Inhibition of β-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin: Structure and mechanism

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6551-6559

  Price, Allen C ^a   Choi, Keum Hwa ^a   Heath, Richard J ^a   Li, Zhenmei ^a   White, Stephen W ^a   Rock, Charles O ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; FATTY ACIDS; HYDROGEN BONDS; SUBSTRATES;

BINARY COMPLEXES;

ENZYMES;

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ANTIBIOTIC AGENT; CERULENIN; THIOLACTOMYCIN; BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE I; BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE I; ENZYME INHIBITOR; ISOENZYME; THIOPHENE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; STRUCTURE ACTIVITY RELATION;

ESCHERICHIA COLI;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; BINDING SITES; CERULENIN; ENZYME INHIBITORS; ISOENZYMES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 0035794127     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007101200     Document Type: Article

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