A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA

Journal of Virology

Volumn 73, Issue 9, 1999, Pages 7694-7702

  Oh, Jong Won ^a   Ito, Takayoshi ^a   Lai, Michael M C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT ENZYME; RNA DIRECTED RNA POLYMERASE; VIRUS ENZYME; VIRUS RNA;

ARTICLE; ENZYME ACTIVITY; GENE SEQUENCE; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; RNA TRANSCRIPTION; RNA TRANSLATION; SEQUENCE ANALYSIS; VIRUS REPLICATION;

EID: 0032816079     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.9.7694-7702.1999     Document Type: Article

References (50)

1. Ali, N., and A. Siddiqui. 1995. Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J. Virol. 69:6367-6375.
2. Arnaud-Barbe, N., V. Cheynet-Sauvion, G. Oriol, B. Mandrand, and F. Mallet. 1998. Transcription of RNA templates by T7 RNA polymerase. Nucleic Acids Res. 26:3350-3354.
3. Ball, L. A. 1994. Replication of the genomic RNA of a positive-strand RNA animal virus from negative-sense transcripts. Proc. Natl. Acad. Sci. USA 91:12443-12447.
4. Behrens, S.-E., L. Tomei, and R. De Francesco. 1996. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15:12-22.
5. Blumenthal, T., and G. G. Carmichael. 1979. RNA replication: function and structure of Qβ-replicase. Annu. Rev. Biochem. 48:525-548.
6. Brown, E. A., H. Zhang, L. H. Ping, and S. M. Lemon. 1992. Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res. 20:5041-5045.
7. Chen, P.-J., M.-H. Lin, K.-F. Tai, P.-C. Liu, C.-J. Lin, and D.-S. Chen. 1992. The Taiwanese hepatitis C virus genome: sequence determination and mapping of the 5′ termini of viral genomic and antigenomic RNA. Virology 188:102-113.
8. Cormack, B. 1994. Introduction of a point mutation by sequential PCR steps, p. 8.5.7-8.5.9. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. John Wiley & Sons, New York, N. Y.
9. Dreher, T. W., and T. C. Hall. 1988. Mutational analysis of the sequences and structural requirements in brome mosaic virus RNA for minus strand promoter activity. J. Mol. Biol. 201:31-44.
10. Ferrai, E., J. Wright-Minogue, J. W. S. Fang, B. M. Baroudy, J. Y. N. Lau, and Z. Hong. 1999. Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J. Virol. 73:1649-1654.
11. Garaier, M., R. Mamoun, and J. M. Bove. 1980. TYMV RNA replication in vivo: replicative intermediate is mainly single stranded. Virology 104:357-374.
12. Gargouri-Bouzid, R., C. David, and A.-L. Haenni. 1991. The 3′ promoter region involved in RNA synthesis directed by the turnip yellow mosaic virus genome in vitro. FEBS Lett. 294:56-58.
13. Hayes, R. I., and K. W. Buck. 1990. Complete replication of a eukaryotic virus RNA in vitro by a purified RNA-dependent RNA polymerase. Cell 63:363-368.
14. Houghton, M. 1996. Hepatitis C viruses, p. 1035-1058. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Virology. Lippincott-Raven Publishers, Philadelphia, Pa.
15. Hwang, S. B., K.-J. Park, Y.-S. Kim, Y. C. Sung, and M. M. C. Lai. 1997. Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization. Virology 227:439-446.
16. Ito, T., and M. M. C. Lai. 1997. Determination of the secondary structure of and cellular protein binding to the 3′-untranslated region of the hepatitis C virus RNA genome. J. Virol. 71:8698-8706.
17. Ito, T., S. M. Tahara, and M. M. C. Lai. 1998. The 3′-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site. J. Virol. 72:8789-8796.
18. Jacques, J. P., and D. Kolakofsky. 1991. Pseudo-template transcription by Escherichia coli RNA polymerase at a mutant promoter. Genes Dev. 5:707-713.
19. Jeong, S. W., W. H. Lang, and R. H. Reeder. 1996. The yeast transcription terminator for RNA polymerase I is designed to prevent polymerase slippage. J. Biol. Chem. 271:16104-16110.
20. Kolykhalov, A. A., S. M. Feinstone, and C. M. Rice. 1996. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J. Virol. 70:3363-3371.
21. Koonin, E. V. 1991. The phylogeny of RNA-dependent RNA polymerase of positive-strand RNA viruses. J. Gen. Virol. 72:2197-2206.
22. Lin, Y.-J., C.-L. Liao, and M. M. C. Lai. 1994. Identification of the cis-acting signal for minus-strand RNA synthesis of a murine coronavirus: implications for the role of minus-strand RNA in RNA replication and transcription. J. Virol. 68:8131-8140.
23. Lohmann, V., F. Körner, U. Herian, and R. Bartenschlager. 1997. Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J. Virol. 71:8416-8428.
24. Lubinski, J. M., L. J. Ransone, and A. Dasgupta. 1987. Primer-dependent synthesis of covalently linked dimeric RNA molecules by poliovirus replicase. J. Virol. 61:2997-3003.
25. Major, M. E., and S. M. Feinstone. 1997. The molecular virology of hepatitis C. Hepatology 25:1527-1538.
