-
1
-
-
0035415911
-
Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety
-
Menozzi, G.; Mosti, L.; Fossa, P.; et al. Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety. Il Farmaco, 2001, 56, 633-640.
-
(2001)
Il Farmaco
, vol.56
, pp. 633-640
-
-
Menozzi, G.1
Mosti, L.2
Fossa, P.3
-
2
-
-
0011723947
-
Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes[J]
-
Naito, H.; Ohsuki, S.; Sugimori, M.; et al. Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes[J]. Chemical and pharmaceutical bulletin, 2002, 50, 453-462.
-
(2002)
Chemical and pharmaceutical bulletin
, vol.50
, pp. 453-462
-
-
Naito, H.1
Ohsuki, S.2
Sugimori, M.3
-
3
-
-
20444415984
-
Identification of antitumor activity of pyrazole oxime ethers
-
Park, H.J.; Lee, K.; Park, S.J.; et al. Identification of antitumor activity of pyrazole oxime ethers. Bioorganic & medicinal chemistry letters, 2005, 15, 3307-3312.
-
(2005)
Bioorganic & medicinal chemistry letters
, vol.15
, pp. 3307-3312
-
-
Park, H.J.1
Lee, K.2
Park, S.J.3
-
4
-
-
33846265019
-
Constrained analogs of CB-1 antagonists: 1, 5, 6, 7-Tetrahydro-4H-pyrrolo [3, 2-c] pyridine-4-one derivatives
-
Smith, R.A.; Fathi, Z.; Brown, S.E.; et al. Constrained analogs of CB-1 antagonists: 1, 5, 6, 7-Tetrahydro-4H-pyrrolo [3, 2-c] pyridine-4-one derivatives. Bioorganic & medicinal chemistry letters, 2007, 17, 673-678.
-
(2007)
Bioorganic & medicinal chemistry letters
, vol.17
, pp. 673-678
-
-
Smith, R.A.1
Fathi, Z.2
Brown, S.E.3
-
5
-
-
33847614837
-
Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists
-
Jorand-Lebrun, C.; Brondyk, B.; Lin, J.; et al. Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists. Bioorganic & medicinal chemistry letters, 2007, 17, 2080-2085.
-
(2007)
Bioorganic & medicinal chemistry letters
, vol.17
, pp. 2080-2085
-
-
Jorand-Lebrun, C.1
Brondyk, B.2
Lin, J.3
-
6
-
-
33846586359
-
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl) pyrid-2-yl and 4-nitrile
-
Sakya, S.M.; Hou, X.; Minich, M.L.; et al. 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl) pyrid-2-yl and 4-nitrile. Bioorganic & medicinal chemistry letters, 2007, 17, 1067-1072.
-
(2007)
Bioorganic & medicinal chemistry letters
, vol.17
, pp. 1067-1072
-
-
Sakya, S.M.1
Hou, X.2
Minich, M.L.3
-
7
-
-
35148824608
-
3, 5-Bis (3'-indolyl) pyrazoles, analogues of marine alkaloid nortopsentin: Synthesis and antitumor properties
-
Diana, P.; Carbone, A.; Barraja, P.; et al. 3, 5-Bis (3'-indolyl) pyrazoles, analogues of marine alkaloid nortopsentin: Synthesis and antitumor properties. Bioorganic & medicinal chemistry letters, 2007, 17, 6134-6137.
-
(2007)
Bioorganic & medicinal chemistry letters
, vol.17
, pp. 6134-6137
-
-
Diana, P.1
Carbone, A.2
Barraja, P.3
-
8
-
-
33646175956
-
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3, 5-diaryl-4, 5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP
-
Cox, C.D.; Torrent, M.; Breslin, M.J.; et al. Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3, 5-diaryl-4, 5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP. Bioorganic & medicinal chemistry letters, 2006, 16, 3175-3179.
-
(2006)
Bioorganic & medicinal chemistry letters
, vol.16
, pp. 3175-3179
-
-
Cox, C.D.1
Torrent, M.2
Breslin, M.J.3
-
9
-
-
77954213883
-
Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents
-
Lv, P.C.; Li, H.Q.; Sun, J.; et al. Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents. Bioorganic & medicinal chemistry, 2010, 18, 4606-4614.
