Enzymology of human cytosolic sulfotransferases

FASEB Journal

Volumn 11, Issue 4, 1997, Pages 206-216

  Falany, Charles N ^a,b  

^a UNIVERSITY OF ALABAMA   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

drug metabolism; human; steroid; sulfation; xenobiotics

Indexed keywords

ARYL SULFOTRANSFERASE; ESTROGEN; HYDROXYSTEROID; PRASTERONE; SULFOTRANSFERASE;

BILE ACID METABOLISM; BIOTRANSFORMATION; CYTOSOL; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; HUMAN; PRIORITY JOURNAL; REVIEW; SULFATION; XENOBIOTIC METABOLISM;

EID: 0030996250     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.4.9068609     Document Type: Review

References (106)

1. Baumann, E. (1876) Ueber sulfosauren im harn. In Ber. Dtsch. Chem. Ges., p. 54
2. Jakoby, W. B., Sekura, R. D., Lyon, E. S., Marcus, C. J., and Wang, J.-L. (1980) Sulfotransferases. In Enzymatic Basis of Detoxication (Jakoby, W., B., ed) Vol. II, pp. 199-227. Academic Press, New York
3. Mulder, G. J. In Progress in Drug Metabolism (Bridges, J. W., and Chasseaud, L. F., eds) Vol. 8, pp. 35-100, Taylor & Francis, London (1984)
4. Mulder, G. J., and Jakoby, W. B. (1990) Sulfation. In Conjugation Reactions in Drug Metabolism (Mulder, G. J., ed) pp. 107-161, Taylor & Francis, London
5. McCall, J. M., Aiken, J. W., Chidester, C. G., DuCharme D. W., and Wendling M. G. (1983) Pyrimidine and triazine 3-oxide sulfates: A new family of vasodilators. J. Med. Chem. 26, 1791-1793
6. Waldon, D. J., Buhl, A. E., Baker, C. A., and Johnson, G. A. (1989) Is minoxidil sulfate the active metabolite for hair growth? J. Invest. Dermatol. 92, 538-545
7. Meisheri, K. D., Cipkus, L. A., and Taylor, C. J. (1988) Mechanism of action of minoxidil sulfate-induced vasodilatation: A role for increased K+ permeability. J. Pharm. Exp. Ther. 245, 751-760
8. Robbins, P. W., and Lippman, F. (1956) Identification of enzymatically active sulfate as adenosine-3′-phosphate-5′-pbosphosulfate. J. Am. Chem. Soc. 78, 2652-2654
9. Pang, K. S. (1990) Kinetics of conjugation reactions in eliminating organs. In Conjugation Reactions in Drug Metabolism (Mulder G. J., ed) pp. 5-39. Taylor & Francis, London
10. Morris, M. E., and Levy, G. (1983) Serum concentration and renal excretion by normal adults of inorganic sulfate after acetaminophen, ascorbic acid, and sodium sulfate. Clin. Pharm. Ther. 33, 529-535
11. Hendrix-Treacy, S., Wallace, S. M., Hindmarsh, K. W., Wyant, G. M., and Danilkewich, A. (1986) The effect of acetaminophen on its distribution and body stores of sulphate. Eur. J. Clin. Pharmacol. 30, 273-280
12. Huttner, W. B. (1988) Tyrosine sulfation and the secretory pathway. Annu. Rev. Physiol. 50, 363-376
13. Baeuerle, P. A., and Huttner, W. B. (1987) Tyrosine sulfation is a trans-Golgi specific modification. J. Cell Biol. 105, 2655-2664
14. Roth, J. A. (1986) Sulfoconjugation: role in neurotransmitter and secretory protein activity. Trends Pharmacol. Sci. 1, 404-407
15. Weinshilboum, R. M., Otterness, D. M., Aksoy, I. A., Wood, T. C., Her, C., and Raftogianis, H. B. (1996) Sulfotransferase molecular biology: cDNAs and genes. FASEB J. 11, 3-14
16. Wang, D. Y., Bulbrook, R. D., Sneddon, A., and Hamilton, T. (1967) The metabolic clearance rates of dehydroepiandrosterone, testosterone and their sulphate esters in man, rat and rabbit. J. Endocrinol. 38, 307-318
