Cofactor Hydrogen Bonding onto the Protein Main Chain is Conserved in the Short Chain Dehydrogenase/Reductase Family and Contributes to Nicotinamide Orientation

Journal of Biological Chemistry

Volumn 279, Issue 16, 2004, Pages 16778-16785

  Shi, Rong ^a   Lin, Sheng Xiang ^a  

^a UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; COMPLEXATION; HORMONES; HYDROGEN BONDS; PROTEINS;

BONDING INTERACTION; ESTROGENS;

BIOCHEMISTRY;

ANDROSTENEDIONE DERIVATIVE; HYDROGEN; HYDROXYL GROUP; LEUCINE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITROGEN; OXIDOREDUCTASE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE 17BETA DEHYDROGENASE; VALINE; WATER;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENSITY; ENZYME SPECIFICITY; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

17-HYDROXYSTEROID DEHYDROGENASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; NIACINAMIDE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1942437384     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313156200     Document Type: Article

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