메뉴 건너뛰기




Volumn , Issue , 2009, Pages 61-88

Hepatitis C virus genome replication

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84887197508     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/b135974_4     Document Type: Chapter
Times cited : (3)

References (205)
  • 2
    • 2942715265 scopus 로고    scopus 로고
    • Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts
    • Aizaki, H., Lee, K. J., Sung, V. M., Ishiko, H. and Lai, M. M. 2004. Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts. Virology 324: 450-61.
    • (2004) Virology , vol.324 , pp. 450-461
    • Aizaki, H.1    Lee, K.J.2    Sung, V.M.3    Ishiko, H.4    Lai, M.M.5
  • 3
    • 0031951177 scopus 로고    scopus 로고
    • Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli
    • Al, R. H., Xie, Y., Wang, Y. and Hagedorn, C. H. 1998. Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli. Virus Res 53: 141-9.
    • (1998) Virus Res , vol.53 , pp. 141-149
    • Al, R.H.1    Xie, Y.2    Wang, Y.3    Hagedorn, C.H.4
  • 4
    • 0036889329 scopus 로고    scopus 로고
    • Cell-free replication of the hepatitis C virus subgenomic replicon
    • Ali, N., Tardif, K. D. and Siddiqui, A. 2002. Cell-free replication of the hepatitis C virus subgenomic replicon. J Virol 76: 12001-7.
    • (2002) J Virol , vol.76 , pp. 12001-12007
    • Ali, N.1    Tardif, K.D.2    Siddiqui, A.3
  • 5
    • 0033932001 scopus 로고    scopus 로고
    • Recovery, persistence, and sequelae in hepatitis C virus infection: A perspective on long-term outcome
    • Alter, H. J. and Seeff, L. B. 2000. Recovery, persistence, and sequelae in hepatitis C virus infection: A perspective on long-term outcome. Semin Liver Dis 20: 17-35.
    • (2000) Semin Liver Dis , vol.20 , pp. 17-35
    • Alter, H.J.1    Seeff, L.B.2
  • 6
    • 0034602386 scopus 로고    scopus 로고
    • Demonstration of functional requirement of polypyrimidine tract-binding protein by SELEX RNA during hepatitis C virus internal ribosome entry site-mediated translation initiation
    • Anwar, A., Ali, N., Tanveer, R. and Siddiqui, A. 2000. Demonstration of functional requirement of polypyrimidine tract-binding protein by SELEX RNA during hepatitis C virus internal ribosome entry site-mediated translation initiation. J Biol Chem 275: 34231-5.
    • (2000) J Biol Chem , vol.275 , pp. 34231-34235
    • Anwar, A.1    Ali, N.2    Tanveer, R.3    Siddiqui, A.4
  • 7
    • 11144227045 scopus 로고    scopus 로고
    • Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A
    • Appel, N., Herian, U. and Bartenschlager, R. 2005a. Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A. J Virol 79: 896-909.
    • (2005) J Virol , vol.79 , pp. 896-909
    • Appel, N.1    Herian, U.2    Bartenschlager, R.3
  • 8
    • 13944263525 scopus 로고    scopus 로고
    • Mutational analysis of hepatitis C virus nonstructural protein 5A: Potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain
    • Appel, N., Pietschmann, T. and Bartenschlager, R. 2005b. Mutational analysis of hepatitis C virus nonstructural protein 5A: Potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain. J Virol 79: 3187-94.
    • (2005) J Virol , vol.79 , pp. 3187-3194
    • Appel, N.1    Pietschmann, T.2    Bartenschlager, R.3
  • 9
    • 11144246127 scopus 로고    scopus 로고
    • Novel insights into hepatitis C virus replication and persistence
    • Bartenschlager, R., Frese, M. and Pietschmann, T. 2004. Novel insights into hepatitis C virus replication and persistence. Adv Virus Res 63: 71-180.
    • (2004) Adv Virus Res , vol.63 , pp. 71-180
    • Bartenschlager, R.1    Frese, M.2    Pietschmann, T.3
  • 10
    • 35348865571 scopus 로고    scopus 로고
    • Interactions between brome mosaic virus RNAs and cytoplasmic processing bodies
    • Beckham, C. J., Light, H. R., Nissan, T. A., Ahlquist, P., Parker, R. and Noueiry, A. 2007. Interactions between brome mosaic virus RNAs and cytoplasmic processing bodies. J Virol 81: 9759-68.
    • (2007) J Virol , vol.81 , pp. 9759-9768
    • Beckham, C.J.1    Light, H.R.2    Nissan, T.A.3    Ahlquist, P.4    Parker, R.5    Noueiry, A.6
  • 11
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNAdependent RNA polymerase of hepatitis C virus
    • Behrens, S. E., Tomei, L. and De Francesco, R. 1996. Identification and properties of the RNAdependent RNA polymerase of hepatitis C virus. EMBO J 15: 12-22.
    • (1996) EMBO J , vol.15 , pp. 12-22
    • Behrens, S.E.1    Tomei, L.2    De Francesco, R.3
  • 12
    • 36849075152 scopus 로고    scopus 로고
    • The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate
    • Beran, R. K., Serebrov, V. and Pyle, A. M. 2007. The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate. J Biol Chem 282: 34913-20.
    • (2007) J Biol Chem , vol.282 , pp. 34913-34920
    • Beran, R.K.1    Serebrov, V.2    Pyle, A.M.3
  • 14
    • 36348936640 scopus 로고    scopus 로고
    • Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy
    • Binder, M., Kochs, G., Bartenschlager, R. and Lohmann, V. 2007a. Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology 46: 1365-74.
    • (2007) Hepatology , vol.46 , pp. 1365-1374
    • Binder, M.1    Kochs, G.2    Bartenschlager, R.3    Lohmann, V.4
  • 15
    • 34248365628 scopus 로고    scopus 로고
    • Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras
    • Binder, M., Quinkert, D., Bochkarova, O., Klein, R., Kezmic, N., Bartenschlager, R. and Lohmann, V. 2007b. Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol 81: 5270-83.
    • (2007) J Virol , vol.81 , pp. 5270-5283
    • Binder, M.1    Quinkert, D.2    Bochkarova, O.3    Klein, R.4    Kezmic, N.5    Bartenschlager, R.6    Lohmann, V.7
  • 16
    • 23744436747 scopus 로고    scopus 로고
    • Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors
    • Biswal, B. K., Cherney, M.M., Wang, M., Chan, L., Yannopoulos, C. G., Bilimoria, D., Nicolas, O., Bedard, J. and James, M. N. 2005. Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem 280: 18202-10.
    • (2005) J Biol Chem , vol.280 , pp. 18202-18210
    • Biswal, B.K.1    Cherney, M.M.2    Wang, M.3    Chan, L.4    Yannopoulos, C.G.5    Bilimoria, D.6    Nicolas, O.7    Bedard, J.8    James, M.N.9
  • 17
    • 34249792383 scopus 로고    scopus 로고
    • Allelic variation in the hepatitis C virus NS4B protein dramatically influences RNA replication
    • Blight, K. J. 2007. Allelic variation in the hepatitis C virus NS4B protein dramatically influences RNA replication. J Virol 81: 5724-36.
    • (2007) J Virol , vol.81 , pp. 5724-5736
    • Blight, K.J.1
  • 18
    • 0034623816 scopus 로고    scopus 로고
    • Efficient initiation of HCV RNA replication in cell culture
    • Blight, K. J., Kolykhalov, A. A. and Rice, C. M. 2000. Efficient initiation of HCV RNA replication in cell culture. Science 290: 1972-4.
    • (2000) Science , vol.290 , pp. 1972-1974
    • Blight, K.J.1    Kolykhalov, A.A.2    Rice, C.M.3
  • 19
    • 0030823630 scopus 로고    scopus 로고
    • Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA
    • Blight, K. J. and Rice, C. M. 1997. Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA. J Virol 71: 7345-52.
    • (1997) J Virol , vol.71 , pp. 7345-7352
    • Blight, K.J.1    Rice, C.M.2
  • 20
    • 33644869671 scopus 로고    scopus 로고
    • The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase
    • Bradrick, S. S., Walters, R.W. and Gromeier, M. 2006. The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase. Nucleic Acids Res 34: 1293-303.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1293-1303
    • Bradrick, S.S.1    Walters, R.W.2    Gromeier, M.3
  • 21
    • 14644415892 scopus 로고    scopus 로고
    • The hepatitis C virus alternate reading frame (ARF) and its family of novel products: The alternate reading frame protein/F-protein, the double-frameshift protein, and others
    • Branch, A. D., Stump, D. D., Gutierrez, J. A., Eng, F. and Walewski, J. L. 2005. The hepatitis C virus alternate reading frame (ARF) and its family of novel products: The alternate reading frame protein/F-protein, the double-frameshift protein, and others. Semin Liver Dis 25: 105-17.
    • (2005) Semin Liver Dis , vol.25 , pp. 105-117
    • Branch, A.D.1    Stump, D.D.2    Gutierrez, J.A.3    Eng, F.4    Walewski, J.L.5
  • 22
    • 0037040923 scopus 로고    scopus 로고
    • An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A
    • Brass, V., Bieck, E., Montserret, R., Wolk, B., Hellings, J. A., Blum, H. E., Penin, F. and Moradpour, D. 2002. An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A. J Biol Chem 277: 8130-9.
    • (2002) J Biol Chem , vol.277 , pp. 8130-8139
    • Brass, V.1    Bieck, E.2    Montserret, R.3    Wolk, B.4    Hellings, J.A.5    Blum, H.E.6    Penin, F.7    Moradpour, D.8
  • 23
    • 33947413114 scopus 로고    scopus 로고
    • Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses
    • Brass, V., Pal, Z., Sapay, N., Deleage, G., Blum, H. E., Penin, F. and Moradpour, D. 2007. Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses. J Virol 81: 2745-57.
