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Volumn 50, Issue 11, 2012, Pages 4221-4231

Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize

Author keywords

Endocrine disrupting effects; Glyphosate based herbicides; GMO; NK603; Rat; Roundup

Indexed keywords

DNA; HERBICIDE; SEX HORMONE;

EID: 84867230284     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.08.005     Document Type: Article
Times cited : (283)

References (56)
  • 1
    • 77953287129 scopus 로고    scopus 로고
    • Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats
    • Baskaran N., Manoharan S., Balakrishnan S., Pugalendhi P. Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats. Eur. J. Pharmacol. 2010, 637:22-29.
    • (2010) Eur. J. Pharmacol. , vol.637 , pp. 22-29
    • Baskaran, N.1    Manoharan, S.2    Balakrishnan, S.3    Pugalendhi, P.4
  • 2
    • 61849171735 scopus 로고    scopus 로고
    • Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells
    • Benachour N., Seralini G.E. Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. Chem. Res. Toxicol. 2009, 22:97-105.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 97-105
    • Benachour, N.1    Seralini, G.E.2
  • 4
    • 22244437298 scopus 로고    scopus 로고
    • Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program
    • Brix A.E., Nyska A., Haseman J.K., Sells D.M., Jokinen M.P., Walker N.J. Incidences of selected lesions in control female Harlan Sprague-Dawley rats from two-year studies performed by the National Toxicology Program. Toxicol. Pathol. 2005, 33:477-483.
    • (2005) Toxicol. Pathol. , vol.33 , pp. 477-483
    • Brix, A.E.1    Nyska, A.2    Haseman, J.K.3    Sells, D.M.4    Jokinen, M.P.5    Walker, N.J.6
  • 5
    • 0026733538 scopus 로고
    • Spontaneous neoplasms in aged Sprague-Dawley rats
    • Chandra M., Riley M.G., Johnson D.E. Spontaneous neoplasms in aged Sprague-Dawley rats. Arch. Toxicol. 1992, 66:496-502.
    • (1992) Arch. Toxicol. , vol.66 , pp. 496-502
    • Chandra, M.1    Riley, M.G.2    Johnson, D.E.3
  • 7
    • 33747786945 scopus 로고    scopus 로고
    • Herbicide factsheet - Glyphosate
    • Cox C. Herbicide factsheet - Glyphosate. J. pestic. reform 2004, 24:10-15.
    • (2004) J. pestic. reform , vol.24 , pp. 10-15
    • Cox, C.1
  • 8
    • 33845311498 scopus 로고    scopus 로고
    • Unidentified inert ingredients in pesticides: implications for human and environmental health
    • Cox C., Surgan M. Unidentified inert ingredients in pesticides: implications for human and environmental health. Environ. Health Perspect. 2006, 114:1803-1806.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 1803-1806
    • Cox, C.1    Surgan, M.2
  • 9
    • 79952901043 scopus 로고    scopus 로고
    • A literature review on the safety assessment of genetically modified plants
    • Domingo J.L., Giné Bordonaba J. A literature review on the safety assessment of genetically modified plants. Environ. Int. 2011, 37:734-742.
    • (2011) Environ. Int. , vol.37 , pp. 734-742
    • Domingo, J.L.1    Giné Bordonaba, J.2
  • 10
    • 0037226084 scopus 로고    scopus 로고
    • Isoflavone, glyphosate, and aminomethylphosphonic acid levels in seeds of glyphosate-treated, glyphosate-resistant soybean
    • Duke S.O., Rimando A.M., Pace P.F., Reddy K.N., Smeda R.J. Isoflavone, glyphosate, and aminomethylphosphonic acid levels in seeds of glyphosate-treated, glyphosate-resistant soybean. J. Agric. Food. Chem. 2003, 51:340-344.
    • (2003) J. Agric. Food. Chem. , vol.51 , pp. 340-344
    • Duke, S.O.1    Rimando, A.M.2    Pace, P.F.3    Reddy, K.N.4    Smeda, R.J.5
  • 11
    • 84878088247 scopus 로고    scopus 로고
    • EPA, Basic Information about Glyphosate in Drinking Water. (Last access June).
    • EPA, 2012. Basic Information about Glyphosate in Drinking Water. (Last access June). http://water.epa.gov/drink/contaminants/basicinformation/glyphosate.cfm.
    • (2012)
  • 15
    • 67651014408 scopus 로고    scopus 로고
    • Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines
    • Gasnier C., Dumont C., Benachour N., Clair E., Chagnon M.C., Seralini G.E. Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology 2009, 262:184-191.
    • (2009) Toxicology , vol.262 , pp. 184-191
    • Gasnier, C.1    Dumont, C.2    Benachour, N.3    Clair, E.4    Chagnon, M.C.5    Seralini, G.E.6
  • 17
    • 1942489665 scopus 로고    scopus 로고
    • Results of a 13week safety assurance study with rats fed grain from glyphosate tolerant corn
    • Hammond B., Dudek R., Lemen J., Nemeth M. Results of a 13week safety assurance study with rats fed grain from glyphosate tolerant corn. Food Chem. Toxicol. 2004, 42:1003-1014.
    • (2004) Food Chem. Toxicol. , vol.42 , pp. 1003-1014
    • Hammond, B.1    Dudek, R.2    Lemen, J.3    Nemeth, M.4
  • 18
    • 28844459033 scopus 로고    scopus 로고
    • Results of a 90day safety assurance study with rats fed grain from corn rootworm-protected corn
    • Hammond B., Lemen J., Dudek R., Ward D., Jiang C., Nemeth M., Burns J. Results of a 90day safety assurance study with rats fed grain from corn rootworm-protected corn. Food Chem. Toxicol. 2006, 44:147-160.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 147-160
    • Hammond, B.1    Lemen, J.2    Dudek, R.3    Ward, D.4    Jiang, C.5    Nemeth, M.6    Burns, J.7
  • 19
    • 33744903623 scopus 로고    scopus 로고
    • Results of a 90day safety assurance study with rats fed grain from corn borer-protected corn
    • Hammond B.G., Dudek R., Lemen J.K., Nemeth M.A. Results of a 90day safety assurance study with rats fed grain from corn borer-protected corn. Food Chem. Toxicol. 2006, 44:1092-1099.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 1092-1099
    • Hammond, B.G.1    Dudek, R.2    Lemen, J.K.3    Nemeth, M.A.4
  • 20
    • 1842563805 scopus 로고    scopus 로고
    • A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment
    • Hard G.C., Khan K.N. A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol. Pathol. 2004, 32:171-180.
    • (2004) Toxicol. Pathol. , vol.32 , pp. 171-180
    • Hard, G.C.1    Khan, K.N.2
  • 21
    • 0034646213 scopus 로고    scopus 로고
    • Rat strain-specific actions of 17beta-estradiol in the mammary gland: correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers
    • Harvell D.M., Strecker T.E., Tochacek M., Xie B., Pennington K.L., McComb R.D., Roy S.K., Shull J.D. Rat strain-specific actions of 17beta-estradiol in the mammary gland: correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers. Proc. Natl. Acad. Sci. USA 2000, 97:2779-2784.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2779-2784
    • Harvell, D.M.1    Strecker, T.E.2    Tochacek, M.3    Xie, B.4    Pennington, K.L.5    McComb, R.D.6    Roy, S.K.7    Shull, J.D.8
  • 22
    • 76449105111 scopus 로고    scopus 로고
    • Unintended compositional changes in transgenic rice seeds (Oryza sativa L.) studied by spectral and chromatographic analysis coupled with chemometrics methods
    • Jiao Z., Si X.X., Li G.K., Zhang Z.M., Xu X.P. Unintended compositional changes in transgenic rice seeds (Oryza sativa L.) studied by spectral and chromatographic analysis coupled with chemometrics methods. J. Agric. Food. Chem. 2010, 58:1746-1754.
    • (2010) J. Agric. Food. Chem. , vol.58 , pp. 1746-1754
    • Jiao, Z.1    Si, X.X.2    Li, G.K.3    Zhang, Z.M.4    Xu, X.P.5
  • 23
    • 0037165813 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry method to determine alcohol ethoxylates and alkylamine ethoxylates in soil interstitial water, ground water and surface water samples
    • Krogh K.A., Vejrup K.V., Mogensen B.B., Halling-Sørensen B. Liquid chromatography-mass spectrometry method to determine alcohol ethoxylates and alkylamine ethoxylates in soil interstitial water, ground water and surface water samples. J. Chromatogr. A 2002, 957:45-57.
    • (2002) J. Chromatogr. A , vol.957 , pp. 45-57
    • Krogh, K.A.1    Vejrup, K.V.2    Mogensen, B.B.3    Halling-Sørensen, B.4
