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Bioorganic and Medicinal Chemistry

Volumn 18, Issue 13, 2010, Pages 4606-4614

Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents

(5) Lv, Peng Cheng a Li, Huan Qiu a Sun, Juan a Zhou, Yang a Zhu, Hai Liang a

a NANJING UNIVERSITY (China)

Author keywords

Anticancer; EGFR; Inhibitors; Pyrazole derivatives; Thiourea

Indexed keywords

3 (3,4 DIBROMOPHENYL) 5 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIBROMOPHENYL) 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIBROMOPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIBROMOPHENYL) 5 (4 TOLYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DICHLOROPHENYL) 5 (2 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DICHLOROPHENYL) 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DICHLOROPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DICHLOROPHENYL) 5 (4 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DICHLOROPHENYL) 5 (4 TOLYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIMETHYLPHENYL) 5 (2 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIMETHYLPHENYL) 5 (4 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIMETHYLPHENYL) 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIMETHYLPHENYL) 5 (4 NITROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 3 (3,4 DIMETHYLPHENYL) 5 (4 TOLYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (2 BROMOPHENYL) 3 (3,4 DICHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (2 BROMOPHENYL) 3 (3,4 DIMETHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (2 CHLOROPHENYL) 3 (3,4 DICHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (2 CHLOROPHENYL) 3 (3,4 DIMETHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (3,4 DICHLOROPHENYL) 3 (3,4 DIMETHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (4 BROMOPHENYL) 3 (3,4 DIBROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (4 BROMOPHENYL) 3 (3,4 DICHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (4 BROMOPHENYL) 3 (3,4 DIMETHYLPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (4 CHLOROPHENYL) 3 (3,4 DIBROMOPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; 5 (4 CHLOROPHENYL) 3 (3,4 DICHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOTHIOAMIDE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; PYRAZOLE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; IC 50; MOLECULAR DOCKING; SIMULATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; NEOPLASMS; PYRAZOLES; RECEPTOR, EPIDERMAL GROWTH FACTOR; THIOAMIDES; THIOUREA;

EID: 77954213883 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.05.034 Document Type: Article

Times cited : (278)

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