X-ray structure of human aromatase reveals an androgen-specific active site

Journal of Steroid Biochemistry and Molecular Biology

Volumn 118, Issue 4-5, 2010, Pages 197-202

  Ghosh, Debashis ^a,b   Griswold, Jennifer ^a   Erman, Mary ^a   Pangborn, Walter ^a  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Androstenedione; Aromatase; Aromatization; Cytochrome P450; Estrogen biosynthesis; Estrone; Human placenta; Membrane protein; X ray crystallography

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; AROMATASE;

AROMATIZATION; CATALYSIS; CONFERENCE PAPER; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MEMBRANE STRUCTURE; PLACENTA; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; FEMALE; ISOLATION AND PURIFICATION; METABOLISM; PREGNANCY; PROTEIN BINDING; PROTEIN CONFORMATION;

ANDROSTENEDIONE; AROMATASE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; MODELS, MOLECULAR; PLACENTA; PREGNANCY; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 77950348123     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.09.012     Document Type: Conference Paper

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