Synthesis, biological evaluation, and molecular docking studies of N,1,3-triphenyl-1H-pyrazole-4-carboxamide derivatives as anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 11, 2012, Pages 3589-3593

  Li, Xi ^a   Lu, Xiang ^a   Xing, Man ^a   Yang, Xian Hui ^a   Zhao, Ting Ting ^a   Gong, Hai Bin ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Aurora A kinase; Molecular docking; N,1,3 triphenyl 1H pyrazole 4 carboxamide; Structure activity relationship

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; AURORA A KINASE; N 1,3 TRIPHENYL 1H PYRAZOLE 4 CARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN HCT116; CELL STRAIN MCF 7; CONTROLLED STUDY; HUMAN; MOLECULAR DOCKING; SYNTHESIS; WESTERN BLOTTING;

AMIDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; HCT116 CELLS; HUMANS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES;

EID: 84861197424     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.066     Document Type: Article

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