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Volumn 71, Issue 11, 1997, Pages 8416-8428

Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; POLYADENYLIC ACID; POLYCYTIDYLIC ACID; POLYGUANYLIC ACID; POLYURIDYLIC ACID; RNA DIRECTED DNA POLYMERASE;

EID: 1842289764     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.11.8416-8428.1997     Document Type: Article
Times cited : (495)

References (59)
  • 1
    • 0026815645 scopus 로고
    • Bromovirus RNA replication and transcription
    • Ahlquist, P. 1992. Bromovirus RNA replication and transcription. Curr. Opin. Genet. Dev. 2:71-76.
    • (1992) Curr. Opin. Genet. Dev. , vol.2 , pp. 71-76
    • Ahlquist, P.1
  • 2
    • 0022446435 scopus 로고
    • Purification of a terminal uridylyl-transferase that acts as host factor in the in vitro poliovirus replicase reaction
    • Andrews, N. C., and D. Baltimore. 1986. Purification of a terminal uridylyl-transferase that acts as host factor in the in vitro poliovirus replicase reaction. Proc. Natl. Acad. Sci. USA 83:221-225.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 221-225
    • Andrews, N.C.1    Baltimore, D.2
  • 3
    • 0025026431 scopus 로고
    • The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation
    • Bartenschlager, R., M. Junker-Niepmann, and H. Schaller. 1990. The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation. J. Virol. 64:5324-5332.
    • (1990) J. Virol. , vol.64 , pp. 5324-5332
    • Bartenschlager, R.1    Junker-Niepmann, M.2    Schaller, H.3
  • 4
    • 0030862814 scopus 로고    scopus 로고
    • Molecular targets in inhibition of hepatitis C virus replication
    • Bartenschlager, R. 1997. Molecular targets in inhibition of hepatitis C virus replication. Antiviral Chem. Chemother. 8:281-301.
    • (1997) Antiviral Chem. Chemother. , vol.8 , pp. 281-301
    • Bartenschlager, R.1
  • 5
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager, R., L. Ahlborn-Laake, J. Mous, and H. Jacobsen. 1993. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J. Virol. 67:3835-3844.
    • (1993) J. Virol. , vol.67 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 6
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • Behrens, S.-E., L. Tomei, and R. De Francesco. 1996. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15:12-22.
    • (1996) EMBO J. , vol.15 , pp. 12-22
    • Behrens, S.-E.1    Tomei, L.2    De Francesco, R.3
  • 7
    • 0025236535 scopus 로고
    • Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region
    • Bienz, K., D. Egger, M. Troxler, and L. Pasamontes. 1990. Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region. J. Virol. 64:1156-1163.
    • (1990) J. Virol. , vol.64 , pp. 1156-1163
    • Bienz, K.1    Egger, D.2    Troxler, M.3    Pasamontes, L.4
  • 8
    • 0001847422 scopus 로고
    • Buffer systems and transfer parameters for semidry electroblotting with a horizontal apparatus
    • M. J Dunn (ed.), Deerfield Beach, Fla.
    • Bjerrum, O. J., and C. Schafer-Nielsen. 1986. Buffer systems and transfer parameters for semidry electroblotting with a horizontal apparatus, p. 315-327. In M. J Dunn (ed.), Electrophoresis '86 VCH Publishers, Deerfield Beach, Fla.
    • (1986) Electrophoresis '86 VCH Publishers , pp. 315-327
    • Bjerrum, O.J.1    Schafer-Nielsen, C.2
  • 9
    • 0025969881 scopus 로고
    • Suggestions for "safe" residue substitutions in site-directed mutagenesis
    • Bordo, D., and P. Argos. 1991. Suggestions for "safe" residue substitutions in site-directed mutagenesis. J. Mol. Biol. 217:721-729.
    • (1991) J. Mol. Biol. , vol.217 , pp. 721-729
    • Bordo, D.1    Argos, P.2
  • 10
    • 0027501562 scopus 로고
    • Binding of encephalomyocarditis virus RNA polymerase to the 3′-noncoding region of the viral RNA is specific and requires the 3′-poly(A) tail
    • Cui, T., S. Sankar, and A. G. Porter. 1993. Binding of encephalomyocarditis virus RNA polymerase to the 3′-noncoding region of the viral RNA is specific and requires the 3′-poly(A) tail. J. Biol. Chem. 268:26093-26098.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26093-26098
    • Cui, T.1    Sankar, S.2    Porter, A.G.3
  • 11
    • 0027942956 scopus 로고
    • Hepatitis C: Progress and problems
    • Cuthbert, J. A. 1994. Hepatitis C: progress and problems. Clin. Microbiol. Rev. 7:505-532.
