Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D

Neuropharmacology

Volumn 77, Issue , 2014, Pages 120-130

  Sierksma, A S R ^a   Van Den Hove, D L A ^a,b   Pfau, F ^a   Philippens, M ^a   Bruno, O ^c   Fedele, E ^c   Ricciarelli, R ^c   Steinbusch, H W M ^a   Vanmierlo, T ^a   Prickaerts, J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

APP PS1; BDNF; Cognition; CREB; GEBR 7b; Phosphodiesterase inhibitors

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CORTICOSTERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GEBR 7B; GLYCOGEN SYNTHASE KINASE 3BETA; NEUROTROPHIN RECEPTOR P75; PHOSPHODIESTERASE IV INHIBITOR; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPTOPHYSIN; TAU PROTEIN; UNCLASSIFIED DRUG;

AFFECT; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE MODEL; ENZYME INHIBITION; FEMALE; FORCED SWIMMING TEST; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY CONSOLIDATION; MOUSE; NERVE CELL PLASTICITY; NESTING; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SPATIAL MEMORY; SUGAR INTAKE; SYNAPSE; SYNAPTIC DENSITY; TREATMENT DURATION;

AD; ALZHEIMER'S DISEASE; AMYLOID-Β; ANALYSIS OF VARIANCE; ANOVA; APP/PS1; AΒ; BDNF; BRAIN-DERIVED NEUROTROPHIC FACTOR; CAMP; CAMP RESPONSE ELEMENT-BINDING PROTEIN; COGNITION; CREB; CYCLIC ADENOSINE MONOPHOSPHATE; D2; DIMETHYLSULPHOXIDE; DISCRIMINATION INDEX OF THE OLT; DMSO; E; ELEVATED ZERO MAZE; EXPLORATION TIME DURING A TRIAL OF THE OLT; EZM; FORCED SWIM TEST; FST; GEBR-7B; GLYCOGEN SYNTHASE KINASE 3Β; GSK3Β; HPA AXIS; HYPOTHALAMO-PITUITARY-ADRENAL AXIS; LONG-TERM POTENTIATION; LTP; M; MONTHS OF AGE; OBJECT LOCATION TASK; OF; OLT; OPEN FIELD; P75 NEUROTROPHIN RECEPTOR; P75(NTR); PCREB; PDE; PDE-IS; PGSK3Β-SER9; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATED CREB; PHOSPHORYLATED GSK3Β AT SERINE 9; PKA; POSTSYNAPTIC DENSITY 95; PROTEIN KINASE A; PSD95; S.C.; SEM; SIT; STANDARD ERROR OF THE MEAN; SUBCUTANEOUS; SUCROSE INTAKE TEST; T; TRIAL OF THE OLT; TRKB; TROPOMYOSIN-RELATED KINASE B; WILD-TYPE; WT; Y-MAZE; Y-MAZE SPONTANEOUS ALTERNATION TEST;

ALZHEIMER DISEASE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DISEASE MODELS, ANIMAL; GUANYLATE KINASE; HIPPOCAMPUS; IMINES; MAZE LEARNING; MEMBRANE PROTEINS; MEMORY; MICE; MORPHOLINES; PHOSPHODIESTERASE 4 INHIBITORS; PHOSPHORYLATION;

EID: 84886247782     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.09.015     Document Type: Article

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