26. Makino, S., and M. M. C. Lai. 1989. High-frequency leader switching during coronavirus defective interfering RNA replication. J. Virol. 63:5285-5292.
27. Miller, W. A., J. J. Bujarski, T. W. Dreher, and T. C. Hall. 1986. Minus-strand initiation by brome mosaic virus replicase within the 3′ tRNA-like structure of native and modified RNA templates. J. Mol. Biol. 187:537-546.
28. Oh, J.-W., Q. Kong, C. Song, C. D. Carpenter, and A. E. Simon. 1995. Open reading frames of turnip crinkle virus involved in satellite symptom expression and incompatibility with Arabidopsis thaliana ecotype Dijon. Mol. Plant-Microbe Interact. 8:979-987.
29. Osman, T. A. M., and K. W. Buck. 1996. Complete replication in vitro of tobacco mosaic virus RNA by a template-dependent, membrane-bound RNA polymerase. J. Virol. 70:6227-6234.
30. Plotch, S. J., O. Palant, and Y. Gluzman. 1989. Purification and properties of poliovirus RNA polymerase expressed in Escherichia coli. J. Virol. 63: 216-225.
31. Saito, I., T. Miyamura, A. Ohbayashi, H. Harada, T. Katayama, S. Kikuchi, Y. Watanabe, S. Koi, M. Onji, Y. Ohta, Q.-L. Choo, M. Houghton, and G. Kuo. 1990. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87:6917-6921.
32. Sankar, S., and A. G. Porter. 1991. Expression, purification, and properties of recombinant encephalomyocarditis virus RNA-dependent RNA polymerase. J. Virol. 65:2993-3000.
33. Sarnow, P., H. D. Bernstein, and D. Baltimore. 1986. A poliovirus temperature-sensitive mutant located in a noncoding region of the genome. Proc. Natl. Acad. Sci. USA 83:571-575.
34. Sarnow, P. 1989. Role of 3′-end sequences in infectivity of poliovirus transcripts made in vitro. J. Virol. 63:467-470.
35. Singh, R. N., and T. W. Dreher. 1997. Turnip yellow mosaic virus RNA-dependent RNA polymerase: initiation of minus strand synthesis in vitro. Virology 233:430-439.
36. Song, C., and A. E. Simon. 1994. RNA-dependent RNA polymerase from plants infected with turnip crinkle virus can transcribe (+)- and (-)-strands of virus-associated RNAs. Proc. Natl. Acad. Sci. USA 91:8792-8796.
37. Strauss, J. H., and E. G. Strauss. 1994. The alphaviruses: gene expression, replication, and evolution. Microbiol. Rev. 58:491-562.
38. Tanaka, T., N. Kato, M.-J. Cho, K. Sugiyama, and K. Shimotohno. 1996. Structure of the 3′ terminus of the hepatitis C virus genome. J. Virol. 70:3307-3312.
39. Triana-Alonso, F. J., M. Dabrowski, J. Wadzack, and K. H. Nierhaus. 1995. Self-coded 3′-extension of run-off transcripts produces aberrant products during in vitro transcription with T7 RNA polymerase. J. Biol. Chem. 270: 6298-6307.
40. Tsuchihara, K., T. Tanaka, M. Hijikata, S. Kuge, H. Toyoda, A. Nomoto, N. Yamamoto, and K. Shimotohno. 1997. Specific interaction of polypyrimidine tract-binding protein with the extreme 3′-terminal structure of the hepatitis C virus genome, the 3′X. J. Virol. 71:6720-6726.
41. Tsukiyama-Kohara, K., N. Iizuka, M. Kohara, and A. Nomota. 1992. Internal ribosome entry site within hepatitis C virus RNA. J. Virol. 64:1476-1483.
42. van der Kury, A. C., K. Langereis, C. J. Houwing, E. M. J. Jaspars, and J. F. Bol. 1990. cis-acting elements involved in replication of alfalfa mosaic virus RNAs in vitro. Virology 176:346-354.
43. Vazquez, A. L., J. M. M. Alonso, R. Casais, J. A. Boga, and F. Parra. 1998. Expression of enzymatically active rabbit hemorrhagic disease virus RNA-dependent RNA polymerase in Escharichia coli J. Virol. 72:2999-3004.
44. Wang, C., P. Sarnow, and A. Siddiqui. 1994. A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA. J. Virol. 68:7301-7307.
45. Wu, S.-H., and P. Kaesberg. 1991. Synthesis of template-sense, single-strand flockhouse virus RNA in a cell-free replication system. Virology 183:392-396.
46. Yamada, N., K. Tanihara, A. Takada, T. Yorihuzi, M. Tsutsumi, H. Shimomura, T. Tsuji, and T. Date. 1996. Genetic organization and diversity of the 3′ noncoding region of the hepatitis C virus genome. Virology 223:255-261.
47. Yamashita, T., S. Kaneko, Y. Shirota, W. Qin, T. Nomura, K. Kobayashi, and S. Murakami. 1998. RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region. J. Biol. Chem. 273:15479-15486.
48. Yanagi, M., M. S. Claire, M. Shapiro, S. U. Emerson, R. H. Purcell, and J. Bukh. 1998. Transcripts of a chimeric cDNA of hepatitis C virus genotype 1b are infectious in vivo. Virology 244:161-172.
49. Young, D. C., D. M. Tuschall, and J. B. Flanegan. 1985. Poliovirus RNA-dependent RNA polymerase and host cell protein synthesize product RNA twice the size of poliovirion RNA in vitro. J. Virol. 54:256-264.
50. Zhong, W., L. L. Gutshall, and A. M. Del Vecchio. 1998. Identification and characterization of an RNA-dependent RNA polymerase within the non-structural protein 5B region of bovine viral diarrhea virus. J. Virol. 72:9365-9369.