Crystal structures of human sulfotransferases: Insights into the mechanisms of action and substrate selectivity

Expert Opinion on Drug Metabolism and Toxicology

Volumn 8, Issue 6, 2012, Pages 635-646

  Dong, Dong ^a   Ako, Roland ^a   Wu, Baojian ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Crystal structure; Phase II metabolism; Substrate inhibition; Sulfonation; SULTs

Indexed keywords

3 CYANO 7 HYDROXYCOUMARIN; 3 HYDROXYCOUMARIN; 4 NITROPHENOL; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; DAIDZEIN; ESTRADIOL; FLAVONE DERIVATIVE; FLAVONOL DERIVATIVE; GENISTEIN; HYDROGEN; ISOFLAVONE; KAEMPFEROL; PRASTERONE; RESVERATROL; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1A2; SULFOTRANSFERASE 1A3; SULFOTRANSFERASE 1B1; SULFOTRANSFERASE 1C1; SULFOTRANSFERASE 1C2; SULFOTRANSFERASE 1C3; SULFOTRANSFERASE 1E1; SULFOTRANSFERASE 2A1; SULFOTRANSFERASE 2B1; SULFOTRANSFERASE 2B1A; SULFOTRANSFERASE 2B1B; SULFOTRANSFERASE 4A1; SULFOTRANSFERASE M137; SULFOTRANSFERASE Y238; UNCLASSIFIED DRUG;

BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; HYDROGEN BOND; MOLECULAR DOCKING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; HUMANS; METABOLIC DETOXICATION, PHASE II; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOADENOSINE PHOSPHOSULFATE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFOTRANSFERASES;

EID: 84862073598     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2012.677027     Document Type: Review

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