17. Feher, T., and Halmy, L. (1975) Dehydroepiandrosterone and dehydroepiandrosterone sulfate dynamics in obesity. Can. J. Biochem. 53, 215-222
18. Gurpide, E., Marks, C., de Ziegler, D., Berk, P., and Brandes, J. (1982) Asymmetric release of estrone and estradiol derived from labeled precursors in perfused human placentas. Amer. J. Obstet. Gynecol. 144, 551-554
19. Oentreich, N., Brind, J. L., Rizer, R. L., and Vogelman, J. H. (1984) Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J. Cin. Endocr. & Metab. 59, 551-555
20. Hornsby, P. J. (1995) Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline. Ann. N.Y. Acad. Sci. 774, 29-46
21. Longcope, C. (1995) Metabolism of dehydroepiandrosterone. Ann. N.Y. Acad. Sci. 774, 143-148
22. Mortola, J. F., and Yen, S. S. C. (1990) The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J. Clin. Endocr. & Metab. 71, 696-704
23. Schwartz, A. G., Witcomb, J. M., Nyce, J. W., Lewbart, M. L., and Pashko, L. L. (1988) Dehydroepiandrosterone and structural analogs; a new class of cancer chemopreventive agents. In Advances in Cancer Research, pp. 391-424, Academic Press, New York
24. Barrett-Conner, E., Khaw, K. T., and Yen, S. S. C. A (1986) prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease. New Engl. J. Med. 315, 1519-1524
25. Majewska, M. D. (1995) Neuronal actions of debydroepiandrosterone: Possible roles in brain development, aging, memory, and affect. Ann. N.Y. Acad. Sci. 774, 111-120
26. Otterness, D. M., Wieben, E. D., Wood, T. C., Watson, R. W. G., Madden, B. J., McGormick, D. J., and Weinshilboum, R. M. (1992) Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of the cDNA. Mol. Pharmacol. 41, 865-872
27. Falany, C. N., Vazquez, M. E., and Kalb, J. M. (1989) Purification and characterization of human liver dehydroepiandrosterone sulfotransferase. Arch. Biochem. Biophys. 260, 641-646
28. Comer, K. A., and Falany, C. N. (1992) Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenals. Mol. Pharmacol. 41, 645-651
29. Adams, J. B., and McDonald, D. (1979) Enzymatic synthesis of steroid sulphates. XII. Isolation of dehydroepiandrosterone sulphotransferase front human adrenals by affinity chromatography. Biochim. Biophys. Acta 567, 114-153
30. Kong, A.-N. T., Yang, L., Ma, M., Tao, D., and Bjornsson, T. D. (1992) Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. Biochem. Biophys. Res. Commun. 187, 448-454
31. Comer, K. A., Falany, J. L., and Falany, C. M. (1993) Cloning and expression of human liver dehydroepiandrosterone sulfotransferase. Biochem. J. 289, 233-240
32. Forbes, K. J., Hagen, M., Glatt, H., Hume, R., and Coughtrie, M. W. H. (1995) Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterization of the expressed enzyme. Mol. Cell. Endocrinol. 112, 53-60
33. Falany, C. N., Wheeler, J., Oh, T. S., and Falany, J. L. (1994) Steroid sulfation by expressed human cytosolic sulfotransferases. J. Steroid Biochem. Mol. Biol. 48, 369-375
34. Otterness, D., Mohrenweiser, H. W., Brandiff, B. F., and Weinshilboum, R. M. (1995) Dehydroepiandrosterone sulfotransferase gene (STD): Localization to human chromosome 19q13.3. Cytogenet. Cell Genet. 70, 15-52
35. Matsui, M., and Homma, H. (1994) Biochemistry and molecular biology of drug-metabolizing sulfotransferases. Int. J. Biochem. 26, 1237-1247
