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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4657-4660

Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors

(5) Lv, Peng Cheng a Sun, Juan a Luo, Yin a Yang, Ying a Zhu, Hai Liang a

a NANJING UNIVERSITY (China)

Author keywords

Antibacterial; Design; FabH inhibitors; Pyrazole derivatives; Structure activity relationship; Synthesis

Indexed keywords

1 (5 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL)ETHANONE; 1 (5 (4 FLUOROPHENYL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1 H PYRAZOL 1 YL)ETHANONE; 1 ACETYL 3,5 DIPHENYL 4,5 DIHYDRO (1H) PYRAZOLE; ACYL CARRIER PROTEIN; ANTIINFECTIVE AGENT; PROTEIN FABH; PROTEIN INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; SIMULATION; STRUCTURE ACTIVITY RELATION;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; POSIBACTERIA;

EID: 77955421223 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.05.105 Document Type: Article

Times cited : (87)

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