-
(2010)
Bioorganic & medicinal chemistry
, vol.18
, pp. 4606-4614
-
-
Lv, P.C.1
Li, H.Q.2
Sun, J.3
-
10
-
-
84870012206
-
Synthesis and biological activity of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles derivatives as ROS receptor tyrosine kinase inhibitors
-
Park, B.S.; El-Deeb, I.M.; Yoo, K.H.; et al. Synthesis and biological activity of new 4-(pyridin-4-yl)-(3-methoxy-5-methylphenyl)-1H-pyrazoles derivatives as ROS receptor tyrosine kinase inhibitors. Bull Korean Chem Soc, 2012, 33, 3629-34.
-
(2012)
Bull Korean Chem Soc
, vol.33
, pp. 3629-3634
-
-
Park, B.S.1
El-Deeb, I.M.2
Yoo, K.H.3
-
11
-
-
1542331641
-
Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles
-
Ranatunge, R.R.; Garvey, D.S.; Janero, D.R.; et al. Synthesis and selective cyclooxygenase-2 (COX-2) inhibitory activity of a series of novel bicyclic pyrazoles. Bioorganic & medicinal chemistry, 2004, 12, 1357-1366.
-
(2004)
Bioorganic & medicinal chemistry
, vol.12
, pp. 1357-1366
-
-
Ranatunge, R.R.1
Garvey, D.S.2
Janero, D.R.3
-
12
-
-
33144455243
-
Synthesis and Biological Evaluation of Some Hydroxypyrazole Derivatives as Anti-inflammatory-Antimicrobial Agents
-
Bekhit, A.A.; Abdel-Rahman, H.M.; Guemei, A.A.; Synthesis and Biological Evaluation of Some Hydroxypyrazole Derivatives as Anti-inflammatory-Antimicrobial Agents. Archiv der Pharmazie, 2006, 339, 81-87.
-
(2006)
Archiv der Pharmazie
, vol.339
, pp. 81-87
-
-
Bekhit, A.A.1
Abdel-Rahman, H.M.2
Guemei, A.A.3
-
13
-
-
38749136641
-
Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero) aryl triazoles and pyrazoles in canine COX inhibition
-
Sakya, S.M.; Shavnya, A.; Cheng, H.; et al. Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero) aryl triazoles and pyrazoles in canine COX inhibition. Bioorganic & medicinal chemistry letters, 2008, 18, 1042-1045.
-
(2008)
Bioorganic & medicinal chemistry letters
, vol.18
, pp. 1042-1045
-
-
Sakya, S.M.1
Shavnya, A.2
Cheng, H.3
-
14
-
-
2342485135
-
Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity
-
Tanitame, A.; Oyamada, Y.; Ofuji, K.; et al. Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity. Bioorganic & medicinal chemistry letters, 2004, 14, 2857-2862.
-
(2004)
Bioorganic & medicinal chemistry letters
, vol.14
, pp. 2857-2862
-
-
Tanitame, A.1
Oyamada, Y.2
Ofuji, K.3
-
15
-
-
1642461641
-
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatoryantimicrobial agents
-
Bekhit, A.A.; Abdel-Aziem, T.; Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatoryantimicrobial agents. Bioorganic & medicinal chemistry, 2004, 12, 1935-1945.
-
(2004)
Bioorganic & medicinal chemistry
, vol.12
, pp. 1935-1945
-
-
Bekhit, A.A.1
Abdel-Aziem, T.2
-
16
-
-
4644248307
-
Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring
-
Tanitame, A.; Oyamada, Y.; Ofuji, K.; et al. Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring. Bioorganic & medicinal chemistry, 2004, 12, 5515-5524.
-
(2004)
Bioorganic & medicinal chemistry
, vol.12
, pp. 5515-5524
-
-
Tanitame, A.1
Oyamada, Y.2
Ofuji, K.3
-
17
-
-
40049108415
-
Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1 H-pyrazole as anti-inflammatory antimicrobial agents
-
Bekhit, A.A.; Ashour, H.; Abdel, Y.S.; et al. Synthesis and biological evaluation of some thiazolyl and thiadiazolyl derivatives of 1 H-pyrazole as anti-inflammatory antimicrobial agents. European journal of medicinal chemistry, 2008, 43, 456-463.
-
(2008)
European journal of medicinal chemistry
, vol.43
, pp. 456-463
-
-
Bekhit, A.A.1
Ashour, H.2
Abdel, Y.S.3
-
18
-
-
0026414089
-
Acyclic analogues of pyrazofurin: Syntheses and antiviral evaluation
-
Comber, R.N.; Gray, R.J.; Secrist III, J.A.; Acyclic analogues of pyrazofurin: syntheses and antiviral evaluation. Carbohydrate research, 1992, 216, 441-452.