36. Barnes, S., Buchina, E. S., King, R. J., McBurnett, T., and Taylor, K. B. (1989) Bile acid sulfotransferase I from rat liver sulfates bile acids and 3-hydroxy steroids: purification, N-terminal amino acid sequence, and kinetic properties. J. Lipid Res. 30, 529-540
37. Homma, H., Nakagome, I., Kamakura, M., Hirota, M., Takahashi, M., and Matsui, M. (1994) Studies on rat hydroxysteroid sulfotransferase -immunochemistry, development and pI varients. Chem.-Bio. Interact. 92, 15-24
38. Falany, C. N., Wheeler, J., Coward, L., Keehan, D., Falany, J. L., and Barnes, S. (1992) Bioactivation of 7-hydroxymethyl-12-methylbenz(a)anthracene by rat liver bile acid sulfotransferase I. J. Biochem. Toxicol. 7, 241-248
39. Runge-Morris, M., and Wilusz, J. (1991) Age and gender-related gene expression of hydroxysteroid sulfotransferase-a in rat liver. Biochem. Biophys. Res. Commun. 175, 1051-1056
40. McAllister, J. M., and Hornsby, P. J. (1988) Dual regulation of 3β-hydroxysteroid dehydrogenase, 17X-hydroxylase, and dehydroepiandrosterone sulfotransferase by adenosine 3′,5′-monophosphate and activators of protein kinase C in cultured human adrenocortical cells. Endocrinology 122, 2012-2018
41. Obinata, K., Nemeth, A., Ellin, A., and Strandvik, B. (1994) Bile salt sulfotransferase activity in the liver of cholestatic infants. Scand. J. Clin. Lab. Invest. 54, 285-290
42. Aksoy, I. A., Otterness, D. M., and Weinshilboum, R. M. (1993) Cholesterol sulfation in human liver: catalysis by dehydropeiandrosterone sulfotransferase. Drug Metab. Dispos. 21, 268-276
43. Casey, M. L., and MacDonald, P. C. (1983) Sulfurylation of deoxycorticosterone in human fetal tissues. J. steroid Biochem. 19, 1403-1406
44. Stiehl, A., Czygan, P., Frohling, W., Liersch, M., and Kommerell, B. (1977) Sulphation of bile acids. In Liver and Bile (Bianchi, L., Gerok, W., and Stichinger, K., eds) pp. 129-138. Universily Park Press, Baltimore, Md.
45. Radominska, A., Comer, K. A., Ziminak, P., Falany, J., Iscan, M., and Falany, C. N. (1991) Human liver steroid sulfotransferase sulphates bile acids. Biochem. J. 273, 597-604
46. Barnes, S. (1991) Metabolism of bile acids. In Oxford Textbook of Clinical Hepatology (McIntyre, N., Benhamon, J. P., Bircher, J., Rizzeito, M., and Rhodes, J., eds) pp. 115-129, Oxford University Press, Oxford, U.K.
47. Whittemore, R. M., Pearce, L. B., and Roth, J. A. (1985) Purification and characterization of a dopamine-sulfating form of phenol sulfotransferase from human brain. Biochemistry 24, 2477-2482
48. Heroux, J. A., Falany, C. N., and Roth, J. A. (1989) Immunological characterization of human phenol sulfotransferase. Mol. Pharmacol. 36, 29-33
49. Aksoy, I. A., Sochorova, V., and Weinshilboum, R. M. (1993) Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variation. Clin. Pharmacol. & Ther. 54, 498-506
50. Barker, E. V., Hume, R., Hallas, A., and Coughtrie, M. W. H. (1994) Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterisation of the hepatic, renal and adrenal enzymes. Endocrinology 134, 982-989
51. Parker, C. R., Falany, C. N., Stockard, C. R., Stankovic, A. K., and Grizzle, W. E. (1993) Immunohistochemical localization of dehydroepiandrosterone sulfotransferase in human fetal tissues. J. Clin. Endocr. & Metab. 78, 234-236