    • (2007) J Virol , vol.81 , pp. 2745-2757
    • Brass, V.1    Pal, Z.2    Sapay, N.3    Deleage, G.4    Blum, H.E.5    Penin, F.6    Moradpour, D.7
  • 24
    • 15244346528 scopus 로고    scopus 로고
    • Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon
    • Breiman, A., Grandvaux, N., Lin, R., Ottone, C., Akira, S., Yoneyama, M., Fujita, T., Hiscott, J. and Meurs, E. F. 2005. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. J Virol 79: 3969-78.
    • (2005) J Virol , vol.79 , pp. 3969-3978
    • Breiman, A.1    Grandvaux, N.2    Lin, R.3    Ottone, C.4    Akira, S.5    Yoneyama, M.6    Fujita, T.7    Hiscott, J.8    Meurs, E.F.9
  • 25
    • 0036120573 scopus 로고    scopus 로고
    • Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
    • Bressanelli, S., Tomei, L., Rey, F. A. and De Francesco, R. 2002. Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol 76: 3482-92.
    • (2002) J Virol , vol.76 , pp. 3482-3492
    • Bressanelli, S.1    Tomei, L.2    Rey, F.A.3    De Francesco, R.4
  • 27
    • 24644499394 scopus 로고    scopus 로고
    • Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase
    • Cai, Z., Yi, M., Zhang, C. and Luo, G. 2005. Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase. J Virol 79: 11607-17.
    • (2005) J Virol , vol.79 , pp. 11607-11617
    • Cai, Z.1    Yi, M.2    Zhang, C.3    Luo, G.4
  • 28
    • 0036305913 scopus 로고    scopus 로고
    • Mutations in NS5B polymerase of hepatitis C virus: Impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture
    • Cheney, I. W., Naim, S., Lai, V. C., Dempsey, S., Bellows, D., Walker, M. P., Shim, J. H., Horscroft, N., Hong, Z. and Zhong, W. 2002. Mutations in NS5B polymerase of hepatitis C virus: Impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture. Virology 297: 298-306.
    • (2002) Virology , vol.297 , pp. 298-306
    • Cheney, I.W.1    Naim, S.2    Lai, V.C.3    Dempsey, S.4    Bellows, D.5    Walker, M.P.6    Shim, J.H.7    Horscroft, N.8    Hong, Z.9    Zhong, W.10
  • 29
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo, Q.-L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W. and Houghton, M: 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244: 359-62.
    • (1989) Science , vol.244 , pp. 359-362
    • Choo, Q.-L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 31
    • 0035811016 scopus 로고    scopus 로고
    • RNA virus error catastrophe: Direct molecular test by using ribavirin
    • Crotty, S., Cameron, C. E. and Andino, R. 2001. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci USA 98: 6895-900.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6895-6900
    • Crotty, S.1    Cameron, C.E.2    Andino, R.3
  • 32
    • 0037367315 scopus 로고    scopus 로고
    • Approaching a new era for hepatitis C virus therapy: Inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
    • De Francesco, R., Tomei, L., Altamura, S., Summa, V. and Migliaccio, G. 2003. Approaching a new era for hepatitis C virus therapy: Inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase. Antiviral Res 58: 1-16.
    • (2003) Antiviral Res , vol.58 , pp. 1-16
    • De Francesco, R.1    Tomei, L.2    Altamura, S.3    Summa, V.4    Migliaccio, G.5
  • 33
    • 30144436268 scopus 로고    scopus 로고
    • RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP
    • Dumont, S., Cheng, W., Serebrov, V., Beran, R. K., Tinoco, I. Jr., Pyle, A. M. and Bustamante, C. 2006. RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature 439: 105-8.
    • (2006) Nature , vol.439 , pp. 105-108
    • Dumont, S.1    Cheng, W.2    Serebrov, V.3    Beran, R.K.4    Tinoco, I.5    Pyle, A.M.6    Bustamante, C.7
  • 34
    • 0036100578 scopus 로고    scopus 로고
    • Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex
    • Egger, D., Wolk, B., Gosert, R., Bianchi, L., Blum, H. E., Moradpour, D. and Bienz, K. 2002. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex. J Virol 76: 5974-84.
    • (2002) J Virol , vol.76 , pp. 5974-5984
    • Egger, D.1    Wolk, B.2    Gosert, R.3    Bianchi, L.4    Blum, H.E.5    Moradpour, D.6    Bienz, K.7
  • 35
    • 4644222500 scopus 로고    scopus 로고
    • A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication
    • Einav, S., Elazar, M., Danieli, T. and Glenn, J. S. 2004. A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication. J Virol 78: 11288-95.
    • (2004) J Virol , vol.78 , pp. 11288-11295
    • Einav, S.1    Elazar, M.2    Danieli, T.3    Glenn, J.S.4
  • 36
    • 0038415985 scopus 로고    scopus 로고
    • Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication
    • Elazar, M., Cheong, K. H., Liu, P., Greenberg, H. B., Rice, C. M. and Glenn, J. S. 2003. Amphipathic helix-dependent localization of NS5A mediates hepatitis C virus RNA replication. J Virol 77: 6055-61.
    • (2003) J Virol , vol.77 , pp. 6055-6061
    • Elazar, M.1    Cheong, K.H.2    Liu, P.3    Greenberg, H.B.4    Rice, C.M.5    Glenn, J.S.6
  • 37
    • 4644281168 scopus 로고    scopus 로고
    • An N-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication
    • Elazar, M., Liu, P., Rice, C. M. and Glenn, J. S. 2004. An N-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication. J Virol 78: 11393-400.
    • (2004) J Virol , vol.78 , pp. 11393-11400
    • Elazar, M.1    Liu, P.2    Rice, C.M.3    Glenn, J.S.4
  • 38
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • Enomoto, N., Sakuma, I., Asahina, Y., Kurosaki, M., Murakami, T., Yamamoto, C., Izumi, N., Marumo, F. and Sato, C: 1995. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 96: 224-30.
    • (1995) J Clin Invest , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Izumi, N.7    Marumo, F.8    Sato, C.9
  • 39
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto, N., Sakuma, I., Asahina, Y., Kurosaki, M., Murakami, T., Yamamoto, C., Ogura, Y., Izumi, N., Marumo, F. and Sato, C: 1996. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl JMed 334: 77-81.
    • (1996) N Engl JMed , vol.334 , pp. 77-81
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Ogura, Y.7    Izumi, N.8    Marumo, F.9    Sato, C.10
  • 40
    • 4444377616 scopus 로고    scopus 로고
    • Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
    • Evans, M. J., Rice, C. M. and Goff, S. P. 2004. Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication. Proc Natl Acad Sci USA 101: 13038-43.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13038-13043
    • Evans, M.J.1    Rice, C.M.2    Goff, S.P.3
  • 41
    • 36349034692 scopus 로고    scopus 로고
    • Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B
    • Fernandes, F., Poole, D. S., Hoover, S., Middleton, R., Andrei, A. C., Gerstner, J. and Striker, R. 2007. Sensitivity of hepatitis C virus to cyclosporine A depends on nonstructural proteins NS5A and NS5B. Hepatology 46: 1026-33.
    • (2007) Hepatology , vol.46 , pp. 1026-1033
    • Fernandes, F.1    Poole, D.S.2    Hoover, S.3    Middleton, R.4    Andrei, A.C.5    Gerstner, J.6    Striker, R.7
  • 42
    • 0032902564 scopus 로고    scopus 로고
    • Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli
    • Ferrari, E., Wright-Minogue, J., Fang, J. W., Baroudy, B. M., Lau, J. Y. and Hong, Z: 1999. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol 73: 1649-54.
    • (1999) J Virol , vol.73 , pp. 1649-1654
    • Ferrari, E.1    Wright-Minogue, J.2    Fang, J.W.3    Baroudy, B.M.4    Lau, J.Y.5    Hong, Z.6
  • 43
    • 20144379712 scopus 로고    scopus 로고
    • Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease
    • Ferreon, J. C., Ferreon, A. C., Li, K. and Lemon, S. M. 2005. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J Biol Chem 280: 20483-92.
    • (2005) J Biol Chem , vol.280 , pp. 20483-20492
    • Ferreon, J.C.1    Ferreon, A.C.2    Li, K.3    Lemon, S.M.4
  • 45
    • 33845623845 scopus 로고    scopus 로고
    • Structural and mechanistic insights into hepatitis C viral translation initiation
    • Fraser, C. S. and Doudna, J. A. 2007. Structural and mechanistic insights into hepatitis C viral translation initiation. Nat Rev Microbiol 5: 29-38.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 29-38
    • Fraser, C.S.1    Doudna, J.A.2
  • 46
    • 0036094885 scopus 로고    scopus 로고
    • Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication
    • Friebe, P. and Bartenschlager, R. 2002. Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication. J Virol 76: 5326-38.
    • (2002) J Virol , vol.76 , pp. 5326-5338
    • Friebe, P.1    Bartenschlager, R.2
  • 47
    • 10644226734 scopus 로고    scopus 로고
    • Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication
    • Friebe, P., Boudet, J., Simorre, J. P. and Bartenschlager, R. 2005. Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. J Virol 79: 380-92.
