The use of whole food animal studies in the safety assessment of genetically modified crops: Limitations and recommendations

Critical Reviews in Toxicology

Volumn 43, Issue SUPPL.2, 2013, Pages 1-24

  Bartholomaeus, Andrew ^a,b   Parrott, Wayne ^c   Bondy, Genevieve ^d   Walker, Kate ^e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF CANBERRA   (Australia)

^c UNIVERSITY OF GEORGIA   (United States)

^d HEALTH CANADA   (Canada)

^e International Life Sciences Institute   (United States)

Author keywords

Animal; Animal ethics; Biotechnology; Food; Genetically modified; Safety; Toxicity; Whole food

Indexed keywords

AMINO ACID; CARBOHYDRATE; ENZYME; FAT; FATTY ACID; GENISTEIN; HERBICIDE; LECTIN; MINERAL; MYCOTOXIN; NUCLEIC ACID; PHYTOESTROGEN; PLANT TOXIN; PROTEIN; REGULATOR PROTEIN; STARCH; STRYCHNINE; TRACE ELEMENT; VITAMIN;

AGRONOMIC TRAIT; ALLERGENICITY; ANIMAL FOOD; BACILLUS THURINGIENSIS; BACKCROSSING; BIOASSAY; BIOMASS; BLOOD CHEMISTRY; BODY WEIGHT; CARCINOGENICITY; CATTLE; CELL TRANSFORMATION; CHEMICAL ANALYSIS; CHEMICAL BOND; CHICKEN; CHILE; CLIMATE; CLINICAL CHEMISTRY; COMPARATIVE STUDY; COTTON; COW; DOMESTIC ANIMAL; DRUG SURVEILLANCE PROGRAM; DRY WEIGHT; ELECTRON MICROSCOPY; ENVIRONMENTAL STRESS; FOOD COMPOSITION; FOOD CROP; FOOD HANDLING; FOOD INTAKE; FOOD IRRADIATION; FOOD POISONING; FOOD PROCESSING; FOOD SAFETY; FREEZE DRYING; GENE EXPRESSION; GENE INSERTION; GENETIC DIFFERENCE; GENETIC ENGINEERING; GENETIC MANIPULATION; GENETIC VARIABILITY; GENETICALLY MODIFIED FOOD; GRINDING; GROWING SEASON; HEALTH HAZARD; HEMATOLOGY; HISTIOCYTOSIS; HISTOLOGY; HISTOPATHOLOGY; HUMAN; INCIDENCE; KIDNEY DISEASE; LD 50; LIVER; LIVER FUNCTION; LIVER WEIGHT; LIVESTOCK; MACRONUTRIENT; MAIZE; MAXIMUM TOLERATED DOSE; METABOLITE; MOISTURE; MORBIDITY; MORTALITY; NEAR ISOGENIC LINE; NONHUMAN; NUTRITIONAL ASSESSMENT; NUTRITIONAL DEFICIENCY; NUTRITIONAL REQUIREMENT; ONION; ORGAN WEIGHT; ORGANOLEPTIC PROPERTY; PALATABILITY; PANCREAS; PHASEOLUS VULGARIS; PHENOTYPE; PLANT BREEDING; PLANT DEVELOPMENT; PLANT GENOME; POISONOUS PLANT; PORTION SIZE; POTATO; POULTRY; PREDICTION; RADIOACTIVITY; RADIOCHEMISTRY; RADIOLYSIS; RAPESEED; RECOMBINANT DNA TECHNOLOGY; RELIABILITY; REVIEW; RICE; RICINUS COMMUNIS; RISK ASSESSMENT; SEX DIFFERENCE; SMALL INTESTINE; SOYBEAN; SPECIES DIFFERENCE; STOMACH; STRYCHNOS NUX VOMICA; SUGAR BEET; SWEET PEPPER; SWINE; TARGET ORGANISM; TERATOGENICITY; TOMATO; TOXICOKINETICS; TRANSGENE; TRANSGENIC CROP; TRANSGENIC PLANT; VARIETAS; WINE;

ANIMAL EXPERIMENTATION; ANIMALS; FOOD SAFETY; FOOD, GENETICALLY MODIFIED; GENETIC ENGINEERING; HUMANS; PLANTS, GENETICALLY MODIFIED; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TOXICITY TESTS;

EID: 84887175807     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.3109/10408444.2013.842955     Document Type: Review

References (193)