-
(1992)
Carbohydrate research
, vol.216
, pp. 441-452
-
-
Comber, R.N.1
Gray, R.J.2
Secrist III, J.A.3
-
19
-
-
8444238236
-
The RAF proteins take centre stage
-
Wellbrock, C.; Karasarides, M.; Marais, R.; The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology, 2004, 5, 875-885.
-
(2004)
Nature Reviews Molecular Cell Biology
, vol.5
, pp. 875-885
-
-
Wellbrock, C.1
Karasarides, M.2
Marais, R.3
-
20
-
-
0033590636
-
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
-
Hoshino, R.; Chatani, Y.; Yamori, T.; et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene, 1999, 18, 813-822.
-
(1999)
Oncogene
, vol.18
, pp. 813-822
-
-
Hoshino, R.1
Chatani, Y.2
Yamori, T.3
-
21
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H.; Bignell, G.R.; Cox, C.; et al. Mutations of the BRAF gene in human cancer. Nature, 2002, 417, 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
22
-
-
0042173193
-
Analysis of BRAF and NRAS mutations in metastatic melanoma tissues
-
Gorden, A.; Osman, I.; Gai, W.; et al. Analysis of BRAF and NRAS mutations in metastatic melanoma tissues. Cancer research, 2003, 63, 3955-3957.
-
(2003)
Cancer research
, vol.63
, pp. 3955-3957
-
-
Gorden, A.1
Osman, I.2
Gai, W.3
-
23
-
-
0036894746
-
BRAF and RAS mutations in human lung cancer and melanoma
-
Brose, M.S.; Volpe, P.; Feldman, M.; et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer research, 2002, 62, 6997-7000.
-
(2002)
Cancer research
, vol.62
, pp. 6997-7000
-
-
Brose, M.S.1
Volpe, P.2
Feldman, M.3
-
24
-
-
0037379904
-
High Prevalence of BRAF Mutations in Thyroid Cancer Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma
-
Kimura, E.T.; Nikiforova, M.N.; Zhu, Z.; et al. High Prevalence of BRAF Mutations in Thyroid Cancer Genetic Evidence for Constitutive Activation of the RET/PTC-RAS-BRAF Signaling Pathway in Papillary Thyroid Carcinoma. Cancer Research, 2003, 63, 1454-1457.
-
(2003)
Cancer Research
, vol.63
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
-
25
-
-
0041589377
-
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
-
Xu, X.; Quiros, R.M.; Gattuso, P.; et al. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Research, 2003, 63, 4561-4567.
-
(2003)
Cancer Research
, vol.63
, pp. 4561-4567
-
-
Xu, X.1
Quiros, R.M.2
Gattuso, P.3
-
26
-
-
17744388986
-
The role of BRAF in melanoma
-
Gray-Schopfer, V.C.; da Rocha Dias S, Marais, R.; The role of BRAF in melanoma. Cancer and Metastasis Reviews, 2005, 24, 165-183.
-
(2005)
Cancer and Metastasis Reviews
, vol.24
, pp. 165-183
-
-
Gray-Schopfer, V.C.1
da Rocha Dias, S.2
Marais, R.3
-
27
-
-
13944277101
-
p53 modulates RPA-dependent and RPA-independent WRN helicase activity
-
Sommers, J.A.; Sharma, S.; Doherty, K.M.; et al. p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer research, 2005, 65, 1223-1233.
-
(2005)
Cancer research
, vol.65
, pp. 1223-1233
-
-
Sommers, J.A.1
Sharma, S.2
Doherty, K.M.3
-
28
-
-
4344584872
-
B-RAF is a therapeutic target in melanoma
-
Karasarides, M.; Chiloeches, A.; Hayward, R.; et al. B-RAF is a therapeutic target in melanoma. Oncogene, 2004, 23, 6292-6298.
-
(2004)
Oncogene
, vol.23
, pp. 6292-6298
-
-
Karasarides, M.1
Chiloeches, A.2
Hayward, R.3
-
29
-
-
27944490693
-
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
-
Takle, A.K.; Brown, M.J.B.; Davies, S.; et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorganic & medicinal chemistry letters, 2006, 16, 378-381.