    • (2005) J Virol , vol.79 , pp. 380-392
    • Friebe, P.1    Boudet, J.2    Simorre, J.P.3    Bartenschlager, R.4
  • 48
    • 0034747214 scopus 로고    scopus 로고
    • Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication
    • Friebe, P., Lohmann, V., Krieger, N. and Bartenschlager, R. 2001. Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication. J Virol 75: 12047-57.
    • (2001) J Virol , vol.75 , pp. 12047-12057
    • Friebe, P.1    Lohmann, V.2    Krieger, N.3    Bartenschlager, R.4
  • 49
    • 0035062268 scopus 로고    scopus 로고
    • Interaction of poly(rC)-binding protein 2 with the 5'-terminal stem loop of the hepatitis C-virus genome
    • Fukushi, S., Okada, M., Kageyama, T., Hoshino, F. B., Nagai, K. and Katayama, K. 2001. Interaction of poly(rC)-binding protein 2 with the 5'-terminal stem loop of the hepatitis C-virus genome. Virus Res 73: 67-79.
    • (2001) Virus Res , vol.73 , pp. 67-79
    • Fukushi, S.1    Okada, M.2    Kageyama, T.3    Hoshino, F.B.4    Nagai, K.5    Katayama, K.6
  • 51
    • 0344765507 scopus 로고    scopus 로고
    • Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: A potential mechanism of interferon resistance
    • Gale, M. J. Jr., Korth, M. J. and Katze, M. G: 1998b. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: A potential mechanism of interferon resistance. Clin Diagn Virol 10: 157-62.
    • (1998) Clin Diagn Virol , vol.10 , pp. 157-162
    • Gale, M.J.1    Korth, M.J.2    Katze, M.G.3
  • 52
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • Gale, M. J. Jr., Korth, M. J., Tang, N. M., Tan, S. L., Hopkins, D. A., Dever, T. E., Polyak, S. J., Gretch, D. R. and Katze, M. G: 1997. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230: 217-27.
    • (1997) Virology , vol.230 , pp. 217-227
    • Gale, M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 53
    • 1842457783 scopus 로고    scopus 로고
    • Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft
    • Gao, L., Aizaki, H., He, J. W. and Lai, M. M. 2004. Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft. J Virol 78: 3480-8.
    • (2004) J Virol , vol.78 , pp. 3480-3488
    • Gao, L.1    Aizaki, H.2    He, J.W.3    Lai, M.M.4
  • 54
    • 0345144016 scopus 로고    scopus 로고
    • Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons
    • Gosert, R., Egger, D., Lohmann, V., Bartenschlager, R., Blum, H. E., Bienz, K. and Moradpour, D. 2003. Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J Virol 77: 5487-92.
    • (2003) J Virol , vol.77 , pp. 5487-5492
    • Gosert, R.1    Egger, D.2    Lohmann, V.3    Bartenschlager, R.4    Blum, H.E.5    Bienz, K.6    Moradpour, D.7
  • 56
    • 0036233219 scopus 로고    scopus 로고
    • Activation and evasion of the antiviral 2'-5'oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA
    • Han, J. Q. and Barton, D. J. 2002. Activation and evasion of the antiviral 2'-5'oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA. RNA 8: 512-25.
    • (2002) RNA , vol.8 , pp. 512-525
    • Han, J.Q.1    Barton, D.J.2
  • 57
    • 0037303327 scopus 로고    scopus 로고
    • Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells
    • Hardy, R.W., Marcotrigiano, J., Blight, K. J., Majors, J. E. and Rice, C. M. 2003. Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells. J Virol 77: 2029-37.
    • (2003) J Virol , vol.77 , pp. 2029-2037
    • Hardy, R.W.1    Marcotrigiano, J.2    Blight, K.J.3    Majors, J.E.4    Rice, C.M.5
  • 58
    • 0027163740 scopus 로고
    • Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    • Hijikata, M., Mizushima, H., Akagi, T., Mori, S., Kakiuchi, N., Kato, N., Tanaka, T., Kimura, K. and Shimotohno, K: 1993. Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol 67: 4665-75.
    • (1993) J Virol , vol.67 , pp. 4665-4675
    • Hijikata, M.1    Mizushima, H.2    Akagi, T.3    Mori, S.4    Kakiuchi, N.5    Kato, N.6    Tanaka, T.7    Kimura, K.8    Shimotohno, K.9
  • 59
    • 0035919073 scopus 로고    scopus 로고
    • A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase
    • Hong, Z., Cameron, C. E., Walker, M. P., Castro, C., Yao, N., Lau, J. Y. and Zhong, W. 2001. A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology 285: 6-11.
    • (2001) Virology , vol.285 , pp. 6-11
    • Hong, Z.1    Cameron, C.E.2    Walker, M.P.3    Castro, C.4    Yao, N.5    Lau, J.Y.6    Zhong, W.7
  • 62
    • 3543067010 scopus 로고    scopus 로고
    • Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli
    • Huang, L., Sineva, E. V., Hargittai, M. R., Sharma, S. D., Suthar, M., Raney, K. D. and Cameron, C. E. 2004. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif 37: 144-53.
    • (2004) Protein Expr Purif , vol.37 , pp. 144-153
    • Huang, L.1    Sineva, E.V.2    Hargittai, M.R.3    Sharma, S.D.4    Suthar, M.5    Raney, K.D.6    Cameron, C.E.7
  • 63
    • 34249664478 scopus 로고    scopus 로고
    • Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?
    • Huang, Y., Staschke, K., De Francesco, R. and Tan, S. L. 2007. Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication? Virology 364: 1-9.
    • (2007) Virology , vol.364 , pp. 1-9
    • Huang, Y.1    Staschke, K.2    De Francesco, R.3    Tan, S.L.4
  • 64
  • 66
    • 0033557046 scopus 로고    scopus 로고
    • An internal polypyrimidine-tract-binding protein-binding site in the hepatitis C virus RNA attenuates translation, which is relieved by the 3'-untranslated sequence
    • Ito, T. and Lai, M. M: 1999. An internal polypyrimidine-tract-binding protein-binding site in the hepatitis C virus RNA attenuates translation, which is relieved by the 3'-untranslated sequence. Virology 254: 288-96.
    • (1999) Virology , vol.254 , pp. 288-296
    • Ito, T.1    Lai, M.M.2
  • 67
    • 0031658923 scopus 로고    scopus 로고
    • The 3'-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site
    • Ito, T., Tahara, S. M. and Lai, M. M: 1998. The 3'-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site. J Virol 72: 8789-96.
    • (1998) J Virol , vol.72 , pp. 8789-8796
    • Ito, T.1    Tahara, S.M.2    Lai, M.M.3
  • 68
    • 0036891849 scopus 로고    scopus 로고
    • The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment
    • Ivashkina, N., Wolk, B., Lohmann, V., Bartenschlager, R., Blum, H. E., Penin, F. and Moradpour, D. 2002. The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment. J Virol 76: 13088-93.
    • (2002) J Virol , vol.76 , pp. 13088-13093
    • Ivashkina, N.1    Wolk, B.2    Lohmann, V.3    Bartenschlager, R.4    Blum, H.E.5    Penin, F.6    Moradpour, D.7
  • 69
    • 10344243545 scopus 로고    scopus 로고
    • Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
    • Ji, H., Fraser, C. S., Yu, Y., Leary, J. and Doudna, J. A. 2004. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc Natl Acad Sci USA 101: 16990-5.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16990-16995
    • Ji, H.1    Fraser, C.S.2    Yu, Y.3    Leary, J.4    Doudna, J.A.5
  • 70
    • 30544444850 scopus 로고    scopus 로고
    • CARD games between virus and host get a new player
    • Johnson, C. L. and Gale, M. Jr. 2006. CARD games between virus and host get a new player. Trends Immunol 27: 1-4.
    • (2006) Trends Immunol , vol.27 , pp. 1-4
    • Johnson, C.L.1    Gale, M.2
  • 71
    • 34547734952 scopus 로고    scopus 로고
    • Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    • Jones, C. T., Murray, C. L., Eastman, D. K., Tassello, J. and Rice, C. M. 2007. Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 81: 8374-83.
    • (2007) J Virol , vol.81 , pp. 8374-8383
    • Jones, C.T.1    Murray, C.L.2    Eastman, D.K.3    Tassello, J.4    Rice, C.M.5
  • 72
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M. and Sarnow, P. 2005. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309: 1577-81.
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 73
    • 0028800155 scopus 로고
    • Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase
    • Kanai, A., Tanabe, K. and Kohara, M: 1995. Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase. FEBS Lett 376: 221-4.
    • (1995) FEBS Lett , vol.376 , pp. 221-224
    • Kanai, A.1    Tanabe, K.2    Kohara, M.3
  • 75
    • 0034468107 scopus 로고    scopus 로고
    • Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase
    • Kao, C. C., Yang, X., Kline, A., Wang, Q. M., Barket, D. and Heinz, B. A. 2000. Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase. J Virol 74: 11121-8.
    • (2000) J Virol , vol.74 , pp. 11121-11128
    • Kao, C.C.1    Yang, X.2    Kline, A.3    Wang, Q.M.4    Barket, D.5    Heinz, B.A.6
  • 76
    • 33845802481 scopus 로고    scopus 로고
    • Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I
    • Kapadia, S. B., Barth, H., Baumert, T., McKeating, J. A. and Chisari, F. V. 2007. Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I. J Virol 81: 374-83.
    • (2007) J Virol , vol.81 , pp. 374-383
    • Kapadia, S.B.1    Barth, H.2    Baumert, T.3    McKeating, J.A.4    Chisari, F.V.5
  • 77
    • 14044265120 scopus 로고    scopus 로고
    • Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids
    • Kapadia, S. B. and Chisari, F. V. 2005. Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proc Natl Acad Sci USA 102: 2561-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2561-2566
    • Kapadia, S.B.1    Chisari, F.V.2
  • 78
    • 24344463962 scopus 로고    scopus 로고
    • The hepatitis C virus NS3/4A protease complex interferes with pathways of the innate immune response
    • Karayiannis, P. 2005. The hepatitis C virus NS3/4A protease complex interferes with pathways of the innate immune response. J Hepatol 43: 743-5.
