The molecular basis for the broad substrate specificity of human sulfotransferase 1A1

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Berger, Ilana ^a   Guttman, Chen ^a   Amar, Dotan ^a   Zarivach, Raz ^a   Aharoni, Amir ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE; ISOLEUCINE; LYSINE; PHENYLALANINE; SULFOTRANSFERASE 1A1; VALINE;

ALPHA HELIX; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; PROTEIN ENGINEERING; THERMOSTABILITY;

ARYLSULFOTRANSFERASE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; COUMARINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NITRILES; NITROPHENOLS; PROTEIN BINDING; PROTEIN CONFORMATION; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 80055109953     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026794     Document Type: Article

References (35)

1. Chapman E, Best MD, Hanson SR, Wong CH, (2004) Sulfotransferases: structure, mechanism, biological activity, inhibition, and synthetic utility. Angew Chem Int Ed Engl 43: 3526-3548.
2. Gamage N, Barnett A, Hempel N, Duggleby RG, Windmill KF, et al. (2006) Human sulfotransferases and their role in chemical metabolism. Toxicol Sci 90: 5-22.
3. Negishi M, Pedersen LG, Petrotchenko E, Shevtsov S, Gorokhov A, et al. (2001) Structure and function of sulfotransferases. Arch Biochem Biophys 390: 149-157.
4. Wang Y, Spitz MR, Tsou AM, Zhang K, Makan N, et al. (2002) Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis. Lung Cancer 35: 137-142.
5. Blanchard RL, Freimuth RR, Buck J, Weinshilboum RM, Coughtrie MW, (2004) A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics 14: 199-211.
6. Falany CN, (1997) Enzymology of human cytosolic sulfotransferases. Faseb J 11: 206-216.
7. Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, et al. (2007) Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol 5: e97.
8. Hempel N, Gamage N, Martin JL, McManus ME, (2007) Human cytosolic sulfotransferase SULT1A1. Int J Biochem Cell Biol 39: 685-689.
9. Kakuta Y, Pedersen LG, Carter CW, Negishi M, Pedersen LC, (1997) Crystal structure of estrogen sulphotransferase. Nat Struct Biol 4: 904-908.
10. Gamage NU, Duggleby RG, Barnett AC, Tresillian M, Latham CF, et al. (2003) Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. J Biol Chem 278: 7655-7662.
11. Gamage NU, Tsvetanov S, Duggleby RG, McManus ME, Martin JL, (2005) The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. J Biol Chem 280: 41482-41486.
12. Bidwell LM, McManus ME, Gaedigk A, Kakuta Y, Negishi M, et al. (1999) Crystal structure of human catecholamine sulfotransferase. J Mol Biol 293: 521-530.
13. Dajani R, Cleasby A, Neu M, Wonacott AJ, Jhoti H, et al. (1999) X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity. J Biol Chem 274: 37862-37868.
14. Wolfenden R, (1985) Affinities of organic compounds for solvent water; hydrophilic and hydrophobic character. J Chem Scie 94: 121-138.
15. Aharoni A, Griffiths AD, Tawfik DS, (2005) High-throughput screens and selections of enzyme-encoding genes. Curr Opin Chem Biol 9: 210-216.
16. Arnold FH, Wintrode PL, Miyazaki K, Gershenson A, (2001) How enzymes adapt: lessons from directed evolution. Trends Biochem Sci 26: 100-106.
17. Tao H, Cornish VW, (2002) Milestones in directed enzyme evolution. Curr Opin Chem Biol 6: 858-864.
18. Tokuriki N, Tawfik DS, (2009) Stability effects of mutations and protein evolvability. Curr Opin Struct Biol 19 (5): 596-604.
19. Bershtein S, Goldin K, Tawfik DS, (2008) Intense neutral drifts yield robust and evolvable consensus proteins. J Mol Biol 379: 1029-1044.
20. Herman A, Tawfik DS, (2007) Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating targeted libraries. Protein Eng Des Sel 20: 219-226.
21. Barnett AC, Tsvetanov S, Gamage N, Martin JL, Duggleby RG, et al. (2004) Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3. J Biol Chem 279: 18799-18805.
22. Alcolombri U, Elias M, Tawfik DS, (2011) Directed Evolution of Sulfotransferases and Paraoxonases by Ancestral Libraries. J Mol Biol 411 (4): 837-53.
23. Wang X, Minasov G, Shoichet BK, (2002) Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs. J Mol Biol 320: 85-95.
24. Bloom JD, Labthavikul ST, Otey CR, Arnold FH, (2006) Protein stability promotes evolvability. Proc Natl Acad Sci U S A 103: 5869-5874.
25. Otwinowski Z, Minor W, (1997) Processing of X-ray Diffraction Data Collected in Oscillation Mode. pp. 307-326 Methods in Enzymology, Volume 276: Macromolecular Crystallography, part A.
26. (1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50: 760-763.
27. Evans P, (2006) Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr 62: 72-82.
28. McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, et al. (2007) Phaser crystallographic software. J Appl Crystallogr 40: 658-674.
29. Murshudov GN, Vagin AA, Dodson EJ, (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 53: 240-255.
30. Emsley P, Cowtan K, (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60: 2126-2132.
31. Guex N, Peitsch MC, (1997) SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. Electrophoresis 18: 2714-2723.
32. DeLano WL, (2002) The PyMOL Molecular Graphics System. (DeLano Scientific, San Carlos) Release 0.99.
33. Baker NA, Sept D, Joseph S, Holst MJ, McCammon JA, (2001) Electrostatics of nanosystems: application to microtubules and the ribosome. Proc Natl Acad Sci U S A 98: 10037-10041.
34. Ho BK, Gruswitz F, (2008) HOLLOW: generating accurate representations of channel and interior surfaces in molecular structures. BMC Struct Biol 8: 49.
35. Zaccolo M, Williams DM, Brown DM, Gherardi E, (1996) An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues. J Mol Biol 255: 589-603.