-
(2006)
Bioorganic & medicinal chemistry letters
, vol.16
, pp. 378-381
-
-
Takle, A.K.1
Brown, M.J.B.2
Davies, S.3
-
30
-
-
77955416938
-
Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors
-
Blackburn, C.; Duffey, M.O.; Gould, A.E.; et al. Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors. Bioorganic & medicinal chemistry letters, 2010, 20, 4795-4799.
-
(2010)
Bioorganic & medicinal chemistry letters
, vol.20
, pp. 4795-4799
-
-
Blackburn, C.1
Duffey, M.O.2
Gould, A.E.3
-
31
-
-
84861580384
-
Synthesis, biological evaluation and 3D-QSAR studies of novel 4, 5-dihydro-1 H-pyrazole niacinamide derivatives as BRAF inhibitors
-
Li, C.Y.; Li, Q.S.; Yan, L.; et al. Synthesis, biological evaluation and 3D-QSAR studies of novel 4, 5-dihydro-1 H-pyrazole niacinamide derivatives as BRAF inhibitors. Bioorganic & medicinal chemistry, 2012, 20, 3746-3755.
-
(2012)
Bioorganic & medicinal chemistry
, vol.20
, pp. 3746-3755
-
-
Li, C.Y.1
Li, Q.S.2
Yan, L.3
-
32
-
-
84867572651
-
Identification of novel 3, 5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents
-
Qing-Shan, Li.; Xian-Hai, Lv.; Yan-Bin, Zhang.; et al. Identification of novel 3, 5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents. Bioorganic & medicinal chemistry letters, 2012, 22, 6596-6601.
-
(2012)
Bioorganic & medicinal chemistry letters
, vol.22
, pp. 6596-6601
-
-
Qing-Shan, L.1
Xian-Hai, L.2
Yan-Bin, Z.3
-
33
-
-
84866916846
-
Design, modification and 3D QSAR studies of novel 2, 3-dihydrobenzo [b][1, 4] dioxin-containing 4, 5-dihydro-1 H-pyrazole derivatives as inhibitors of B-Raf kinase
-
Yu-Shun, Yang.; Qing-Shan, Li.; Shuai, Sun.; et al. Design, modification and 3D QSAR studies of novel 2, 3-dihydrobenzo [b][1, 4] dioxin-containing 4, 5-dihydro-1 H-pyrazole derivatives as inhibitors of B-Raf kinase. Bioorganic & medicinal chemistry, 2012, 20, 6048-6058.
-
(2012)
Bioorganic & medicinal chemistry
, vol.20
, pp. 6048-6058
-
-
Yu-Shun, Y.1
Qing-Shan, L.2
Shuai, S.3
-
34
-
-
79952453681
-
Structure based design and syntheses of amino-1 H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells
-
Kim, M.; Kim, M.; Yu, H.; et al. Structure based design and syntheses of amino-1 H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells. Bioorganic & medicinal chemistry, 2011, 19, 1915-1923.
-
(2011)
Bioorganic & medicinal chemistry
, vol.19
, pp. 1915-1923
-
-
Kim, M.1
Kim, M.2
Yu, H.3
-
35
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon, D.J.; Clark, G, M.; Wong, S.G.; et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 1987, 235, 177-182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
-
36
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon, D.J.; Godolphin, W.; Jones, L.A.; et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science, 1989, 244, 707-712.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
37
-
-
84873693153
-
Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents[J]
-
Wen, Yang.; Yang, Hua.; Yu-Shun, Yang.; et al. Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents[J]. Bioorganic & medicinal chemistry, 2013, 21, 1050-1063.
-
(2013)
Bioorganic & medicinal chemistry
, vol.21
, pp. 1050-1063
-
-
Wen, Y.1
Yang, H.2
Yu-Shun, Y.3
-
38
-
-
0035253719
-
Cellular senescence as a tumorprotection mechanism: The essential role of counting
-
Wright, W.E.; Shay, J.W.; Cellular senescence as a tumorprotection mechanism: the essential role of counting. Current opinion in genetics & development, 2001, 11, 98-103.