    • (2005) J Hepatol , vol.43 , pp. 743-745
    • Karayiannis, P.1
  • 80
    • 0034535457 scopus 로고    scopus 로고
    • Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A
    • Katze, M. G., Kwieciszewski, B., Goodlett, D. R., Blakely, C. M., Neddermann, P., Tan, S. L. and Aebersold, R. 2000. Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A. Virology 278: 501-13.
    • (2000) Virology , vol.278 , pp. 501-513
    • Katze, M.G.1    Kwieciszewski, B.2    Goodlett, D.R.3    Blakely, C.M.4    Neddermann, P.5    Tan, S.L.6    Aebersold, R.7
  • 81
    • 0036636431 scopus 로고    scopus 로고
    • Template requirements for de novo RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase on the viral X RNA
    • Kim, M., Kim, H., Cho, S. P. and Min, M. K. 2002a. Template requirements for de novo RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase on the viral X RNA. J Virol 76: 6944-56.
    • (2002) J Virol , vol.76 , pp. 6944-6956
    • Kim, M.1    Kim, H.2    Cho, S.P.3    Min, M.K.4
  • 82
    • 9644252822 scopus 로고    scopus 로고
    • Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylation
    • Kim, S. J., Kim, J. H., Kim, Y. G., Lim, H. S. and Oh, J. W. 2004. Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylation. J Biol Chem 279: 50031-41.
    • (2004) J Biol Chem , vol.279 , pp. 50031-50041
    • Kim, S.J.1    Kim, J.H.2    Kim, Y.G.3    Lim, H.S.4    Oh, J.W.5
  • 83
    • 0036291407 scopus 로고    scopus 로고
    • Domains I and II in the 5' nontranslated region of the HCV genome are required for RNA replication
    • Kim, Y. K., Kim, C. S., Lee, S. H. and Jang, S. K. 2002b. Domains I and II in the 5' nontranslated region of the HCV genome are required for RNA replication. Biochem Biophys Res Commun 290: 105-12.
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 105-112
    • Kim, Y.K.1    Kim, C.S.2    Lee, S.H.3    Jang, S.K.4
  • 84
    • 0033590926 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein is phosphorylated by casein kinase II
    • Kim, J., Lee, D. and Choe, J: 1999. Hepatitis C virus NS5A protein is phosphorylated by casein kinase II. Biochem Biophys Res Commun 257: 777-81.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 777-781
    • Kim, J.1    Lee, D.2    Choe, J.3
  • 85
    • 0037407151 scopus 로고    scopus 로고
    • Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation
    • Kim, Y. K., Lee, S. H., Kim, C. S., Seol, S. K. and Jang, S. K. 2003. Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation. RNA 9: 599-606.
    • (2003) RNA , vol.9 , pp. 599-606
    • Kim, Y.K.1    Lee, S.H.2    Kim, C.S.3    Seol, S.K.4    Jang, S.K.5
  • 86
    • 27844523217 scopus 로고    scopus 로고
    • Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase
    • Kim, Y. C., Russell, W. K., Ranjith-Kumar, C. T., Thomson, M., Russell, D. H. and Kao, C. C. 2005. Functional analysis of RNA binding by the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem 280: 38011-9.
    • (2005) J Biol Chem , vol.280 , pp. 38011-38019
    • Kim, Y.C.1    Russell, W.K.2    Ranjith-Kumar, C.T.3    Thomson, M.4    Russell, D.H.5    Kao, C.C.6
  • 87
    • 0032837572 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B
    • Koch, J. O. and Bartenschlager, R: 1999. Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B. J Virol 73: 7138-46.
    • (1999) J Virol , vol.73 , pp. 7138-7146
    • Koch, J.O.1    Bartenschlager, R.2
  • 89
    • 0029938477 scopus 로고    scopus 로고
    • Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA
    • Kolykhalov, A. A., Feinstone, S. M. and Rice, C. M: 1996. Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA. J Virol 70: 3363-71.
    • (1996) J Virol , vol.70 , pp. 3363-3371
    • Kolykhalov, A.A.1    Feinstone, S.M.2    Rice, C.M.3
  • 90
    • 0033920304 scopus 로고    scopus 로고
    • Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
    • Kolykhalov, A. A., Mihalik, K., Feinstone, S. M. and Rice, C. M. 2000. Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J Virol 74: 2046-51.
    • (2000) J Virol , vol.74 , pp. 2046-2051
    • Kolykhalov, A.A.1    Mihalik, K.2    Feinstone, S.M.3    Rice, C.M.4
  • 91
    • 34548679815 scopus 로고    scopus 로고
    • Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle
    • Kopek, B. G., Perkins, G., Miller, D. J., Ellisman, M. H. and Ahlquist, P. 2007. Three-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelle. PLoS Biol 5: e220.
    • (2007) PLoS Biol , vol.5 , pp. e220
    • Kopek, B.G.1    Perkins, G.2    Miller, D.J.3    Ellisman, M.H.4    Ahlquist, P.5
  • 92
    • 0037303634 scopus 로고    scopus 로고
    • In vitro RNA replication directed by replicase complexes isolated from the subgenomic replicon cells of hepatitis C virus
    • Lai, V. C., Dempsey, S., Lau, J. Y., Hong, Z. and Zhong, W. 2003. In vitro RNA replication directed by replicase complexes isolated from the subgenomic replicon cells of hepatitis C virus. J Virol 77: 2295-300.
    • (2003) J Virol , vol.77 , pp. 2295-2300
    • Lai, V.C.1    Dempsey, S.2    Lau, J.Y.3    Hong, Z.4    Zhong, W.5
  • 93
    • 0028818269 scopus 로고
    • Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR
    • Lanford, R. E., Chavez, D., Chisari, F. V. and Sureau, C: 1995. Lack of detection of negative-strand hepatitis C virus RNA in peripheral blood mononuclear cells and other extrahepatic tissues by the highly strand-specific rTth reverse transcriptase PCR. J Virol 69: 8079-83.
    • (1995) J Virol , vol.69 , pp. 8079-8083
    • Lanford, R.E.1    Chavez, D.2    Chisari, F.V.3    Sureau, C.4
  • 94
    • 33750707966 scopus 로고    scopus 로고
    • The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A
    • Lee, H., Liu, Y., Mejia, E., Paul, A. V. and Wimmer, E. 2006. The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A. J Virol 80: 11343-54.
    • (2006) J Virol , vol.80 , pp. 11343-11354
    • Lee, H.1    Liu, Y.2    Mejia, E.3    Paul, A.V.4    Wimmer, E.5
  • 95
    • 4644328613 scopus 로고    scopus 로고
    • Cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome
    • Lee, H., Shin, H., Wimmer, E. and Paul, A. V. 2004. cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome. J Virol 78: 10865-77.
    • (2004) J Virol , vol.78 , pp. 10865-10877
    • Lee, H.1    Shin, H.2    Wimmer, E.3    Paul, A.V.4
  • 96
    • 0032876683 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
    • Lesburg, C. A., Cable, M. B., Ferrari, E., Hong, Z., Mannarino, A. F. and Weber, P. C: 1999. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol 6: 937-43.
    • (1999) Nat Struct Biol , vol.6 , pp. 937-943
    • Lesburg, C.A.1    Cable, M.B.2    Ferrari, E.3    Hong, Z.4    Mannarino, A.F.5    Weber, P.C.6
  • 97
    • 0041707714 scopus 로고    scopus 로고
    • Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: Structural and biochemical analysis
    • Ĺeveque, V. J., Johnson, R. B., Parsons, S., Ren, J., Xie, C., Zhang, F. and Wang, Q. M. 2003. Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: Structural and biochemical analysis. J Virol 77: 9020-8.
    • (2003) J Virol , vol.77 , pp. 9020-9028
    • Ĺeveque, V.J.1    Johnson, R.B.2    Parsons, S.3    Ren, J.4    Xie, C.5    Zhang, F.6    Wang, Q.M.7
  • 98
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
    • Li, K., Foy, E., Ferreon, J. C., Nakamura, M., Ferreon, A. C., Ikeda, M., Ray, S. C., Gale, M. Jr. and Lemon, S. M. 2005a. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA 102: 2992-7.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3    Nakamura, M.4    Ferreon, A.C.5    Ikeda, M.6    Ray, S.C.7    Gale, M.8    Lemon, S.M.9
  • 99
    • 29144462494 scopus 로고    scopus 로고
    • Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
    • Li, X. D., Sun, L., Seth, R. B., Pineda, G. and Chen, Z. J. 2005b. Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci USA 102: 17717-22.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17717-17722
    • Li, X.D.1    Sun, L.2    Seth, R.B.3    Pineda, G.4    Chen, Z.J.5
  • 100
    • 33748302052 scopus 로고    scopus 로고
    • Molecular and structural characterization of the domain 2 of hepatitis C virus non-structural protein 5A
    • Liang, Y., Kang, C. B. and Yoon, H. S. 2006. Molecular and structural characterization of the domain 2 of hepatitis C virus non-structural protein 5A. Mol Cells 22: 13-20.
    • (2006) Mol Cells , vol.22 , pp. 13-20
    • Liang, Y.1    Kang, C.B.2    Yoon, H.S.3
  • 101
    • 35348891616 scopus 로고    scopus 로고
    • Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded
    • Liang, Y., Ye, H., Kang, C. B. and Yoon, H. S. 2007. Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded. Biochemistry 46: 11550-8.