    • (1994) Clin. Microbiol. Rev. , vol.7 , pp. 505-532
    • Cuthbert, J.A.1
  • 12
    • 0020525065 scopus 로고
    • Purification of host factor required for in vitro transcription of poliovirus RNA
    • Dasgupta, A. 1983. Purification of host factor required for in vitro transcription of poliovirus RNA. Virology 128:245-251.
    • (1983) Virology , vol.128 , pp. 245-251
    • Dasgupta, A.1
  • 13
    • 0018872675 scopus 로고
    • Dependence of the activity of the poliovirus replicase on a host cell protein
    • Dasgupta, A., P. Zabel, and D. Baltimore. 1980. Dependence of the activity of the poliovirus replicase on a host cell protein. Cell 19:423-429.
    • (1980) Cell , vol.19 , pp. 423-429
    • Dasgupta, A.1    Zabel, P.2    Baltimore, D.3
  • 14
    • 0027476809 scopus 로고
    • Expression and identification of hepatitis C virus polyprotein cleavage products
    • Grakoui, A., C. Wychowski, C. Lin, S. M. Feinstone, and C. M. Rice. 1993. Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67:1385-1395.
    • (1993) J. Virol. , vol.67 , pp. 1385-1395
    • Grakoui, A.1    Wychowski, C.2    Lin, C.3    Feinstone, S.M.4    Rice, C.M.5
  • 15
    • 0023031091 scopus 로고
    • Characterization of West Nile virus RNA-dependcnt RNA polymerase and cellular terminal adenylyl and uridylyl transferases in cell-free extracts
    • Grun, J. B., and M. A. Brinton. 1986. Characterization of West Nile virus RNA-dependcnt RNA polymerase and cellular terminal adenylyl and uridylyl transferases in cell-free extracts. J. Virol. 60:1113-1124.
    • (1986) J. Virol. , vol.60 , pp. 1113-1124
    • Grun, J.B.1    Brinton, M.A.2
  • 16
    • 0030583249 scopus 로고    scopus 로고
    • Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein
    • Gwack, Y., D. W. Kim, J. H. Han, and J. Choe. 1996. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem. Biophys. Res. Commun. 225:654-659.
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 654-659
    • Gwack, Y.1    Kim, D.W.2    Han, J.H.3    Choe, J.4
  • 17
    • 0022458866 scopus 로고
    • Synthesis of plus- And minus-strand RNA from poliovirion RNA template in vitro
    • Hey, T. D., O. C. Richards, and E. Ehrenfeld. 1986. Synthesis of plus-and minus-strand RNA from poliovirion RNA template in vitro. J. Virol. 58: 790-796.
    • (1986) J. Virol. , vol.58 , pp. 790-796
    • Hey, T.D.1    Richards, O.C.2    Ehrenfeld, E.3
  • 19
    • 0025991559 scopus 로고
    • Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
    • Hijikata, M., N. Kato, Y. Ootsuyama, and M. Nakagawa. 1991. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc. Natl. Acad. Sci. USA 88:5547-5551.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5547-5551
    • Hijikata, M.1    Kato, N.2    Ootsuyama, Y.3    Nakagawa, M.4
  • 20
    • 0024520745 scopus 로고
    • Site-directed mutagenesis by overlap extension using the polymerase chain reaction
    • Ho, S. N., H. Hunt, R. Horton, J. Pullen, and L. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
    • (1989) Gene , vol.77 , pp. 51-59
    • Ho, S.N.1    Hunt, H.2    Horton, R.3    Pullen, J.4    Pease, L.5
  • 21
    • 0030219426 scopus 로고    scopus 로고
    • Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA
    • Honda, M., L.-H. Ping, R. C. Rijnbrand, E. Amphlett, B. Clarke, D. Rowlands, and S. M. Lemon. 1996. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 222:31-42.
    • (1996) Virology , vol.222 , pp. 31-42
    • Honda, M.1    Ping, L.-H.2    Rijnbrand, R.C.3    Amphlett, E.4    Clarke, B.5    Rowlands, D.6    Lemon, S.M.7
  • 22
    • 0029950090 scopus 로고    scopus 로고
    • Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system
    • Hong, Z., E. Ferrari, J. Wright-Minogue, R. Chase, C. Risano, G. Seelig, C. Lee, and A. D. Kwong. 1996. Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J. Virol. 70:4261-4268.