-
(2001)
Current opinion in genetics & development
, vol.11
, pp. 98-103
-
-
Wright, W.E.1
Shay, J.W.2
-
39
-
-
0010045614
-
Extension of lifespan by introduction of telomerase into normal human cells
-
Bodnar, A.G.; Ouellette, M.; Frolkis, M.; et al. Extension of lifespan by introduction of telomerase into normal human cells. Science, 1998, 279, 349-352.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
40
-
-
79955559793
-
Design and synthesis of N-phenylacetyl (sulfonyl) 4, 5-dihydropyrazole derivatives as potential antitumor agents
-
Liu, X.H.; Ruan, B.F.; Liu, J.X.; et al. Design and synthesis of N-phenylacetyl (sulfonyl) 4, 5-dihydropyrazole derivatives as potential antitumor agents. Bioorganic & medicinal chemistry letters, 2011, 21, 2916-2920.
-
(2011)
Bioorganic & medicinal chemistry letters
, vol.21
, pp. 2916-2920
-
-
Liu, X.H.1
Ruan, B.F.2
Liu, J.X.3
-
41
-
-
84872929346
-
Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors
-
Yin, Luo.; Shuai, Zhang.; Ke-Ming, Qiu.; et al. Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors. Bioorganic & medicinal chemistry letters, 2012, 23, 1091-1095
-
(2012)
Bioorganic & medicinal chemistry letters
, vol.23
, pp. 1091-1095
-
-
Yin, L.1
Shuai, Z.2
Ke-Ming, Q.3
-
42
-
-
77955418695
-
3-Cyano-6-(5-methyl-3-pyrazoloamino) pyridines: Selective Aurora A kinase inhibitors
-
Ando, R.; Ikegami, H.; Sakiyama, M.; et al. 3-Cyano-6-(5-methyl-3-pyrazoloamino) pyridines: Selective Aurora A kinase inhibitors. Bioorganic & medicinal chemistry letters, 2010, 20, 4709-4711.
-
(2010)
Bioorganic & medicinal chemistry letters
, vol.20
, pp. 4709-4711
-
-
Ando, R.1
Ikegami, H.2
Sakiyama, M.3
-
43
-
-
77956320877
-
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine Aurora kinase inhibitor
-
Cee, V.J.; Schenkel, L.B.; Hodous, B.L.; et al. Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine Aurora kinase inhibitor. Journal of medicinal chemistry, 2010, 53, 6368-6377.
-
(2010)
Journal of medicinal chemistry
, vol.53
, pp. 6368-6377
-
-
Cee, V.J.1
Schenkel, L.B.2
Hodous, B.L.3
-
44
-
-
39749138724
-
Specific Small-Molecule Activator of Aurora Kinase A Induces Autophosphorylation in a Cell-Free System
-
Kishore, A.H.; Vedamurthy, B.M.; Mantelingu, K.; et al. Specific Small-Molecule Activator of Aurora Kinase A Induces Autophosphorylation in a Cell-Free System. Journal of medicinal chemistry, 2008, 51, 792-797.
-
(2008)
Journal of medicinal chemistry
, vol.51
, pp. 792-797
-
-
Kishore, A.H.1
Vedamurthy, B.M.2
Mantelingu, K.3
-
45
-
-
49449091410
-
A Pentacyclic Aurora Kinase Inhibitor (AKI-001) with High in Vivo Potency and Oral Bioavailability
-
Rawson, T.E.; Ruth, M.; Blackwood, E.; et al. A Pentacyclic Aurora Kinase Inhibitor (AKI-001) with High in Vivo Potency and Oral Bioavailability. Journal of medicinal chemistry, 2008, 51, 4465-4475.
-
(2008)
Journal of medicinal chemistry
, vol.51
, pp. 4465-4475
-
-
Rawson, T.E.1
Ruth, M.2
Blackwood, E.3
-
46
-
-
77954325013
-
Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification
-
Coumar, M.S.; Chu, C.Y.; Lin, C.W.; et al. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification. Journal of medicinal chemistry, 2010, 53, 4980-4988.
-
(2010)
Journal of medicinal chemistry
, vol.53
, pp. 4980-4988
-
-
Coumar, M.S.1
Chu, C.Y.2
Lin, C.W.3
-
48
-
-
20944437351
-
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition
-
Fancelli, D.; Berta, D.; Bindi, S.; et al. Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. Journal of medicinal chemistry, 2005, 48, 3080-3084.
-
(2005)
Journal of medicinal chemistry
, vol.48
, pp. 3080-3084
-
-
Fancelli, D.1
Berta, D.2
Bindi, S.3
-
49
-
-
84861197424
-
Synthesis, biological evaluation, and molecular docking studies of N, 1, 3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents
-
Li, X.; Lu, X.; Xing, M.; et al. Synthesis, biological evaluation, and molecular docking studies of N, 1, 3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents. Bioorganic & medicinal chemistry letters, 2012, 22, 3589-3593.