    • (2007) Biochemistry , vol.46 , pp. 11550-11558
    • Liang, Y.1    Ye, H.2    Kang, C.B.3    Yoon, H.S.4
  • 103
    • 34548188701 scopus 로고    scopus 로고
    • The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication
    • Lindenbach, B. D., Pragai, B. M., Montserret, R., Beran, R. K., Pyle, A. M., Penin, F. and Rice, C. M. 2007a. The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication. J Virol 81: 8905-18.
    • (2007) J Virol , vol.81 , pp. 8905-8918
    • Lindenbach, B.D.1    Pragai, B.M.2    Montserret, R.3    Beran, R.K.4    Pyle, A.M.5    Penin, F.6    Rice, C.M.7
  • 104
    • 31644439149 scopus 로고    scopus 로고
    • Insertion and deletion analyses identify regions of non-structural protein 5A of Hepatitis C virus that are dispensable for viral genome replication
    • Liu, S., Ansari, I. H., Das, S. C. and Pattnaik, A. K. 2006. Insertion and deletion analyses identify regions of non-structural protein 5A of Hepatitis C virus that are dispensable for viral genome replication. J Gen Virol 87: 323-7.
    • (2006) J Gen Virol , vol.87 , pp. 323-327
    • Liu, S.1    Ansari, I.H.2    Das, S.C.3    Pattnaik, A.K.4
  • 105
    • 0037369066 scopus 로고    scopus 로고
    • Viral and cellular determinants of hepatitis C virus RNA replication in cell culture
    • Lohmann, V., Hoffmann, S., Herian, U., Penin, F. and Bartenschlager, R. 2003. Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J. Virol. 77: 3007-19.
    • (2003) J. Virol , vol.77 , pp. 3007-3019
    • Lohmann, V.1    Hoffmann, S.2    Herian, U.3    Penin, F.4    Bartenschlager, R.5
  • 106
    • 0035157218 scopus 로고    scopus 로고
    • Mutations in hepatitis C virus RNAs conferring cell culture adaptation
    • Lohmann, V., Korner, F., Dobierzewska, A. and Bartenschlager, R. 2001. Mutations in hepatitis C virus RNAs conferring cell culture adaptation. J Virol 75: 1437-49.
    • (2001) J Virol , vol.75 , pp. 1437-1449
    • Lohmann, V.1    Korner, F.2    Dobierzewska, A.3    Bartenschlager, R.4
  • 107
    • 1842289764 scopus 로고    scopus 로고
    • Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
    • Lohmann, V., Korner, F., Herian, U. and Bartenschlager, R: 1997. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol 71: 8416-28.
    • (1997) J Virol , vol.71 , pp. 8416-8428
    • Lohmann, V.1    Korner, F.2    Herian, U.3    Bartenschlager, R.4
  • 109
    • 0034038622 scopus 로고    scopus 로고
    • Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
    • Lohmann, V., Roos, A., Korner, F., Koch, J. O. and Bartenschlager, R. 2000. Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus. J Viral Hepat 7: 167-74.
    • (2000) J Viral Hepat , vol.7 , pp. 167-174
    • Lohmann, V.1    Roos, A.2    Korner, F.3    Koch, J.O.4    Bartenschlager, R.5
  • 110
    • 33747452685 scopus 로고    scopus 로고
    • Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
    • Lorenz, I. C., Marcotrigiano, J., Dentzer, T. G. and Rice, C. M. 2006. Structure of the catalytic domain of the hepatitis C virus NS2-3 protease. Nature 442: 831-5.
    • (2006) Nature , vol.442 , pp. 831-835
    • Lorenz, I.C.1    Marcotrigiano, J.2    Dentzer, T.G.3    Rice, C.M.4
  • 111
    • 33750249579 scopus 로고    scopus 로고
    • Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein
    • Lundin, M., Lindstrom, H., Gronwall, C. and Persson, M. A. 2006. Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein. J Gen Virol 87: 3263-72.
    • (2006) J Gen Virol , vol.87 , pp. 3263-3272
    • Lundin, M.1    Lindstrom, H.2    Gronwall, C.3    Persson, M.A.4
  • 112
    • 0344373790 scopus 로고    scopus 로고
    • Topology of the membrane-associated hepatitis C virus protein NS4B
    • Lundin, M., Monne, M., Widell, A., Von Heijne, G. and Persson, M. A. 2003. Topology of the membrane-associated hepatitis C virus protein NS4B. J Virol 77: 5428-38.
    • (2003) J Virol , vol.77 , pp. 5428-5438
    • Lundin, M.1    Monne, M.2    Widell, A.3    Von Heijne, G.4    Persson, M.A.5
  • 113
    • 0033989278 scopus 로고    scopus 로고
    • De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus
    • Luo, G., Hamatake, R. K., Mathis, D. M., Racela, J., Rigat, K. L., Lemm, J. and Colonno, R. J. 2000. De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus. J Virol 74: 851-63.
    • (2000) J Virol , vol.74 , pp. 851-863
    • Luo, G.1    Hamatake, R.K.2    Mathis, D.M.3    Racela, J.4    Rigat, K.L.5    Lemm, J.6    Colonno, R.J.7
  • 114
    • 4544336360 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A: Tales of a promiscuous protein
    • Macdonald, A. and Harris, M. 2004. Hepatitis C virus NS5A: Tales of a promiscuous protein. J Gen Virol 85: 2485-502.
    • (2004) J Gen Virol , vol.85 , pp. 2485-2502
    • Macdonald, A.1    Harris, M.2
  • 115
    • 33645645084 scopus 로고    scopus 로고
    • Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus
    • Mackintosh, S. G., Lu, J. Z., Jordan, J. B., Harrison, M. K., Sikora, B., Sharma, S. D., Cameron, C. E., Raney, K. D. and Sakon, J. 2006. Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus. J Biol Chem 281: 3528-35.
    • (2006) J Biol Chem , vol.281 , pp. 3528-3535
    • Mackintosh, S.G.1    Lu, J.Z.2    Jordan, J.B.3    Harrison, M.K.4    Sikora, B.5    Sharma, S.D.6    Cameron, C.E.7    Raney, K.D.8    Sakon, J.9
  • 117
  • 119
    • 27144440476 scopus 로고    scopus 로고
    • Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
    • Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R. and Tschopp, J. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-72.
    • (2005) Nature , vol.437 , pp. 1167-1172
    • Meylan, E.1    Curran, J.2    Hofmann, K.3    Moradpour, D.4    Binder, M.5    Bartenschlager, R.6    Tschopp, J.7
  • 120
    • 0346118919 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication
    • Miyanari, Y., Hijikata, M., Yamaji, M., Hosaka, M., Takahashi, H. and Shimotohno, K. 2003. Hepatitis C virus non-structural proteins in the probable membranous compartment function in viral genome replication. J Biol Chem 278: 50301-8.
    • (2003) J Biol Chem , vol.278 , pp. 50301-50308
    • Miyanari, Y.1    Hijikata, M.2    Yamaji, M.3    Hosaka, M.4    Takahashi, H.5    Shimotohno, K.6
  • 121
  • 122
    • 3142764760 scopus 로고    scopus 로고
    • Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes
    • Moradpour, D., Evans, M. J., Gosert, R., Yuan, Z., Blum, H. E., Goff, S. P., Lindenbach, B. D. and Rice, C. M. 2004b. Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes. J Virol 78: 7400-9.
    • (2004) J Virol , vol.78 , pp. 7400-7409
    • Moradpour, D.1    Evans, M.J.2    Gosert, R.3    Yuan, Z.4    Blum, H.E.5    Goff, S.P.6    Lindenbach, B.D.7    Rice, C.M.8
  • 123
    • 34547595373 scopus 로고    scopus 로고
    • Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase
    • Myong, S., Bruno, M. M., Pyle, A. M. and Ha, T. 2007. Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase. Science 317: 513-6.
    • (2007) Science , vol.317 , pp. 513-516
    • Myong, S.1    Bruno, M.M.2    Pyle, A.M.3    Ha, T.4
  • 124
    • 0019966544 scopus 로고
    • Growth of human hepatoma cells lines with differentiated functions in chemically defined medium
    • Nakabayashi, H., Taketa, K., Miyano, K., Yamane, T. and Sato, J: 1982. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res 42: 3858-63.
    • (1982) Cancer Res , vol.42 , pp. 3858-3863
    • Nakabayashi, H.1    Taketa, K.2    Miyano, K.3    Yamane, T.4    Sato, J.5
  • 127
    • 0032710924 scopus 로고    scopus 로고
    • Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein
    • Neddermann, P., Clementi, A. and De Francesco, R: 1999. Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J Virol 73: 9984-91.
    • (1999) J Virol , vol.73 , pp. 9984-9991
    • Neddermann, P.1    Clementi, A.2    De Francesco, R.3
  • 128
    • 8644290077 scopus 로고    scopus 로고
    • Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture
    • Neddermann, P., Quintavalle, M., Di Pietro, C., Clementi, A., Cerretani, M., Altamura, S., Bartholomew, L. and De Francesco, R. 2004. Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture. J Virol 78: 13306-14.
    • (2004) J Virol , vol.78 , pp. 13306-13314
    • Neddermann, P.1    Quintavalle, M.2    Di Pietro, C.3    Clementi, A.4    Cerretani, M.5    Altamura, S.6    Bartholomew, L.7    De Francesco, R.8
  • 129
    • 0037470586 scopus 로고    scopus 로고
    • Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): Structural evidence for nucleotide import and de-novo initiation
    • O'Farrell, D., Trowbridge, R., Rowlands, D. and Jäger, J. 2003. Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): Structural evidence for nucleotide import and de-novo initiation. J Mol Biol 326: 1025-35.
