Slow onset inhibition of bacterial β-ketoacyl-acyl carrier protein synthases by thiolactomycin

Journal of Biological Chemistry

Volumn 285, Issue 9, 2010, Pages 6161-6169

  Machutta, Carl A ^a   Bommineni, Gopal R ^a   Luckner, Sylvia R ^b   Kapilashrami, Kanishk ^a   Ruzsicska, Bela ^a   Simmerling, Carlos ^a   Kisker, Caroline ^b   Tonge, Peter J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYME KINETICS; ESCHERICHIA COLI; HYDROGEN BONDS;

ACYL CARRIER PROTEINS; ANTI-BACTERIAL ACTIVITY; BACTERIAL FATTY ACIDS; KLEBSIELLA PNEUMONIA; MECHANISTIC DATA; MYCOBACTERIUM TUBERCULOSIS; NATURAL PRODUCTS; SERRATIA MARCESCENS;

FATTY ACIDS;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE A; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE B; ESCHERICHIA COLI PROTEIN; GLUTAMINE; PROTEIN FABB; PROTEIN FABF; THIOLACTOMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ENZYME INHIBITOR; THIOPHENE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE OVEREXPRESSION; HYDROGEN BOND; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SERRATIA MARCESCENS; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MYCOBACTERIUM TUBERCULOSIS; NOCARDIA; SERRATIA MARCESCENS; STREPTOMYCES;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THIOPHENES;

EID: 77949880039     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.077909     Document Type: Article

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