-
(2012)
Bioorganic & medicinal chemistry letters
, vol.22
, pp. 3589-3593
-
-
Li, X.1
Lu, X.2
Xing, M.3
-
50
-
-
69949108857
-
Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors
-
El-Deeb, I.M.; Park, B.S.; Jung, S.J.; et al. Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors. Bioorganic & medicinal chemistry letters, 2009, 19, 5622-5626.
-
(2009)
Bioorganic & medicinal chemistry letters
, vol.19
, pp. 5622-5626
-
-
El-Deeb, I.M.1
Park, B.S.2
Jung, S.J.3
-
51
-
-
0028926813
-
New insights into the mode of action of anti-inflammatory drugs
-
Vane, J.R.; Botting, R.M.; New insights into the mode of action of anti-inflammatory drugs. Inflammation research, 1995, 44, 1-10.
-
(1995)
Inflammation research
, vol.44
, pp. 1-10
-
-
Vane, J.R.1
Botting, R.M.2
-
52
-
-
0033761157
-
COX-2 selectivity and inflammatory processes
-
Ryn, J.; Trummlitz, G.; Pairet, M.; COX-2 selectivity and inflammatory processes. Current medicinal chemistry, 2000, 7, 1145-1161.
-
(2000)
Current medicinal chemistry
, vol.7
, pp. 1145-1161
-
-
Ryn, J.1
Trummlitz, G.2
Pairet, M.3
-
53
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
-
Vane, J.R.; Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, 1971, 231, 232-235.
-
(1971)
Nature
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
54
-
-
0033106171
-
Nonsteroidal antiinflammatory drugs: A new generation of cyclooxygenase inhibitors
-
Beuck, M.; Nonsteroidal antiinflammatory drugs: a new generation of cyclooxygenase inhibitors. Angewandte Chemie International Edition, 1999, 38, 631-633.
-
(1999)
Angewandte Chemie International Edition
, vol.38
, pp. 631-633
-
-
Beuck, M.1
-
55
-
-
0003158105
-
Anti-inflammatory Agents
-
Juby, P.F.; Scerrer, R.A.; Whitehouse M W. Anti-inflammatory Agents. Academic Press, 1984, 1, 91-127.
-
(1984)
Academic Press
, vol.1
, pp. 91-127
-
-
Juby, P.F.1
Scerrer, R.A.2
Whitehouse, M.W.3
-
56
-
-
84867772622
-
Synthesis and Pharmacological Investigation of 5-Substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic Acid Ethyl Esters as New Analgesic and Anti-inflammatory Agents
-
Gokulan, P.D.; Jayakar, B.; Alagarsamy, V.; et al. Synthesis and Pharmacological Investigation of 5-Substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic Acid Ethyl Esters as New Analgesic and Anti-inflammatory Agents. Arzneimittelforschung, 2012, 62, 457-462.
-
(2012)
Arzneimittelforschung
, vol.62
, pp. 457-462
-
-
Gokulan, P.D.1
Jayakar, B.2
Alagarsamy, V.3
-
57
-
-
0015237292
-
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
-
Vane, J.R.; Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature, 1971, 231, 232-235.
-
(1971)
Nature
, vol.231
, pp. 232-235
-
-
Vane, J.R.1
-
58
-
-
0015237275
-
Aspirin selectively inhibits prostaglandin production in human platelets
-
Smith, J.B.; Willis, A.L.; Aspirin selectively inhibits prostaglandin production in human platelets. Nature, 1971, 231, 235-237.
-
(1971)
Nature
, vol.231
, pp. 235-237
-
-
Smith, J.B.1
Willis, A.L.2
-
59
-
-
33644870565
-
COX isoforms in the cardiovascular system: Understanding the activities of non-steroidal antiinflammatory drugs
-
Mitchell, J.A.; Warner, T.D. COX isoforms in the cardiovascular system: understanding the activities of non-steroidal antiinflammatory drugs. Nature Reviews Drug Discovery, 2006, 5, 75-86.
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, pp. 75-86
-
-
Mitchell, J.A.1
Warner, T.D.2
-
60
-
-
79955428056
-
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase
-
Hwang, S.H.; Wagner, K.M.; Morisseau, C.; et al. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. Journal of medicinal chemistry, 2011, 54, 3037-3050.
