The structural biology of oestrogen metabolism

Journal of Steroid Biochemistry and Molecular Biology

Volumn 137, Issue , 2013, Pages 27-49

  Thomas, Mark P ^a   Potter, Barry V L ^a  

^a University of Bath   (United Kingdom)

Author keywords

17 Hydroxysteroid dehydrogenase; Aromatase; Oestrogen; Protein structure; Reaction mechanism; Sulfatase; Sulfotransferase

Indexed keywords

AROMATASE; CATECHOL METHYLTRANSFERASE; ESTRADIOL 17BETA DEHYDROGENASE; ESTROGEN; ESTROGEN SULFOTRANSFERASE; STERYL SULFATASE; SULFOTRANSFERASE 1A1;

ALPHA HELIX; AUTOOXIDATION; BETA SHEET; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CYTOPLASM; DISEASE COURSE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ESTROGEN SYNTHESIS; HORMONE STRUCTURE; HUMAN; HYDROGEN BOND; HYDROLYSIS; HYDROPHOBICITY; HYDROXYLATION; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOPHILICITY; OXIDATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW; STEROID HYDROXYLATION; STEROID METABOLISM; SULFONATION;

17Β-HSD; 17Β-HYDROXYSTEROID DEHYDROGENASE; 3′-PHOSPHOADENOSINE-5′-PHOSPHATE; 3′-PHOSPHOADENOSINE-5′-PHOSPHOSULFATE; 3,5-DINITROCATECHOL; 3-(((8R,9S,13S,14S,16R,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-16-YL)METHYL)BENZAMIDE; AROMATASE; CATECHOL-O-METHYL TRANSFERASE; COMT; DEHYDROEPIANDROSTERONE (SULFATE); DHEA(S); DHETNA; DNC; E1(S); E2(S); E2B; E3; E4; ER; ESTETROL; ESTRADIOL (SULFATE); ESTRIOL; ESTROGEN RECEPTOR; ESTRONE (SULFATE); FAD/FMN; FG; FLAVIN ADENINE DINUCLEOTIDE/FLAVIN MONONUCLEOTIDE; FORMYLGLYCINE; HFG(S); HYDROXYFORMYLGLYCINE (SULFATE); MB-COMT; MEMBRANE-BOUND COMT; NADP(+); NADPH; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDISED); NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED); O5′-[9-(3,17Β-DIHYDROXY-1,3,5(10)-ESTRATRIEN-16Β-YL)-NONANOYL]ADENOSINE; OESTROGEN; PAP; PAPS; PROTEIN STRUCTURE; REACTION MECHANISM; S-ADENOSYL METHIONINE; S-COMT; SAM; SDR; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; SOLUBLE COMT; SULFATASE; SULFOTRANSFERASE;

17-HYDROXYSTEROID DEHYDROGENASES; AMINO ACID SEQUENCE; ANIMALS; AROMATASE; BIOCATALYSIS; CATECHOL O-METHYLTRANSFERASE; ESTROGENS; HUMANS; HYDROXYLATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SEQUENCE HOMOLOGY, AMINO ACID; STERYL-SULFATASE; SULFOTRANSFERASES;

EID: 84886586747     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2012.12.014     Document Type: Review

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