1. Aeschbacher K, Messikommer R, Meile L, Wenk C. (2005). Bt176 corn in poultry nutrition: physiological characteristics and fate of recombinant plant DNA in chickens. Poult Sci, 84, 385-94. (Pubitemid 40346486)
2. Alba R, Phillips A, Mackie S, et al. (2010). Improvements to the international life sciences institute crop composition database. J Food Comp Anal, 23, 741-8.
3. Appenzeller LM, Munley SM, Hoban D, et al. (2008). Subchronic feeding study of herbicide-tolerant soybean DP-356Ø43 5 in Sprague-Dawley rats. Food Chem Tox, 46, 2201-13.
4. Appenzeller LM, Malley L, Mackenzie SA, et al. (2009a). Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1xDAS-59122-7) maize grain in Sprague-Dawley rats. Food Chem Toxicol, 47, 1512-20.
5. Appenzeller LM, Munley SM, Hoban D, et al. (2009b). Subchronic feeding study of grain from herbicide-tolerant maize DP-Ø9814Ø-6 in Sprague-Dawley rats. Food Chem Toxicol, 47, 2269-80.
6. Arjo G, Portero M, Pinol C, et al. (2013). Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Seralini et al. study claiming that Roundup Ready corn or the herbicide Roundup cause cancer in rats. Transgenic Res, 2013, 255-67.
7. Aulrich K, Bohme H, Daenicke R, et al. (2001). Genetically modified feeds in animal nutrition 1st communication: Bacillus thuringiensis (Bt) corn in poultry, pig and ruminant nutrition. Arch Anim Nutr, 54, 183-95.
8. Balint GA. (1974). Ricin: The toxic protein of castor oil seeds. Toxicology, 2, 77-102.
9. Batke M, Escher S, Hoffmann-Doerr S, et al. (2011). Evaluation of time extrapolation factors based on the database RepDose. Toxicol Lett, 205, 122-9.
10. Bohme H, Aulrich K, Daenicke R, Flachowsky G. (2001). Genetically modified feeds in animal nutrition 2nd communication: glufisinate tolerant sugar beets (roots and silage) and maize grains for ruminants and pigs. Arch Anim Nutr, 54, 197-207.
11. Brake DG, Evenson DP. (2004). A generational study of glyphosatetolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development. Food Chem Toxicol, 42, 29-36. (Pubitemid 37421323)
12. Brake DG, Thaler R, Evenson DP. (2004). Evaluation of Bt (Bacillus thuringiensis) corn on mouse testicular development by dual parameter flow cytometry. J Agric Food Chem, 52, 2097-102.
13. Brake J, Vlachos D. (1998). Evaluation of transgenic event 176 ''Bt'' corn in broiler chickens. Poult Sci, 77, 648-53. (Pubitemid 128526722)
14. Brake J, Faust MA, Stein J. (2003). Evaluation of transgenic event Bt11 hybrid corn in broiler chickens. Poult Sci, 82, 551-9. (Pubitemid 38641928)
15. Brake J, Faust MA, Stein J. (2005). Evaluation of transgenic corn (VIP3A) in broiler chickens. Poult Sci, 84, 503-12. (Pubitemid 40346501)
16. Brouk MJ, Cvetkovic B, Rice DW, et al. (2011). Performance of lactating dairy cows fed corn as whole plant silage and grain produced from genetically modified corn containing event DAS-59122-7 compared to a nontransgenic, near-isogenic control. J Dairy Sci, 94, 1961-6.
17. Burachik M. (2012). Regulation of GM crops in Argentina. GM crops and food. Biotechnol Agrice Food Chain, 3, 48-51.
18. Calsamiglia S, Hernandez B, Hartnell GF, Phipps R. (2007). Effects of corn silage derived from a genetically modified variety containing two transgenes on feed intake, milk production, and composition, and the absence of detectable transgenic deoxyribonucleic acid in milk in Holstein dairy cows. J Dairy Sci, 90, 4718-23. (Pubitemid 350045155)
19. Carman JA, Vlieger HR, Ver Steeg LJ, et al. (2013). A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize diet. J Organic Sys, 8, 38-54.
20. Cellini F, Chesson A, Colquhoun I, et al. (2004). Unintended effects and their detection in genetically modified crops. Food Chem Toxicol, 42, 1089-125. (Pubitemid 38584592)
21. Chapman AL, Morgan LC, Gartlehner G. (2009). Semi-automating the manual literature search for systematic reviews increases efficiency. Health Info Lib J, 27, 22-7.
22. Charles River. (2012). Baseline colony data. Available from: http://www.criver.com/en-US/ProdServ/ByType/ResModOver/baselinecolony/Pages/ baselinecolonydatabyparameter.aspx [last accessed 10 Feb 2013].
23. Chen ZL, Gu H, Li Y, et al. (2003). Safety assessment for genetically modified sweet pepper and tomato. Toxicology, 188, 297-307. (Pubitemid 36588907)
24. Chen S, Huang J, Zhou B, et al. (1996). A safety assessment of feeding rats and quails with cotton-seed meal from Bt-transgenic cotton plants. Jiangsu J Agr Sci, 12, 17-22.
25. Chukwudebe A, Privalle L, Reed A, et al. (2012). Health and nutritional status of Wistar rats following subchronic exposure to CV127 soybeans. Food Chem Tox, 50, 956-71.
26. Cockburn A. (2001). Assuring the safety of genetically modified (GM) foods: the importance of an holistic, integrative approach. J Biotechnol, 98, 79-106.
27. Codex Alimentarius Commission. (2009). Foods derived from modern biotechnology. 2nd ed. Rome, Italy: FAO/WHO.
28. Combs DK, Hartnell GF. (2008). Alfalfa containing the glyphosatetolerant trait has no effect on feed intake, milk composition, or milk production of dairy cattle. J Dairy Sci, 91, 673-8. (Pubitemid 351455792)
29. Creton S, Saghir SA, Bartels MJ, et al. (2012). Use of toxicokinetics to support chemical evaluation: informing high dose selection and study interpretation. Regul Toxicol Pharmacol, 62, 241-7.
30. Cromwell GL, Lindemann MD, Randolph JH, et al. (2002). Soybean meal from Roundup Ready or conventional soybeans in diets for growing-finishing swine. J Anim Sci, 80, 708-15. (Pubitemid 41138518)
31. Cromwell GL, Henry BJ, Scott AL, et al. (2005). Glufosinate herbicidetolerant (LibertyLink) rice vs. conventional rice in diets for growingfinishing swine. J Anim Sci, 83, 1068-74.
