Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5622-5626

  El Deeb, Ibrahim M ^b   Park, Byung Sun ^c   Jung, Su Jin ^a   Yoo, Kyung Ho ^a   Oh, Chang Hyun ^a   Cho, Seung Joo ^d   Han, Dong Keun ^a   Lee, Jae Yeol ^c   Lee, So Ha ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

^d Chosun University   (South Korea)

Author keywords

Glioblastoma multiforme; Homology modeling; Kinase inhibitors; Pyrazole; ROS1

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR ROS1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR INTERACTION; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; CRESOLS; DRUG DESIGN; HUMANS; HYDROGEN BONDING; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69949108857     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.029     Document Type: Article

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