    • (2003) J Mol Biol , vol.326 , pp. 1025-1035
    • O'Farrell, D.1    Trowbridge, R.2    Rowlands, D.3    Jäger, J.4
  • 130
    • 0032816079 scopus 로고    scopus 로고
    • A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA
    • Oh, J. W., Ito, T. and Lai, M. M: 1999. A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA. J Virol 73: 7694-702.
    • (1999) J Virol , vol.73 , pp. 7694-7702
    • Oh, J.W.1    Ito, T.2    Lai, M.M.3
  • 131
    • 0034625351 scopus 로고    scopus 로고
    • Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template
    • Oh, J. W., Sheu, G. T. and Lai, M. M. 2000. Template requirement and initiation site selection by hepatitis C virus polymerase on a minimal viral RNA template. J Biol Chem 275: 17710-7.
    • (2000) J Biol Chem , vol.275 , pp. 17710-17717
    • Oh, J.W.1    Sheu, G.T.2    Lai, M.M.3
  • 133
    • 7044228006 scopus 로고    scopus 로고
    • The pathway of HCV IRES-mediated translation initiation
    • Otto, G. A. and Puglisi, J. D. 2004. The pathway of HCV IRES-mediated translation initiation. Cell 119: 369-80.
    • (2004) Cell , vol.119 , pp. 369-380
    • Otto, G.A.1    Puglisi, J.D.2
  • 135
    • 0036500976 scopus 로고    scopus 로고
    • The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
    • Pang, P. S., Jankowsky, E., Planet, P. J. and Pyle, A. M. 2002. The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding. EMBO J 21: 1168-76.
    • (2002) EMBO J , vol.21 , pp. 1168-1176
    • Pang, P.S.1    Jankowsky, E.2    Planet, P.J.3    Pyle, A.M.4
  • 136
    • 33847417585 scopus 로고    scopus 로고
    • P bodies and the control of mRNA translation and degradation
    • Parker, R. and Sheth, U. 2007. P bodies and the control of mRNA translation and degradation. Mol Cell 25: 635-46.
    • (2007) Mol Cell , vol.25 , pp. 635-646
    • Parker, R.1    Sheth, U.2
  • 137
    • 0032799663 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) NS5A protein: Role in HCV replication and resistance to interferon-alpha
    • Pawlotsky, J. M: 1999. Hepatitis C virus (HCV) NS5A protein: role in HCV replication and resistance to interferon-alpha. J Viral Hepat 6 Suppl 1: 47-8.
    • (1999) J Viral Hepat , vol.6 , pp. 47-48
    • Pawlotsky, J.M.1
  • 140
  • 141
    • 0031905698 scopus 로고    scopus 로고
    • A prokaryoticlike mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
    • Pestova, T. V., Shatsky, I. N., Fletcher, S. P., Jackson, R. J. and Hellen, C. U: 1998. A prokaryoticlike mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev 12: 67-83.
    • (1998) Genes Dev , vol.12 , pp. 67-83
    • Pestova, T.V.1    Shatsky, I.N.2    Fletcher, S.P.3    Jackson, R.J.4    Hellen, C.U.5
  • 142
    • 0347457077 scopus 로고    scopus 로고
    • Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the nonstructural (NS) 3 helicase and the NS4B membrane protein
    • Piccininni, S., Varaklioti, A., Nardelli, M., Dave, B., Raney, K. D. and McCarthy, J. E. 2002. Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the nonstructural (NS) 3 helicase and the NS4B membrane protein. J Biol Chem 277: 45670-9.
    • (2002) J Biol Chem , vol.277 , pp. 45670-45679
    • Piccininni, S.1    Varaklioti, A.2    Nardelli, M.3    Dave, B.4    Raney, K.D.5    McCarthy, J.E.6
  • 143
    • 0034969251 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response
    • Polyak, S. J., Khabar, K. S., Paschal, D. M., Ezelle, H. J., Duverlie, G., Barber, G. N., Levy, D. E., Mukaida, N. and Gretch, D. R. 2001. Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J Virol 75: 6095-106.
    • (2001) J Virol , vol.75 , pp. 6095-6106
    • Polyak, S.J.1    Khabar, K.S.2    Paschal, D.M.3    Ezelle, H.J.4    Duverlie, G.5    Barber, G.N.6    Levy, D.E.7    Mukaida, N.8    Gretch, D.R.9
  • 144
    • 27144513392 scopus 로고    scopus 로고
    • Quantitative analysis of the hepatitis C virus replication complex
    • Quinkert, D., Bartenschlager, R. and Lohmann, V. 2005. Quantitative analysis of the hepatitis C virus replication complex. J Virol 79: 13594-605.
    • (2005) J Virol , vol.79 , pp. 13594-13605
    • Quinkert, D.1    Bartenschlager, R.2    Lohmann, V.3
  • 145
    • 33750737787 scopus 로고    scopus 로고
    • The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation
    • Quintavalle, M., Sambucini, S., Di Pietro, C., De Francesco, R. and Neddermann, P. 2006. The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation. J Virol 80: 11305-12.
    • (2006) J Virol , vol.80 , pp. 11305-11312
    • Quintavalle, M.1    Sambucini, S.2    Di Pietro, C.3    De Francesco, R.4    Neddermann, P.5
  • 146
    • 34247117377 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors
    • Quintavalle, M., Sambucini, S., Summa, V., Orsatti, L., Talamo, F., De Francesco, R. and Neddermann, P. 2007. Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors. J Biol Chem 282: 5536-44.
    • (2007) J Biol Chem , vol.282 , pp. 5536-5544
    • Quintavalle, M.1    Sambucini, S.2    Summa, V.3    Orsatti, L.4    Talamo, F.5    De Francesco, R.6    Neddermann, P.7
  • 148
    • 0034881065 scopus 로고    scopus 로고
    • Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: Implication for viral RNA synthesis
    • Ranjith-Kumar, C. T., Gajewski, J., Gutshall, L., Maley, D., Sarisky, R. T. and Kao, C. C. 2001. Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: Implication for viral RNA synthesis. J Virol 75: 8615-23.
    • (2001) J Virol , vol.75 , pp. 8615-8623
    • Ranjith-Kumar, C.T.1    Gajewski, J.2    Gutshall, L.3    Maley, D.4    Sarisky, R.T.5    Kao, C.C.6
  • 149
    • 0042243502 scopus 로고    scopus 로고
    • Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis
    • Ranjith-Kumar, C. T., Gutshall, L., Sarisky, R. T. and Kao, C. C. 2003. Multiple interactions within the hepatitis C virus RNA polymerase repress primer-dependent RNA synthesis. J Mol Biol 330: 675-85.
    • (2003) J Mol Biol , vol.330 , pp. 675-685
    • Ranjith-Kumar, C.T.1    Gutshall, L.2    Sarisky, R.T.3    Kao, C.C.4
  • 150
    • 31044446937 scopus 로고    scopus 로고
    • Recombinant viral RdRps can initiate RNA synthesis from circular templates
    • Ranjith-Kumar, C. T. and Kao, C. C. 2006. Recombinant viral RdRps can initiate RNA synthesis from circular templates. RNA 12: 303-12.
    • (2006) RNA , vol.12 , pp. 303-312
    • Ranjith-Kumar, C.T.1    Kao, C.C.2
  • 151
    • 7644227543 scopus 로고    scopus 로고
    • De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities
    • Ranjith-Kumar, C. T., Sarisky, R. T., Gutshall, L., Thomson, M. and Kao, C. C. 2004. De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities. J Virol 78: 12207-17.
    • (2004) J Virol , vol.78 , pp. 12207-12217
    • Ranjith-Kumar, C.T.1    Sarisky, R.T.2    Gutshall, L.3    Thomson, M.4    Kao, C.C.5
  • 152
    • 0033600812 scopus 로고    scopus 로고
    • Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321
    • Reed, K. E. and Rice, C. M: 1999. Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321. J Biol Chem 274: 28011-8.
    • (1999) J Biol Chem , vol.274 , pp. 28011-28018
    • Reed, K.E.1    Rice, C.M.2
  • 153
    • 0030828466 scopus 로고    scopus 로고
    • Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: Properties of the NS5A-associated kinase
    • Reed, K. E., Xu, J. and Rice, C. M: 1997. Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: Properties of the NS5A-associated kinase. J Virol 71: 7187-97.
    • (1997) J Virol , vol.71 , pp. 7187-7197
    • Reed, K.E.1    Xu, J.2    Rice, C.M.3
  • 154
    • 0035004139 scopus 로고    scopus 로고
    • The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs
    • Rijnbrand, R., Bredenbeek, P. J., Haasnoot, P. C., Kieft, J. S., Spaan, W. J. and Lemon, S. M. 2001. The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs. Rna 7: 585-97.
    • (2001) Rna , vol.7 , pp. 585-597
    • Rijnbrand, R.1    Bredenbeek, P.J.2    Haasnoot, P.C.3    Kieft, J.S.4    Spaan, W.J.5    Lemon, S.M.6
  • 155
    • 34249817897 scopus 로고    scopus 로고
    • Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro
    • Robida, J. M., Nelson, H. B., Liu, Z. and Tang, H. 2007. Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro. J Virol 81: 5829-40.
    • (2007) J Virol , vol.81 , pp. 5829-5840
    • Robida, J.M.1    Nelson, H.B.2    Liu, Z.3    Tang, H.4
  • 156
    • 33144486308 scopus 로고    scopus 로고
    • NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus
    • Sapay, N., Montserret, R., Chipot, C., Brass, V., Moradpour, D., Deleage, G. and Penin, F. 2006. NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus. Biochemistry 45: 2221-33.