52. Kennerson, A. R., McDonald, D. A., and Adams, J. B. (1983) Dehydroepiandrosterone sulfotransferase localization in human adrenal glands: a light and electron microscopic study. J. Clin. Endocr. & Metab. 56, 786-790
53. Falany, C. N., Comer, K. A., Dooley, T. P., and Glatt, H. (1995) Human dehydroepiandrosterone sulfotransferase: purification, molecular cloning, and characterization. Ann. N.Y. Acad. Sci. 774, 59-72
54. Baxter, J. D., and Tyrrell, J. B. (1987) The Adrenal Cortex. In Endocrinology and Metabolism (Felig, P., Baxter, J. D., Broadus, A. E., and Frohman, L. A., eds) pp. 511-632, McGraw-Hill, New York
55. Brooks, S. C., Christensen, C., Meyers, S., Corombos, J., and Pack, B. A. (1983) Endocrine implications of endometrial estrogen sulfurylation. In Steroids and Endometrial Cancer (Jasonni, V., M., et al., eds) pp. 145-155, Raven Press, New York
56. Roy, A. K. (1992) Regulation of steroid hormone action in target cells by specific hormone-inactivating enzymes. Proc. Soc. Exp. Biol. Med. 199, 265-272
57. Hobkirk, R. (1993) Steroid sulfation. 4, 69-74
58. Falany, C. N., Krasnykh, V., and Falany, J. L. (1995) Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. J. Steroid Biochem. Mol. Biol. 52, 529-539
59. Aksoy, I. A., Wood, T. C., and Weinshilboum, R. M. (1993) Human liver estrogen sulfotransferase (EST): polymerase chain reaction (PCR) cloning of cDNA. Biochem. Biophys. Res. Commun. 4, 181
60. Tseng, L., Mazella, J., Lee, L. U., and Stone, M. L. (1983) Estrogen sulfatase and estrogen sulfotransferase in human primary mammary carcinoma. J. Steroid Biochem. 19, 1413-1417
61. Grosso, D. S., and Way, D. L. (1984) Characterization of cytosolic estrogen sulfotransferase from RL95-2 endometrial cancer cells. J. Clin. Endocr. & Metab. 59, 829-833 (1984)
62. Her, C., Aksoy, I. A., and Weinshilboum, R. M. (1995) Human estrogen sulfotransferase gene (STE): Cloning, structure and chromosomal localization. Genomics 29, 16-23
63. Falany, J. L., and Falany, C. N. (1996) Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines. Cancer Res. 56. 1551-1555
64. Clarke, C. L., Adams, J. B., and Wren, B. G. (1982) Induction of estrogen sulfotransferase in the human endometrium by progesterone in organ culture. J. Clin. Endocrin. Metab. 55, 70-75
65. Pack, B. A., Tovar, R., Booth, E., and Brooks, S. C. (1979) The cyclic relationship of estrogen sulfurylation to the nuclear receptor level in human endometrial curettings. J. Clin. Endocr. & Metab. 48, 420424
66. Liu, H.-C., and Tseng, L. (1979) Estradiol metabolism in isolated human endometrial epithelial glands and stromal cells. Endocrinology 104, 1674-1694
67. Falany, J. L., and Falany, C. N. (1996) Regulation of estrogen sulfotransferase in human endometrial adenocarcinoma cells by progesterone. Endocrinology 137, 1395-1401
68. Hart, R. F., Renskers, K. J., Nelson, E. B., and Roth, J. A. (1979) Localization and characterization of phenol sulfotransferase in human platelets. Life Sci. 24, 125-130
69. Weinshilboum, R. M. (1986) Phenol Sulfotransferase in Humans: properties, regulation, and function. Federation Proc. 45, 2223-2228
70. Forbes-Bamforth, K. J., and Coughtrie, M. W. H. (1994) Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogens. Biochem. Biophys. Res. Commun. 198, 707-711
71. Veronese, M. E., Burgess, W., Zhu, X., and McManus, M. E. (1994) Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies. Biochem. J. 302, 497-502
