Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 4, 2013, Pages 1091-1095

  Luo, Yin ^a   Zhang, Shuai ^a   Qiu, Ke Ming ^a   Liu, Zhi Jun ^a   Yang, Yu Shun ^a   Fu, Jie ^a   Zhong, Wei Qing ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

3D QSAR; Antiproliferative; Aryl 2H pyrazole; Telomerase inhibitor

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 1,4 BENZODIOXAN DERIVATIVE; ANTINEOPLASTIC AGENT; ETHIDIUM BROMIDE; FLUOROURACIL; PYRAZOLE DERIVATIVE; TELOMERASE INHIBITOR;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MELANOMA CELL; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIMULATION;

BINDING SITES; CELL GROWTH PROCESSES; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 84872929346     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.12.010     Document Type: Article

References (23)

1. W.E. Wright, and J.W. Shay Curr. Opin. Genet. Dev. 11 2001 98
2. A.G. Bodnar, M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, and W.E. Wright Science 279 1998 349
3. J.G. Andrew, P.S. Anthony, and S. Emmanuel Nature 455 2008 633
4. X.H. Liu, B.F. Ruan, J. Li, B.A. Song, H.L. Zhu, and P.S. Bhadury Mini-Rev. Med. Chem. 11 2011 771
5. K.S. Girisha, B. Kalluraya, N. Vijaya, and Padmashree Eur. J. Med. Chem. 45 2010 4640
6. F. Hayat, A. Salahuddin, S. Umar, and A. Azam Eur. J. Med. Chem. 45 2010 4669
7. F.E. Boyer, J.V.N. Vara Prasad, A.L. Choy, L. Chupak, and M.R. Dermyer Bioorg. Med. Chem. Lett. 17 2007 4694
8. D. Havrylyuk, B. Zimenkovsky, O. Vasylenko, L. Zaprutko, A. Gzella, and R. Lesyk Eur. J. Med. Chem. 44 2009 1396
9. M. Shaharyar, M.M. Abdullah, M.A. Bakht, and J. Majeed Eur. J. Med. Chem. 45 2010 114
10. B. Insuasty, A. Tigreros, F. Orozco, J. Quiroga, R. Abonía, M. Nogueras, A. Sanchez, and J. Cobo Bioorg. Med. Chem. Lett. 18 2010 4965
11. P.C. Lv, K.R. Wang, W.J. Mao, J. Xiong, H.Q. Li, Y. Yang, and L. Shi ChemMedChem 4 2009 1
12. M.T. Vazquez, G. Rosell, and M.D. Pujol Farmaco 51 1996 215
13. Y. Harrak, G. Rosell, G. Daidone, S. Plescia, D. Schillaci, and M.D. Pujol Bioorg. Med. Chem. Lett. 15 2007 4876
14. M.Z. Xu, W.S. Lee, J.M. Han, H.W. Oh, D.S. Park, G.R. Tian, T.S. Jeong, and H.Y. Park Bioorg. Med. Chem. Lett. 14 2006 7826
15. X.M. Zhang, M. Qiu, J. Sun, Y.B. Zhang, Y.S. Yang, X.L. Wang, J.F. Tang, and H.L. Zhu Bioorg. Med. Chem. Lett. 19 2011 6518
16. X.H. Liu, H.F. Liu, X. Shen, B.A. Song, and H.L. Zhu Bioorg. Med. Chem. Lett. 20 2010 4163
17. X.H. Liu, X.F. Liu, J. Chen, and H.L. Zhu Bioorg. Med. Chem. Lett. 20 2010 5705
18. X.H. Liu, B.F. Ruan, J.X. Liu, B.A. Song, and H.L. Zhu Bioorg. Med. Chem. Lett. 21 2011 2916
19. N.W. Kim, M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L. Ho, G.M. Coviello, W.E. Wright, S.L. Weinrich, and J.W. Shay Science 266 1994 2011
20. H. Han, L.H. Hurly, and M. Salazar Nucleic AcidS Res. 27 1999 537
21. B. Insuasty, L. Chamizo, J. Munoz, A. Tigreros, J. Quiroga, R. Abonia, M. Nogueras, and J. Cobo Arch. Pharm. Chem. Life Sci. 345 2012 275
22. P. Kirkpatrick Nat. Rev. Drug Disc. 3 2004 299
23. G. Kothandana, C.G. Gadhe, T. Madhavan, C.H. Choi, and S.J. Cho Eur. J. Med. Chem. 46 2011 4078