    • (1996) J. Virol. , vol.70 , pp. 4261-4268
    • Hong, Z.1    Ferrari, E.2    Wright-Minogue, J.3    Chase, R.4    Risano, C.5    Seelig, G.6    Lee, C.7    Kwong, A.D.8
  • 23
    • 0000361013 scopus 로고    scopus 로고
    • Hepatitis C viruses
    • B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Lippincott-Raven Publishers, Philadelphia, Pa.
    • Houghton, M. 1996. Hepatitis C viruses, p. 1035-1058. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Virology. Lippincott-Raven Publishers, Philadelphia, Pa.
    • (1996) Virology , pp. 1035-1058
    • Houghton, M.1
  • 24
    • 0031579246 scopus 로고    scopus 로고
    • Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization
    • Hwang, S. B., K.-J. Park, Y.-S. Kim, Y. C. Sung, and M. M. C. Lai. 1997. Hepatitis C virus NS5B protein is a membrane-associated phosphoprotein with a predominantly perinuclear localization. Virology 227:439-446.
    • (1997) Virology , vol.227 , pp. 439-446
    • Hwang, S.B.1    Park, K.-J.2    Kim, Y.-S.3    Sung, Y.C.4    Lai, M.M.C.5
  • 25
    • 0026096150 scopus 로고
    • Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif
    • Jablonski, S. A., M. Luo, and C. D. Morrow. 1991. Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif. J. Virol. 65:4565-4572.
    • (1991) J. Virol. , vol.65 , pp. 4565-4572
    • Jablonski, S.A.1    Luo, M.2    Morrow, C.D.3
  • 26
    • 0028881713 scopus 로고
    • Polymerase structures and function: Variations on a theme?
    • Joyce, C. M., and T. A. Steitz. 1995. Polymerase structures and function: variations on a theme? J. Bacteriol. 177:6321-6329.
    • (1995) J. Bacteriol. , vol.177 , pp. 6321-6329
    • Joyce, C.M.1    Steitz, T.A.2
  • 27
    • 0028817781 scopus 로고
    • C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase
    • Kim, D. W., Y. Gwack, J. H. Han, and J. Choe. 1995. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase. Biochem. Biophys. Res. Commun. 215:160-166.
    • (1995) Biochem. Biophys. Res. Commun. , vol.215 , pp. 160-166
    • Kim, D.W.1    Gwack, Y.2    Han, J.H.3    Choe, J.4
  • 29
    • 0029938477 scopus 로고    scopus 로고
    • Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
    • Kolykhalov, A. A., S. M. Feinstone, and C. M. Rice. 1996. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J. Virol. 70:3363-3371.
    • (1996) J. Virol. , vol.70 , pp. 3363-3371
    • Kolykhalov, A.A.1    Feinstone, S.M.2    Rice, C.M.3
  • 31
    • 0028290389 scopus 로고
    • Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • Lin, C., B. D. Lindenbach, B. M. Pragai, D. W. McCourt, and C. M. Rice. 1994. Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J. Virol. 68:5063-73.
    • (1994) J. Virol. , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Pragai, B.M.3    McCourt, D.W.4    Rice, C.M.5
  • 33
    • 0030592514 scopus 로고    scopus 로고
    • The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
    • Love, R. A., H. E. Parge, J. A. Wickersham, Z. Hostomsky, N. Habuka, E. W. Moomaw, T. Adachi, and Z. Hostomska. 1996. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 87:331-342.
    • (1996) Cell , vol.87 , pp. 331-342
    • Love, R.A.1    Parge, H.E.2    Wickersham, J.A.3    Hostomsky, Z.4    Habuka, N.5    Moomaw, E.W.6    Adachi, T.7    Hostomska, Z.8
  • 34
    • 0023253984 scopus 로고
    • Primer-dependent synthesis of covalently linked dimeric RNA molecules by poliovirus replicase
    • Lubinski, J. M., L. J. Ransone, and A. Dasgupta. 1987. Primer-dependent synthesis of covalently linked dimeric RNA molecules by poliovirus replicase. J. Virol. 61:2997-3003.
    • (1987) J. Virol. , vol.61 , pp. 2997-3003
    • Lubinski, J.M.1    Ransone, L.J.2    Dasgupta, A.3
  • 36
    • 0021970469 scopus 로고
    • Purification of a soluble template-dependent rhinovirus RNA polymerase and its dependence on a host cell protein for viral RNA synthesis
    • Morrow, C. D., J. Lubinski, J. Hocko, G. F. Gibbons, and A. Dasgupta. 1985. Purification of a soluble template-dependent rhinovirus RNA polymerase and its dependence on a host cell protein for viral RNA synthesis. J. Virol. 53:266-272.
