A 90-day feeding study of glyphosate-tolerant maize with the G2-aroA gene in Sprague-Dawley rats

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 280-287

  Zhu, Yaxi ^a   He, Xiaoyun ^a,b   Luo, Yunbo ^a,b   Zou, Shiying ^b   Zhou, Xin ^b   Huang, Kunlun ^a,b   Xu, Wentao ^a,b  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b AGRO ENVIRONMENTAL PROTECTION INSTITUTE   (China)

Author keywords

90 Day feeding study; G2 aroA; Genetically modified; Glyphosate tolerant; Maize

Indexed keywords

GLYPHOSATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FOOD INTAKE; FOOD SAFETY; G2 AROA GENE; GENETICALLY MODIFIED FOOD; GRAIN; HEMATOLOGICAL PARAMETERS; MAIZE; MALE; NONHUMAN; ORGAN WEIGHT; PATHOLOGY; PLANT GENE; RAT; SERUM CHARACTERISTICS;

ANIMAL FEED; ANIMALS; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; FEMALE; GENES, PLANT; GLYCINE; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PLANTS, GENETICALLY MODIFIED; RATS; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS; ZEA MAYS;

RATTUS; RODENTIA; ZEA MAYS;

EID: 84868217053     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.09.008     Document Type: Article

References (41)