-
(2011)
Journal of medicinal chemistry
, vol.54
, pp. 3037-3050
-
-
Hwang, S.H.1
Wagner, K.M.2
Morisseau, C.3
-
61
-
-
0025754779
-
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
-
Xie, W.L.; Chipman, J.G.; Robertson, D.L.; et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proceedings of the National Academy of Sciences, 1991, 88, 2692-2696.
-
(1991)
Proceedings of the National Academy of Sciences
, vol.88
, pp. 2692-2696
-
-
Xie, W.L.1
Chipman, J.G.2
Robertson, D.L.3
-
62
-
-
0025871150
-
Herschman TIS10 a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells encodes a novel prostaglandin synthase/cyclo-oxygenase homologue
-
Kubuju, B.S.; Fletcher, B.C.; Varnum, R.W.; Lim, H.R.; Herschman TIS10 a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells encodes a novel prostaglandin synthase/cyclo-oxygenase homologue. J Biol Chem, 1991, 86, 12866-12872.
-
(1991)
J Biol Chem
, vol.86
, pp. 12866-12872
-
-
Kubuju, B.S.1
Fletcher, B.C.2
Varnum, R.W.3
Lim, H.R.4
-
64
-
-
84866416420
-
Synthesis and antiinflammatory evaluation of some new 3, 6-disubstituted-1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazoles bearing pyrazole moiety
-
Malladi, S.; Isloor, A.M.; Shetty, P.; et al. Synthesis and antiinflammatory evaluation of some new 3, 6-disubstituted-1, 2, 4-triazolo-[3, 4-b]-1, 3, 4-thiadiazoles bearing pyrazole moiety. Medicinal Chemistry Research, 2012, 21, 3272-3280.
-
(2012)
Medicinal Chemistry Research
, vol.21
, pp. 3272-3280
-
-
Malladi, S.1
Isloor, A.M.2
Shetty, P.3
-
65
-
-
77957232473
-
Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4, 5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors
-
Iñiguez, M.A.; Punzón, C.; Cacheiro-Llaguno, C.; et al. Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4, 5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors. International immunopharmacology, 2010, 10, 1295-1304.
-
(2010)
International immunopharmacology
, vol.10
, pp. 1295-1304
-
-
Iñiguez, M.A.1
Punzón, C.2
Cacheiro-Llaguno, C.3
-
66
-
-
84867843793
-
Synthesis, biological evaluation and molecular modeling of dihydropyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors
-
Ke-Ming, Qiu.; Ru, Yan.; Hai-Hong, Wang.; et al. Synthesis, biological evaluation and molecular modeling of dihydropyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors. Bioorganic & medicinal chemistry, 2012, 20, 6648-6654
-
(2012)
Bioorganic & medicinal chemistry
, vol.20
, pp. 6648-6654
-
-
Ke-Ming, Q.1
Ru, Y.2
Hai-Hong, W.3
-
67
-
-
0026015132
-
DNA gyrase: Structure and function
-
Reece, R.J.; Maxwell, A.; Wang, J.C.; DNA gyrase: structure and function. Critical reviews in biochemistry and molecular biology, 1991, 26, 335-375.
-
(1991)
Critical reviews in biochemistry and molecular biology
, vol.26
, pp. 335-375
-
-
Reece, R.J.1
Maxwell, A.2
Wang, J.C.3
-
68
-
-
34247385516
-
Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis
-
Gomez, L.; Hack, M.D.; Wu, J.; et al. Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis. Bioorganic & medicinal chemistry letters, 2007, 17, 2723-2727.
-
(2007)
Bioorganic & medicinal chemistry letters
, vol.17
, pp. 2723-2727
-
-
Gomez, L.1
Hack, M.D.2
Wu, J.3
-
69
-
-
1642288258
-
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening
-
Boehm, H.J.; Boehringer, M.; Bur, D.; et al. Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening. Journal of medicinal chemistry, 2000, 43, 2664-2674.
-
(2000)
Journal of medicinal chemistry
, vol.43
, pp. 2664-2674
-
-
Boehm, H.J.1
Boehringer, M.2
Bur, D.3
-
70
-
-
0342313482
-
Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors
-
Lübbers, T.; Angehrn, P.; Gmünder, H.; et al. Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors. Bioorganic & medicinal chemistry letters, 2000, 10, 821-826.
