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Angewandte Chemie - International Edition

Volumn 48, Issue 4, 2009, Pages 811-814

Cation-π interactions at the active site of factor Xa: Dramatic enhancement upon stepwise N-alkylation of ammonium ions

(10) Salonen, Laura M b Bucher, Christoph b Banner, David W a Haap, Wolfgang a Mary, Jean Luc a Benz, Jörg a Kuster, Olivier a Seiler, Paul b Schweizer, W Bernd b Diederich, François b

a F HOFFMANN LA ROCHE LTD (Switzerland)

b ETH ZURICH (Switzerland)

Author keywords

Dipolar interactions; Enzymes; Inhibitors; Molecular recognition; Pi interactions

Indexed keywords

AMINES; AMMONIUM COMPOUNDS; BINDING ENERGY; CATALYSTS; ENZYMES; HYDROCARBONS; IONS; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; POSITIVE IONS; PROTEINS;

ACTIVE SITES; AMMONIUM IONS; AROMATIC BOXES; BINDING AFFINITIES; DIPOLAR INTERACTIONS; DRAMATIC ENHANCEMENTS; INHIBITORS; NEW CLASSES; PI INTERACTIONS; POTENT INHIBITORS; QUATERNARY AMMONIUM IONS;

FLOW INTERACTIONS;

ANILINE DERIVATIVE; BLOOD CLOTTING FACTOR 10A; CATION; ENZYME INHIBITOR; LIGAND; QUATERNARY AMMONIUM DERIVATIVE;

ALKYLATION; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALKYLATION; ANILINE COMPOUNDS; CATALYTIC DOMAIN; CATIONS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FACTOR XA; LIGANDS; QUATERNARY AMMONIUM COMPOUNDS; THERMODYNAMICS;

EID: 58249100150 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/anie.200804695 Document Type: Article

Times cited : (71)

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