72. Ozawa, S. H., Nagata, K., Shimada, M., Ueda, M., Tsuzuki, T., Yamazoe, Y., and Kata, R. (1995) Primary structures and properties of two related forms of aryl sulfotransferase in human liver. Pharmacogenetics 5, S135-S140
73. Kiehlbauch, C. C., Lam, Y. F., and Ringer, D. P. (1995) Homodimeric and heterodimeric aryl sulfotransferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene. J. Biol. Chem. 270, 18941-18947
74. Heroux, J. A., and Roth, J. A. (1988) Physical characterization of a monoamine-sulfating form of phenol sulfotransferase from human platelets. Mol. Pharmacol. 34, 29-33
75. Falany, C. N., Vazquez, M. E., Heroux, J. A., and Roth, J. A. (1990) Purification and characterization of human liver phenol-sulfating phenol sulfotransferase. Arch. Biochem. Biophys. 278, 312-318
76. Wood, T. C., Aksoy, I. A., Aksoy, S., and Weinshilboum, R. M. (1994) Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. Biochem. Biopys. Res. Commun. 198, 1119-1127
77. Ganguly, T. G., Krasnykh, V., and Falany, C. N. (1995) Bacterial expression and kinetic characterization of the human monoamine-sulfating form of phenol sulfotransferase. Drug Metab. Dispos. 23, 945-950
78. Glatt, H., Pauly, K., Czich, A., Falany, J. L., and Falany, C. N. (1995) Activation of benzylic alcohols to mutagens by rat and human sulfotransferases expressed in E. coli. Eur. J. Pharmacol. 293, 173-181
79. Dooley, T. P., Probst, P., Obermoeller, R. D., Siciliano, M. J., Doggett, N. V., Callen, D. F., Mitchison, H. M., and Mole, S. E. (1993) Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. Genomics 18, 440-443
80. Dooley, T. P., Mitchison, H. M., Munroe, P. B., Probst, P., Neal, M., Siciliano, M. J., Deng, Z., Doggett, N. A., Callen, D. F., Gardiner, R. M., and Mole, S. E. (1994) Mapping of two phenol sulphotransferase genes, STP and STM, to 16p: candidate genes for Batten disease. Biochem. Biophys. Res. Commun. 205, 482-489
81. Young, W. F., Gorman, C. A., and Weinshilboum, R. M. (1988) Triiodothyronine: a substrate for the thermostable and thermolabile forms of human phenol sulfotransferase. Endocrinology 122, 1816-1824
82. Hernandez, J. S., William, R., Watson, G., Wood, T. C., and Weinshilboum, R. M. (1992) Sulfation of estrone and 17β-estradiol in human liver. Drug Metab. Dispos. 20, 113-422
83. Falany, C. N., and Kerl, E. A. (1990) Sulfation of minoxidil by human liver phenol sulfotransferase. Biochem. Pharmacol. 40, 1027-1032
84. Walle, T., and Walle, U. K. (1992) Stereoselective sulfate conjugation of 4-hydroxypropranolol and terbutaline by human liver sulfotransferases. Drug Metab. Dispos. 20, 333-336
85. Walle, T., Walle, U. K., Thornburg, K. R., and Schey, K. L. (1993) Stereoselective sulfation of albuterol in humans. Drug Metab. Dispos. 21, 76-80
86. Walle, T., Walle, L. K., Schwed, J. A., Thornburg, K. R., Mathis, C. E., and Pesola, G. R. (1994) Human phenolsulfotransferases: chiral substrates and expression in Hep G2 cells. Chem.-Bio. Interact. 92, 47-55
87. Kudlecek, P. E., Clemens, D. L., and Anderson, R. J. (1995) Characterization of recombinant human liver thermolabile phenol sulfotransferase with minoxidil as the substrate. Biochem. Biophys. Res. Commun. 210, 363-369