32. Custodio MG, Powers WJ, Huff-Lonergan E, et al. (2006). Growth, pork quality, and excretion characteristics of pigs fed Bt corn or nontransgenic corn. Can J Anim Sci, 86, 461-9. (Pubitemid 46586215)
33. de Vendomois JS, Roullier F, Cellier D, Seralini GE. (2009). A comparison of the effects of three GM corn varieties on mammalian health. Int J Biol Sci, 5, 706-26.
34. Delaney B, Appenzeller LM, Munley SM, et al. (2008a). Subchronic feeding study of high oleic acid soybeans (event DP 3Ø5423 1) in Sprague Dawley Rats. Food Chem Toxicol, 46, 3808-17.
35. Delaney B, Astwood JD, Cunny H, et al; ILSI International Food Biotechnology Committee Task Force on Protein Safety. (2008b). Evaluation of protein safety in the context of agricultural biotechnology. Food Chem Toxicol, 46, S71-97.
36. Donkin SS, Velez JC, Totten AK, et al. (2003). Effects of feeding silage and grain from glyphosate-tolerant or insect-protected corn hybrids on feed intake, ruminal digestion, and milk production in dairy cattle. J Dairy Sci, 86, 1780-8. (Pubitemid 38995070)
37. Dornbos DL, McDonald MB. (1986). Mass and composition of developing soybean seeds at five reproductive growth stages. Crop Sci, 26, 624-30.
38. Doull J, Gaylor D, Greim HA, et al. (2007). Report of an Expert Panel on the reanalysis by of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863). Food Chem Toxicol, 45, 2073-85. (Pubitemid 47470002)
39. Dryzga MD, Yano BL, Andrus AK, Mattsson JL. (2007). Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats. Food Chem Toxicol, 45, 1994-2004. (Pubitemid 47238215)
40. EFSA. (2005a). Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA GMO UK 2004 01) for the placing on the market of glyphosate-tolerant and insect-resistant genetically modified maize NK603-MON810, for food and feed uses, and import and processing under Regulation (EC) No 1829/2003 from Monsanto (Question No EFSA Q-2004-086). EFSA J, 309, 1-22.
41. EFSA. (2005b). Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA GMO UK 2004 06) for the placing on the market of insect-protected glyphosate-tolerant genetically modified maize MON863-NK603, for food and feed uses, and import and processing under Regulation (EC) No 1829/2003 from Monsanto (Question No EFSA Q 2004 154). EFSA J, 255, 1-21.
42. EFSA. (2005c). Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA GMO BE 2004 07) for the placing on the market of insect protected glyphosate-tolerant genetically modified maize MON863-MON810-NK603, for food and feed uses, and import and processing under Regulation (EC) No 1829/2003 from Monsanto (Question No EFSA Q 2004 159). EFSA J, 256, 1-25.
43. EFSA. (2005d). Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the notification (Reference C/DE/02/9) for the placing on the market of insect-protected genetically modified maize MON 863 x MON 810, for import and processing, under Part C of Directove 2001/18/EC from Monsanto (Question No EFSA-Q-2003-089). EFSA J, 251, 1-22.
44. EFSA. (2006a). Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-UK-2005-14) for the placing on the market of genetically modified potato EH92-527-1 with altered starch composition, for production of starch and food/feed uses, under Regulation (EC) no. 1829/2003 from BASF Plant Science (Question No EFSA-Q-2005-070). EFSA J, 324, 1-20.
45. EFSA. (2006b). Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-UK-2004-08) for the placing on the market of products produced from glyphosatetolerant genetically modified sugar beet H7-1, for food and feed uses, under Regulation (EC) No 1829/2003 from KWS SAAT AG and Monsanto (Question No EFSA-Q-2004-164). EFSA J, 431, 1-18.
46. EFSA. (2007). Opinion of the Scientific Panel on Genetically Modified Organisms on application (reference EFSA GMO UK 2005 19 and EFSA GMO RX GA21) for the placing on the market of the glyphosate-tolerant genetically modified maize GA21, for food and feed uses, import and processing and for renewal of the authorization of maize GA 21 as existing product, both under Regulation (EC) No 1829/2003 from Syngenta Seeds S.A.S on behalf of Syngenta Crop Protection AG. EFSA J, 541, 1-25.
47. EFSA. (2008a). GMO Panel Working Group on Animal Feeding Trials. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials. Food Chem Toxicol, 46, S2-70.
48. EFSA. (2008b). Opinion of the Scientific Panel on Genetically Modified Organisms on application (reference EFSA GMO NL 2006 36) for the placing on the market of the glyphosate tolerant genetically modified soybean MON89788, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto. EFSA J, 758, 1-23.
49. EFSA. (2008c). Scientific opinion. Application (Reference EFSA-GMONL-2007-37) for the placing on the market of the insect-resistant genetically modified maize MON89034, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto. EFSA J, 909, 1-30.
50. EFSA. (2009a). Adopted part of the minutes of the 55th plenary meeting of the Scientific Panel on Genetically Modified Organisms held on 27-28 January 2010. GMO Panel deliberations on the paper by de Vendomois et al. (2009, A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health). Int J Biol Sci, 5, 706-26.
51. EFSA. (2009b). Scientific opinion. Application (Reference EFSA-GMOUK-2005-11) for the placing on the market of insect-resistant genetically modified maize MIR604 event, for food and feed uses, import and processing under the Regulation (EC) No 1829/2003 from Syngenta Seeds S.A.S. on behalf of Syngenta Crop Protection AG. EFSA J, 1193, 1-26.
52. EFSA. (2011). EFSA Guidance on conducting repeated-dose 90-day oral toxicity study in rodents on whole food/feed. Available from: http://www.efsa.europa.eu/de/efsajournal/pub/2438.htm [last accessed 10 Feb 2013].
53. EFSA. (2012a). Scientific opinion on application (EFSA-GMO-DE-2010-82) for the placing on the market of insect-resistant genetically modified maize MIR162 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Syngenta. EFSA J, 10, 1-27.