    • (2006) Biochemistry , vol.45 , pp. 2221-2233
    • Sapay, N.1    Montserret, R.2    Chipot, C.3    Brass, V.4    Moradpour, D.5    Deleage, G.6    Penin, F.7
  • 157
    • 0035941344 scopus 로고    scopus 로고
    • Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase
    • Schmidt-Mende, J., Bieck, E., Hugle, T., Penin, F., Rice, C. M., Blum, H. E. and Moradpour, D. 2001. Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase. J Biol Chem 276: 44052-63.
    • (2001) J Biol Chem , vol.276 , pp. 44052-44063
    • Schmidt-Mende, J.1    Bieck, E.2    Hugle, T.3    Penin, F.4    Rice, C.M.5    Blum, H.E.6    Moradpour, D.7
  • 158
    • 0036204740 scopus 로고    scopus 로고
    • A positivestrand RNA virus replication complex parallels form and function of retrovirus capsids
    • Schwartz, M., Chen, J., Janda, M., Sullivan, M., den Boon, J. and Ahlquist, P. 2002. A positivestrand RNA virus replication complex parallels form and function of retrovirus capsids. Mol Cell 9: 505-14.
    • (2002) Mol Cell , vol.9 , pp. 505-514
    • Schwartz, M.1    Chen, J.2    Janda, M.3    Sullivan, M.4    Den Boon, J.5    Ahlquist, P.6
  • 159
    • 3342896727 scopus 로고    scopus 로고
    • Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase
    • Serebrov, V. and Pyle, A. M. 2004. Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase. Nature 430: 476-80.
    • (2004) Nature , vol.430 , pp. 476-480
    • Serebrov, V.1    Pyle, A.M.2
  • 160
    • 0036631865 scopus 로고    scopus 로고
    • Selection of 3-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase
    • Shim, J. H., Larson, G., Wu, J. Z. and Hong, Z. 2002. Selection of 3-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase. J Virol 76: 7030-9.
    • (2002) J Virol , vol.76 , pp. 7030-7039
    • Shim, J.H.1    Larson, G.2    Wu, J.Z.3    Hong, Z.4
  • 161
    • 0037192863 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity
    • Shirota, Y., Luo, H., Qin, W., Kaneko, S., Yamashita, T., Kobayashi, K. and Murakami, S. 2002. Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity. J Biol Chem 277: 11149-55.
    • (2002) J Biol Chem , vol.277 , pp. 11149-11155
    • Shirota, Y.1    Luo, H.2    Qin, W.3    Kaneko, S.4    Yamashita, T.5    Kobayashi, K.6    Murakami, S.7
  • 163
    • 4344619191 scopus 로고    scopus 로고
    • Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence
    • Simmonds, P., Tuplin, A. and Evans, D. J. 2004. Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence. RNA 10: 1337-51.
    • (2004) RNA , vol.10 , pp. 1337-1351
    • Simmonds, P.1    Tuplin, A.2    Evans, D.J.3
  • 164
    • 28544439977 scopus 로고    scopus 로고
    • Structural roles for human translation factor eIF3 in initiation of protein synthesis
    • Siridechadilok, B., Fraser, C. S., Hall, R. J., Doudna, J. A. and Nogales, E. 2005. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science 310: 1513-5.
    • (2005) Science , vol.310 , pp. 1513-1515
    • Siridechadilok, B.1    Fraser, C.S.2    Hall, R.J.3    Doudna, J.A.4    Nogales, E.5
  • 166
  • 167
    • 33751203577 scopus 로고    scopus 로고
    • The hepatitis C virus RNA 3-untranslated region strongly enhances translation directed by the internal ribosome entry site
    • Song, Y., Friebe, P., Tzima, E., Junemann, C., Bartenschlager, R. and Niepmann, M. 2006. The hepatitis C virus RNA 3-untranslated region strongly enhances translation directed by the internal ribosome entry site. J Virol 80: 11579-88.
    • (2006) J Virol , vol.80 , pp. 11579-11588
    • Song, Y.1    Friebe, P.2    Tzima, E.3    Junemann, C.4    Bartenschlager, R.5    Niepmann, M.6
  • 168
    • 0035831269 scopus 로고    scopus 로고
    • Hepatitis C virus IRES RNA-induced changes in the conformation of the 40 s ribosomal subunit
    • Spahn, C. M., Kieft, J. S., Grassucci, R. A., Penczek, P. A., Zhou, K., Doudna, J. A. and Frank, J. 2001. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40 s ribosomal subunit. Science 291: 1959-62.
    • (2001) Science , vol.291 , pp. 1959-1962
    • Spahn, C.M.1    Kieft, J.S.2    Grassucci, R.A.3    Penczek, P.A.4    Zhou, K.5    Doudna, J.A.6    Frank, J.7
  • 169
    • 0345711548 scopus 로고    scopus 로고
    • Poly(C)-binding protein interacts with the hepatitis C virus 5-untranslated region
    • Spangberg, K. and Schwartz, S: 1999. Poly(C)-binding protein interacts with the hepatitis C virus 5-untranslated region. J Gen Virol 80 (Pt 6): 1371-6.
    • (1999) J Gen Virol , vol.80 , pp. 1371-1376
    • Spangberg, K.1    Schwartz, S.2
  • 170
    • 0034284997 scopus 로고    scopus 로고
    • HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3 ends of hepatitis C virus RNA of both polarities
    • Spangberg, K., Wiklund, L. and Schwartz, S. 2000. HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3 ends of hepatitis C virus RNA of both polarities. Virology 274: 378-90.
    • (2000) Virology , vol.274 , pp. 378-390
    • Spangberg, K.1    Wiklund, L.2    Schwartz, S.3
  • 172
    • 34247559591 scopus 로고    scopus 로고
    • Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery
    • Stone, M., Jia, S., Heo, W. D., Meyer, T. and Konan, K. V. 2007. Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol 81: 4551-63.
    • (2007) J Virol , vol.81 , pp. 4551-4563
    • Stone, M.1    Jia, S.2    Heo, W.D.3    Meyer, T.4    Konan, K.V.5
  • 174
    • 13944253573 scopus 로고    scopus 로고
    • Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase
    • Sumpter, R. Jr., Loo, Y. M., Foy, E., Li, K., Yoneyama, M., Fujita, T., Lemon, S. M. and Gale, M. Jr. 2005. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol 79: 2689-99.
    • (2005) RIG-I. J Virol , vol.79 , pp. 2689-2699
    • Sumpter, R.1    Loo, Y.M.2    Foy, E.3    Li, K.4    Yoneyama, M.5    Fujita, T.6    Lemon, S.M.7    Gale, M.8
  • 175
    • 0034708233 scopus 로고    scopus 로고
    • De novo RNA synthesis catalyzed by HCV RNA-dependent RNA polymerase
    • Sun, X. L., Johnson, R. B., Hockman, M. A. and Wang, Q. M. 2000. De novo RNA synthesis catalyzed by HCV RNA-dependent RNA polymerase. Biochem Biophys Res Commun 268: 798-803.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 798-803
    • Sun, X.L.1    Johnson, R.B.2    Hockman, M.A.3    Wang, Q.M.4
  • 176
    • 0027199917 scopus 로고
    • Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes
    • Suzich, J. A., Tamura, J. K., Palmer-Hill, F., Warrener, P., Grakoui, A., Rice, C. M., Feinstone, S. M. and Collett, M. S: 1993. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes. J Virol 67: 6152-8.
    • (1993) J Virol , vol.67 , pp. 6152-6158
    • Suzich, J.A.1    Tamura, J.K.2    Palmer-Hill, F.3    Warrener, P.4    Grakoui, A.5    Rice, C.M.6    Feinstone, S.M.7    Collett, M.S.8
  • 177
    • 0035947270 scopus 로고    scopus 로고
    • How hepatitis C virus counteracts the interferon response: The jury is still out on NS5A
    • Tan, S. L. and Katze, M. G. 2001. How hepatitis C virus counteracts the interferon response: The jury is still out on NS5A. Virology 284: 1-12.
    • (2001) Virology , vol.284 , pp. 1-12
    • Tan, S.L.1    Katze, M.G.2
  • 178
    • 0028785460 scopus 로고
    • A novel sequence found at the 3terminus of hepatitis C virus genome
    • Tanaka, T., Kato, N., Cho, M. J. and Shimotohno, K: 1995. A novel sequence found at the 3terminus of hepatitis C virus genome. Biochem Biophys Res Commun 215: 744-9.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 744-749
    • Tanaka, T.1    Kato, N.2    Cho, M.J.3    Shimotohno, K.4
  • 179
    • 0029927642 scopus 로고    scopus 로고
    • Structure of the 3terminus of the hepatitis C virus genome
    • Tanaka, T., Kato, N., Cho, M. J., Sugiyama, K. and Shimotohno, K: 1996. Structure of the 3terminus of the hepatitis C virus genome. J Virol 70: 3307-12.
    • (1996) J Virol , vol.70 , pp. 3307-3312
    • Tanaka, T.1    Kato, N.2    Cho, M.J.3    Sugiyama, K.4    Shimotohno, K.5
  • 180
    • 0028978937 scopus 로고
    • Phosphorylation of hepatitis C virusencoded nonstructural protein NS5A
    • Tanji, Y., Kaneko, T., Satoh, S. and Shimotohno, K: 1995. Phosphorylation of hepatitis C virusencoded nonstructural protein NS5A. J Virol 69: 3980-6.
