Biosynthetic origins of the natural product, thiolactomycin: A unique and selective inhibitor of type II dissociated fatty acid synthases

Journal of the American Chemical Society

Volumn 125, Issue 34, 2003, Pages 10166-10167

  Brown, Maria S ^a   Akopiants, Konstantin ^b   Resceck, Diane M ^a   McArthur, Hamish A I ^a   McCormick, Ellen ^a   Reynolds, Kevin A ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; FATTY ACID SYNTHASE; NATURAL PRODUCT; THIOLACTOMYCIN;

ANTIMALARIAL ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTAL STRUCTURE; CYCLIZATION; DRUG ISOLATION; FATTY ACID SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; PROTON NUCLEAR MAGNETIC RESONANCE;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; FERMENTATION; MULTIENZYME COMPLEXES; NOCARDIA; THIOPHENES;

EID: 0041429652     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034540i     Document Type: Article

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