54. EFSA. (2012b). Scientific opinion on application (EFSA-GMO-NL-2010-78) for the placing on the market of herbicide-tolerant, increased oleic acid genetically modified soybean MON 87705 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto. EFSA J, 10, 1-34.
55. El Sanhoty R, El-Rahman AAA, Bogl KW. (2004). Quality and safety evaluation of genetically modified potatoes Spunta with Cry V gene: Compositional analysis, determination of some toxins, antinutrients compounds and feeding study in rats. Nahrung/Food, 48, 13-18. (Pubitemid 38368281)
56. Elias PS. (1980). The wholesomeness of irradiated food. Ecotoxicol Environ Saf, 4, 172-83. (Pubitemid 10022654)
57. Erickson GE, Robbins ND, Simon JJ, et al. (2003). Effect of feeding glyphosate-tolerant (Roundup-Ready events GA21 or nk603) corn compared with reference hybrids on feedlot steer performance and carcass characteristics. J Anim Sci, 81, 2600-8. (Pubitemid 38571665)
58. Ermakova IV. (2007). GM soybeans-revisiting a controversial format. Nat Biotechnol, 25, 1351-4.
59. European Commission. (2010a). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union, L276. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010: 276:0033:0079:en:PDF [last accessed on 10 Feb 2013].
60. European Commission. (2010b). A decade of EU-funded GMO research, 2001-2010. European Commission. Directorate-General for Research Communication, Luxembourg, Publications Office of the European Commission. Available from: http://ec.europa.eu/research/biosociety/pdf/a-decade-of-eu-funded-gmo-research. pdf/[last accessed 10 Feb 2013].
61. Ewen SW, Pusztai A. (1999). Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet, 354, 1353-4. (Pubitemid 29481633)
62. FAO/WHO. (2000). Safety Aspects of Genetically Modified Foods of Plant Origin. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology, Geneva, Switzerland, May 29-June 2, 2000. Rome, Italy: Food and Agriculture Organization of the United Nations.
63. FDA 2010 Guidance for Industry, Non-Inferiority Clinical Trials. Available from: http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/UCM202140.pdf [last accessed 3 Mar 2013].
64. Filipecki M, Malepszy S. (2006). Unintended consequences of plant transformation: a molecular insight. J Appl Genet, 47, 277-86. (Pubitemid 44893723)
65. Flachowsky G, Aulrich K, Bohme H, Halle I. (2007). Studies on feeds from genetically modified plants (GMP)-contributions to nutritional and safety assessment. Anim Feed Sci Tech, 133, 2-30. (Pubitemid 44920285)
66. FSANZ. (2011). FSANZ response to studies cited as evidence of adverse effects from GM Foods. Available from: http://www.foodstandards.-gov.au/ consumerinformation/gmfoods/gmtableofstudies.cfm [last accessed 28 Feb 2013].
67. Gad SC. (2007). Animal models in toxicology. 2nd ed. Boca Raton, FL: Taylor and Francis.
68. Giddings G. (1992). Chemical safety of irradiated food. In: Finley JW, Robinson SF, Armstrong DJ, eds. Food safety assessment. Vol 484. Washington, DC: American Chemical Society, 332-45.
69. Gold LS, Bernstein L, Magaw R, Slone TH. (1989). Interspecies extrapolation in carcinogenesis: prediction between rats and mice. Environ Health Perspect, 81, 211-19. (Pubitemid 19156887)
70. Goodman S. (1992). A comment on replication, p-values and evidence. Stat Med, 11, 875-9.
71. Grant RJ, Fanning KC, Kleinschmit D, et al. (2003). Influence of glyphosate-tolerant event nk603) and corn rootworm protected (event MON863) corn silage and grain on feed consumption and milk production in Holstein cattle. J Dairy Sci, 86, 1707-15. (Pubitemid 38995063)
72. Grunewald W, Bury J. (2012). Comment on ''Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize'' by Seralini et al. Food Chem Tox, 53, 447-8.
73. Hammond B, Cockburn A. (2008). The safety assessment of proteins introduced into crops developed through agricultural biotechnology: a consolidated approach to meet current and future needs. In: Hammond BG, ed. Food safety of proteins in agricultural biotechnology. New York: CRC Press, Taylor and Francis, 259-88.
74. Hammond B, Dudek R, Lemen J, Nemeth M. (2004). Results of a 13-week safety assurance study with rats fed grain from glyphosate tolerant corn. Food Chem Toxicol, 42, 1003-14. (Pubitemid 38515785)
75. Hammond BG, Dudek R, Lemen JK, Nemeth MA. (2006a). Results of a 90-day safety assurance study with rats fed grain from corn borer protected corn. Food Chem Toxicol, 44, 1092-9. (Pubitemid 43850078)
76. Hammond B, Lemen J, Dudek R, et al. (2006b). Results of a 90 day safety assurance study with rats fed grain from corn rootworm protected corn. Food Chem Toxicol, 44, 147-60. (Pubitemid 41773809)
77. Hammond BG, Lemen JK, Ahmed G, et al. (2008). Safety assessment of SDA soybean oil: results of a 28-day gavage study and a 90-day/one generation reproduction feeding study in rats. Regul Toxicol Pharmacol, 52, 311-23.
78. Hammond B, Rogers SG, Fuchs RL. (1996a). Limitations of whole food feeding studies in food safety assessment. In: Thomas JA, Fuchs RL. Food safety evaluation. Paris: Organization for Economic Co-operation and Development, 85-97.
79. Hammond BG, Vicini JL, Hartnell GF, et al. (1996b). The feeding value of soybeans fed to rats, poultry, catfish and dairy cattle is not altered by incorporation of glyphosate tolerance. J Nutr, 126, 717-27. (Pubitemid 26081181)
80. Hard GC, Johnson KJ, Cohen SM. (2009). A comparison of rat chronic progressive nephropathy with human renal disease-implications for human risk assessment. Crit Rev Toxicol, 39, 332-46.
81. Harrigan GG, Glenn KC, Ridley WP. (2010). Assessing the natural variability in crop composition. Reg Toxicol Pharmacol, 58, S13-20.
