Structure-based design, synthesis, and study of potent inhibitors of β-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents

Journal of Medicinal Chemistry

Volumn 48, Issue 5, 2005, Pages 1596-1609

  Nie, Zhe ^a   Perretta, Carin ^a   Lu, Jia ^a   Su, Ying ^a   Margosiak, Stephen ^a   Gajiwala, Ketan S ^a   Cortez, Joseph ^a   Nikulin, Victor ^a   Yager, Kraig M ^a   Appelt, Krzysztof ^b   Chu, Shaosong ^a  

^a Quorex Pharmaceuticals   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; 3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE III INHIBITOR; AMINOBENZOIC ACID DERIVATIVE; ANTIINFECTIVE AGENT; BENZOYLAMINOBENZOIC ACID DERIVATIVE; FATTY ACID; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITOR INTERACTION; FATTY ACID SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLIZATION; DRUG DESIGN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20144370577     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049141s     Document Type: Article

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