88. Spaulding, S. W., Smith, T. J., Hinkel, P. M., Davis, F. B., Kung, M. P., and Roth, J. A. (1992) Studies of the biological activity of triiodothyronine sulfate. J. Clin. Endocr. & Metab. 74, 1062-1067
89. Visser, T. J. Role of sulfate in thyroid hormone sulfation. Eur. J. Endocrinol. 134, 12-14 (1996)
90. Reiter, C., Mwaluko, G., Dunnette, J., Van Loon, J., and Weinshilboum, R. (1983) Thermolabile and thermostable human platelet phenol sulfotransferase: Substrate specificity and physical separation. Naunyn-Schmied. Arch. Pharmacol. 324, 140-147
91. Weinshilboum, R. (1990) Sulfotransferase pharmacogenetics. Pharmacol. & Ther. 45, 93-107
92. Weinshilboum, R. (1988) Phenol sulfotransferase inheritance. Cell. Mol. Neurol. 8, 27-34
93. Reveley, A. M., Carter, S. M. B., Revely, M. A., and Sandler, M. A. (1982/1983) genetic study of platelet phenol sulfotransferase activity in normal and schizophrenic twins. J. Psychiatr. Res. 17, 303-307
94. Campbell, N. R. C., Van Loon, J. A., and Weinshilboum, R. M. (1987) Human liver phenol sulfotransferase: Assay conditions, biochemical properties and partial purification of isozymes of the thermostable form. Biochem. Pharmacol. 36, 1435-1446
95. Zhu, X., Veronese, M. E., Bernard, C. A., Sansom, L. N., and McManus, M. E. (1993) Identification of two human brain aryl sulfotransferase cDNAs. Biochem. Biophys. Res. Commun. 195, 120-127
96. Jones, A. L., Hagen, M., Coughtrie, M. W. H., Roberts, R. C., and Glatt, H. (1995) Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic varient of the phenol-sulfating form. Biochem. Biophys. Res. Commun. 208, 855-862
97. Sundaram, R. S., Van Loon, J. A., Tucker, R., and Weinshilboum, R. M. (1989) Sulfation pharmacogenetics: correlation of human platelet and small intestinal phenol sulfotransferase. Clin. Pharmacol. & Ther. 46, 501-509
98. Young, W. F., Jr., Laws, E. R., Sharbrough, F. W., and Weinshilboum, R. M. (1985) Human phenol sulfotransferase: correlation of brain and platelet activities. J. Neurochem. 44, 1131-1137
99. Moueli, M. E., and Kaufman, F. C. (1986) Sublobular distribution of transferases and hydrolases associated with glucuronide, sulfate and glutathione conjugation in human liver. Hepatology 6, 450-456
100. Zou, J., Pentney, R., and Roth, J. A. (1990) Immunohistochemical detection of phenol sulfotransferase-containing Neurons in human brain. J. Neurochem. 55, 1154-1158
101. Hume, R., and Coughtrie, M. W. H. (1994) Phenolsulfotransferase: localization in kidney during human embryonic and fetal development. Histochem. J. 26, 850-855
102. Hume, R., Barker, E. V., and Coughtrie, M. W. H. (1996) Differential expression and immunohistochemical localisation of the phenol and hydroxysteroid sulfotransferase enzyme families in the developing lung. Histochem. Cell Biol. 105, 147-152
103. Tyce, H. L., Sharpless, N. S., Kerr, F. W. L., and Muenter, M. D. (1980) Dopamine conjugate in cerebrospinal fluid. J. Neurochem. 34, 210-212
104. Roth, J. A., and Rivett, A. J. (1982) Does sulfate conjugation contribute to the metabolic inactivation of catecholamines in humans? Biochem. Pharmacol. 31, 3017-3021
105. Miller, E. C., Miller, J. A., Boberg, E. W., Delclos, K. B., Lai, C. C., Fennell, T. R., Wiseman, R. W., and Liem, A. (1985) Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver. Carcinogenesis (London) 11, 93-107
106. Glatt, H. Bioactivation of mutagens via sulfation. FASEB J. 11. In press