82. Haslberger AG. (2003). Codex guidelines for GM foods include the analysis of unintended effects. Nat Biotechnol, 21, 739-41. (Pubitemid 36791385)
83. He XY, Huang KL, Li X, et al. (2008). Comparison of grain from corn rootworm resistant transgenic DAS-59122-7 maize with non-transgenic maize grain in a 90-day feeding study in Sprague-Dawley rats. Food Chem Toxicol, 46, 1994-2002.
84. He XY, Tang MZ, Luo YB, et al. (2009). A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats. Food Chem Toxicol, 47, 425-32.
85. Healy C, Hammond B, Kirkpatrick J. (2008). Results of a 13-week safety assurance study with rats fed grain from corn rootworm-protected, glyphosate-tolerant MON 88017 corn. Food Chem Toxicol, 46, 2517-24.
86. Herman RA, Dunville CM, Juberg DR, et al. (2011a). Performance of broiler chickens fed event DAS-40278-9 maize containing the aryloxyalkanoate dioxygenase-1 protein. Regul Toxicol Pharmacol, 60, 296-9.
87. Herman RA, Dunville CM, Juberg DR, et al. (2011b). Performance of broiler chickens fed diets containing DAS-68416-4 soybean meal. GM Crops, 2, 169-75.
88. Huang J, Yang J. (2011). China's agricultural biotechnology regulations-export and import considerations. Washington DC: International Food and Agricultural Trade Policy Council. Available from: http://www.agritrade.org/ Publications/documents/LLPChina.pdf [last accessed 24 Jul 2013].
89. Hyun Y, Bressner GE, Ellis M, et al. (2004). Performance of growingfinishing pigs fed diets containing Roundup Ready corn (event nk603), a nontransgenic genetically similar corn, or conventional corn lines. J Anim Sci, 82, 571-80. (Pubitemid 38572390)
90. Hyun Y, Bressner GE, Fischer RL, et al. (2005). Performance of growing-finishing pigs fed diets containing YieldGard Rootworm corn (MON 863), a nontransgenic genetically similar corn, or conventional corn hybrids. J Anim Sci, 83, 1581-90.
91. IFBiC. (1990). Safety evaluation of whole foods and other complex mixtures. Reg Toxicol Pharmacol, 12, S136-58.
92. ILSI. (2003). Best practices for the conduct of animal studies to evaluate crops genetically modified for input traits. Washington DC: International Life Sciences Institute.
93. ILSI. (2004). Nutritional and safety assessments of foods and feeds nutritionally improved through biotechnology: an executive summary. J Food Sci, 69, 62-8.
94. ILSI. (2008). Nutritional and safety assessments of foods and feeds nutritionally improved through biotechnology: case studies, prepared by a task force of the International Life Sciences Institute, Washington, DC. Comp Rev Food Sci Food Safety, 7, 50-112.
95. INCHEM (International Program on Chemical Safety). (2012). Chemical safety information from intergovernmental organizations: strychnine. Available from: http://www.inchem.org/documents/pims/chemical/pim507.htm [last accessed 25 September 2013].
96. Ipharraguerre IR, Younker RS, Clark JH, et al. (2003). Performance of lactating dairy cows fed corn as whole plant silage and grain produced from a glyphosate-tolerant hybrid (event NK603). J Dairy Sci, 86, 1734-41. (Pubitemid 38995066)
97. Ioannidis JPA. (2005). Why most published research findings are false. PLoS Med, 2, e124.
98. Jacobs CM, Utterback PL, Parsons CM, et al. (2008). Performance of laying hens fed diets containing DAS-59122-7 maize grain compared with diets containing nontransgenic maize grain. Poult Sci, 87, 475-9. (Pubitemid 351406122)
99. James C. (2011). ISAAA briefs. Global status of commercialized biotech/GM Crops: 2010. Brief 42. Ithaca, NY: ISAAA.
100. James C. (2012). ISAAA Briefs. Global status of commercialized biotech/GM Crops: 2012. Brief 44. Ithaca, NY: ISAAA.
101. Juskiewicz J, Zdunczyk Z, Fornal J. (2005). Nutritional properties of tubers of conventionally bred and transgenic lines of potato resistant to necrotic strain of Potato virus Y (PVYN). Acta Biochim Pol, 52, 725-9. (Pubitemid 41571721)
102. Kamal A, Kamal YT, Ahmad S, et al. (2012). Simultaneous HPTLC determination of strychnine and brucine in strychnos nux-vomica seed. J Pharm Bioallied Sci, 4, 134-9.
103. Keenan C, Elmore S, Francke-Carroll S, et al. (2009). Best practices for use of historical control data of proliferative rodent lesions. Toxicol Pathol, 37, 679-93.
104. Kilic A, Akay MT. (2008). A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation. Food Chem Toxicol, 46, 1164-70.
105. Kim SL, Berhow MA, Kim JT, et al. (2006). Evaluation of soya saponin, isoflavone, protein, lipid, and free sugar accumulation in developing soybean seeds. J Ag Food Chem, 54, 10003-10. (Pubitemid 46159003)
106. Kitta K, Ebihara M, Hino A, et al. (2005). Food composition database for safety assessment of genetically modified crops as foods and feeds. Jpn J Food Chem, 12, 1-9 [in Japanese].
107. Kok EJ, Keijer J, Kleter GA, Kuiper HA. (2008). Comparative safety assessment of plant-derived foods. Regul Toxicol Pharmacol, 50, 98-113. (Pubitemid 350298166)
108. Konig A, Cockburn A, Crevel RW, et al. (2004). Assessment of the safety of foods derived from genetically modified (GM) crops. Food Chem Toxicol, 42, 1047-88. (Pubitemid 38584591)
109. Kuiper HA, Kleter GA. (2003). The scientific basis for risk assessment and regulation of genetically modified foods. Trends Food Sci Technol, 14, 277-93. (Pubitemid 36774651)
110. Lavrik PB, Bartnicki DE, Feldman J, et al. (1995). Safety assessment of potatoes resistant to Colorado potato beetle. In: Engel K-H, Takeoka GR, Teranishi R, eds. Genetically modified foods. Washington, DC: American Chemical Society, 148-58.
111. Lewis RW, Billington R, Debryune E, et al. (2002). Recognition of adverse and nonadverse effects in toxicity studies. Toxicol Pathol, 30, 66-74. (Pubitemid 34194560)