1. Appenzeller L.M., Munley S.M., Hoban D., Sykes G.P., Malley L.A., Delaney B. Subchronic feeding study of herbicide-tolerant soybean DP-356-5 in Sprague-Dawley rats. Food Chem. Toxicol. 2008, 46:2201-2213.
2. Appenzeller L.M., Malley L., MacKenzie S.A., Hoban D., Delaney B. Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1×DAS-59122-7) maize grain in Sprague-Dawley rats. Food Chem. Toxicol. 2009, 47:1512-1520.
3. Appenzeller L.M., Munley S.M., Hoban D., Sykes G.P., Malley L.A., Delaney B. Subchronic feeding study of grain from herbicide-tolerant maize DP-Ø9814Ø-6 in Sprague-Dawley rats. Food Chem. Toxicol. 2009, 47:2269-2280.
4. Briggs S.P., Koziel M. Engineering new plant strains for commercial markets. Curr. Opin. Biotechnol. 1998, 9:233-235.
5. Castle L.A., Siehl D.L., Gorton R., Patten P.A., Chen Y.H., Bertain S., Cho H.J., Duck N., Wong J., Liu D., Lassner M.W. Discovery and directed evolution of a glyphosate tolerance gene. Science 2004, 304:1151-1154.
6. Comai L., Facciotti D., Hiatt W.R., Thompson G., Rose R.E., Stalker D.M. Expression in plants of a mutant aroA gene from Salmonella typhimurium confers tolerance to glyphosate. Nature 1985, 317:741-745.
7. Dill G.M., CaJacob C.A., Padgette S.R. Glyphosate-resistant crops: adoption, use and future considerations. Pest Manage. Sci. 2008, 64:326-331.
8. Doull J., Gaylor D., Greim H.A., Lovell D.P., Lynch B., Munro I.C. Report of an expert panel on the reanalysis by Séralini et al. (2007) of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety(MON 863). Food Chem. Toxicol. 2007, 45:2073-2085.
9. Dryzga M.D., Yano B.L., Andrus A.K., Mattsson J.L. Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats. Food Chem. Toxicol. 2007, 45:1994-2004.
10. Duke S.O. Taking stock of herbicide-resistant crops ten years after introduction. Pest Manage. Sci. 2005, 61:211-218.
11. Dun B.Q., Wang X.J., Lu W., Zhao Z.L., Hou S.N., Zhang B.M., Li G.Y., Evans T.C., Xu M.Q., Lin M. Reconstitution of glyphosate resistance from a split 5-enolpyruvyl shikimate -3-phosphate synthase gene in Escherichia coli and transgenic tobacco. Appl. Environ. Microbiol. 2007, 73:7997-8000.
12. Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials. Food Chem. Toxicol. 2008, 46:S2-S70. EFSA.
13. FAO, 1996. Biotechnology and food safety. Report of a joint FAO/WHO consultation. FAO Food and Nutrition Paper 61, Food and Agriculture Organization of the United Nations, Rome, Italy.
14. FAO/WHO, 2000. Safety aspects of genetically modified foods of plant origin. Report of a joint FAO/WHO expert consultation on foods derived from biotechnology, Geneva, Switzerland, 29 May-2 June 2000, Food and Agriculture Organization of the United Nations, Rome, Italy.
15. Fillatti J.J., Kiser J., Rose R., Comai L. Efficient transfer of glyphosate tolerance gene into tomato using a binary Agrobacterium tumefaciens vector. Nat. Biotechnol. 1987, 5:726-730.
16. Green J.M., Hazel C.B., Forney D.B., Pugh L.M. New multiple-herbicide crop resistance and formulation technology to augment the utility of glyphosate. Pest Manage. Sci. 2008, 64:332-339.
17. Green J.M. Evolution of glyphosate-resistant crop technology. Weed Sci. 2009, 57:108-117.
18. James, C., 2012, Executive summary: global status of commercialized biotech/GM crops: 2012. ISAAA Brief. No. 44.
19. Hammond B., Dudek R., Lemen J., Nemeth M. Results of a 13 week safety assurance study with rats fed grain from glyphosate-tolerant corn. Food Chem. Toxicol. 2004, 42:1003-1014.
20. Hammond B., Lemen J., Dudek R., Ward D., Jiang C., Nemeth M., Burns J. Results of a 90-day safety assurance study with rats fed grain from corn rootworm-protected corn. Food Chem. Toxicol. 2006, 44:147-160.
21. Hammond B., Dudek R., Lemen J., Nemeth M. Results of a 90-day safety assurance study with rats fed grain from corn borer-protected corn. Food Chem. Toxicol. 2006, 44:1092-1099.
22. He X.Y., Huang K.L., Li X., Qin W., Delaney B., Luo Y.B. Comparison of grain from corn rootworm resistant transgenic DAS-59122-7 maize with non-transgenic maize grain in a 90-day feeding study in Sprague-Dawley rats. Food Chem. Toxicol. 2008, 46:1994-2002.
23. He X.Y., Tang M.Z., Luo Y.B., Li X., Cao S.S., Yu J.J., Delaney B., Huang K.L. A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats. Food Chem. Toxicol. 2009, 47:425-432.
24. Herouet-Guicheney C., Rouquié D., Freyssinet M., Currier T., Martone A., Zhou J., Bates E.E.M., Ferullo J.M., Hendrickx K., Rouan D. Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants. Regul. Toxicol. Pharm. 2009, 54:143-153.
25. ILSI (International Life Sciences Institute), 1996. The safety assessment of novel foods: guidelines prepared by ILSI Europe Novel Food and Task Force. International Life Sciences Institute, European Branch, Brussels, Belgium.
26. Kroghsbo S., Madsen C., Poulsen M., Schrøder M., Kvist P.H., Taylor M., Gatehouse A., Shu Q.Y., Knudesn I.B. Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats. Toxicology 2008, 245:24-34.
27. MacKenzie S.A., Lamb I., Schmidt J., Deege L., Morrisey M.J., Harper M., Layton R.J., Prochaska L.M., Sanders C., Locke M., Mattsson J.L., Fuentes A., Delaney B. Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats. Food Chem. Toxicol. 2007, 45:551-562.
28. Malley L.A., Everds N.E., Reynolds J., Mann P.C., Lamb I., Rood T., Schmidt J., Layton R.J., Prochaska L.M., Hinds M., Locke M., Chui C.F., Claussen F., Mattsson J.L., Delaney B. Subchronic feeding study of DAS-59122-7 maize grain in Sprague-Dawley rats. Food Chem. Toxicol. 2007, 45:1277-1292.
29. Noteborn H.P.J.M., Bienenmann-Ploum M.E., Van Den Berg J.H.J., Alink G.M., Zolla L., Reynaerts A., Pensa M., Kuiper H.A. Safety assessment of the Bacillus thuringiensis insecticidal crystal protein CRYIA(b) expressed in transgenic tomatoes. In: Genetically Modified Foods-Safety Aspects, ACS Symposium Series 605. J. Am. Chem. Soc. 1995, 12:134-147.
30. OECD, 1993. Safety Evaluation of Foods Produced by Modern Biotechnology, Concepts and Principles. Organization for Economic Cooperation and Development, Paris, France.
31. OECD, 1996. Food Safety Evaluation. Organization for Economic Cooperation and Development (OECD), Paris, France.
32. OECD, 1997. Report of the OECD Workshop on the Toxicological and Nutritional Testing of Novel Foods. Aussois, France, 5-8 March 1997. Organization for Economic Cooperation and Development (OECD), Paris, France.
33. Schroder M., Poulsen M., Wilcks A., Kroghsbo S., Miller A., Frenzel T., Danier J., Rychlik M., Emami K., Gatehouse A., Shu Q., Engel K.-H., Altosaar I., Knudsen I. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem. Toxicol. 2007, 45:339-349.
34. Padgette S.R., Taylor N.B., Nida D.L., Bailey M.R., Macdonald J., Holden L.R., Fuchs R.L. The composition of glyphosate-tolerant soybean seeds is equivalent to that of conventional soybeans. J. Nutr. 1996, 126:702-716.
35. Pauli G.H., Takeguchi C.A. Irradiation of foods - an FDA perspective. Food Rev. Int. 1986, 2:79-107.
36. Shan D.M., Horsch R.B., Klee H.J., Kishore G.M., Winter J.M., Tumer N.E., Hironaka C.M., Sanders P.R., Gasser C.S., Aykent S., Siegel N.R., Rogers S.G., Fraley R.T. Engineering herbicide tolerance in transgenic plants. Science 1986, 233:478-481.
37. WHO, 1991. Strategies for assessing the safety of foods produced by biotechnology. Report of a Joint FAO/WHO Consultation. World Health Organization, Geneva, Switzerland.
38. WHO, 1995. Application of the principles of substantial equivalence to the safety evaluation of foods and food components from plants derived from modern biotechnology. Report of a WHO Workshop. World Health Organization, Geneva, Switzerland.
39. Wang Z.H., Wang Y., Cui H.R., Xia Y.W., Altosaar I., Shu Q.Y. Toxicological evaluation of transgenic rice flour with a synthetic cry1Ab gene from Bacillus thuringiensis. J. Sci. Food Agric. 2002, 82:738-744.
40. Zhu Y., Yu Z.L., Lin M. Bioresistance or biodegradation of glyphosate and construction of transgenic plants. Mol. Plant Breed. 2003, 4:435-441.
41. Zhu Y., Li D., Wang F., Yin J., Jin H. Nutritional assessment and fate of DNA of soybean meal from Roundup Ready or conventional soybeans using rats. Arch. Anim. Nutr. 2004, 58:295-310.