Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

Journal of Biological Chemistry

Volumn 280, Issue 18, 2005, Pages 18202-18210

  Biswal, Bichitra K ^a   Cherney, Maia M ^a   Wang, Meitian ^a   Chan, Laval ^b   Yannopoulos, Constantin G ^b   Bilimoria, Darius ^b   Nicolas, Olivier ^b   Bedard, Jean ^b   James, Michael N G ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ViroChem Pharma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; GENES; HYDROGEN BONDS; MOLECULES; RNA;

GENOTYPE; NUCLEOSIDE; POLYMERASE; VAN DER WAALS INTERACTIONS;

ENZYMES;

RNA DIRECTED DNA POLYMERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE; ENZYME INHIBITOR; NS 5 PROTEIN, HEPATITIS C VIRUS; NS-5 PROTEIN, HEPATITIS C VIRUS; THIOPHENE 2 CARBOXYLIC ACID HYDRAZIDE; THIOPHENE DERIVATIVE; THIOPHENE-2-CARBOXYLIC ACID HYDRAZIDE; VIRUS PROTEIN;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITOR COMPLEX; ENZYME STRUCTURE; GENOTYPE; HEPATITIS C VIRUS; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS; VIRUS MORPHOLOGY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GENOTYPE; HEPACIVIRUS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RNA REPLICASE; SEQUENCE HOMOLOGY, AMINO ACID; THIOPHENES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 23744436747     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413410200     Document Type: Article

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