112. Liu P, He X, Chen D, et al. (2012). A 90-day subchronic feeding study of genetically modified maize expressing Cry1Ac-M protein in Sprague-Dawley rats. Food Chem Tox, 50, 3215-21.
113. Llorente B, Alonso GD, Bravo-Almonacid F, et al. (2011). Safety assessment of nonbrowning potatoes: opening the discussion about the relevance of substantial equivalence on next generation biotech crops. Plant Biotech J, 9, 136-50.
114. MacKenzie SA, Lamb I, Schmidt J, et al. (2007). Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats. Food Chem Toxicol, 45, 551-62. (Pubitemid 46209457)
115. Magana-Gomez JA, Cervantes GL, Yepiz-Plascencia G, de la Barca AM. (2008). Pancreatic response of rats fed genetically modified soybean. J Appl Toxicol, 28, 217-26. (Pubitemid 351428295)
116. Malatesta M, Caporaloni C, Gavaudan S, et al. (2002a). Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean. Cell Struct Func, 27, 173-80. (Pubitemid 35423156)
117. Malatesta M, Caporaloni C, Rossi L, et al. (2002b). Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean. J Anat, 201, 409-15. (Pubitemid 35331711)
118. Malatesta M, Biggiogera M, Manuali E, et al. (2003). Fine structural analyses of pancreatic acinar cell nuclei from mice fed on genetically modified soybean. Eur J Histochem, 47, 385-8. (Pubitemid 38029620)
119. Malatesta M, Tiberi C, Baldelli B, et al. (2005). Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean. Eur J Histochem, 49, 237-42.
120. Malatesta M, Boraldi F, Annovi G, et al. (2008). A long-term study on female mice fed on a genetically modified soybean: effect on liver ageing. Histochem Cell Biol, 130, 967-77.
121. Malley LA, Everds NE, Reynolds J, et al. (2007). Subchronic feeding study of DAS-59122-7 maize grain in Sprague Dawley rats. Food Chem Toxicol, 45, 1277-92. (Pubitemid 46590568)
122. McDonald JH. (2009). Handbook of biological statistics. 2nd ed. Baltimore, MD: Sparky House Publishing.
123. McNaughton J, Roberts M, Smith B, et al. (2007). Comparison of broiler performance when fed diets containing event DP-356Ø43-5 (Optimum GAT), nontransgenic near-isoline control, or commercial reference soybean meal, hulls, and oil. Poult Sci, 86, 2569-81. (Pubitemid 350223835)
124. McNaughton J, Roberts M, Smith B, et al. (2008). Comparison of broiler performance and carcass yields when fed diets containing transgenic maize grains from event DP-O9814O-6 (Optimum GAT), nearisogenic control maize grain, or commercial reference maize grains. Poult Sci, 87, 2562-72.
125. McNaughton J, Roberts M, Rice D, et al. (2011a). Comparison of broiler performance and carcass yields when fed transgenic maize grain containing event DP-O9814O-6 and processed fractions from transgenic soybeans containing event DP-356O43-5. Poult Sci, 90, 1701-11.
126. McNaughton J, Roberts M, Rice D, et al. (2011b). Nutritional equivalency evaluation of transgenic maize grain from event DPO9814O-6 and transgenic soybeans containing event DP-356O43-5: laying hen performance and egg quality measures. Poult Sci, 90, 377-89.
127. Meija L, Jacobs CM, Utterback PL, et al. (2010). Evaluation of the nutritional equivalency of soybean meal with the genetically modified trait DP-3Ç5423-1 when fed to laying hens. Poult Sci, 89, 2634-9.
128. Mitra S, Sukla VJ, Acharya R. (2011). Effect of Shodhana (processing) on Kupeelu (Strychnos nux-vomica Linn.) with special reference to strychnine and brucine content. Ayu J, 32, 402-7.
129. Mohanta RK, Singhal KK, Tyagi AK, et al. (2010). Nutritional evaluation of transgenic cottonseed in the ration of lactating dairy cows. Trop Anim Health Prod, 42, 431-8.
130. Momma K, Hashimoto W, Yoon HJ, et al. (2000). Safety assessment of rice genetically modified with soybean glycinin by feeding studies on rats. Biosci Biotechnol Biochem, 64, 1881-6.
131. Mugford CA, Kedderis GL. (1998). Sex-dependent metabolism of xenobiotics. Drug Metab Rev, 30, 441-98. (Pubitemid 28384436)
132. Noteborn HPJM, Bienenmann-Ploum ME, Alink GM, et al. (1995). Safety assessment of the Bacillus thuringiensis insecticidal crystal protein Cry1A9b) expressed in transgenic tomatoes. In: Fenwick GR, Hedley C, Richards RL, Khokhar S, eds. Agri-food quality: an interdisciplinary approach. Cambridge, UK: Royal Society of Chemistry, 23-6.
133. NNT (Nordic Working Group on Food Toxicology and Risk Assessment). (1991). 1991 Food and new biotechnology-novelty, safety and control aspects of foods made by new biotechnology. NORD (Series) 18. Copenhagen, Stockholm: Nordic Council of Ministers.
134. OECD. (1993). Safety evaluation of foods derived by modern biotechnology. Paris, France, OECD. Available from: http://www.oecd.org/dataoecd/37/18/ 41036698.pdf [last accessed on 10 Feb 2013].
135. OECD. (1997). Report of the OECD workshop on the toxicological and nutritional testing of novel foods. SG/ICGB(98)1. Paris, France: OECD.
136. OECD. (1998). Test No. 408: Repeated dose 90-day oral toxicity study in rodents. In: OECD guidelines for the testing of chemicals, Section, 4, health effects. Paris, France: OECD. Available from: http://browse. oecdbookshop.org/oecd/pdfs/free/9740801e.pdf [last accessed 10 Feb 2013].
137. OECD. (2001). Consensus document on compositional considerations for new varieties of soybean: key food and feed nutrients and antinutrients. ENV/JM/MONO(2001)15. Paris, France: OECD.
138. OECD. (2002). Series on the Safety of Novel Foods and Feeds, No. 6. Consensus document on compositional considerations for new varieties of maize (Zea Mays): Key food and feed nutrients, antinutrients and secondary plant metabolites. ENV/JM/MONO(2002)25. Paris, France: OECD. Available from: http://www.oecd.org/officialdocuments/displaydocumentpdf/?cote=env/jm/mono(2002) 25&doclanguage= en [last accessed on 10 Feb 2013].
