Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 299, Issue 4, 2010, Pages

  Zhu, Bing ^a   Zhang, Li ^a   Creighton, Judy ^a   Alexeyev, Mikhail ^a,b   Strada, Samuel J ^a   Stevens, Troy ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Adenylyl cyclase; Cytoskeleton; Phosphodiesterase

Indexed keywords

ADENYLATE CYCLASE; ALANINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; PEPTIDE; PHOSPHODIESTERASE 4D4; PHOSPHODIESTERASE IV; RECOMBINANT PROTEIN; SERINE; TAU PROTEIN; TAU S214A; TAU40 PROTEIN; UNCLASSIFIED DRUG; CYCLIC AMP PHOSPHODIESTERASE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL COMPARTMENTALIZATION; CELL DISRUPTION; CELL FUNCTION; CONTROLLED STUDY; DEPOLYMERIZATION; ENDOTHELIUM CELL; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; MICROTUBULE; MICROTUBULE ASSEMBLY; MICROTUBULE REORGANIZATION; NONHUMAN; PERMEABILITY BARRIER; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; WILD TYPE; ANIMAL; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CYTOLOGY; CYTOSOL; DRUG EFFECTS; ENZYME IMMUNOASSAY; GENETICS; HUMAN; IMMUNOPRECIPITATION; LUNG; METABOLISM; MUTATION; PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; VASCULAR ENDOTHELIUM; VASCULARIZATION; WESTERN BLOTTING;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSOL; ENDOTHELIUM, VASCULAR; FORSKOLIN; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; LUNG; MICROTUBULES; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; TAU PROTEINS; COLFORSIN;

EID: 77957373809     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00431.2009     Document Type: Article

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