantinidis, A. K., Nwagwu, S., Silverman, C., Smith, W. W., Khandekar, S., Lonsdale, J., and Abdel-Meguid, S. S. (1999) J. Biol. Chem. 274, 36465-36471
51. Qiu, X., Janson, C. A., Smith, W. W., Head, M., Lonsdale, J., and Konstantinidis, A. K. (2001) J. Mol. Biol. 307, 341-356
52. Scarsdale, J. N., Kazanina, G., He, X., Reynolds, K. A., and Wright, H. T. (2001) J. Biol. Chem. 276, 20516-20522
53. Brown, A. K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L. G., Sacchettini, J. C., and Besra, G. S. (2005) J. Biol. Chem. 280, 32539-32547