139. OECD. (2004). Consensus Document on Compositional Considerations for New Varieties of Rice (Oryza sativa): Key Food and Feed Nutrients, Anti-Nutrients (Jt00168114). Paris, France: OECD.
140. OECD. (2006). Series on the Safety of Novel Foods and Feeds, No. 14. An introduction to the food/feed safety consensus documents of the Task Force. Report of the Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. Paris, France: OECD. Available from: http://www.oecd.org/officialdocuments/displaydocumentpdf/?cote=env/jm/mono(2006) 10&doclanguage= en [last accessed 10 Feb 2013].
141. OECD. (2008). Test No. 407: Repeated dose 28-day oral toxicity study in rodents. In: OECD Guidelines for the Testing of Chemicals, Section, 4, Health Effects. Paris, France: OECD. Available from: http://www.oecd-ilibrary.org/ environment/test-no-407-repeated-dose-28-day-oral-toxicity-study-in-rodents- 9789264070684-en [last accessed 10 Feb 2013].
142. OECD. (2012). Consensus documents for the work on the safety of novel foods and feeds. Available from: http://www.oecd.org/document/39/0,3746,en-2649- 34385-46805223-1-1-1-1,00.html [last accessed 10 Feb 2013].
143. Parrott W, Chassy B, Ligon J, et al. (2010). Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops. Food Chem Toxicol, 48, 1773-90.
144. Peterson BA, Hyun Y, Stanisiewski EP, et al. (2008). Performance of growing-finishing pigs fed diets containing Roundup Ready wheat (MON 71800), a non-transgenic genetically similar wheat, or conventional wheat varieties. Animal, 2, 1602-9.
145. Phipps RH, Jones AK, Tingey AP, Abeyasekera S. (2005). Effect of corn silage from an herbicide-tolerant genetically modified variety on milk production and absence of transgenic DNA in milk. J Dairy Sci, 88, 2870-8. (Pubitemid 41096450)
146. Poulsen M, Kroghsbo S, Schrøder M, et al. (2007a). A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem Toxicol, 45, 350-63. (Pubitemid 46176366)
147. Poulsen M, Schrøder M, Wilcks A, et al. (2007b). Safety testing of GMrice expressing PHA-E lectin using a new animal test design. Food Chem Toxicol, 45, 364-77. (Pubitemid 46188377)
148. Qi X, He X, Luo Y, et al. (2012). Subchronic feeding study of stacked trait genetically-modified soybean (3Ç5423x40-3-2) in Sprague-Dawley rats. Food Chem Tox, 50, 3256-63.
149. Reuter T, Aulrich K, Berk A. (2002a). Investigations on genetically modified maize (Bt-maize) in pig nutrition: fattening performance and slaughtering results. Arch Anim Nutr, 56, 319-26.
150. Reuter T, Aulrich K, Berk A, Flachowsky G. (2002b). Investigations on genetically modified maize (Bt-maize) in pig nutrition: chemical composition and nutritional evaluation. Arch Anim Nutr, 56, 23031.
151. Rhee GS, Cho DH, Won YH, et al. (2005). Multigeneration reproductive and developmental toxicity study of bar gene inserted into genetically modified potato in rats. J Toxicol Environ Health A, 68, 2263-76.
152. Rice EA, Lee TC, Rogan G, Bannon GA. (2008). Safety assessment of proteins used in crops developed through agricultural biotechnology-industry perspective. In: Hammond BG, ed. Food safety of proteins in agricultural biotechnology. Boca Raton, FL: CRC Press, Taylor and Francis, 237-58.
153. Ricroch AE. (2012). Assessment of GE food safety using '-omics' techniques and long term animal feeding studies. N Biotechnol, 30, 349-54.
154. Rossi F, Morlacchini M, Fusconi G, et al. (2005). Effect of Bt corn on broiler growth performance and fate of feed-derived DNA in the digestive tract. Poult Sci, 84, 1022-30. (Pubitemid 41097334)
155. Royal Society. (1999). Review of data on possible toxicity of GM potatoes. The Royal Society Ref 11/99. London, UK: Royal Society. Available from: http://royalsociety.org/policy/publications/1999/toxicity-gm-potatoes/ [last accessed 10 Feb 2013].
156. Schorsch F, Alison A, Groters S, et al. (2013). Letter to the editor: Serious inadequacies regarding the pathology data presented in the paper by Seralini et al. (2012). Food Chem Toxicol, 53, 465-6.
157. Schrøder M, Poulsen M, Wilcks A, et al. (2007). A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem Toxicol, 45, 339-49. (Pubitemid 46176364)
158. Seralini GE, Cellier D, de Vendomois JS. (2007). New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity. Arch Environ Contam Toxicol, 52, 596-602. (Pubitemid 46626285)
159. Seralini GE, de Vendomois JS, Cellier D, et al. (2009). How subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals. Int J Biol Sci, 5, 438-43.
160. Seralini GE, Clair E, Mesnage R, et al. (2012). Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem Toxicol, 53, 4221-331.
161. Shimada N, Murata H, Mikami O, et al. (2006). Effects of feeding calves genetically modified corn Bt11: a clinico-biochemical study. J Vet Med Sci, 68, 1113-15. (Pubitemid 44721880)
162. Sidhu RS, Hammond BG, Fuchs RL, et al. (2000). Glyphosate-tolerant corn: the composition and feeding value of grain from glyphosatetolerant corn is equivalent to that of conventional corn (Zea mays L.). J Agric Food Chem, 48, 2305-12. (Pubitemid 30431232)
163. Singhal KK, Tyagi AK, Rajput YS, et al. (2011). Feed intake, milk production and composition of crossbred cows fed with insectprotected Bollgard II cottonseed containing Cry1Ac and Cry2Ab proteins. Animal, 5, 1769-73.
164. Snell, C., Bernheim A, Berge J, et al. (2012). Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food Chem Tox, 50, 1134-48.
165. Stein HH, Rice DW, Smith BL, et al. (2009). Evaluation of corn grain with the genetically modified input trait DAS-59122-7 fed to growing-finishing pigs. J Anim Sci, 87, 1254-60.
166. Steiner H-Y, Halpin C, Jez JM, et al. (2013). Editor's choice: Evaluating the potential for adverse interactions within genetically engineered breeding stacks. Plant Physiol, 161, 1587-94.