  • 27
    • 0036704287 scopus 로고    scopus 로고
    • Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean
    • Malatesta M., Caporaloni C., Gavaudan S., Rocchi M.B., Serafini S., Tiberi C., Gazzanelli G. Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean. Cell Struct. Funct. 2002, 27:173-180.
    • (2002) Cell Struct. Funct. , vol.27 , pp. 173-180
    • Malatesta, M.1    Caporaloni, C.2    Gavaudan, S.3    Rocchi, M.B.4    Serafini, S.5    Tiberi, C.6    Gazzanelli, G.7
  • 29
    • 85006851353 scopus 로고    scopus 로고
    • Hepatoma tissue culture (HTC) cells as a model for investigating the effects of low concentrations of herbicide on cell structure and function
    • Malatesta M., Perdoni F., Santin G., Battistelli S., Muller S., Biggiogera M. Hepatoma tissue culture (HTC) cells as a model for investigating the effects of low concentrations of herbicide on cell structure and function. Toxicol. In Vitro 2008, 22:1853-1860.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 1853-1860
    • Malatesta, M.1    Perdoni, F.2    Santin, G.3    Battistelli, S.4    Muller, S.5    Biggiogera, M.6
  • 31
    • 84856418881 scopus 로고    scopus 로고
    • Roundup in Genetically modified crops: Regulation and toxicity in mammals
    • Mesnage R., Clair E., Séralini G.-E. Roundup in Genetically modified crops: Regulation and toxicity in mammals. Theorie in der ökologie 2010, 16:31-33.
    • (2010) Theorie in der ökologie , vol.16 , pp. 31-33
    • Mesnage, R.1    Clair, E.2    Séralini, G.-E.3
  • 32
    • 18044373629 scopus 로고    scopus 로고
    • Chemical mixtures: considering the evolution of toxicology and chemical assessment
    • Monosson E. Chemical mixtures: considering the evolution of toxicology and chemical assessment. Environ. Health Perspect. 2005, 113:383-390.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 383-390
    • Monosson, E.1
  • 33
    • 27644553925 scopus 로고    scopus 로고
    • Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation
    • Peixoto F. Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation. Chemosphere 2005, 61:1115-1122.
    • (2005) Chemosphere , vol.61 , pp. 1115-1122
    • Peixoto, F.1
  • 34
    • 79960291279 scopus 로고    scopus 로고
    • Regulation of pituitary inhibin/activin subunits and follistatin gene expression by GnRH in female rats
    • Popovics P., Rekasi Z., Stewart A.J., Kovacs M. Regulation of pituitary inhibin/activin subunits and follistatin gene expression by GnRH in female rats. J. Endocrinol. 2011, 210:71-79.
    • (2011) J. Endocrinol. , vol.210 , pp. 71-79
    • Popovics, P.1    Rekasi, Z.2    Stewart, A.J.3    Kovacs, M.4
  • 37
    • 77950479726 scopus 로고    scopus 로고
    • Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology
    • Romano R.M., Romano M.A., Bernardi M.M., Furtado P.V., Oliveira C.A. Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology. Arch. Toxicol. 2010, 84:309-317.
    • (2010) Arch. Toxicol. , vol.84 , pp. 309-317
    • Romano, R.M.1    Romano, M.A.2    Bernardi, M.M.3    Furtado, P.V.4    Oliveira, C.A.5
  • 38
    • 42649119421 scopus 로고    scopus 로고
    • Characterisation of 3' transgene insertion site and derived mRNAs in MON810 YieldGard maize
    • Rosati A., Bogani P., Santarlasci A., Buiatti M. Characterisation of 3' transgene insertion site and derived mRNAs in MON810 YieldGard maize. Plant Mol. Biol. 2008, 67:271-281.
    • (2008) Plant Mol. Biol. , vol.67 , pp. 271-281
    • Rosati, A.1    Bogani, P.2    Santarlasci, A.3    Buiatti, M.4
  • 39
    • 34247253329 scopus 로고    scopus 로고
    • New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity
    • Séralini G.-E., Cellier D., de Vendomois J.S. New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity. Arch. Environ. Contam. Toxicol. 2007, 52:596-602.
    • (2007) Arch. Environ. Contam. Toxicol. , vol.52 , pp. 596-602
    • Séralini, G.-E.1    Cellier, D.2    de Vendomois, J.S.3
  • 42
    • 84856494518 scopus 로고    scopus 로고
    • Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review
    • Snell C., Bernheim A., Bergé J.-B., Kuntz M., Pascal G., Paris A., Ricroch A.E. Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food Chem. Toxicol. 2011, 50:1134-1148.
    • (2011) Food Chem. Toxicol. , vol.50 , pp. 1134-1148
    • Snell, C.1    Bernheim, A.2    Bergé, J.-B.3    Kuntz, M.4    Pascal, G.5    Paris, A.6    Ricroch, A.E.7
  • 46
    • 84857376217 scopus 로고    scopus 로고
    • Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats
    • U Rehman M., Sultana S. Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats. Mol. Cell. Biochem. 2011, 357:115-124.
    • (2011) Mol. Cell. Biochem. , vol.357 , pp. 115-124
    • U Rehman, M.1    Sultana, S.2
  • 48
    • 77952378742 scopus 로고    scopus 로고
    • Raloxifene and/or estradiol decrease anxiety-like and depressive-like behavior, whereas only estradiol increases carcinogen-induced tumorigenesis and uterine proliferation among ovariectomized rats
    • Walf A.A., Frye C.A. Raloxifene and/or estradiol decrease anxiety-like and depressive-like behavior, whereas only estradiol increases carcinogen-induced tumorigenesis and uterine proliferation among ovariectomized rats. Behav. Pharmacol. 2010, 21:231-240.
    • (2010) Behav. Pharmacol. , vol.21 , pp. 231-240
    • Walf, A.A.1    Frye, C.A.2
  • 49
    • 79958766576 scopus 로고    scopus 로고
    • 1H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system
    • 1H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system. J. Biomol. NMR 2011, 49:185-193.
    • (2011) J. Biomol. NMR , vol.49 , pp. 185-193
    • Weljie, A.M.1    Bondareva, A.2    Zang, P.3    Jirik, F.R.4
  • 50
    • 84878053750 scopus 로고    scopus 로고
    • WHO, World Health Statistics. WHO Press. (Last access August).
    • WHO, 2012. World Health Statistics. WHO Press. (Last access August).
    • (2012)
  • 52
    • 0034070443 scopus 로고    scopus 로고
    • Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans
    • Williams G.M., Kroes R., Munro I.C. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 2000, 31:117-165.
    • (2000) Regul. Toxicol. Pharmacol. , vol.31 , pp. 117-165
    • Williams, G.M.1    Kroes, R.2    Munro, I.C.3
  • 53
    • 79955063551 scopus 로고    scopus 로고
    • Transformation-induced mutations in transgenic plants: analysis and biosafety implications
    • Wilson A.K., Latham J.R., Steinbrecher R.A. Transformation-induced mutations in transgenic plants: analysis and biosafety implications. Biotechnol. Genet. Eng. Rev. 2006, 23:209-237.
    • (2006) Biotechnol. Genet. Eng. Rev. , vol.23 , pp. 209-237
    • Wilson, A.K.1    Latham, J.R.2    Steinbrecher, R.A.3
  • 55
    • 61649091386 scopus 로고    scopus 로고
    • Metabolic profiling of transgenic rice with cryIAc and sck genes: an evaluation of unintended effects at metabolic level by using GC-FID and GC-MS
    • Zhou J., Ma C., Xu H., Yuan K., Lu X., Zhu Z., Wu Y., Xu G. Metabolic profiling of transgenic rice with cryIAc and sck genes: an evaluation of unintended effects at metabolic level by using GC-FID and GC-MS. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2009, 877:725-732.
    • (2009) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.877 , pp. 725-732
    • Zhou, J.1    Ma, C.2    Xu, H.3    Yuan, K.4    Lu, X.5    Zhu, Z.6    Wu, Y.7    Xu, G.8
  • 56
    • 52049102730 scopus 로고    scopus 로고
    • Proteomics as a complementary tool for identifying unintended side effects occurring in transgenic maize seeds as a result of genetic modifications
    • Zolla L., Rinalducci S., Antonioli P., Righetti P.G. Proteomics as a complementary tool for identifying unintended side effects occurring in transgenic maize seeds as a result of genetic modifications. J. Proteome Res. 2008, 7:1850-1861.
    • (2008) J. Proteome Res. , vol.7 , pp. 1850-1861
    • Zolla, L.1    Rinalducci, S.2    Antonioli, P.3    Righetti, P.G.4


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