    • (1985) J. Virol. , vol.53 , pp. 266-272
    • Morrow, C.D.1    Lubinski, J.2    Hocko, J.3    Gibbons, G.F.4    Dasgupta, A.5
  • 37
    • 0028176691 scopus 로고
    • Rift valley fever virus L segment: Correction of the sequence and possible functional role of newly identified regions conserved in RNA-dcpendent polymerases
    • Müller, R. O. Poch, M. Delarue, D. H. L. Bishop, and M. Bouloy. 1994. Rift valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dcpendent polymerases. J. Gen. Virol. 75:1345-1352.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1345-1352
    • Müller1    Poch, R.O.2    Delarue, M.3    Bishop, D.H.L.4    Bouloy, M.5
  • 40
    • 0026325741 scopus 로고
    • Purification, characterization and comparison of poliovirus RNA polymerase from native and recombinant sources
    • Neufeld, K. L., O. C. Richards, and E. Ehrenfeld. 1991. Purification, characterization and comparison of poliovirus RNA polymerase from native and recombinant sources. J. Biol. Chem. 266:24212-24219.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24212-24219
    • Neufeld, K.L.1    Richards, O.C.2    Ehrenfeld, E.3
  • 41
    • 0023743797 scopus 로고
    • Measurement of poliovirus RNA polymerase binding in poliovirion and nonviral RNA using a filter-binding assay
    • Oberste, M. S., and J. B. Flanegan. 1988. Measurement of poliovirus RNA polymerase binding in poliovirion and nonviral RNA using a filter-binding assay. Nucleic Acids Res. 16:10339-10341.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 10339-10341
    • Oberste, M.S.1    Flanegan, J.B.2
  • 42
    • 0017613512 scopus 로고
    • A simplification of the protein assay method of Lowry et al. which is more generally applicable
    • Peterson, G. L. 1977. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83:346-356.
    • (1977) Anal. Biochem. , vol.83 , pp. 346-356
    • Peterson, G.L.1
  • 43
    • 0024495371 scopus 로고
    • Purification and properties of poliovirus RNA polymerase expressed in Escherichia coli
    • Plotch, S. J., O. Palant, and Y. Gluzman. 1989. Purification and properties of poliovirus RNA polymerase expressed in Escherichia coli. J. Virol. 63: 216-225.
    • (1989) J. Virol. , vol.63 , pp. 216-225
    • Plotch, S.J.1    Palant, O.2    Gluzman, Y.3
  • 44
    • 0024784519 scopus 로고
    • Identification of four conserved motifs among the RNA-dependent polymerase encoding elements
    • Poch, O., I. Sauvaget, M. Delarue, and N. Tordo. 1989. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J. 8:3867-3874.
    • (1989) EMBO J. , vol.8 , pp. 3867-3874
    • Poch, O.1    Sauvaget, I.2    Delarue, M.3    Tordo, N.4
  • 45
    • 0027422866 scopus 로고
    • Picornavirus nonstructural proteins: Emerging roles in virus replication and inhibition of host cell functions
    • Porter, A. G. 1993. Picornavirus nonstructural proteins: emerging roles in virus replication and inhibition of host cell functions. J. Virol. 67:6917-6921.
    • (1993) J. Virol. , vol.67 , pp. 6917-6921
    • Porter, A.G.1
  • 46
    • 0025125267 scopus 로고
    • Purification and characterization of brome mosaic virus RNA-dependent RNA polymerase
    • Quandt, R., and E. M. Jaspars. 1990. Purification and characterization of brome mosaic virus RNA-dependent RNA polymerase. Virology 178:189-194.
    • (1990) Virology , vol.178 , pp. 189-194
    • Quandt, R.1    Jaspars, E.M.2
  • 47
    • 0001424128 scopus 로고    scopus 로고
    • Flaviviridae: The viruses and their replication
    • B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Lippincott-Raven Publishers, Philadelphia, Pa.
    • Rice, C. M. 1996. Flaviviridae: the viruses and their replication, p. 931-959. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Virology. Lippincott-Raven Publishers, Philadelphia, Pa.
    • (1996) Virology , pp. 931-959
    • Rice, C.M.1
  • 49
    • 0026046236 scopus 로고
    • Expression, purification, and properties of recombinant encephalomyocarditis virus RNA-dependent RNA polymerase
    • Sankar, S., and A. G. Porter. 1991. Expression, purification, and properties of recombinant encephalomyocarditis virus RNA-dependent RNA polymerase. J. Virol. 65:2993-3000.