167. Steinke K, Guertler P, Paul V, et al. (2010). Effects of long-term feeding of genetically modified corn (event MON810) on the performance of lactating dairy cows. J Anim Physiol Anim Nutr (Berl), 94, e185-93.
168. Tang M, Xie T, Cheng W, et al. (2011). A 90-day safety study of genetically modified rice expressing rhIGF-1 protein in C57BL/6J rats. Transgenic Res, 21, 499-510.
169. Taylor M, Hartnell G, Lucas D, et al. (2007a). Comparison of broiler performance and carcass parameters when fed diets containing soybean meal produced from glyphosate-tolerant (MON 89788), control, or conventional reference soybeans. Poult Sci, 86, 2608-14. (Pubitemid 350223839)
170. Taylor M, Hartnell G, Nemeth M, et al. (2007b). Comparison of broiler performance when fed diets containing grain from second-generation insect-protected and glyphosate-tolerant, conventional control or commercial reference corn. Poult Sci, 86, 1972-9. (Pubitemid 47580904)
171. Taylor M, Lucas D, Nemeth M, et al. (2007c). Comparison of broiler performance and carcass parameters when fed diets containing combined trait insect-protected and glyphosate-tolerant corn (MON 89034 X NK603), control, or conventional reference corn. Poult Sci, 86, 1988-94. (Pubitemid 47580906)
172. Taylor ML, Hartnell GF, Riordan SG, et al. (2003). Comparison of broiler performance when fed diets containing grain from Roundup Ready (NK603), YieldGard X Roundup Ready (MON810 X NK603), non-transgenic control, or commercial corn. Poult Sci, 82, 443-53. (Pubitemid 38641963)
173. Taylor ML, Stanisiewski EP, Riordan SG, et al. (2004). Comparison of broiler performance when fed diets containing Roundup Ready (event RT73), nontransgenic control, or commercial canola meal. Poult Sci, 83, 456-61. (Pubitemid 39197265)
174. Taylor ML, Hartnell G, Nemeth M, et al. (2005). Comparison of broiler performance when fed diets containing corn grain with insectprotected (corn rootworm and European corn borer) and herbicidetolerant (glyphosate) traits, control corn, or commercial reference corn-revisited. Poult Sci, 84, 1893-9. (Pubitemid 44509946)
175. Teshima R, Akiyama H, Okunuki H, et al. (2000). Effect of GM and non-GM soybeans on the immune system of BN rats and B10A mice. J Food Hygenic Soc Japan, 41, 188-93. (Pubitemid 30484397)
176. Teshima R, Watnabe T, Okunuki H, et al. (2002). Effect of subchronic feeding of genetically modified corn (CBH351) on immune system in BN rats and B10A mice. J Food Hygenic Soc Japan, 43, 273-9. (Pubitemid 35428923)
177. Tomatis L, Partensky C, Montesano R. (1973). The predictive value of mouse liver tumour induction in carcinogenicity testing-a literature survey. Int J Cancer, 12, 1-20.
178. Tony MA, Butschke A, Broll H, et al. (2003). Safety assessment of Bt 176 maize in broiler nutrition: degradation of maize-DNA and its metabolic fate. Arch Anim Nutr, 57, 235-52.
179. US EPA. (2012). History of food irradiation. Available from: http://www.epa.gov/radiation/sources/food-history.html [last accessed 10 Feb 2013].
180. Velimirov A, Binter C, Zentek J. (2008). Biological effects of transgenic maize NK603xMON810 fed in long-term reproduction studies in mice. Food Standards Australia New Zealand, April 2010. Available from: http://www.biosicherheit.de/pdf/aktuell/zentek-studie-2008.pdf [last accessed 18 March 2013].
181. Wainwright PE, Huang YS, DeMichele SJ, et al. (2003). Effects of highgamma-linolenic acid canola oil compared with borage oil on reproduction, growth, and brain and behavioral development in mice. Lipids, 38, 171-8. (Pubitemid 36457726)
182. Walsh MC, Buzoianu SG, Gardiner GE, et al. (2012). Effects of short-term feeding of Bt MON810 maize on growth performance, organ morphology and function in pigs. Br J Nutr, 107, 364-71.
183. Watson SA. (2003). Description, development, structure and composition of the corn kernel. In: White PJ, Johnson LA, eds. Corn: chemistry and technology. 2nd ed. St. Paul, MN: American Association of Cereal Chemists, 69-106.
184. Weber N, Halpin C, Hannah LC, et al. (2012). Editor's choice: crop genome plasticity and its relevance to food and feed safety of genetically engineered breeding stacks. Plant Physiol, 160, 1842-53.
185. WHO. (1999). Technical Report Series 890. High-dose irradiation: wholesomeness of food irradiated with doses above 10kGy. Report of a Joint FAO/IAEA/WHO Study Group. Geneva, Switzerland: World Health Organization.
186. Williams AL, DeSesso JM. (2010). Genetically-modified soybeans-a critical evaluation of studies addressing potential ultrastructural changes associated with ingestion. Toxicologist, 114, 1154.
187. Yazdi-Samadi B, Rinne RW, Seif RD. (1977). Components of developing soybean seeds; oil, protein, sugars, starch, organic acids, and amino acids. Agron J, 69, 481-6.
188. Yonemochi C, Fujisaki H, Harada C, et al. (2002). Evaluation of transgenic event CBH 351 (StarLink) corn in broiler chicks. Anim Sci J, 73, 221-8.
189. Yonemochi C, Ikeda T, Harada C, et al. (2003). Influence of transgenic corn (CBH 351, named Starlink) on health condition of dairy cows and transfer of Cry9C protein and cry9c gene to milk, blood, liver and muscle. Anim Sci J, 74, 81-8. (Pubitemid 37458051)
190. Yonemochi C, Suga K, Harada C, Hanazumi M. (2010). Evaluation of transgenic event CBH 351 (StarLink) corn in pig. Anim Sci J, 81, 94-101.
191. Zhou XH, Dong Y, Xiao X, et al. (2011). A 90-day toxicology study of high-amylose transgenic rice grain in Sprague-Dawley rats. Food Chem Tox, 49, 3112-18.
192. Zhu Y, He X, Luo Y, et al. (2013). A 90-day feeding study of glyphosatetolerant maize with the G2-aroA gene in Sprague-Dawley rats. Food Chem Tox, 51, 280-7.
193. Zhu Y, Li D, Wang F, et al. (2004). Nutritional assessment and fate of DNA of soybean meal from Roundup Ready or conventional soybeans using rats. Arch Anim Nutr, 58, 295-31.