Fatty acid synthesis: Role of active site histidines and lysine in Cys-His-His-type β-ketoacyl-acyl carrier protein synthases

FEBS Journal

Volumn 273, Issue 4, 2006, Pages 695-710

  Von Wettstein Knowles, Penny ^a,c   Olsen, Johan G ^b   McGuire, Kirsten A ^a   Henriksen, Anette ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b CARLSBERG LABORATORY   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

ketoacyl ACP synthase; Active site mutations; Condensation reaction; Fatty acid synthase; Reaction mechanism

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; BACTERIAL ENZYME; CYSTEINE; FATTY ACID; FATTY ACID SYNTHASE; HISTIDINE; LYSINE;

ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ESCHERICHIA COLI; ESTERIFICATION; FATTY ACID SYNTHESIS; HYDROGEN BOND; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; REACTION ANALYSIS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ACYL CARRIER PROTEIN; BINDING SITES; CATIONS; ESCHERICHIA COLI; FATTY ACIDS; HISTIDINE; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POINT MUTATION; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 33644945944     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.05101.x     Document Type: Article

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