    • (1995) J Virol , vol.69 , pp. 3980-3986
    • Tanji, Y.1    Kaneko, T.2    Satoh, S.3    Shimotohno, K.4
  • 181
    • 34548183744 scopus 로고    scopus 로고
    • Studying hepatitis C virus: Making the best of a bad virus
    • Tellinghuisen, T. L., Evans, M. J., von Hahn, T., You, S. and Rice, C. M. 2007. Studying hepatitis C virus: Making the best of a bad virus. J Virol 81: 8853-67.
    • (2007) J Virol , vol.81 , pp. 8853-8867
    • Tellinghuisen, T.L.1    Evans, M.J.2    Von Hahn, T.3    You, S.4    Rice, C.M.5
  • 183
    • 19644393931 scopus 로고    scopus 로고
    • Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
    • Tellinghuisen, T. L., Marcotrigiano, J. and Rice, C. M. 2005. Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase. Nature 435: 374-9.
    • (2005) Nature , vol.435 , pp. 374-379
    • Tellinghuisen, T.L.1    Marcotrigiano, J.2    Rice, C.M.3
  • 184
    • 30044452234 scopus 로고    scopus 로고
    • Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein
    • Teterina, N. L., Gorbalenya, A. E., Egger, D., Bienz, K., Rinaudo, M. S. and Ehrenfeld, E. 2006. Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein. Virology 344: 453-67.
    • (2006) Virology , vol.344 , pp. 453-467
    • Teterina, N.L.1    Gorbalenya, A.E.2    Egger, D.3    Bienz, K.4    Rinaudo, M.S.5    Ehrenfeld, E.6
  • 185
    • 7044269394 scopus 로고    scopus 로고
    • Polypyrimidine tractbinding protein (PTB) inhibits Hepatitis C virus internal ribosome entry site (HCV IRES)- mediated translation, but does not affect HCV replication
    • Tischendorf, J. J., Beger, C., Korf, M., Manns, M. P. and Kruger, M. 2004. Polypyrimidine tractbinding protein (PTB) inhibits Hepatitis C virus internal ribosome entry site (HCV IRES)- mediated translation, but does not affect HCV replication. Arch Virol 149: 1955-70.
    • (2004) Arch Virol , vol.149 , pp. 1955-1970
    • Tischendorf, J.J.1    Beger, C.2    Korf, M.3    Manns, M.P.4    Kruger, M.5
  • 186
    • 30644460414 scopus 로고    scopus 로고
    • Trans-complementation of HCV replication by non-structural protein 5A
    • Tong, X. and Malcolm, B. A. 2006. Trans-complementation of HCV replication by non-structural protein 5A. Virus Res 115: 122-30.
    • (2006) Virus Res , vol.115 , pp. 122-130
    • Tong, X.1    Malcolm, B.A.2
  • 187
    • 0030861248 scopus 로고    scopus 로고
    • Specific interaction of polypyrimidine tract-binding protein with the extreme 3-terminal structure of the hepatitis C virus genome, the 3 X
    • Tsuchihara, K., Tanaka, T., Hijikata, M., Kuge, S., Toyoda, H., Nomoto, A., Yamamoto, N. and Shimotohno, K: 1997. Specific interaction of polypyrimidine tract-binding protein with the extreme 3-terminal structure of the hepatitis C virus genome, the 3 X. J Virol 71: 6720-6.
    • (1997) J Virol , vol.71 , pp. 6720-6726
    • Tsuchihara, K.1    Tanaka, T.2    Hijikata, M.3    Kuge, S.4    Toyoda, H.5    Nomoto, A.6    Yamamoto, N.7    Shimotohno, K.8
  • 190
    • 18944366522 scopus 로고    scopus 로고
    • Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication
    • Wang, C., Gale, M. Jr., Keller, B. C., Huang, H., Brown, M. S., Goldstein, J. L. and Ye, J. 2005. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell 18: 425-34.
    • (2005) Mol Cell , vol.18 , pp. 425-434
    • Wang, C.1    Gale, M.2    Keller, B.C.3    Huang, H.4    Brown, M.S.5    Goldstein, J.L.6    Ye, J.7
  • 192
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    • Watashi, K., Hijikata, M., Hosaka, M., Yamaji, M. and Shimotohno, K. 2003. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 38: 1282-8.
    • (2003) Hepatology , vol.38 , pp. 1282-1288
    • Watashi, K.1    Hijikata, M.2    Hosaka, M.3    Yamaji, M.4    Shimotohno, K.5
  • 194
    • 0032546963 scopus 로고    scopus 로고
    • RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region
    • Yamashita, T., Kaneko, S., Shirota, Y., Qin, W., Nomura, T., Kobayashi, K. and Murakami, S: 1998. RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region. J Biol Chem 273: 15479-86.
    • (1998) J Biol Chem , vol.273 , pp. 15479-15486
    • Yamashita, T.1    Kaneko, S.2    Shirota, Y.3    Qin, W.4    Nomura, T.5    Kobayashi, K.6    Murakami, S.7
  • 195
    • 0030740520 scopus 로고    scopus 로고
    • Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee
    • Yanagi, M., Purcell, R. H., Emerson, S. U. and Bukh, J: 1997. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci USA 94: 8738-43.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8738-8743
    • Yanagi, M.1    Purcell, R.H.2    Emerson, S.U.3    Bukh, J.4
  • 196
    • 0033515094 scopus 로고    scopus 로고
    • In vivo analysis of the 3 untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone
    • Yanagi, M., St Claire, M., Emerson, S. U., Purcell, R. H. and Bukh, J: 1999. In vivo analysis of the 3 untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone. Proc Natl Acad Sci USA 96: 2291-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2291-2295
    • Yanagi, M.1    St Claire, M.2    Emerson, S.U.3    Purcell, R.H.4    Bukh, J.5
  • 197
    • 4444270620 scopus 로고    scopus 로고
    • Newly synthesized hepatitis C virus replicon RNA is protected from nuclease activity by a protease-sensitive factor(s)
    • Yang, G., Pevear, D. C., Collett, M. S., Chunduru, S., Young, D. C., Benetatos, C. and Jordan, R. 2004. Newly synthesized hepatitis C virus replicon RNA is protected from nuclease activity by a protease-sensitive factor(s). J Virol 78: 10202-5.
    • (2004) J Virol , vol.78 , pp. 10202-10205
    • Yang, G.1    Pevear, D.C.2    Collett, M.S.3    Chunduru, S.4    Young, D.C.5    Benetatos, C.6    Jordan, R.7
  • 198
    • 0346103657 scopus 로고    scopus 로고
    • Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
    • Ye, J., Wang, C., Sumpter, R. Jr., Brown, M. S., Goldstein, J. L. and Gale, M. Jr. 2003. Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc Natl Acad Sci USA 100: 15865-70.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15865-15870
    • Ye, J.1    Wang, C.2    Sumpter, R.3    Brown, M.S.4    Goldstein, J.L.5    Gale, M.6
  • 199
    • 0037332361 scopus 로고    scopus 로고
    • 3 nontranslated RNA signals required for replication of hepatitis C virus RNA
    • Yi, M. and Lemon, S. M. 2003. 3 nontranslated RNA signals required for replication of hepatitis C virus RNA. J Virol 77: 3557-68.
    • (2003) J Virol , vol.77 , pp. 3557-3568
    • Yi, M.1    Lemon, S.M.2
  • 200
    • 37349012884 scopus 로고    scopus 로고
    • 3 RNA elements in hepatitis C virus replication: Kissing partners and long poly (U)
    • You, S. and Rice, C. M. 2007. 3 RNA elements in hepatitis C virus replication: Kissing partners and long poly (U). J Virol 82: 184-95.
    • (2007) J Virol , vol.82 , pp. 184-195
    • You, S.1    Rice, C.M.2
  • 201
    • 0347634413 scopus 로고    scopus 로고
    • A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication
    • You, S., Stump, D. D., Branch, A. D. and Rice, C. M. 2004. A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication. J Virol 78: 1352-66.
    • (2004) J Virol , vol.78 , pp. 1352-1366
    • You, S.1    Stump, D.D.2    Branch, A.D.3    Rice, C.M.4
  • 202
    • 33744921881 scopus 로고    scopus 로고
    • Palmitoylation and polymerization of hepatitis C virus NS4B protein
    • Yu, G. Y., Lee, K. J., Gao, L. and Lai, M. M. 2006. Palmitoylation and polymerization of hepatitis C virus NS4B protein. J Virol 80: 6013-23.
    • (2006) J Virol , vol.80 , pp. 6013-6023
    • Yu, G.Y.1    Lee, K.J.2    Gao, L.3    Lai, M.M.4
  • 203
    • 30744475504 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response
    • Zheng, Y., Gao, B., Ye, L., Kong, L., Jing, W., Yang, X., Wu, Z. and Ye, L. 2005. Hepatitis C virus non-structural protein NS4B can modulate an unfolded protein response. J Microbiol 43: 529-36.
    • (2005) J Microbiol , vol.43 , pp. 529-536
    • Zheng, Y.1    Gao, B.2    Ye, L.3    Kong, L.4    Jing, W.5    Yang, X.6    Wu, Z.7    Ye, L.8
  • 205
    • 0033948907 scopus 로고    scopus 로고
    • De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase
    • Zhong, W., Uss, A. S., Ferrari, E., Lau, J. Y. and Hong, Z. 2000. De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase. J Virol 74: 2017-22.
    • (2000) J Virol , vol.74 , pp. 2017-2022
    • Zhong, W.1    Uss, A.S.2    Ferrari, E.3    Lau, J.Y.4    Hong, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.