Non-covalent interactions with aromatic rings: Current understanding and implications for rational drug design

Current Pharmaceutical Design

Volumn 19, Issue 36, 2013, Pages 6522-6533

  Li, Shanshan ^a,b   Xu, Yuan ^b   Shen, Qiancheng ^b   Liu, Xian ^b   Lu, Jing ^b   Chen, Yadong ^a   Lu, Tao ^a   Luo, Cheng ^b   Luo, Xiaomin ^b   Zheng, Mingyue ^b   Jiang, Hualiang ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholine esterase (AChE); Anion p interactions; Cation p interactions; Crystallographic data mining; HMG CoA reductase (HMGR); P p interactions; Quantum mechanical calculations; Rational drug design; Serine protease factor Xa (fXa)

Indexed keywords

ANALGESIC AGENT; ANION; ANTICOAGULANT AGENT; ANTIPYRETIC AGENT; AROMATIC COMPOUND; CATION; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIGAND; NEUROTRANSMITTER; RIVAROXABAN;

BINDING AFFINITY; CHEMICAL INTERACTION; CRYSTALLOGRAPHY; DATA MINING; DRUG CONFORMATION; DRUG DESIGN; GEOMETRY; HYDROGEN BOND; HYDROPHOBICITY; HYPERCHOLESTEROLEMIA; LIGAND BINDING; MOLECULAR RECOGNITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTUM MECHANICS; REVIEW; THERMODYNAMICS;

DRUG DESIGN; HYDROCARBONS, AROMATIC; PHARMACEUTICAL PREPARATIONS; PROTEINS;

EID: 84887874738     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990440     Document Type: Review

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