    • (1991) J. Virol. , vol.65 , pp. 2993-3000
    • Sankar, S.1    Porter, A.G.2
  • 51
    • 0028088152 scopus 로고
    • The alphaviruses: Gene expression, replication, and evolution
    • Strauss, J. H., and E. G. Strauss. 1994. The alphaviruses: gene expression, replication, and evolution. Microbiol. Rev. 58:491-562.
    • (1994) Microbiol. Rev. , vol.58 , pp. 491-562
    • Strauss, J.H.1    Strauss, E.G.2
  • 52
    • 0027199917 scopus 로고
    • Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with related pestivirus and flavivirus enzymes
    • Suzich, J. A., J. K. Tamura, F. Palmer-Hill, P. Warrener, A. Grakoui, C. M. Rice, S. M. Feinstone, and M. S. Collett. 1993. Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with related pestivirus and flavivirus enzymes. J. Virol. 67:6152-6158.
    • (1993) J. Virol. , vol.67 , pp. 6152-6158
    • Suzich, J.A.1    Tamura, J.K.2    Palmer-Hill, F.3    Warrener, P.4    Grakoui, A.5    Rice, C.M.6    Feinstone, S.M.7    Collett, M.S.8
  • 53
    • 0029970903 scopus 로고    scopus 로고
    • The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)
    • Tai, C.-L., W.-K. Chi, D.-S. Chen, and L.-H. Hwang. 1996. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J. Virol. 70:8477-8484.
    • (1996) J. Virol. , vol.70 , pp. 8477-8484
    • Tai, C.-L.1    Chi, W.-K.2    Chen, D.-S.3    Hwang, L.-H.4
  • 54
    • 0029863798 scopus 로고    scopus 로고
    • Recombinant Dengue type 1 virus NS5 protein expressed in Eschenchia coli exhibits RNA-depcndent RNA polymerase activity
    • Tan, B.-H., J. Fu, R. Sugrae, E.-H. Yap, Y.-C. Chan, and Y. H. Tan. 1996. Recombinant Dengue type 1 virus NS5 protein expressed in Eschenchia coli exhibits RNA-depcndent RNA polymerase activity. Virology 216:317-325.
    • (1996) Virology , vol.216 , pp. 317-325
    • Tan, B.-H.1    Fu, J.2    Sugrae, R.3    Yap, E.-H.4    Chan, Y.-C.5    Tan, Y.H.6
  • 55
    • 0028785460 scopus 로고
    • A novel sequence found at the 3′ terminus of hepatitis C virus genome Biochem
    • Tanaka, T., N. Kato, M.-J. Cho, and K. Shimotohno. 1995. A novel sequence found at the 3′ terminus of hepatitis C virus genome Biochem. Biophys. Res. Commun. 215:744-749.
    • (1995) Biophys. Res. Commun. , vol.215 , pp. 744-749
    • Tanaka, T.1    Kato, N.2    Cho, M.-J.3    Shimotohno, K.4
  • 56
    • 0029927642 scopus 로고    scopus 로고
    • Structure of the 3′ terminus of the hepatitis C virus genome
    • Tanaka, T., N. Kato, M.-J. Cho, K. Sugiyama, and K. Shimotohno. 1996. Structure of the 3′ terminus of the hepatitis C virus genome. J. Virol. 70:3307-3312.
    • (1996) J. Virol. , vol.70 , pp. 3307-3312
    • Tanaka, T.1    Kato, N.2    Cho, M.-J.3    Sugiyama, K.4    Shimotohno, K.5
  • 57
    • 0027176287 scopus 로고
    • NS3 is a serine protease required for processing of hepatitis C virus polyprotein
    • Tomei, L., C. Failla, E. Santolini, R. De Francesco, and N. La Monica. 1993. NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J. Virol. 67:4017-4026.
    • (1993) J. Virol. , vol.67 , pp. 4017-4026
    • Tomei, L.1    Failla, C.2    Santolini, E.3    De Francesco, R.4    La Monica, N.5
  • 58
    • 0019951369 scopus 로고
    • Genome-length copies of poliovirion RNA are synthesized in vitro by the poliovirus RNA-dependent RNA polymerase
    • Van Dyke, T. A., R. J. Rickles, and J. B. Flanegan. 1982. Genome-length copies of poliovirion RNA are synthesized in vitro by the poliovirus RNA-dependent RNA polymerase. J. Biol. Chem. 257:4610-4617.
    • (1982) J. Biol. Chem. , vol.257 , pp. 4610-4617
    • Van Dyke, T.A.1    Rickles, R.J.2    Flanegan, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.