-
(2000)
Bioorganic & medicinal chemistry letters
, vol.10
, pp. 821-826
-
-
Lübbers, T.1
Angehrn, P.2
Gmünder, H.3
-
71
-
-
42549142627
-
Synthesis, Characterization and Antibacterial Activity of New 5-(o-Chlorophenyl)-3-(o, p-dichlorophenyl)-4, 5-dihydropyrazol-1-yl Oxime Ester Derivatives
-
Liu, X.H.; Song, B.A.; Zhu, H.L.; et al. Synthesis, Characterization and Antibacterial Activity of New 5-(o-Chlorophenyl)-3-(o, p-dichlorophenyl)-4, 5-dihydropyrazol-1-yl Oxime Ester Derivatives. Chinese Journal of Chemistry, 2008, 26, 505-509.
-
(2008)
Chinese Journal of Chemistry
, vol.26
, pp. 505-509
-
-
Liu, X.H.1
Song, B.A.2
Zhu, H.L.3
-
72
-
-
58949096498
-
Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4, 5-dihydro-1 H-pyrazol-5-yl)-7-substitued-1, 2, 3, 4-tetrahydroisoquinoline derivatives
-
Liu, X.H.; Zhu, J.; Zhou, A.; et al. Synthesis, structure and antibacterial activity of new 2-(1-(2-(substituted-phenyl)-5-methyloxazol-4-yl)-3-(2-substitued-phenyl)-4, 5-dihydro-1 H-pyrazol-5-yl)-7-substitued-1, 2, 3, 4-tetrahydroisoquinoline derivatives. Bioorganic & medicinal chemistry, 2009, 17, 1207-1213.
-
(2009)
Bioorganic & medicinal chemistry
, vol.17
, pp. 1207-1213
-
-
Liu, X.H.1
Zhu, J.2
Zhou, A.3
-
73
-
-
34250649348
-
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
-
Wang, J.; Kodali, S.; Lee, S.H.; et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proceedings of the National Academy of Sciences, 2007, 104, 7612-7616.
-
(2007)
Proceedings of the National Academy of Sciences
, vol.104
, pp. 7612-7616
-
-
Wang, J.1
Kodali, S.2
Lee, S.H.3
-
74
-
-
79960561354
-
Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors
-
Li, Z.L.; Li, Q.S.; Zhang, H.J.; et al. Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors. Bioorganic & medicinal chemistry, 2011, 19, 4413-4420.
-
(2011)
Bioorganic & medicinal chemistry
, vol.19
, pp. 4413-4420
-
-
Li, Z.L.1
Li, Q.S.2
Zhang, H.J.3
-
75
-
-
20144370577
-
Structure-based design, synthesis, and study of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
-
Nie, Z.; Perretta, C.; Lu, J.; et al. Structure-based design, synthesis, and study of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents. Journal of medicinal chemistry, 2005, 48, 1596-1609.
-
(2005)
Journal of medicinal chemistry
, vol.48
, pp. 1596-1609
-
-
Nie, Z.1
Perretta, C.2
Lu, J.3
-
76
-
-
33846485580
-
Structure of the human β-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase
-
Christensen, C.E.; Kragelund, B.B.; von Wettstein-Knowles, P.; et al. Structure of the human β-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase. Protein science, 2007, 16, 261-272.
-
(2007)
Protein science
, vol.16
, pp. 261-272
-
-
Christensen, C.E.1
Kragelund, B.B.2
von Wettstein-Knowles, P.3
-
77
-
-
33750943943
-
Natural flavonoids as antimicrobial agents
-
Bylka, W.; Matlawska, I.; Pilewski, N.A. Natural flavonoids as antimicrobial agents. J Am Neutraceut Assoc, 2004, 7, 24-31.
-
(2004)
J Am Neutraceut Assoc
, vol.7
, pp. 24-31
-
-
Bylka, W.1
Matlawska, I.2
Pilewski, N.A.3
-
78
-
-
77955421223
-
Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors
-
Lv, P.C.; Sun, J.; Luo, Y.; et al. Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. Bioorganic & medicinal chemistry letters, 2010, 20, 4657-4660.
-
(2010)
Bioorganic & medicinal chemistry letters
, vol.20
, pp. 4657-4660
-
-
Lv, P.C.1
Sun, J.2
Luo, Y.3
|