Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus

Journal of Biological Chemistry

Volumn 281, Issue 6, 2006, Pages 3528-3535

  Mackintosh, Samuel G ^a   Lu, Jeff Zhiqiang ^b,d   Jordan, John B ^b   Harrison, Melody K ^a   Sikora, Bartek ^a   Sharma, Suresh D ^c   Cameron, Craig E ^c   Raney, Kevin D ^a   Sakon, Joshua ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; ENZYME KINETICS; INTERFACES (MATERIALS); MOLECULAR BIOLOGY; MUTAGENESIS; RNA; VIRUSES;

BIOCHEMICAL PROPERTIES; HCV REPLICATIVE CAPACITY; MULTIFUNCTIONAL ENZYMES;

PROTEINS;

HELICASE; NONSTRUCTURAL PROTEIN 3; OLIGONUCLEOTIDE; SERINE PROTEINASE; VIRUS PROTEIN; ADENOSINE TRIPHOSPHATASE; DNA; NS3 PROTEIN, HEPATITIS C VIRUS; RECOMBINANT PROTEIN; RNA;

ARTICLE; CRYSTAL STRUCTURE; DNA DENATURATION; ENZYME BINDING; GENOME; HEPATITIS C VIRUS; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REPLICON; RNA SYNTHESIS; VIRUS REPLICATION; CELL LINE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DOSE RESPONSE; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SPECTROPHOTOMETRY; STATISTICAL MODEL; VIRUS GENOME; WESTERN BLOTTING; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS;

ADENOSINE TRIPHOSPHATASES; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOME, VIRAL; HEPACIVIRUS; HUMANS; KINETICS; MODELS, MOLECULAR; MODELS, STATISTICAL; MUTATION; OLIGONUCLEOTIDES; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RNA; SPECTROPHOTOMETRY; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 33645645084     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512100200     Document Type: Article

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