Synthesis and biological evaluation of some hydroxypyrazole derivatives as anti-inflammatory-antimicrobial agents

Archiv der Pharmazie

Volumn 339, Issue 2, 2006, Pages 81-87

  Bekhit, Adnan A ^a   Abdel Rahman, Hamdy M ^b   Guemei, Aida A ^a  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b Assiut University   (Egypt)

Author keywords

Acute toxicity; Anti inflammatory; Antimicrobial; Hydroxypyrazole; Ulcerogenic effect

Indexed keywords

3 (4 AMINOPHENYL) 1H PYRAZOL 5 OL; 3 (4 NITROPHENYL) 1 (4 METHOXYPHENYL) 1H PYRAZOL 5 OL; ACETIC ANHYDRIDE; ACID ANHYDRIDE; AMPICILLIN; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CLOTRIMAZOLE; HYDRAZINE; HYDROXYPYRAZOLE DERIVATIVE; INDOMETACIN; N [4 (5 HYDROXY 1 METHYL 1H PYRAZOL 3 YL)PHENYL]TRIFLUOROACETAMIDE; N [4 (5 HYDROXY 1 TRIFLUOROACETYL 1H PYRAZOL 3 YL)PHENYL]TRIFLUOROACETAMIDE; PYRAZOLE DERIVATIVE; TRIFLUOROACETIC ANHYDRIDE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BIOASSAY; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG SAFETY; DRUG SYNTHESIS; ESCHERICHIA COLI; GRANULOMA; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; REDUCTION; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; ULCEROGENESIS;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; MALE; MICE; MICROBIAL SENSITIVITY TESTS; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 33144455243     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200500197     Document Type: Article

References (23)

1. A. K. Gadad, B. S. Kittur, S. G. Kapsi, C. S. Mahajanshetti, S. B. Rajur, Arzneim. Forsch. 1996, 46, 1082-1085.
2. T. D. Penning, J. J. Talley, S. R. Bertenshaw, J. S. Carter, P. W. Collins, S. Docter, M. J. Graneto, L. F. Lee, J. W. Malecha, J. M. Miyashiro, R. S. Rogers, D. J. Rogier, S. S. Yu, G. D. Anderson, E. G. Burton, J. N. Cogburn, S. A. Gregory, C. M. Koboldt, W. E. Perkins, K. Seibert, A. W. Veenhuizen, Y. Y. Zhang, P. C. Isakson, J. Med. Chem. 1997, 40, 1347-1365.
3. K. Tsuji, K. Nakamura, T. Ogino, N. Konishi, T. Tojo, T. Ochi, N. Seki, M. Matsuo, Chem. Pharm. Bull. 1998, 46, 279-286.
4. S. A. Beers, E. A. Malloy, W. Wu, M. Wachter, J. Ansell, M. Singer, M. Steber, A. Barbone, T. Kirchner, D. Ritchie, D. Argentieri, Bioorg. Med. Chem. Lett. 1997, 5, 779-786.
5. D. H. Boschelli, D. T. Connor, D. A. Bornemeier, R. D. Dyer, J. A. Kennedy, P. J. Kuipers, G. C. Okonkwo, D. J. Schrier, C. D. Wright, J. Med. Chem. 1993, 36, 1802-1810.
6. A. Tanitame, Y. Oyamada, K. Ofuji, Y. Kyoya, K. Suziki, H. Ito, M. Kawasaki, K. Nagai, M. Wachi, J. Yamagishi, Bioorg. Med. Chem. Lett. 2004, 14, 2857-2862.
7. A. Tanitame, Y. Oyamada, K. Ofuji, K. Suziki, H. Ito, M. Kawasaki, M. Wachi, J. Yamagishi, Bioorg. Med. Chem, Lett. 2004, 14, 2863-2866.
8. A. Tanitame, Y. Oyamada, K. Ofuji, M. Fujimoto, N. Iwai, Y. Hiyama, K. Suziki, H. Ito, H. Terauchi, M. Kawasaki, K. Nagai, M. Wachi, J. Yamagishi, J. Med. Chem. 2004, 47, 3693-3696.
9. A. M. Farghaly, A. A. Bekhit, J. Y. Park, Arch. Pharm. Pharm. Med. Chem. 2000, 333, 53-57.
10. nd International Conference for Pharmaceutical and Biological Sciences, 19-21 December 2001, Cairo, Egypt, Abst. P. 34.
11. A. A. Bekhit, H. T. Y. Fahmy, Sh. A. F. Rostom, A. M. Baraka, Eur. J. Med. Chem. 2003, 38, 27-36.
12. A. A. Bekhit, H. T. Y. Fahmy, Arch. Pharm. Pharm. Med. Chem. 2003, 336, 111-118.
13. A. A. Bekhit, T. Abdel-Azeim, Bioorg. Med. Chem. 2004, 12, 1935-1945.
14. A. A. Bekhit, Egyptian Patent, GATT/TRIPS Treaty, Appl. No. 1117, 12, 2003.
15. th April, 2003, Abst. P16.
16. th, 2004, Abst. P57.
17. A. A. Bekhit, H. M. A. Ashour, A. Guemei, Arch. Pharm. Chem. Life Sci. 2005, 338, 167-174.
18. R. Meier, W. Schuler, P. Desaulles, Experientia 1950, 6, 469.
19. M. Di Rosa, D. A. Willoughby, J. Pharm. Pharmcol. 1971, 23, 297-298.
20. M. S. Abou Zeit-Har, T. Verimer, J. P. Long, Pharmazie 1982, 37, 593-595.
21. M. Verma, M. Tripathi, A. K. Saxena, K. Shanker, Eur. J. Med. Chem. 1994, 29, 941-946.
22. J. T. Litchfield, F. Wilcoxon, J. Pharmacol. Exp. Ther. 1949, 96, 99.
23. P. R. Murray, E. J. Baron, M. A. Pfaller, F. C. Tenover, R. H. Yolken in Manual of Clinical Microbiology, (Eds: G. L. Woods, J. A. Washington), Antimicrobial Agents and Susceptibility Testing, Am. Soc. Microbiol., Washington, DC, 1995.